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The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrim... See more...
Aliases for PREX1 Gene
Aliases for PREX1 Gene
- Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 2 3 5
- Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 1 Protein 3 4
- PtdIns(3,4,5)-Dependent Rac Exchanger 1 3 4
- PIP3 Dependent Rac Exchange Factor 1 2 3
- KIAA1415 2 4
- P-REX1 2 3
- Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 2
- P-Rex1 4
- PREX1 5
External Ids for PREX1 Gene
- HGNC: 32594
- Entrez Gene: 57580
- Ensembl: ENSG00000124126
- OMIM: 606905
- UniProtKB: Q8TCU6
Previous GeneCards Identifiers for PREX1 Gene
- GC20M047879
- GC20M047926
- GC20M046674
- GC20M047240
- GC20M043990
Summaries for PREX1 Gene
-
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for PREX1 Gene
PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1) is a Protein Coding gene. Diseases associated with PREX1 include Gastric Tubular Adenocarcinoma. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include enzyme binding and phospholipid binding. An important paralog of this gene is PREX2.
UniProtKB/Swiss-Prot Summary for PREX1 Gene
-
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Additional gene information for PREX1 Gene
- HGNC(32594)
- Entrez Gene(57580)
- Ensembl(ENSG00000124126)
- OMIM(606905)
- UniProtKB(Q8TCU6)
- Open Targets Platform(ENSG00000124126)
- Monarch Initiative
- Search for PREX1 at DataMed
- Search for PREX1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PREX1 Gene
Genomics for PREX1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PREX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PREX1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PREX1
- Top Transcription factor binding sites by QIAGEN in the PREX1 gene promoter:
-
- AML1a
- AREB6
- Olf-1
- PPAR-gamma1
- PPAR-gamma2
- USF-1
- USF-1:USF-2
- USF1
- USF2
Genomic Locations for PREX1 Gene
Genomic Locations for PREX1 Gene
- chr20:48,624,252-48,827,999
- (GRCh38/hg38)
- Size:
- 203,748 bases
- Orientation:
- Minus strand
- chr20:47,240,790-47,444,420
- (GRCh37/hg19)
- Size:
- 203,631 bases
- Orientation:
- Minus strand
Genomic View for PREX1 Gene
Genes around PREX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.13 by HGNC
- 20q13.13 by Entrez Gene
- 20q13.13 by Ensembl
PREX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PREX1 Gene
Proteins for PREX1 Gene
-
Protein details for PREX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TCU6-PREX1_HUMAN
- Recommended name:
- Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
- Protein Accession:
- Q8TCU6
- E1P5X9
- Q5JS95
- Q5JS96
- Q69YL2
- Q7Z2L9
- Q9BQH0
- Q9BX55
- Q9H4Q6
- Q9P2D2
- Q9UGQ4
Protein attributes for PREX1 Gene
- Size:
- 1659 amino acids
- Molecular mass:
- 186203 Da
- Quaternary structure:
-
- Interacts preferentially with RAC2. Interacts with RAC1. Interacts with AUTS2.
Three dimensional structures from OCA and Proteopedia for PREX1 Gene
Protein Expression for PREX1 Gene
Post-translational modifications for PREX1 Gene
Other Protein References for PREX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences PREX1 / P-REX1 Antibody
- G Biosciences Immunotag™ PREX1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for PREX1
- Novus Biologicals Antibodies for PREX1
-
Abcam antibodies for PREX1
- Invitrogen Antibodies for PREX1 (AFLGC-PREX1)
-
Boster Bio Antibodies for PREX1
- Sino Biological Antibodies for PREX1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PREX1
- Origene Custom Protein Services for PREX1
- Novus Biologicals proteins for PREX1
Assay Products
- antibodies-online: Show 7 available PREX1 Elisa Kits ranked by validation data
- Compare Top PREX1 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for PREX1
No data available for DME Specific Peptides for PREX1 Gene
Domains & Families for PREX1 Gene
Gene Families for PREX1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PREX1 Gene
- InterPro:
- Blocks:
-
- PDZ/DHR/GLGF domain
- Pleckstrin-like
- DH domain
- Pleckstrin putative G-protein interacting domain
- ProtoNet:
Suggested Antigen Peptide Sequences for PREX1 Gene
- GenScript: Design optimal peptide antigens:
-
- Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PREX1 Gene
Function for PREX1 Gene
Molecular function for PREX1 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Phenotypes From GWAS Catalog for PREX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | -- |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | TAS | 12123595 |
| GO:0005096 | GTPase activator activity | TAS | 12123595 |
| GO:0005515 | protein binding | IPI | 17565979 |
| GO:0005543 | phospholipid binding | IDA | 11955434 |
Phenotypes for PREX1 Gene
- MGI mutant phenotypes for PREX1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PREX1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability ratio
- Increased G1 DNA content
- Increased shRNA abundance (Z-score > 2)
- Downregulation of Wnt pathway after Wnt3A stimulation
- Increased epidermal growth factor receptor (EGFR) surface abundance
- Decreased shRNA abundance (Z-score < -2)
- Decreased epidermal growth factor (EGF) endocytosis
- Increased homologous recombination repair frequency
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PREX1 - Select products 50% OFF >
- * PREX1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PREX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PREX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PREX1
miRNA for PREX1 Gene
- miRTarBase miRNAs that target PREX1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PREX1
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Clone Products
- Applied Biological Materials (abm): Clones for PREX1 - Select products 50% OFF >
- * PREX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PREX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PREX1
Cell Line Products
-
Horizon Cell Lines for PREX1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PREX1 Gene
Localization for PREX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PREX1 Gene
- Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| nucleus | 3 |
| cytoskeleton | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IBA,TAS | 12123595 |
| GO:0016020 | membrane | IEA | -- |
| GO:0030426 | growth cone | IEA | -- |
Pathways & Interactions for PREX1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling |
.36
|
|
| 2 | Signaling by GPCR | ||
| 3 | Ca, cAMP and Lipid Signaling | ||
| 4 | Cytoskeletal Signaling | ||
| 5 | CCR5 Pathway in Macrophages | ||
Pathways by source for PREX1 Gene
2 BioSystems pathways for PREX1 Gene
10 Reactome pathways for PREX1 Gene
2 KEGG pathways for PREX1 Gene
4 GeneGo (Thomson Reuters) pathways for PREX1 Gene
- Development A1 receptor signaling
- G-protein signaling_Rac2 regulation pathway
- Inhibitory action of Lipoxins on neutrophil migration
- Inhibitory action of Lipoxins on Superoxide production in neutrophils
2 Cell Signaling Technology pathways for PREX1 Gene
Interacting Proteins for PREX1 Gene
Selected Interacting proteins:
Q8TCU6-PREX1_HUMAN
ENSP00000361009
for PREX1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PREX1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006801 | superoxide metabolic process | TAS | 12123595 |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA,TAS | -- |
| GO:0030041 | actin filament polymerization | TAS | 12123595 |
| GO:0030217 | T cell differentiation | IEA | -- |
| GO:0030335 | positive regulation of cell migration | IEA | -- |
Drugs & Compounds for PREX1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphatidylinositol-3,4,5-trisphosphate |
|
|
|
|||
| PI(16:0/16:0) |
|
|
|
|||
| PI(16:0/16:1(9Z)) |
|
|
|
|||
| PI(16:0/16:2(9Z,12Z)) |
|
|
|
|||
| PI(16:0/18:0) |
|
|
|
Transcripts for PREX1 Gene
mRNA/cDNA for PREX1 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000371941 6752 nts (view in UCSC)
- ENST00000482556 4682 nts (view in UCSC)
- ENST00000496915 478 nts (view in UCSC)
- ENST00000620554 362 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PREX1 - Select products 50% OFF >
- * PREX1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PREX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PREX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PREX1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PREX1
- Browse OriGene Inhibitory RNA Products For PREX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PREX1
Clone Products
- Applied Biological Materials (abm): Clones for PREX1 - Select products 50% OFF >
- * PREX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PREX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PREX1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: |
| ExUns: | 24b | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39 | ^ | 40 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||
| SP3: | - |
Relevant External Links for PREX1 Gene
- GeneLoc Exon Structure for
- PREX1
Expression for PREX1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Hematopoietic Bone Marrow
- NULL (Uncategorized)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for PREX1 Gene
This gene is overexpressed in Whole Blood (x12.1).
This gene is overexpressed in Lymph node (17.0), Monocytes (10.5), NK cells (10.4), and Peripheral blood mononuclear cells (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PREX1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PREX1
SOURCE GeneReport for Unigene cluster for PREX1 Gene:
Hs.153310mRNA Expression by UniProt/SwissProt for PREX1 Gene:
Q8TCU6-PREX1_HUMAN
Tissue specificity:
Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
Evidence on tissue expression from TISSUES for PREX1 Gene
- Nervous system(4.8)
- Eye(4.5)
- Liver(4.3)
- Muscle(3.3)
- Lung(3.3)
- Skin(3.1)
- Blood(2.5)
- Lymph node(2.4)
- Intestine(2.3)
- Bone marrow(2.3)
- Spleen(2.2)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for PREX1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PREX1 Gene
Orthologs for PREX1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PREX1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PREX1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PREX1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Prex1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Prex1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PREX1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PREX1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PREX1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PREX1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prex1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68772 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | prex1 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for PREX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PREX1 Gene
- ENSEMBL:
- Gene Tree for PREX1 (if available)
- TreeFam:
- Gene Tree for PREX1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PREX1: view image
Paralogs for PREX1 Gene
Variants for PREX1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PREX1 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710980 | Likely Benign: not provided | 48,655,328(-) | C/T | MISSENSE_VARIANT | |
| 711758 | Benign: not provided | 48,632,347(-) | C/A | MISSENSE_VARIANT | |
| 770000 | Benign: not provided | 48,627,879(-) | C/T | SYNONYMOUS_VARIANT | |
| 774258 | Benign: not provided | 48,666,323(-) | C/T | SYNONYMOUS_VARIANT | |
| 774531 | Benign: not provided | 48,636,586(-) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2665889 | CNV | deletion | 23128226 |
| esv2669528 | CNV | deletion | 23128226 |
| esv2722483 | CNV | deletion | 23290073 |
| esv3375868 | CNV | insertion | 20981092 |
| esv3557151 | CNV | deletion | 23714750 |
| esv3557152 | CNV | deletion | 23714750 |
| esv3646001 | CNV | loss | 21293372 |
| esv3646002 | CNV | loss | 21293372 |
| esv991815 | CNV | deletion | 20482838 |
| nsv1056976 | CNV | loss | 25217958 |
| nsv1072543 | CNV | deletion | 25765185 |
| nsv1136328 | CNV | deletion | 24896259 |
| nsv178670 | CNV | deletion | 16902084 |
| nsv3407 | CNV | insertion | 18451855 |
| nsv472222 | CNV | novel sequence insertion | 20440878 |
| nsv477522 | CNV | novel sequence insertion | 20440878 |
| nsv525312 | CNV | loss | 19592680 |
| nsv586167 | CNV | gain | 21841781 |
| nsv586170 | CNV | loss | 21841781 |
| nsv828735 | CNV | gain | 20364138 |
| nsv833998 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
9.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.43;
95.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PREX1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PREX1 Gene
Disorders for PREX1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastric tubular adenocarcinoma |
|
|
Search PREX1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PREX1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PREX1 Gene
Publications for PREX1 Gene
- Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. (PMID: 18602983) Bento JL … Mychaleckyj JC (Genomics 2008) 3 23 41
- Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity. (PMID: 16301320) Mayeenuddin LH … Garrison JC (The Journal of biological chemistry 2006) 2 3 23
- P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. (PMID: 11955434) Welch HC … Stephens LR (Cell 2002) 2 3 4
- Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis. (PMID: 20018810) Carretero-Ortega J … Vázquez-Prado J (Molecular pharmacology 2010) 3 23
- Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells. (PMID: 20074642) Nie B … Ye RD (Cellular signalling 2010) 3 23
ExternalLinks
Products for PREX1 Gene
- Custom Antibody ServicesOriGene Antibodies for PREX1
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- Custom Assay Services
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- Browse OriGene Inhibitory RNA Products For PREX1
- OriGene qPCR primer pairs for PREX1
- OriGene CRISPR knockouts for PREX1
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- Browse Sino Biological Recombinant Proteins
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- Sino Biological Antibodies for PREX1
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins for PREX1
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- Abcam antibodies for PREX1
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- Invitrogen Antibodies for PREX1 (AFLGC-PREX1)
- VectorBuilder Custom and pre-made DNA vectors for PREX1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PREX1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PREX1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PREX1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PREX1
- antibodies-online: Show 22 available PREX1 Antibodies ranked by validation data
- Compare Top PREX1 Antibodies
- antibodies-online: Show 7 available PREX1 Elisa Kits ranked by validation data
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- antibodies-online: Search results for available PREX1 related products ranked by validation data
- Horizon Cell Lines for PREX1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PREX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PREX1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PREX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PREX1
- Boster Bio Antibodies for PREX1
- Browse Boster Bio ELISA Kits
- Signalway ELISA kits for PREX1
Sources for PREX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB