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The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]
PRDX6 (Peroxiredoxin 6) is a Protein Coding gene. Diseases associated with PRDX6 include Fuchs' Endothelial Dystrophy and Retinoschisis 1, X-Linked, Juvenile. Among its related pathways are Detoxification of Reactive Oxygen Species and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and antioxidant activity. An important paralog of this gene is PRDX1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0004601 | peroxidase activity | IEA | -- |
GO:0004602 | glutathione peroxidase activity | IMP | 10893423 |
GO:0004623 | phospholipase A2 activity | IEA | -- |
GO:0005515 | protein binding | IPI | 16186110 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | HDA | 23580065 |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IDA | 16186110 |
GO:0005737 | cytoplasm | IEA,IDA | 16186110 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Ca, cAMP and Lipid Signaling | ||
3 | Glucose / Energy Metabolism | ||
4 | Glutathione metabolism | ||
5 | Metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006979 | response to oxidative stress | IMP | 10893423 |
GO:0008152 | metabolic process | IEA | -- |
GO:0016042 | lipid catabolic process | IEA | -- |
GO:0034599 | cellular response to oxidative stress | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Oxygen | Approved, Vet_approved | Pharma | 0 | |||
Copper | Approved, Investigational | Pharma | Target | 249 | ||
Carbon dioxide | Approved, Investigational, Vet_approved | Pharma | 0 | |||
Formaldehyde | Approved, Vet_approved | Pharma | 142 | |||
Hydrogen peroxide | Approved, Vet_approved | Pharma | 115 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-Phenylacetamide |
|
103-81-1 |
|
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5-Hydroxyconiferyl alcohol |
|
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||||
Coniferyl alcohol |
|
458-35-5 |
|
|||
Hypothiocyanite |
|
63296-34-4 |
|
|||
methanol |
|
67-56-1 |
|
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
PRDX6 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | PRDX6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PRDX6 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Prdx6 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Prdx6 30 17 31 |
|
OneToMany | |
Prdx6b 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | PRDX6 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PRDX6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PRDX6 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PRDX6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prdx6 30 |
|
||
MGC76137 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | prdx6 30 31 |
|
OneToOne | |
-- 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | TPX5 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Prx6005 30 31 |
|
OneToMany | |
Prx2540-2 31 |
|
OneToMany | |||
Prx2540-1 31 |
|
OneToMany | |||
CG12896 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | prdx-6 30 31 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGR368W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRX1 30 31 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E20285g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PER1 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os07g0638400 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU06031 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10477 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4007 30 |
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
767728 | Benign: not provided | 173,481,318(+) | C/G | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
fuchs' endothelial dystrophy |
|
|
retinoschisis 1, x-linked, juvenile |
|
|
bullous retinoschisis |
|
|
gnathomiasis |
|
|
intrahepatic cholestasis of pregnancy |
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