Aliases for PREX1 Gene
- Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 2 3 5
- Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 1 Protein 3 4
- PtdIns(3,4,5)-Dependent Rac Exchanger 1 3 4
- PIP3 Dependent Rac Exchange Factor 1 2 3
- Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 2
- KIAA1415 4
- P-REX1 3
- P-Rex1 4
External Ids for PREX1 Gene
Previous GeneCards Identifiers for PREX1 Gene
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for PREX1 Gene
PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1) is a Protein Coding gene. Diseases associated with PREX1 include Luminal Breast Carcinoma. Among its related pathways are CCR5 Pathway in Macrophages and RET signaling. Gene Ontology (GO) annotations related to this gene include enzyme binding and phospholipid binding. An important paralog of this gene is PREX2.
UniProtKB/Swiss-Prot Summary for PREX1 Gene
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.