The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be invol... See more...

Aliases for PRG2 Gene

Aliases for PRG2 Gene

  • Proteoglycan 2, Pro Eosinophil Major Basic Protein 2 3 5
  • Proteoglycan 2, Bone Marrow (Natural Killer Cell Activator, Eosinophil Granule Major Basic Protein) 2 3
  • Eosinophil Major Basic Protein 2 3
  • Bone Marrow Proteoglycan 3 4
  • BMPG 3 4
  • MBP 3 4
  • Eosinophil Granule Major Basic Protein 3
  • Natural Killer Cell Activator 3
  • Proteoglycan 2 Preproprotein 3
  • Proteoglycan 2 4
  • ProMBP 3
  • MBP1 3

External Ids for PRG2 Gene

Previous GeneCards Identifiers for PRG2 Gene

  • GC11M059548
  • GC11M058668
  • GC11M057405
  • GC11M056930
  • GC11M056911
  • GC19M000764
  • GC11M057154
  • GC11M053504

Summaries for PRG2 Gene

Entrez Gene Summary for PRG2 Gene

  • The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

GeneCards Summary for PRG2 Gene

PRG2 (Proteoglycan 2, Pro Eosinophil Major Basic Protein) is a Protein Coding gene. Diseases associated with PRG2 include Hypereosinophilic Syndrome and Dermographism, Familial. Among its related pathways are Innate Immune System and ERK Signaling. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and heparin binding. An important paralog of this gene is ENSG00000254979.

UniProtKB/Swiss-Prot Summary for PRG2 Gene

  • Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Gene Wiki entry for PRG2 Gene

Additional gene information for PRG2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRG2 Gene

Genomics for PRG2 Gene

GeneHancer (GH) Regulatory Elements for PRG2 Gene

Promoters and enhancers for PRG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRG2 gene promoter:
  • AML1a

Genomic Locations for PRG2 Gene

Genomic Locations for PRG2 Gene
chr11:57,386,780-57,390,657
(GRCh38/hg38)
Size:
3,878 bases
Orientation:
Minus strand
chr11:57,154,267-57,158,130
(GRCh37/hg19)
Size:
3,864 bases
Orientation:
Minus strand

Genomic View for PRG2 Gene

Genes around PRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRG2 Gene

Proteins for PRG2 Gene

  • Protein details for PRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13727-PRG2_HUMAN
    Recommended name:
    Bone marrow proteoglycan
    Protein Accession:
    P13727
    Secondary Accessions:
    • A6XMW0
    • B2R5I1
    • P81448
    • Q14227
    • Q6ICT2

    Protein attributes for PRG2 Gene

    Size:
    222 amino acids
    Molecular mass:
    25206 Da
    Quaternary structure:
    • In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.
    Miscellaneous:
    • Binds heparin. Does not bind calcium.

    Three dimensional structures from OCA and Proteopedia for PRG2 Gene

    Alternative splice isoforms for PRG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRG2 Gene

Post-translational modifications for PRG2 Gene

  • Nitrated.
  • Glycosylation at Thr23, Ser24, Thr25, Thr34, Ser62, and Asn86
  • Modification sites at PhosphoSitePlus

Other Protein References for PRG2 Gene

No data available for DME Specific Peptides for PRG2 Gene

Domains & Families for PRG2 Gene

Gene Families for PRG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRG2 Gene

GenScript: Design optimal peptide antigens:
  • Proteoglycan 2 (PRG2_HUMAN)
genes like me logo Genes that share domains with PRG2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRG2 Gene

Function for PRG2 Gene

Molecular function for PRG2 Gene

UniProtKB/Swiss-Prot Function:
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Phenotypes From GWAS Catalog for PRG2 Gene

Gene Ontology (GO) - Molecular Function for PRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IEA --
GO:0030021 extracellular matrix structural constituent conferring compression resistance RCA 25037231
GO:0030246 carbohydrate binding IEA,TAS --
genes like me logo Genes that share ontologies with PRG2: view
genes like me logo Genes that share phenotypes with PRG2: view

Animal Models for PRG2 Gene

MGI Knock Outs for PRG2:
  • Prg2 Prg2<tm1Nal>
  • Prg2 Prg2<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for PRG2 Gene

miRTarBase miRNAs that target PRG2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRG2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRG2 Gene

Localization for PRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRG2 Gene

Bone marrow proteoglycan: Secreted. Note=The proform is secreted.
Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRG2 gene
Compartment Confidence
extracellular 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0062023 collagen-containing extracellular matrix HDA 25037231
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with PRG2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRG2 Gene

Pathways & Interactions for PRG2 Gene

PathCards logo

SuperPathways for PRG2 Gene

SuperPathway Contained pathways
1 Integrin Pathway
.67
.67
.56
.56
.50
.38
2 ERK Signaling
.61
.61
.58
.51
.49
3 Innate Immune System
4 Phospholipase-C Pathway
.56
.56
5 Allograft rejection
.44
genes like me logo Genes that share pathways with PRG2: view

Pathways by source for PRG2 Gene

3 Reactome pathways for PRG2 Gene
1 KEGG pathway for PRG2 Gene
13 Qiagen pathways for PRG2 Gene
  • ERK Signaling
  • FAK1 Signaling
  • GnRH Signaling
  • ILK Signaling
  • Inhibition of Angiogenesis by TSP1

Gene Ontology (GO) - Biological Process for PRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0042742 defense response to bacterium IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with PRG2: view

No data available for SIGNOR curated interactions for PRG2 Gene

Drugs & Compounds for PRG2 Gene

(28) Drugs for PRG2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7773
Chymopapain Approved, Withdrawn Pharma Target, degradation 0
Sargramostim Approved, Investigational Pharma Target 1057

(16) Additional Compounds for PRG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRG2: view

Transcripts for PRG2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRG2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRG2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:
SP3:

Relevant External Links for PRG2 Gene

GeneLoc Exon Structure for
PRG2
ECgene alternative splicing isoforms for
PRG2

Expression for PRG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRG2 Gene

This gene is overexpressed in Whole Blood (x31.2).

Protein differential expression in normal tissues from HIPED for PRG2 Gene

This gene is overexpressed in Neutrophil (46.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRG2 Gene



Protein tissue co-expression partners for PRG2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRG2 Gene:

PRG2

SOURCE GeneReport for Unigene cluster for PRG2 Gene:

Hs.512633

mRNA Expression by UniProt/SwissProt for PRG2 Gene:

P13727-PRG2_HUMAN
Tissue specificity: High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.

Evidence on tissue expression from TISSUES for PRG2 Gene

  • Bone marrow(4.5)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with PRG2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRG2 Gene

Orthologs for PRG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRG2 32
  • 99.1 (n)
-- 33
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Prg2 32
  • 68.47 (n)
mouse
(Mus musculus)
Mammalia Prg2 17 33 32
  • 67.72 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 52 (a)
ManyToMany
-- 33
  • 51 (a)
ManyToMany
-- 33
  • 47 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 43 (a)
ManyToMany
-- 33
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 33
  • 33 (a)
OneToMany
Species where no ortholog for PRG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRG2 Gene

ENSEMBL:
Gene Tree for PRG2 (if available)
TreeFam:
Gene Tree for PRG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRG2: view image

Paralogs for PRG2 Gene

Paralogs for PRG2 Gene

(2) SIMAP similar genes for PRG2 Gene using alignment to 2 proteins:

  • PRG2_HUMAN
  • A6XMW0_HUMAN
genes like me logo Genes that share paralogs with PRG2: view

Variants for PRG2 Gene

Sequence variations from dbSNP and Humsavar for PRG2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs142359007 A colorectal cancer sample 57,387,829(-) G/A coding_sequence_variant, missense_variant
rs1000878535 -- 57,387,723(-) T/C intron_variant
rs1002892513 -- 57,390,110(-) C/T intron_variant
rs1003107304 -- 57,391,750(-) C/G upstream_transcript_variant
rs1003174975 -- 57,391,273(-) T/C upstream_transcript_variant

Variation tolerance for PRG2 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRG2 Gene

Disorders for PRG2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for PRG2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypereosinophilic syndrome
  • hypereosinophilic syndrome, idiopathic
dermographism, familial
  • dermodistortive urticaria
eosinophilic colitis
asthma
  • asthma, susceptibility to
rhinitis
  • runny nose
- elite association - COSMIC cancer census association via MalaCards
Search PRG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRG2

genes like me logo Genes that share disorders with PRG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRG2 Gene

Publications for PRG2 Gene

  1. Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins. (PMID: 1565101) Yoshimatsu K … Osawa T (Molecular immunology 1992) 2 3 4 23 56
  2. Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity. (PMID: 11319227) Swaminathan GJ … Acharya KR (The Journal of biological chemistry 2001) 3 4 23 56
  3. Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. (PMID: 7531438) Li MS … Spry CJ (The Biochemical journal 1995) 3 4 23 56
  4. Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta. (PMID: 7526035) Bonno M … Gleich GJ (Laboratory investigation; a journal of technical methods and pathology 1994) 3 4 23 56
  5. Cloning and sequence analysis of the human gene encoding eosinophil major basic protein. (PMID: 2323577) Barker RL … Gleich GJ (Gene 1990) 3 4 23 56

Products for PRG2 Gene

Sources for PRG2 Gene