Aliases for PRELID3A Gene

Aliases for PRELID3A Gene

  • PRELI Domain Containing 3A 2 3 5
  • Erythroid Differentiation And Denucleation Factor 1 2 3
  • PRELI Domain Containing Protein 3A 3 4
  • Protein Slowmo Homolog 1 3 4
  • C18orf43 3 4
  • SLMO1 3 4
  • Chromosome 18 Open Reading Frame 43 2
  • Slowmo Homolog 1 (Drosophila) 2
  • Slowmo Homolog 1 3
  • HFL-EDDG1 3

External Ids for PRELID3A Gene

Previous HGNC Symbols for PRELID3A Gene

  • C18orf43
  • SLMO1

Previous GeneCards Identifiers for PRELID3A Gene

  • GC18P012412
  • GC18P012797
  • GC18P012863
  • GC18P012414
  • GC18P012482
  • GC18P012540
  • GC18P012575
  • GC18P012641
  • GC18P012721

Summaries for PRELID3A Gene

GeneCards Summary for PRELID3A Gene

PRELID3A (PRELI Domain Containing 3A) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and Gene Expression. An important paralog of this gene is PRELID3B.

UniProtKB/Swiss-Prot Summary for PRELID3A Gene

  • In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.

Additional gene information for PRELID3A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRELID3A Gene

Genomics for PRELID3A Gene

GeneHancer (GH) Regulatory Elements for PRELID3A Gene

Promoters and enhancers for PRELID3A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J012419 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 770.5 +12.7 12690 2.4 ZNF785 LCORL MIXL1 MYC SP1 ZNF280D POLR2A AHR CEBPG MLLT1 PRELID3A lnc-TUBB6-1 CEP192 ENSG00000267199 SPIRE1 AFG3L2 ENSG00000267249 ENSG00000260302 PSMG2 PTPN2
GH18J012407 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 763 +0.4 405 2.6 SP1 ZBTB6 POLR2A MYC L3MBTL2 MAX MNT NKRF ZFX SP7 PRELID3A ENSG00000267199 CEP192 lnc-TUBB6-1
GH18J012406 Enhancer 0.4 ENCODE 750.6 -1.8 -1799 0.2 ZNF512 ZNF24 KDM1A HLTF PRELID3A piR-61945-231
GH18J012989 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 46.4 +583.4 583361 3.9 ZNF785 ZBTB40 SP1 ZBTB6 RBPJ SMARCE1 POLR2A USF2 FOS ZNF133 CEP192 ENSG00000266969 PSMG2 ENSG00000267249 PRELID3A RNMT CEP76 PTPN2 ENSG00000267199 ENSG00000260302
GH18J011688 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 38.1 -718.2 -718205 2.2 ZNF785 ZBTB40 ZBTB6 POLR2A CTBP1 ZNF133 ZFP41 ZNF121 ZNF280D ZBTB33 GNAL piR-48209-315 PRELID3A ENSG00000267249 ENSG00000267199 PSMG2 ENSG00000267515
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRELID3A on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRELID3A Gene

Genomic Locations for PRELID3A Gene
chr18:12,407,896-12,432,238
(GRCh38/hg38)
Size:
24,343 bases
Orientation:
Plus strand
chr18:12,407,895-12,432,237
(GRCh37/hg19)
Size:
24,343 bases
Orientation:
Plus strand

Genomic View for PRELID3A Gene

Genes around PRELID3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRELID3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRELID3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRELID3A Gene

Proteins for PRELID3A Gene

  • Protein details for PRELID3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N28-PLD3A_HUMAN
    Recommended name:
    PRELI domain containing protein 3A
    Protein Accession:
    Q96N28
    Secondary Accessions:
    • B0YJ10
    • B4E0C9
    • D3DUJ1
    • Q6AHX2

    Protein attributes for PRELID3A Gene

    Size:
    172 amino acids
    Molecular mass:
    19247 Da
    Quaternary structure:
    • Interacts with TRIAP1.

    Three dimensional structures from OCA and Proteopedia for PRELID3A Gene

    Alternative splice isoforms for PRELID3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRELID3A Gene

Post-translational modifications for PRELID3A Gene

No Post-translational modifications

No data available for DME Specific Peptides for PRELID3A Gene

Domains & Families for PRELID3A Gene

Gene Families for PRELID3A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRELID3A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRELID3A Gene

GenScript: Design optimal peptide antigens:
  • Protein slowmo homolog 1 (SLMO1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96N28

UniProtKB/Swiss-Prot:

PLD3A_HUMAN :
  • Belongs to the slowmo family.
Family:
  • Belongs to the slowmo family.
genes like me logo Genes that share domains with PRELID3A: view

Function for PRELID3A Gene

Molecular function for PRELID3A Gene

UniProtKB/Swiss-Prot Function:
In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.

Phenotypes From GWAS Catalog for PRELID3A Gene

Gene Ontology (GO) - Molecular Function for PRELID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26071602
GO:1990050 phosphatidic acid transporter activity IDA 26071602
genes like me logo Genes that share ontologies with PRELID3A: view
genes like me logo Genes that share phenotypes with PRELID3A: view

Animal Model Products

CRISPR Products

miRNA for PRELID3A Gene

miRTarBase miRNAs that target PRELID3A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRELID3A Gene

Localization for PRELID3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRELID3A Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRELID3A gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PRELID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005758 mitochondrial intermembrane space IBA 21873635
genes like me logo Genes that share ontologies with PRELID3A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRELID3A Gene

Pathways & Interactions for PRELID3A Gene

genes like me logo Genes that share pathways with PRELID3A: view

Gene Ontology (GO) - Biological Process for PRELID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0015914 phospholipid transport IDA 26071602
genes like me logo Genes that share ontologies with PRELID3A: view

No data available for SIGNOR curated interactions for PRELID3A Gene

Drugs & Compounds for PRELID3A Gene

No Compound Related Data Available

Transcripts for PRELID3A Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRELID3A Gene

No ASD Table

Relevant External Links for PRELID3A Gene

GeneLoc Exon Structure for
PRELID3A
ECgene alternative splicing isoforms for
PRELID3A

Expression for PRELID3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PRELID3A Gene:

PRELID3A

Evidence on tissue expression from TISSUES for PRELID3A Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PRELID3A: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRELID3A Gene

Orthologs for PRELID3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRELID3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLMO1 33
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slmo1 32
  • 85.85 (n)
mouse
(Mus musculus)
Mammalia Slmo1 33 32
  • 85.27 (n)
OneToOne
Prelid3a 17
cow
(Bos Taurus)
Mammalia SLMO1 33 32
  • 85.27 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLMO1 33 32
  • 84.68 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLMO1 33
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLMO1 33
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLMO1 33 32
  • 77.03 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slmo1 32
  • 72.87 (n)
zebrafish
(Danio rerio)
Actinopterygii slmo1 33
  • 75 (a)
OneToOne
LOC563270 32
  • 71.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta slmo 33
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F15D3.6 33
  • 31 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18348g 32
  • 48.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UPS2 33 32
  • 45.33 (n)
ManyToMany
UPS3 33
  • 27 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04307 32
  • 46.06 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC36.10 32
  • 42.13 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.655 33
  • 30 (a)
OneToMany
Species where no ortholog for PRELID3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRELID3A Gene

ENSEMBL:
Gene Tree for PRELID3A (if available)
TreeFam:
Gene Tree for PRELID3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRELID3A: view image

Paralogs for PRELID3A Gene

Paralogs for PRELID3A Gene

Pseudogenes.org Pseudogenes for PRELID3A Gene

genes like me logo Genes that share paralogs with PRELID3A: view

Variants for PRELID3A Gene

Sequence variations from dbSNP and Humsavar for PRELID3A Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000204109 -- 12,417,555(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000237699 -- 12,424,953(+) G/T intron_variant
rs1000349587 -- 12,414,909(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000413694 -- 12,426,869(+) G/A intron_variant
rs1000498458 -- 12,419,553(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRELID3A Gene

Variant ID Type Subtype PubMed ID
esv2758714 CNV loss 17122850
esv3341464 CNV duplication 20981092
nsv1060808 CNV gain 25217958
nsv1063125 CNV loss 25217958
nsv130656 CNV deletion 16902084
nsv519557 CNV loss 19592680
nsv576496 CNV gain 21841781
nsv9610 CNV gain 18304495

Variation tolerance for PRELID3A Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRELID3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRELID3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRELID3A Gene

Disorders for PRELID3A Gene

Additional Disease Information for PRELID3A

No disorders were found for PRELID3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRELID3A Gene

Publications for PRELID3A Gene

  1. Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. (PMID: 26071602) Miliara X … Matthews S (EMBO reports 2015) 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. (PMID: 26527279) Campos EI … Reinberg D (Molecular cell 2015) 3 56
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56

Products for PRELID3A Gene

Sources for PRELID3A Gene