This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified. [provided by ... See more...

Aliases for PRELID1 Gene

Aliases for PRELID1 Gene

  • PRELI Domain Containing 1 2 3 5
  • Px19-Like Protein 2 3 4
  • 25 KDa Protein Of Relevant Evolutionary And Lymphoid Interest 3 4
  • PRELI Domain-Containing Protein 1, Mitochondrial 3 4
  • PRELI 3 4
  • Protein Of Relevant Evolutionary And Lymphoid Interest 2
  • CGI-106 3
  • SBBI12 3
  • PX19 3

External Ids for PRELID1 Gene

Previous GeneCards Identifiers for PRELID1 Gene

  • GC05P176665
  • GC05P176730
  • GC05P171651

Summaries for PRELID1 Gene

Entrez Gene Summary for PRELID1 Gene

  • This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]

GeneCards Summary for PRELID1 Gene

PRELID1 (PRELI Domain Containing 1) is a Protein Coding gene. Diseases associated with PRELID1 include Chronic Closed-Angle Glaucoma. Among its related pathways are Regulation of TP53 Activity and Gene Expression. Gene Ontology (GO) annotations related to this gene include phosphatidic acid transporter activity. An important paralog of this gene is PRELID3B.

UniProtKB/Swiss-Prot Summary for PRELID1 Gene

  • Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.

Additional gene information for PRELID1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRELID1 Gene

Genomics for PRELID1 Gene

GeneHancer (GH) Regulatory Elements for PRELID1 Gene

Promoters and enhancers for PRELID1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRELID1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRELID1 gene promoter:
  • AML1a
  • ARP-1
  • Gfi-1
  • HEN1
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • STAT3

Genomic Locations for PRELID1 Gene

Genomic Locations for PRELID1 Gene
chr5:177,303,762-177,306,959
(GRCh38/hg38)
Size:
3,198 bases
Orientation:
Plus strand
chr5:176,730,775-176,733,960
(GRCh37/hg19)
Size:
3,186 bases
Orientation:
Plus strand

Genomic View for PRELID1 Gene

Genes around PRELID1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRELID1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRELID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRELID1 Gene

Proteins for PRELID1 Gene

  • Protein details for PRELID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y255-PRLD1_HUMAN
    Recommended name:
    PRELI domain-containing protein 1, mitochondrial
    Protein Accession:
    Q9Y255
    Secondary Accessions:
    • B2R5F7
    • D6RD25
    • Q549N2
    • Q9UI13
    • Q9UJS9

    Protein attributes for PRELID1 Gene

    Size:
    219 amino acids
    Molecular mass:
    25181 Da
    Quaternary structure:
    • Forms a complex with TRIAP1 in the mitochondrion intermembrane space. Interacts with OPA1 and AIFM1.

    Three dimensional structures from OCA and Proteopedia for PRELID1 Gene

    Alternative splice isoforms for PRELID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRELID1 Gene

Post-translational modifications for PRELID1 Gene

  • Ubiquitination at Lys49
  • Modification sites at PhosphoSitePlus

Other Protein References for PRELID1 Gene

No data available for DME Specific Peptides for PRELID1 Gene

Domains & Families for PRELID1 Gene

Gene Families for PRELID1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PRELID1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRELID1 Gene

GenScript: Design optimal peptide antigens:
  • Px19-like protein (PRLD1_HUMAN)
genes like me logo Genes that share domains with PRELID1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRELID1 Gene

Function for PRELID1 Gene

Molecular function for PRELID1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to activation in primary T helper cells.

Phenotypes From GWAS Catalog for PRELID1 Gene

Gene Ontology (GO) - Molecular Function for PRELID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21364629
GO:1990050 contributes_to phosphatidic acid transporter activity IBA,IMP 23931759
genes like me logo Genes that share ontologies with PRELID1: view
genes like me logo Genes that share phenotypes with PRELID1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRELID1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRELID1 Gene

Localization for PRELID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRELID1 Gene

Mitochondrion. Mitochondrion intermembrane space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRELID1 gene
Compartment Confidence
mitochondrion 5
nucleus 4
peroxisome 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRELID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion ISS --
GO:0005758 mitochondrial intermembrane space IEA,TAS --
GO:0032991 protein-containing complex IDA 23931759
genes like me logo Genes that share ontologies with PRELID1: view

Pathways & Interactions for PRELID1 Gene

genes like me logo Genes that share pathways with PRELID1: view

Gene Ontology (GO) - Biological Process for PRELID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0006915 apoptotic process IEA --
GO:0006955 immune response TAS 10784606
GO:0007275 multicellular organism development TAS 10784606
GO:0010917 negative regulation of mitochondrial membrane potential IDA 18945965
genes like me logo Genes that share ontologies with PRELID1: view

No data available for SIGNOR curated interactions for PRELID1 Gene

Drugs & Compounds for PRELID1 Gene

No Compound Related Data Available

Transcripts for PRELID1 Gene

mRNA/cDNA for PRELID1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRELID1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRELID1 Gene

No ASD Table

Relevant External Links for PRELID1 Gene

GeneLoc Exon Structure for
PRELID1
ECgene alternative splicing isoforms for
PRELID1

Expression for PRELID1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRELID1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRELID1 Gene

This gene is overexpressed in Whole Blood (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRELID1 Gene



NURSA nuclear receptor signaling pathways regulating expression of PRELID1 Gene:

PRELID1

SOURCE GeneReport for Unigene cluster for PRELID1 Gene:

Hs.744904

mRNA Expression by UniProt/SwissProt for PRELID1 Gene:

Q9Y255-PRLD1_HUMAN
Tissue specificity: Highly expressed in fetal liver; less expressed in fetal brain, lung, and kidney. At the adult stage, expression is drastically reduced in the liver but highly expressed in the spleen, brain, lung, lymph nodes and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for PRELID1 Gene

  • Skin(4.4)
  • Nervous system(4.4)
  • Adrenal gland(4.2)
  • Eye(4.2)
  • Pancreas(2.3)
  • Lung(2)
genes like me logo Genes that share expression patterns with PRELID1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRELID1 Gene

Orthologs for PRELID1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRELID1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRELID1 32
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia PRELID1 33 32
  • 96.19 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 95 (a)
OneToMany
-- 33
  • 94 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PRELID1 33 32
  • 94.37 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prelid1 32
  • 93.64 (n)
mouse
(Mus musculus)
Mammalia Prelid1 17 33 32
  • 93.33 (n)
chicken
(Gallus gallus)
Aves PRELID1 33 32
  • 78.99 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRELID1 33
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prelid1 32
  • 73.14 (n)
zebrafish
(Danio rerio)
Actinopterygii prelid1a 33 32
  • 66.99 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta prel 33 32
  • 54.49 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010959 32
  • 54.34 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_B0334.4 32
  • 44.83 (n)
B0334.4 33
  • 25 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR075C 32
  • 46.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UPS1 33 32
  • 44.44 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19581g 32
  • 43.64 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAP8A3.10 32
  • 43.87 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 28 (a)
OneToOne
Species where no ortholog for PRELID1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRELID1 Gene

ENSEMBL:
Gene Tree for PRELID1 (if available)
TreeFam:
Gene Tree for PRELID1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRELID1: view image

Paralogs for PRELID1 Gene

Paralogs for PRELID1 Gene

(2) SIMAP similar genes for PRELID1 Gene using alignment to 5 proteins:

  • PRLD1_HUMAN
  • D6RC47_HUMAN
  • D6RD25_HUMAN
  • D6REW1_HUMAN
  • H0YA79_HUMAN
genes like me logo Genes that share paralogs with PRELID1: view

Variants for PRELID1 Gene

Sequence variations from dbSNP and Humsavar for PRELID1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000945330 -- 177,303,274(+) G/A upstream_transcript_variant
rs1001397878 -- 177,302,923(+) G/C upstream_transcript_variant
rs1002048416 -- 177,307,431(+) A/G downstream_transcript_variant
rs1002825693 -- 177,304,318(+) G/A intron_variant
rs1003185797 -- 177,304,838(+) C/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for PRELID1 Gene

Variant ID Type Subtype PubMed ID
esv2759396 CNV gain 17122850
nsv1161311 CNV duplication 26073780
nsv428132 CNV gain 18775914
nsv600364 CNV loss 21841781
nsv980764 CNV duplication 23825009

Variation tolerance for PRELID1 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRELID1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRELID1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRELID1 Gene

Disorders for PRELID1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRELID1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic closed-angle glaucoma
  • anatomical narrow angle glaucoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PRELID1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRELID1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRELID1 Gene

Publications for PRELID1 Gene

  1. PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein. (PMID: 14640972) Fox EJ … Wright SC (The Biochemical journal 2004) 2 3 4 56
  2. PRELI, the human homologue of the avian px19, is expressed by germinal center B lymphocytes. (PMID: 10784606) Guzman-Rojas L … Martinez-Valdez H (International immunology 2000) 2 3 4 56
  3. TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid. (PMID: 23931759) Potting C … Langer T (Cell metabolism 2013) 3 4 56
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 43 56
  5. Vital function of PRELI and essential requirement of its LEA motif. (PMID: 21364629) McKeller MR … Martinez-Valdez H (Cell death & disease 2010) 3 4 56

Products for PRELID1 Gene

Sources for PRELID1 Gene