Aliases for PRG3 Gene

Aliases for PRG3 Gene

  • Proteoglycan 3, Pro Eosinophil Major Basic Protein 2 2 3 5
  • Proteoglycan 3 2 3 4
  • Eosinophil Major Basic Protein Homolog 3 4
  • Prepro-Major Basic Protein Homolog 3 4
  • Prepro-MBPH 3 4
  • MBPH 3 4
  • MBP2 3

External Ids for PRG3 Gene

Previous GeneCards Identifiers for PRG3 Gene

  • GC11M059538
  • GC11M058657
  • GC11M057395
  • GC11M056919
  • GC11M056900
  • GC00U921626
  • GC11M057144
  • GC11M053493

Summaries for PRG3 Gene

GeneCards Summary for PRG3 Gene

PRG3 (Proteoglycan 3, Pro Eosinophil Major Basic Protein 2) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is PRG2.

UniProtKB/Swiss-Prot Summary for PRG3 Gene

  • Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils.

Additional gene information for PRG3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRG3 Gene

Genomics for PRG3 Gene

GeneHancer (GH) Regulatory Elements for PRG3 Gene

Promoters and enhancers for PRG3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J057381 Promoter 0.3 EPDnew 750.6 0.0 -20 0.1 PRG3 PRG2
GH11J057637 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.5 -258.2 -258203 4.8 CTCF MLX RBPJ NR2F1 NR2F6 MIXL1 MYC NFYC RAD21 POLR2A CLP1 ENSG00000254602 MIR130A TIMM10 ZDHHC5 ENSG00000269570 UBE2L6 RPS4XP13 SERPING1 MED19
GH11J057457 Enhancer 1.1 FANTOM5 ENCODE 1.4 -76.6 -76619 1.3 CTCF L3MBTL2 RAD21 SP1 MAFK KAT8 ZNF644 DPF2 GLIS2 ARID2 SERPING1 SLC43A1 PRG3 RTN4RL2 RN7SKP259 lnc-RTN4RL2-1
GH11J057383 Enhancer 0.6 Ensembl 0.6 -2.4 -2353 0.6 SMARCE1 SMARCA4 ZNF639 MTA1 REST ZNF740 HDAC1 EP300 SOX6 MTA3 SLC43A3 ENSG00000254979 RN7SKP259 RTN4RL2 PRG2 P2RX3 SSRP1 ENSG00000254602 CLP1 YPEL4
GH11J057377 Enhancer 0.3 Ensembl 0.6 +3.2 3249 1.8 RFX1 RARA RF01045-026 RTN4RL2 ENSG00000254979 SLC43A3 P2RX3 SSRP1 PRG2 TNKS1BP1 ENSG00000254662 RN7SKP259
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRG3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRG3 gene promoter:
  • AML1a
  • POU2F1

Genomic Locations for PRG3 Gene

Genomic Locations for PRG3 Gene
chr11:57,376,769-57,381,150
(GRCh38/hg38)
Size:
4,382 bases
Orientation:
Minus strand
chr11:57,144,242-57,148,623
(GRCh37/hg19)
Size:
4,382 bases
Orientation:
Minus strand

Genomic View for PRG3 Gene

Genes around PRG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRG3 Gene

Proteins for PRG3 Gene

  • Protein details for PRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Y8-PRG3_HUMAN
    Recommended name:
    Proteoglycan 3
    Protein Accession:
    Q9Y2Y8

    Protein attributes for PRG3 Gene

    Size:
    225 amino acids
    Molecular mass:
    25406 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRG3 Gene

Post-translational modifications for PRG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRG3 Gene

Domains & Families for PRG3 Gene

Gene Families for PRG3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRG3 Gene

GenScript: Design optimal peptide antigens:
  • Prepro-major basic protein homolog (PRG3_HUMAN)
genes like me logo Genes that share domains with PRG3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRG3 Gene

Function for PRG3 Gene

Molecular function for PRG3 Gene

UniProtKB/Swiss-Prot Function:
Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils.

Phenotypes From GWAS Catalog for PRG3 Gene

Gene Ontology (GO) - Molecular Function for PRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030021 extracellular matrix structural constituent conferring compression resistance RCA 25037231
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with PRG3: view
genes like me logo Genes that share phenotypes with PRG3: view

Animal Models for PRG3 Gene

MGI Knock Outs for PRG3:
  • Prg3 Prg3<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for PRG3

CRISPR Products

miRNA for PRG3 Gene

miRTarBase miRNAs that target PRG3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRG3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRG3 Gene

Localization for PRG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRG3 Gene

Cytoplasmic granule. Note=Localized to the eosinophil secondary granule.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRG3 gene
Compartment Confidence
extracellular 5
peroxisome 1
plasma membrane 0

Gene Ontology (GO) - Cellular Components for PRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0035580 specific granule lumen TAS --
GO:0062023 collagen-containing extracellular matrix HDA 25037231
GO:1904724 tertiary granule lumen TAS --
genes like me logo Genes that share ontologies with PRG3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRG3 Gene

Pathways & Interactions for PRG3 Gene

PathCards logo

SuperPathways for PRG3 Gene

genes like me logo Genes that share pathways with PRG3: view

Pathways by source for PRG3 Gene

3 Reactome pathways for PRG3 Gene

Gene Ontology (GO) - Biological Process for PRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001694 histamine biosynthetic process IDA 10318872
GO:0006955 immune response IEA --
GO:0017148 negative regulation of translation IDA 10318872
GO:0019370 leukotriene biosynthetic process IDA 10318872
GO:0042119 neutrophil activation IDA 10318872
genes like me logo Genes that share ontologies with PRG3: view

No data available for SIGNOR curated interactions for PRG3 Gene

Drugs & Compounds for PRG3 Gene

No Compound Related Data Available

Transcripts for PRG3 Gene

mRNA/cDNA for PRG3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRG3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRG3 Gene

No ASD Table

Relevant External Links for PRG3 Gene

GeneLoc Exon Structure for
PRG3
ECgene alternative splicing isoforms for
PRG3

Expression for PRG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRG3 Gene

This gene is overexpressed in Whole Blood (x50.8).

Protein differential expression in normal tissues from HIPED for PRG3 Gene

This gene is overexpressed in Neutrophil (33.3), Rectum (8.7), and Esophagus (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRG3 Gene



NURSA nuclear receptor signaling pathways regulating expression of PRG3 Gene:

PRG3

SOURCE GeneReport for Unigene cluster for PRG3 Gene:

Hs.251386

mRNA Expression by UniProt/SwissProt for PRG3 Gene:

Q9Y2Y8-PRG3_HUMAN
Tissue specificity: Expressed in bone marrow. Not detected in placenta.

Evidence on tissue expression from TISSUES for PRG3 Gene

  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with PRG3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRG3 Gene

Orthologs for PRG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRG3 33 32
  • 99.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRG3 33 32
  • 76.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prg3 32
  • 74.96 (n)
mouse
(Mus musculus)
Mammalia Prg3 17 33 32
  • 73.97 (n)
cow
(Bos Taurus)
Mammalia PRG3 33 33
  • 59 (a)
OneToMany
-- 33
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 50 (a)
ManyToMany
-- 33
  • 49 (a)
ManyToMany
-- 33
  • 45 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 42 (a)
ManyToMany
-- 33
  • 32 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 33
  • 33 (a)
OneToMany
Species where no ortholog for PRG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRG3 Gene

ENSEMBL:
Gene Tree for PRG3 (if available)
TreeFam:
Gene Tree for PRG3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRG3: view image

Paralogs for PRG3 Gene

Paralogs for PRG3 Gene

(2) SIMAP similar genes for PRG3 Gene using alignment to 1 proteins:

  • PRG3_HUMAN

Pseudogenes.org Pseudogenes for PRG3 Gene

genes like me logo Genes that share paralogs with PRG3: view

Variants for PRG3 Gene

Sequence variations from dbSNP and Humsavar for PRG3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000018362 -- 57,381,978(-) G/A/T upstream_transcript_variant
rs1000603115 -- 57,381,730(-) GG/G upstream_transcript_variant
rs1001496687 -- 57,378,398(-) G/A intron_variant
rs1003572712 -- 57,380,008(-) G/A intron_variant
rs1003942659 -- 57,380,036(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRG3 Gene

Variant ID Type Subtype PubMed ID
esv2585995 CNV insertion 19546169
esv29013 CNV gain 19812545
nsv555102 CNV loss 21841781

Variation tolerance for PRG3 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRG3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRG3 Gene

Disorders for PRG3 Gene

Additional Disease Information for PRG3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PRG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRG3 Gene

Publications for PRG3 Gene

  1. Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes. (PMID: 11170744) Plager DA … Gleich GJ (Genomics 2001) 2 3 4 23 56
  2. A novel and highly divergent homolog of human eosinophil granule major basic protein. (PMID: 10318872) Plager DA … Gleich GJ (The Journal of biological chemistry 1999) 2 3 4 56
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 56

Products for PRG3 Gene

Sources for PRG3 Gene