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PRDX6 Gene(Protein Coding)

Peroxiredoxin 6

GCID:
GC01P173477
GIFtS:
52
Genes Participants
UDN Logo

Aliases for PRDX6 Gene

Aliases for PRDX6 Gene

  • Peroxiredoxin 6 2 3 5
  • Acidic Calcium-Independent Phospholipase A2 3 4
  • Non-Selenium Glutathione Peroxidase 3 4
  • Red Blood Cells Page Spot 12 3 4
  • Antioxidant Protein 2 3 4
  • Liver 2D Page Spot 40 3 4
  • 1-Cys Peroxiredoxin 3 4
  • 24 KDa Protein 3 4
  • 1-Cys PRX 3 4
  • AiPLA2 3 4
  • NSGPx 3 4
  • AOP2 3 4
  • Epididymis Secretory Sperm Binding Protein Li 128m 3
  • Peroxiredoxin-6 3
  • EC 1.11.1.15 4
  • HEL-S-128m 3
  • EC 3.1.1.4 4
  • KIAA0106 4
  • 1-Cys 3
  • PRX 3
  • P29 3

External Ids for PRDX6 Gene

Previous GeneCards Identifiers for PRDX6 Gene

  • GC01P169075
  • GC01P170027
  • GC01P170685
  • GC01P170178
  • GC01P171713
  • GC01P173446
  • GC01P144671

Summaries for PRDX6 Gene

Entrez Gene Summary for PRDX6 Gene

  • The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRDX6 Gene

PRDX6 (Peroxiredoxin 6) is a Protein Coding gene. Diseases associated with PRDX6 include Gnathomiasis and Fuchs' Endothelial Dystrophy. Among its related pathways are Ca, cAMP and Lipid Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and antioxidant activity.

UniProtKB/Swiss-Prot for PRDX6 Gene

  • Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis.

Gene Wiki entry for PRDX6 Gene

Additional gene information for PRDX6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX6 Gene

Genomics for PRDX6 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for PRDX6 Gene

Promoters and enhancers for PRDX6 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J173473 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 664.8 -0.4 -445 7.1 CLOCK DMAP1 YY1 E2F8 SP3 NFYC MEF2D ZNF610 ZNF585B GLIS1 PRDX6 LOC100506023 TNFSF4 KLHL20 GAS5 GAS5-AS1 CENPL DARS2 LOC101928673
GH01J173420 Enhancer 1.3 Ensembl ENCODE dbSUPER 21.4 -56.7 -56661 0.9 HDGF ATF1 ARNT NFRKB SIN3A RAD21 RFX5 CHAMP1 ARID2 ZNF143 PRDX6 RC3H1 CENPL DARS2 LOC101928673 KLHL20 GC01M173428 LOC100506023 LOC646870
GH01J173506 Enhancer 1.1 Ensembl ENCODE 22.9 +30.1 30091 1.8 PKNOX1 FOXA2 ZFP64 FEZF1 YY1 GLIS2 ZNF143 KLF7 FOS KLF13 PRDX6 ANKRD45 ENSG00000238272 KLHL20 SLC9C2 GAS5 PIR59510
GH01J173428 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -46.8 -46824 3.5 PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF766 E2F8 ZNF143 REST GC01M173428 PRDX6 SLC9C2 GC01P173448 LOC101928673 LOC100506023
GH01J173409 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -66.9 -66867 2.6 HDGF PKNOX1 RB1 BATF KLF5 IRF4 ZNF143 ATF7 ETV6 BCLAF1 KLHL20 CENPL DARS2 PRDX6 ENSG00000224228 TNFSF4 GC01M173428 LOC646870 LOC100506023
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRDX6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRDX6 gene promoter:
  • STAT1
  • Pax-2a
  • Pax-2
  • AML1a
  • C/EBPbeta
  • aMEF-2
  • MEF-2
  • MEF-2A
  • NF-kappaB

Genomic Locations for PRDX6 Gene

Genomic Locations for PRDX6 Gene
chr1:173,477,266-173,488,807
(GRCh38/hg38)
Size:
11,542 bases
Orientation:
Plus strand
chr1:173,446,405-173,457,946
(GRCh37/hg19)
Size:
11,542 bases
Orientation:
Plus strand

Genomic View for PRDX6 Gene

Genes around PRDX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PRDX6 Gene

Proteins for PRDX6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PRDX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30041-PRDX6_HUMAN
    Recommended name:
    Peroxiredoxin-6
    Protein Accession:
    P30041
    Secondary Accessions:
    • A8JZY7
    • P32077
    • Q5TAH4
    • Q5ZEZ8

    Protein attributes for PRDX6 Gene

    Size:
    224 amino acids
    Molecular mass:
    25035 Da
    Quaternary structure:
    • Homodimer (PubMed:9587003, PubMed:27353378). Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration (By similarity). Interacts with APEX1 (PubMed:19188445). Interacts with STH (PubMed:16186110). May interact with FAM168B (PubMed:20716133). May interact with HTR2A (By similarity).
    Miscellaneous:
    • The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. C(P) is reactivated by glutathionylation mediated by glutathione S-transferase Pi, followed by spontaneous reduction of the enzyme with glutathione.

    Three dimensional structures from OCA and Proteopedia for PRDX6 Gene

neXtProt entry for PRDX6 Gene

Protein Expression for PRDX6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PRDX6 Gene

  • Irreversibly inactivated by overoxidation of Cys-47 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress.
  • Phosphorylation at Thr-177 by MAP kinases increases the phospholipase activity of the enzyme.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRDX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRDX6 Gene

Domains & Families for PRDX6 Gene

Gene Families for PRDX6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PRDX6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PRDX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30041

UniProtKB/Swiss-Prot:

PRDX6_HUMAN :
  • Belongs to the peroxiredoxin family. Prx6 subfamily.
Family:
  • Belongs to the peroxiredoxin family. Prx6 subfamily.
genes like me logo Genes that share domains with PRDX6: view

Function for PRDX6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PRDX6 Gene

UniProtKB/Swiss-Prot Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis.
UniProtKB/Swiss-Prot CatalyticActivity:
2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.

Enzyme Numbers (IUBMB) for PRDX6 Gene

Gene Ontology (GO) - Molecular Function for PRDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IBA,IEA --
GO:0004602 glutathione peroxidase activity IMP 10893423
GO:0004623 phospholipase A2 activity IEA --
GO:0005515 protein binding IPI 16186110
GO:0016209 antioxidant activity IEA --
genes like me logo Genes that share ontologies with PRDX6: view
genes like me logo Genes that share phenotypes with PRDX6: view

Animal Models for PRDX6 Gene

MGI Knock Outs for PRDX6:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRDX6

miRNA for PRDX6 Gene

miRTarBase miRNAs that target PRDX6

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX6 Gene

Localization for PRDX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX6 Gene

Cytoplasm. Lysosome. Note=Also found in lung secretory organelles (lamellar bodies). {ECO:0000250 UniProtKB:O35244}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDX6 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
lysosome 5
plasma membrane 3
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA 23580065
GO:0005623 cell IEA --
GO:0005634 nucleus IDA 16186110
GO:0005737 cytoplasm IEA,IDA 16186110
genes like me logo Genes that share ontologies with PRDX6: view

Pathways & Interactions for PRDX6 Gene

genes like me logo Genes that share pathways with PRDX6: view

Pathways by source for PRDX6 Gene

1 BioSystems pathway for PRDX6 Gene
1 KEGG pathway for PRDX6 Gene
1 GeneGo (Thomson Reuters) pathway for PRDX6 Gene
2 Cell Signaling Technology pathways for PRDX6 Gene

SIGNOR curated interactions for PRDX6 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PRDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006979 response to oxidative stress IMP 10893423
GO:0008152 metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0034599 cellular response to oxidative stress TAS --
genes like me logo Genes that share ontologies with PRDX6: view

Drugs & Compounds for PRDX6 Gene

Products:

  1. Drug

(19) Drugs for PRDX6 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopropyl alcohol Approved, Investigational Pharma Target 0
Oxygen Approved, Vet_approved Pharma 0
Copper Approved, Investigational Pharma Target 202
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Formaldehyde Approved, Vet_approved Pharma 102

(20) Additional Compounds for PRDX6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Phenylacetamide
  • alpha-Phenylacetamide
  • alpha-Toluamide
  • Benzeneacetamide
  • Phenyl-beta-acetylamine
  • Phenylacetamide
 103-81-1
5-Hydroxyconiferyl alcohol
Coniferyl alcohol
  • (e)-Coniferol
  • 4-(3-Hydroxy-1-propenyl)-2-methoxyphenol
  • 4-[(1E)-3-Hydroxy-1-propenyl]-2-methoxyphenol
  • (e) 3-(4-Hydroxy-3-methoxyphenyl)-2-propen-1-ol
  • 3-(4-Hydroxy-3-methoxyphenyl)-2-propen-1-ol
 458-35-5
Hypothiocyanite
  • Cyanosulfoxylate
  • N,6-didehydro-3,6-dihydro-3-Methyl-adenosine
  • OSCN-hypothiocyanite ion
  • Hypothiocyanite ion
 63296-34-4
methanol
  • Carbinol
  • CH3OH
  • MeOH
  • Methyl alcohol
  • Methylalkohol
 67-56-1
genes like me logo Genes that share compounds with PRDX6: view

Transcripts for PRDX6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PRDX6 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1202) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRDX6 Gene

Peroxiredoxin 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX6 Gene

No ASD Table

Relevant External Links for PRDX6 Gene

GeneLoc Exon Structure for
PRDX6
ECgene alternative splicing isoforms for
PRDX6

Expression for PRDX6 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRDX6 Gene

mRNA expression in normal human tissues for PRDX6 Gene
mRNA expression by BioGPS for PRDX6 GenemRNA expression by GTEx for PRDX6 Gene

mRNA differential expression in normal tissues according to GTEx for PRDX6 Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRDX6 Gene



Protein tissue co-expression partners for PRDX6 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRDX6 Gene:

PRDX6

SOURCE GeneReport for Unigene cluster for PRDX6 Gene:

Hs.120

Evidence on tissue expression from TISSUES for PRDX6 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Blood(4.5)
  • Bone marrow(4.4)
  • Lung(4.4)
  • Eye(3.9)
  • Skin(3.9)
  • Kidney(3.5)
  • Intestine(3.3)
  • Heart(2.9)
  • Muscle(2.9)
  • Stomach(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with PRDX6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX6 Gene

Orthologs for PRDX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia -- 34
  • 100 (a)
 OneToMany
-- 34
  • 100 (a)
 OneToMany
PRDX6 33
  • 99.7 (n)
cow
(Bos Taurus)
 Mammalia PRDX6 34 33
  • 92.86 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia PRDX6 34 33
  • 91.52 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Prdx6 33
  • 88.84 (n)
mouse
(Mus musculus)
 Mammalia Prdx6 16 34 33
  • 87.35 (n)
Prdx6b 34
  • 79 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia PRDX6 34
  • 86 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia PRDX6 34
  • 85 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves PRDX6 34 33
  • 77.98 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia PRDX6 34
  • 81 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia prdx6 33
  • 71.04 (n)
MGC76137 33
zebrafish
(Danio rerio)
 Actinopterygii prdx6 34 33
  • 67.27 (n)
 OneToOne
-- 33
African malaria mosquito
(Anopheles gambiae)
 Insecta TPX5 33
  • 59.73 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Prx6005 34 33
  • 58.87 (n)
 OneToMany
Prx2540-2 34
  • 53 (a)
 OneToMany
Prx2540-1 34
  • 53 (a)
 OneToMany
CG12896 34
  • 52 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea prdx-6 34 33
  • 55.56 (n)
 OneToOne
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AGR368W 33
  • 55.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PRX1 36 34 33
  • 54.81 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E20285g 33
  • 54.65 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons PER1 33
  • 55.77 (n)
rice
(Oryza sativa)
 Liliopsida Os07g0638400 33
  • 56.53 (n)
bread mold
(Neurospora crassa)
 Ascomycetes NCU06031 33
  • 58.73 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.10477 34
  • 55 (a)
 OneToOne
Cin.4007 33
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.4007 33
Species where no ortholog for PRDX6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX6 Gene

ENSEMBL:
Gene Tree for PRDX6 (if available)
TreeFam:
Gene Tree for PRDX6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRDX6: view image

Paralogs for PRDX6 Gene

(1) SIMAP similar genes for PRDX6 Gene using alignment to 1 proteins:

  • PRDX6_HUMAN

Pseudogenes.org Pseudogenes for PRDX6 Gene

genes like me logo Genes that share paralogs with PRDX6: view

No data available for Paralogs for PRDX6 Gene

Variants for PRDX6 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for PRDX6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000196271 -- 173,482,322(+) C/T intron_variant
rs1000227542 -- 173,481,971(+) C/G intron_variant
rs1000324588 -- 173,476,577(+) AACAAACA/AACA upstream_transcript_variant
rs1000541494 -- 173,488,966(+) T/C downstream_transcript_variant
rs1000544094 -- 173,488,584(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PRDX6 Gene

Variant ID Type Subtype PubMed ID
nsv831915 CNV gain+loss 17160897

Variation tolerance for PRDX6 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRDX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDX6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX6 Gene

Disorders for PRDX6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRDX6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gnathomiasis
  • gnathostomiasis
fuchs' endothelial dystrophy
  • fced
- elite association - COSMIC cancer census association via MalaCards
Search PRDX6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRDX6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRDX6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX6 Gene

Publications for PRDX6 Gene

  1. 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. (PMID: 10893423) Chen JW … Fisher AB (The Journal of biological chemistry 2000) 3 4 22 58
  2. AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant. (PMID: 11233154) Phelan SA (Antioxidants & redox signaling 1999) 2 3 22 58
  3. Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. (PMID: 9497358) Kang SW … Rhee SG (The Journal of biological chemistry 1998) 3 4 22 58
  4. Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. (PMID: 9587003) Choi HJ … Ryu SE (Nature structural biology 1998) 3 4 22 58
  5. Crystal structures of human peroxiredoxin 6 in different oxidation states. (PMID: 27353378) Kim KH … Kim EE (Biochemical and biophysical research communications 2016) 3 4 58

Products for PRDX6 Gene

Sources for PRDX6 Gene

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