Aliases for PRDX6 Gene
Aliases for PRDX6 Gene
External Ids for PRDX6 Gene
- HGNC: 16753
- Entrez Gene: 9588
- Ensembl: ENSG00000117592
- OMIM: 602316
- UniProtKB: P30041
Previous GeneCards Identifiers for PRDX6 Gene
- GC01P169075
- GC01P170027
- GC01P170685
- GC01P170178
- GC01P171713
- GC01P173446
- GC01P144671
Summaries for PRDX6 Gene
-
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRDX6 Gene
PRDX6 (Peroxiredoxin 6) is a Protein Coding gene. Diseases associated with PRDX6 include Gnathomiasis and Fuchs' Endothelial Dystrophy. Among its related pathways are Innate Immune System and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and antioxidant activity.
UniProtKB/Swiss-Prot for PRDX6 Gene
-
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis.
Additional gene information for PRDX6 Gene
- Monarch Initiative
- Search for PRDX6 at DataMed
- Search for PRDX6 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX6 Gene
Genomics for PRDX6 Gene
GeneHancer (GH) Regulatory Elements for PRDX6 Gene
Promoters and enhancers for PRDX6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PRDX6 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PRDX6 Gene
Genomic Locations for PRDX6 Gene
- chr1:173,477,266-173,488,807
- (GRCh38/hg38)
- Size:
- 11,542 bases
- Orientation:
- Plus strand
- chr1:173,446,405-173,457,946
- (GRCh37/hg19)
Genomic View for PRDX6 Gene
Genes around PRDX6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.1 by Ensembl
- 1q25.1 by Entrez Gene
- 1q25.1 by HGNC
PRDX6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRDX6 Gene
Proteins for PRDX6 Gene
-
Protein details for PRDX6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30041-PRDX6_HUMAN
- Recommended name:
- Peroxiredoxin-6
- Protein Accession:
- P30041
- A8JZY7
- P32077
- Q5TAH4
- Q5ZEZ8
Protein attributes for PRDX6 Gene
- Size:
- 224 amino acids
- Molecular mass:
- 25035 Da
- Quaternary structure:
-
- Homodimer (PubMed:9587003, PubMed:27353378). Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration (By similarity). Interacts with APEX1 (PubMed:19188445). Interacts with STH (PubMed:16186110). May interact with FAM168B (PubMed:20716133). May interact with HTR2A (By similarity).
- Miscellaneous:
-
- The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. C(P) is reactivated by glutathionylation mediated by glutathione S-transferase Pi, followed by spontaneous reduction of the enzyme with glutathione.
Protein Expression for PRDX6 Gene
Selected DME Specific Peptides for PRDX6 Gene
- P30041:
-
- VATPVDWK
- DFTPVCTTEL
- TTGRNFDE
Post-translational modifications for PRDX6 Gene
- Irreversibly inactivated by overoxidation of Cys-47 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress.
- Phosphorylation at Thr-177 by MAP kinases increases the phospholipase activity of the enzyme.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PRDX6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PRDX6 (Peroxiredoxin 6)
-
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Abcam antibodies for PRDX6
-
Cloud-Clone Corp. Antibodies for PRDX6
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- GeneTex PRDX6 antibody for PRDX6
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRDX6
- Sino Biological Antibodies for PRDX6
Protein Products
-
OriGene Purified Proteins for PRDX6
- Search Origene for MassSpec and Protein Over-expression Lysates for PRDX6
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- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for PRDX6
-
Cloud-Clone Corp. Proteins for PRDX6
- Search GeneTex for Proteins for PRDX6
-
ProSci Proteins for PRDX6
-
Abcam proteins for PRDX6
Assay Products
-
Cloud-Clone Corp. Assay Kits for PRDX6
Domains & Families for PRDX6 Gene
Gene Families for PRDX6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PRDX6 Gene
Suggested Antigen Peptide Sequences for PRDX6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P30041- Family:
-
- Belongs to the peroxiredoxin family. Prx6 subfamily.
Function for PRDX6 Gene
Molecular function for PRDX6 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
- UniProtKB/Swiss-Prot Function:
- Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis.
Enzyme Numbers (IUBMB) for PRDX6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004601 | peroxidase activity | IEA | -- |
| GO:0004602 | glutathione peroxidase activity | IEA,IMP | 10893423 |
| GO:0004623 | phospholipase A2 activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16186110 |
| GO:0016209 | antioxidant activity | IEA | -- |
Phenotypes for PRDX6 Gene
- MGI mutant phenotypes for PRDX6:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for PRDX6:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability ratio
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased transferrin (TF) endocytosis
- Decreased POU5F1-GFP protein expression
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased IL-8 secretion
- Decreased NANOG protein expression
- Decreased OCT4 protein expression
Animal Models for PRDX6 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for PRDX6
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRDX6
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PRDX6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDX6 gene
- Search ViGene Biosciences for PRDX6
CRISPR Products
-
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- Applied Biological Materials CRISPR for PRDX6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDX6
- GenScript: Design CRISPR guide RNA sequences for PRDX6
miRNA for PRDX6 Gene
- miRTarBase miRNAs that target PRDX6
miRNA Products
- Search ViGene Biosciences for PRDX6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRDX6
- Browse OriGene Inhibitory RNA Products For PRDX6
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDX6 gene
Clone Products
- Sino Biological Human cDNA Clone for PRDX6
- VectorBuilder custom plasmid, inducible vectors for PRDX6
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 151 available Peroxiredoxin 6 gene related products
- Overview of 151 available Peroxiredoxin 6 gene related products
- orf clones - Search results for 151 available Peroxiredoxin 6 gene related products
- Overview of 151 available Peroxiredoxin 6 gene related products
- Applied Biological Materials Clones for PRDX6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRDX6
-
ViGene Biosciences adenoviral particle packaged cDNA for PRDX6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PRDX6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDX6 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX6 Gene
Localization for PRDX6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRDX6 Gene
- Cytoplasm. Lysosome. Note=Also found in lung secretory organelles (lamellar bodies). {ECO:0000250 UniProtKB:O35244}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| lysosome | 5 |
| plasma membrane | 3 |
| mitochondrion | 3 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | HDA,IDA | 23580065 |
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IDA | 16186110 |
| GO:0005737 | cytoplasm | IDA,IEA | 16186110 |
Pathways & Interactions for PRDX6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Metabolism | ||
| 3 | Ca, cAMP and Lipid Signaling | ||
| 4 | Glucose / Energy Metabolism | ||
| 5 | Cellular Senescence (REACTOME) | ||
Pathways by source for PRDX6 Gene
1 BioSystems pathway for PRDX6 Gene
5 Reactome pathways for PRDX6 Gene
1 KEGG pathway for PRDX6 Gene
1 GeneGo (Thomson Reuters) pathway for PRDX6 Gene
2 Cell Signaling Technology pathways for PRDX6 Gene
Interacting Proteins for PRDX6 Gene
Selected Interacting proteins:
ENSP00000342026
P30041-PRDX6_HUMAN
for PRDX6 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006979 | response to oxidative stress | IMP | 10893423 |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0016042 | lipid catabolic process | IEA | -- |
| GO:0034599 | cellular response to oxidative stress | TAS | -- |
Drugs & Compounds for PRDX6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Isopropyl alcohol | Approved, Investigational | Pharma | Target | 0 | ||
| Oxygen | Approved, Vet_approved | Pharma | 0 | |||
| Copper | Approved, Investigational | Pharma | Target | 202 | ||
| Carbon dioxide | Approved, Investigational, Vet_approved | Pharma | 0 | |||
| Formaldehyde | Approved, Vet_approved | Pharma | 102 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Phenylacetamide |
|
103-81-1 |
|
|||
| 5-Hydroxyconiferyl alcohol |
|
|
||||
| Coniferyl alcohol |
|
458-35-5 |
|
|||
| Hypothiocyanite |
|
63296-34-4 |
|
|||
| methanol |
|
67-56-1 |
|
Transcripts for PRDX6 Gene
mRNA/cDNA for PRDX6 Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (1202) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PRDX6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PRDX6
- Applied Biological Materials CRISPR for PRDX6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDX6
- GenScript: Design CRISPR guide RNA sequences for PRDX6
miRNA Products
- Search ViGene Biosciences for PRDX6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRDX6
- Browse OriGene Inhibitory RNA Products For PRDX6
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDX6 gene
Clone Products
- Sino Biological Human cDNA Clone for PRDX6
- VectorBuilder custom plasmid, inducible vectors for PRDX6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDX6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 151 available Peroxiredoxin 6 gene related products
- Overview of 151 available Peroxiredoxin 6 gene related products
- orf clones - Search results for 151 available Peroxiredoxin 6 gene related products
- Overview of 151 available Peroxiredoxin 6 gene related products
- Applied Biological Materials Clones for PRDX6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PRDX6 Gene
mRNA differential expression in normal tissues according to GTEx for PRDX6 Gene
This gene is overexpressed in Muscle - Skeletal (x4.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRDX6 Gene
NURSA nuclear receptor signaling pathways regulating expression of PRDX6 Gene:
PRDX6SOURCE GeneReport for Unigene cluster for PRDX6 Gene:
Hs.120Evidence on tissue expression from TISSUES for PRDX6 Gene
- Nervous system(5)
- Liver(4.7)
- Blood(4.5)
- Bone marrow(4.4)
- Lung(4.4)
- Eye(3.9)
- Skin(3.9)
- Kidney(3.5)
- Intestine(3.3)
- Heart(2.9)
- Muscle(2.9)
- Stomach(2.1)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for PRDX6
-
OriGene qPCR primer pairs and template standards for PRDX6
- genomics-online: primer clones - Search results for 151 available Peroxiredoxin 6 gene related products
- Overview of 151 available Peroxiredoxin 6 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX6 Gene
Orthologs for PRDX6 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| PRDX6 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | PRDX6 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PRDX6 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Prdx6 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Prdx6 33 16 34 |
|
||
| Prdx6b 34 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PRDX6 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PRDX6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PRDX6 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PRDX6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prdx6 33 |
|
||
| MGC76137 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | prdx6 33 34 |
|
||
| -- 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | TPX5 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Prx6005 33 34 |
|
||
| Prx2540-1 34 |
|
OneToMany | |||
| Prx2540-2 34 |
|
OneToMany | |||
| CG12896 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | prdx-6 33 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGR368W 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRX1 34 36 33 |
|
OneToOne | |
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E20285g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | PER1 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0638400 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06031 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10477 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4007 33 |
|
- Species where no ortholog for PRDX6 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PRDX6 Gene
(1) SIMAP similar genes for PRDX6 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for PRDX6 Gene
No data available for Paralogs for PRDX6 Gene
Variants for PRDX6 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000196271 | -- | 173,482,322(+) | C/T | intron_variant | |
| rs1000227542 | -- | 173,481,971(+) | C/G | intron_variant | |
| rs1000324588 | -- | 173,476,577(+) | AACAAACA/AACA | upstream_transcript_variant | |
| rs1000541494 | -- | 173,488,966(+) | T/C | downstream_transcript_variant | |
| rs1000544094 | -- | 173,488,584(+) | A/G | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.39;
8.68% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRDX6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRDX6
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX6 Gene
Disorders for PRDX6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gnathomiasis |
|
|
| fuchs' endothelial dystrophy |
|
|
Search PRDX6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRDX6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX6 Gene
Publications for PRDX6 Gene
- 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. (PMID: 10893423) Chen JW … Fisher AB (The Journal of biological chemistry 2000) 3 4 22 58
- AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant. (PMID: 11233154) Phelan SA (Antioxidants & redox signaling 1999) 2 3 22 58
- Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. (PMID: 9497358) Kang SW … Rhee SG (The Journal of biological chemistry 1998) 3 4 22 58
- Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. (PMID: 9587003) Choi HJ … Ryu SE (Nature structural biology 1998) 3 4 22 58
- Crystal structures of human peroxiredoxin 6 in different oxidation states. (PMID: 27353378) Kim KH … Kim EE (Biochemical and biophysical research communications 2016) 3 4 58
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- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for PRDX6
- Cloud-Clone Corp. Antibodies for PRDX6
- Cloud-Clone Corp. Proteins for PRDX6
- Cloud-Clone Corp. Assay Kits for PRDX6
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for PRDX6
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PRDX6
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRDX6
- VectorBuilder custom plasmid, inducible vectors for PRDX6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDX6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 171 available PRDX6 Antibodies ranked by validation data
- Compare Top PRDX6 Antibodies
- antibodies-online: Search results for 21 available PRDX6 Elisa Kits ranked by validation data
- Compare Top PRDX6 Elisa Kits
- antibodies-online: Search results for 30 available PRDX6 Proteins ranked by validation data
- Compare Top PRDX6 Proteins
- GeneTex PRDX6 antibody for PRDX6
- Search GeneTex for Proteins for PRDX6
- ViGene Biosciences adenoviral particle packaged cDNA for PRDX6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PRDX6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PRDX6 gene
- Search ViGene Biosciences for PRDX6
- Santa Cruz Biotechnology (SCBT) Antibodies for PRDX6
- Search Santa Cruz Biotechnology (SCBT) for PRDX6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PRDX6
- Search for PRDX6 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for PRDX6
- Horizon Cell Lines for PRDX6
- genomics-online: cdna clones - Search results for 151 available PRDX6 gene related products
- Overview of 151 available PRDX6 gene related products
- orf clones - Search results for 151 available PRDX6 gene related products
- Overview of 151 available PRDX6 gene related products
- genomics-online: gRNA clones - Search results for 151 available PRDX6 gene related products
- Overview of 151 available PRDX6 gene related products
- genomics-online: primer clones - Search results for 151 available PRDX6 gene related products
- Overview of 151 available PRDX6 gene related products
- genomics-online: shRNA clones - Search results for 151 available PRDX6 gene related products
- Overview of 151 available PRDX6 gene related products
Sources for PRDX6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems