Aliases for PRELID1 Gene
External Ids for PRELID1 Gene
Previous GeneCards Identifiers for PRELID1 Gene
This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]
GeneCards Summary for PRELID1 Gene
PRELID1 (PRELI Domain Containing 1) is a Protein Coding gene. Diseases associated with PRELID1 include Chronic Closed-Angle Glaucoma. Among its related pathways are Regulation of TP53 Activity and Gene Expression. Gene Ontology (GO) annotations related to this gene include phosphatidic acid transporter activity. An important paralog of this gene is PRELID3B.
UniProtKB/Swiss-Prot Summary for PRELID1 Gene
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.