Aliases for PRG4 Gene
- Proteoglycan 4 2 3 3 5
- Lubricin 2 3 4
- Articular Superficial Zone Protein 2 3
- Megakaryocyte Stimulating Factor 2 3
- Superficial Zone Proteoglycan 3 4
- MSF 3 4
- SZP 3 4
- Proteoglycan 4, (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein, Camptodactyly, Arthropathy, Coxa Vara, Pericarditis Syndrome) 2
- Camptodactyly, Arthropathy, Coxa Vara, Pericarditis Syndrome 2
External Ids for PRG4 Gene
Previous HGNC Symbols for PRG4 Gene
Previous GeneCards Identifiers for PRG4 Gene
The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for PRG4 Gene
PRG4 (Proteoglycan 4) is a Protein Coding gene. Diseases associated with PRG4 include Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome and Pericarditis. Among its related pathways are ERK Signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity and polysaccharide binding. An important paralog of this gene is VTN.
UniProtKB/Swiss-Prot for PRG4 Gene
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.
Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.