PRDX6 Gene (Protein Coding)

Peroxiredoxin 6

GCID:: GC01P173477

GIFtS:: 46

Genes Participants

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as i... See more...

Aliases for PRDX6 Gene

Peroxiredoxin 6 ² ³ ⁵
AiPLA2 ² ³ ⁴
NSGPx ² ³ ⁴
AOP2 ² ³ ⁴
Acidic Calcium-Independent Phospholipase A2 ³ ⁴
Non-Selenium Glutathione Peroxidase ³ ⁴
Red Blood Cells Page Spot 12 ³ ⁴
Antioxidant Protein 2 ³ ⁴
Liver 2D Page Spot 40 ³ ⁴
1-Cys Peroxiredoxin ³ ⁴
Peroxiredoxin-6 ³ ⁴
24 KDa Protein ³ ⁴

1-Cys PRX ³ ⁴
KIAA0106 ² ⁴
1-Cys ² ³
PRX ² ³
P29 ² ³
Epididymis Secretory Sperm Binding Protein Li 128m ³
Glutathione-Dependent Peroxiredoxin ⁴
EC 1.11.1.15 ⁵¹
EC 1.11.1.27 ⁴
HEL-S-128m ³
EC 3.1.1.4 ⁴
MGC46173 ²
PRDX6 ⁵

External Ids for PRDX6 Gene

HGNC: 16753
Entrez Gene: 9588
Ensembl: ENSG00000117592
OMIM: 602316
UniProtKB: P30041

Previous GeneCards Identifiers for PRDX6 Gene

GC01P169075
GC01P170027
GC01P170685
GC01P170178
GC01P171713
GC01P173446
GC01P144671

Search aliases for PRDX6 gene in PubMed and other databases

Summaries for PRDX6 Gene

Entrez Gene Summary for PRDX6 Gene

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRDX6 Gene

PRDX6 (Peroxiredoxin 6) is a Protein Coding gene. Diseases associated with PRDX6 include Fuchs' Endothelial Dystrophy and Retinoschisis 1, X-Linked, Juvenile. Among its related pathways are Detoxification of Reactive Oxygen Species and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and antioxidant activity. An important paralog of this gene is PRDX1.

UniProtKB/Swiss-Prot Summary for PRDX6 Gene

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis.
- PRDX6_HUMAN,P30041

Gene Wiki entry for PRDX6 Gene

Additional gene information for PRDX6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRDX6 Gene

Genomics for PRDX6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data

Request up-to-date GeneHancer data

Promoters and enhancers for PRDX6 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH01J173473	Promoter/Enhancer	2.5	EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas	614.7	-0.5	-493	7.1	HNRNPL GATAD2A TEAD4 PRDM10 TFE3 ZNF512 LEF1 IKZF1 POLR2A BACH1	PRDX6 LOC100506023 lnc-PRDX6-2 TNFSF4 KLHL20 GAS5 GAS5-AS1 CENPL DARS2 MN309016
GH01J173526	Enhancer	0.9	Ensembl ENCODE	27.2	+51.1	51064	3.2	CEBPG PRDM1 PKNOX1 SP1 SOX6 CEBPA MGA HMBOX1 CTBP1 BRCA1	PRDX6 ZBTB37 ENSG00000238272 SLC9C2 KLHL20 GAS5 PRDX6-AS1 piR-32810-011 piR-34009-004 lnc-ANKRD45-2
GH01J173506	Enhancer	1.1	Ensembl ENCODE	22.9	+30.2	30171	2.6	CTCF PRDM10 ZNF629 RFX1 ZNF692 PRDM1 ZSCAN4 PATZ1 SP1 ZNF501	PRDX6 ANKRD45 ENSG00000238272 KLHL20 SLC9C2 GAS5 piR-32810-011 piR-47675-005 lnc-ANKRD45-2 TEX50
GH01J173409	Enhancer	1.5	FANTOM5 Ensembl ENCODE dbSUPER	15.1	-63.3	-63330	10.4	SP1 POLR2A BACH1 JUND STAT3 ZNF143 RELA SMAD5 TCF12 IKZF2	LOC107985227 PRDX6 KLHL20 CENPL DARS2 ENSG00000224228 TNFSF4 piR-38426-002 LOC100506023 PRDX6-AS1
GH01J173420	Enhancer	1	ENCODE dbSUPER	21.4	-56.7	-56699	0.9	CREB1 CTCF ZNF512 TARDBP JUND PRDM1 MTA1 REST ZNF24 RAD21	PRDX6 CENPL DARS2 KLHL20 LOC107985227 lnc-SLC9C2-5 TNFSF4 LOC100506023 PRDX6-AS1 TNFSF18

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRDX6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRDX6

Top Transcription factor binding sites by QIAGEN in the PRDX6 gene promoter:

aMEF-2
AML1a
C/EBPbeta
MEF-2
MEF-2A
NF-kappaB
Pax-2
Pax-2a
STAT1

Genomic Locations for PRDX6 Gene

chr1:173,477,330-173,488,815: (GRCh38/hg38)

Size:: 11,486 bases
Orientation:: Plus strand

chr1:173,446,405-173,457,946: (GRCh37/hg19)

Size:: 11,542 bases
Orientation:: Plus strand

Genomic View for PRDX6 Gene

Genes around PRDX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

1q25.1 by HGNC
1q25.1 by Entrez Gene
1q25.1 by Ensembl

PRDX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for PRDX6 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PRDX6 Gene

NC_000001.11

Proteins for PRDX6 Gene

Protein details for PRDX6 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P30041-PRDX6_HUMAN

Recommended name:

Peroxiredoxin-6

Protein Accession:

P30041

Secondary Accessions:
- A8JZY7
- P32077
- Q5TAH4
- Q5ZEZ8
Protein attributes for PRDX6 Gene
Size:

224 amino acids

Molecular mass:

25035 Da
Quaternary structure:
Homodimer (PubMed:9587003, PubMed:27353378). Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration (By similarity). Interacts with APEX1 (PubMed:19188445). Interacts with STH (PubMed:16186110). May interact with FAM168B (PubMed:20716133). May interact with HTR2A (By similarity).
Miscellaneous:
The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. C(P) is reactivated by glutathionylation mediated by glutathione S-transferase Pi, followed by spontaneous reduction of the enzyme with glutathione.
Three dimensional structures from OCA and Proteopedia for PRDX6 Gene
- 1PRX (3D)
- 5B6M (3D)
- 5B6N (3D)

neXtProt entry for PRDX6 Gene

Protein Expression for PRDX6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PRDX6 Gene

P30041:

VATPVDWK
DFTPVCTTEL
TTGRNFDE

Post-translational modifications for PRDX6 Gene

Irreversibly inactivated by overoxidation of Cys-47 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress.
- P30041-PRDX6_HUMAN
Phosphorylation at Thr-177 by MAP kinases increases the phospholipase activity of the enzyme.
- P30041-PRDX6_HUMAN
Ubiquitination at Lys209
- NX_P30041 (NX_P30041-1)
Modification sites at PhosphoSitePlus
- P30041

Other Protein References for PRDX6 Gene

ENSEMBL proteins:

ENSP00000342026

REFSEQ proteins:

NP_004896.1

Antibody Products

G Biosciences Immunotag™ PRDX6 Antibody

NSJ Bioreagents Peroxiredoxin 6 Antibody (PRDX6)

HUABIO Recombinant PRDX6 Monoclonal Antibody (ET1703-62) and PRDX6 Monoclonal Antibody (EM1701-73)

GeneTex Anti-Peroxiredoxin 6 antibody (GTX32779) and Anti-Peroxiredoxin 6 antibody (GTX115262)

Human/Mouse/Rat Peroxiredoxin 6 Antibody (AF3490)

OriGene Antibodies for PRDX6
- AM31704PU-N
- AM31914PU-N
- AP17665PU-N
- AP31423PU-N
- TA307267
- TA321675
- TA321676
- TA326746
- TA327232
- TA327774
- TA346591
- TA346592
Custom Antibody Services

Novus Biologicals Antibodies for PRDX6

Abcam antibodies for PRDX6
- Peroxiredoxin 6

Invitrogen Antibodies for PRDX6 (AFLGC-PRDX6)

antibodies-online: Show 59 available Peroxiredoxin 6 Antibodies ranked by validation data
Compare Top Peroxiredoxin 6 Antibodies
Quality Products:

Biorbyt antibodies for PRDX6
- orb176729
- orb400532
- orb381983
- orb48505
- orb34340
- orb34339

Boster Bio Antibodies for PRDX6
- PB9350
- M01847
- M01847-1

Santa Cruz Biotechnology (SCBT) Antibodies for PRDX6

Sino Biological Antibodies for PRDX6

Protein Products

G Biosciences Human peroxiredoxin 6/PRDX6/AOP2, Liquid

OriGene Purified Proteins for PRDX6
- NM_004905
- NM_004905
- NM_004905
- NM_004905
- NM_004905
- NM_004905
- BC013489
- NM_004905
Search Origene for MassSpec and Protein Over-expression Lysates for PRDX6
Origene Custom Protein Services for PRDX6

Novus Biologicals proteins and lysates for PRDX6

Sino Biological Recombinant Proteins for PRDX6
Browse Sino Biological Cell Lysates

ProSpec Recombinant Proteins for PRDX6

antibodies-online: Show 31 available Peroxiredoxin 6 Proteins ranked by validation data
Compare Top Peroxiredoxin 6 Proteins
Quality Products:

Signalway Proteins for PRDX6
- AP75680
- AP79177
- GP10719

ProSci Proteins for PRDX6
- peroxiredoxin 6

Abcam proteins for PRDX6
- Peroxiredoxin 6

Assay Products

G Biosciences Immunotag™ Human PRDX6 (Peroxiredoxin-6) ELISA and Immunotag™ Peroxiredoxin-6 ELISA Kit

RayBiotech Human/Mouse/Rat Phospho-PTEN (S380) and Total PTEN ELISA and Human/Mouse/Rat Phospho-PTEN (S380) ELISA

antibodies-online: Show 26 available Peroxiredoxin 6 Elisa Kits ranked by validation data
Compare Top Peroxiredoxin 6 Elisa Kits
Quality Products:

Browse Boster Bio ELISA Kits

Signalway ELISA kits for PRDX6
- EK3936
- EK16246

Browse Sino Biological Assays

Domains & Families for PRDX6 Gene

Gene Families for PRDX6 Gene

HGNC:

Peroxiredoxins

Human Protein Atlas (HPA):

Enzymes
Plasma proteins
Predicted intracellular proteins

Protein Domains for PRDX6 Gene

InterPro:

Blocks:

Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

ProtoNet:

P30041

Suggested Antigen Peptide Sequences for PRDX6 Gene

GenScript: Design optimal peptide antigens:

Red blood cells page spot 12 (PRDX6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30041

UniProtKB/Swiss-Prot:

PRDX6_HUMAN :

Belongs to the peroxiredoxin family. Prx6 subfamily.

Family:

Belongs to the peroxiredoxin family. Prx6 subfamily.

Function for PRDX6 Gene

Molecular function for PRDX6 Gene

UniProtKB/Swiss-Prot Function:

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis.

PRDX6_HUMAN,P30041

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O; Xref=Rhea:RHEA:62632, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.27; Evidence={ECO:0000269|PubMed:10893423, ECO:0000269|PubMed:9497358};.

PRDX6_HUMAN,P30041

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000269|PubMed:10893423};.

PRDX6_HUMAN,P30041

Enzyme Numbers (IUBMB) for PRDX6 Gene

Phenotypes From GWAS Catalog for PRDX6 Gene

Gene Ontology (GO) - Molecular Function for PRDX6 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	IEA	--
GO:0004601	peroxidase activity	IEA	--
GO:0004602	glutathione peroxidase activity	IMP	10893423
GO:0004623	phospholipase A2 activity	IEA	--
GO:0005515	protein binding	IPI	16186110

Phenotypes for PRDX6 Gene

MGI mutant phenotypes for PRDX6:

inferred from 5 alleles

GenomeRNAi human phenotypes for PRDX6:

Animal Models for PRDX6 Gene

MGI Knock Outs for PRDX6:

Prdx6 ^{Prdx6<tm1Pgn>}
Prdx6 ^{Prdx6<tm1Abf>}
Prdx6 ^{Prdx6<tm1a(EUCOMM)Wtsi>}

Animal Model Products

Taconic Biosciences Mouse Models for PRDX6
- Prdx6

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for PRDX6 - Select products 50% OFF >
* PRDX6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene CRISPR knockouts for PRDX6
- GA106422
- GA200201
- KN407780
- KN513845

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDX6

Santa Cruz Biotechnology (SCBT) CRISPR for PRDX6

miRNA for PRDX6 Gene

miRTarBase miRNAs that target PRDX6

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for PRDX6

Browse OriGene miRNA Products For PRDX6

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for PRDX6
Browse OriGene Inhibitory RNA Products For PRDX6

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDX6

Search Santa Cruz Biotechnology (SCBT) for PRDX6 siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for PRDX6 - Select products 50% OFF >
* PRDX6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene clones in human,mouse,rat for PRDX6
- SC211606
- MC203805
- MC226261
- RN208912
- SC117092
OriGene ORF clones in human,mouse,rat for PRDX6
- MG202605
- MG202617
- MR202605
- MR202605L3
- MR202605L4
- MR202617
- MR202617L3
- MR202617L4
- MR228472
- RC207780
- RC207780L1
- RC207780L2
- RC207780L3
- RC207780L4
- RG207780
- RR208912
- RR208912L3
- RR208912L4
- MR202605L3V
- MR202605L4V
- MR202617L3V
- MR202617L4V
- RC207780L1V
- RC207780L2V
- RC207780L3V
- RC207780L4V
- RR208912L3V
- RR208912L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for PRDX6

Search Addgene for plasmids for PRDX6

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDX6

Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for PRDX6

Browse GeneCopoeia Cell Lines

VectorBuilder Stable cell line generation for PRDX6

Horizon Cell Lines for PRDX6
- PRDX6 knockout cell line
- PRDX6 knockout cell line

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX6 Gene

Localization for PRDX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX6 Gene

Cytoplasm. Lysosome. Note=Also found in lung secretory organelles (lamellar bodies). {ECO:0000250 UniProtKB:O35244}.

P30041-PRDX6_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
cytosol	5
extracellular	4
mitochondrion	4
lysosome	4
plasma membrane	3
cytoskeleton	2
peroxisome	2
endoplasmic reticulum	2
endosome	1
golgi apparatus	1

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (3)
Plasma membrane (2)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRDX6 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	HDA	23580065
GO:0005623	cell	IEA	--
GO:0005634	nucleus	IDA	16186110
GO:0005737	cytoplasm	IEA,IDA	16186110

Pathways & Interactions for PRDX6 Gene

SuperPathways for PRDX6 Gene

	SuperPathway	Contained pathways
1	Innate Immune System	Immune System .61 Innate Immune System .61	Neutrophil degranulation .38
2	Ca, cAMP and Lipid Signaling	Ca, cAMP and Lipid Signaling -
3	Glucose / Energy Metabolism	Glucose / Energy Metabolism -
4	Glutathione metabolism	Glutathione metabolism .60
5	Metabolism	Metabolic pathways .40

Pathways by source for PRDX6 Gene

1 BioSystems pathway for PRDX6 Gene

NRF2 pathway

5 Reactome pathways for PRDX6 Gene

2 KEGG pathways for PRDX6 Gene

1 GeneGo (Thomson Reuters) pathway for PRDX6 Gene

Immune response CD16 signaling in NK cells

2 Cell Signaling Technology pathways for PRDX6 Gene

Interacting Proteins for PRDX6 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: P30041-PRDX6_HUMAN ENSP00000342026 for PRDX6 Gene via UniProtKB MINT STRING IID

Symbol	External ID(s)	Details
PCNA	P12004 ⁴ ²⁰ ¹²⁶ ENSP00000368458 ²¹	EBI-2255129, EBI-358311 MINT-7995228 STRING: ENSP00000368458 IID: # exp=1
DLD	P09622 ⁴ ¹²⁶ ENSP00000205402 ²¹	EBI-2255129, EBI-353366 STRING: ENSP00000205402 IID: # exp=1
GSTP1	P09211 ⁴ ¹²⁶ ENSP00000381607 ²¹	EBI-2255129, EBI-353467 STRING: ENSP00000381607 IID: # exp=2
VDAC1	P21796 ⁴ ¹²⁶ ENSP00000265333 ²¹	EBI-2255129, EBI-354158 STRING: ENSP00000265333 IID: # exp=1
AHSA1	ENSP00000216479 ²¹ O95433 ¹²⁶	STRING: ENSP00000216479 IID: # exp=1

GPS-Prot Interaction Network for PRDX6

SIGNOR curated interactions for PRDX6 Gene

Is activated by:

MAPK1

Gene Ontology (GO) - Biological Process for PRDX6 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	IEA	--
GO:0006979	response to oxidative stress	IMP	10893423
GO:0008152	metabolic process	IEA	--
GO:0016042	lipid catabolic process	IEA	--
GO:0034599	cellular response to oxidative stress	TAS	--

Drugs & Compounds for PRDX6 Gene

(20) Drugs for PRDX6 Gene - From: DrugBank, HMDB, and Novoseek

Name	Status	Disease Links	Group	Role	Clinical Trials
Oxygen	Approved, Vet_approved	MalaCards Medline Plus	Pharma		0
Copper	Approved, Investigational	MalaCards Medline Plus	Pharma	Target	249
Carbon dioxide	Approved, Investigational, Vet_approved	MalaCards Medline Plus	Pharma		0
Formaldehyde	Approved, Vet_approved	MalaCards Medline Plus	Pharma		142
Hydrogen peroxide	Approved, Vet_approved	MalaCards Medline Plus	Pharma		115

(19) Additional Compounds for PRDX6 Gene - From: HMDB and Novoseek

Name	Synonyms	CAS Number	PubChem IDs	PubMed IDs
2-Phenylacetamide	alpha-Phenylacetamide alpha-Toluamide Benzeneacetamide Phenyl-beta-acetylamine Phenylacetamide	MalaCards Medline Plus	103-81-1	7680
5-Hydroxyconiferyl alcohol		MalaCards Medline Plus		5282095
Coniferyl alcohol	(e)-Coniferol 4-(3-Hydroxy-1-propenyl)-2-methoxyphenol 4-[(1E)-3-Hydroxy-1-propenyl]-2-methoxyphenol (e) 3-(4-Hydroxy-3-methoxyphenyl)-2-propen-1-ol 3-(4-Hydroxy-3-methoxyphenyl)-2-propen-1-ol	MalaCards Medline Plus	458-35-5	1549095
Hypothiocyanite	Cyanosulfoxylate N,6-didehydro-3,6-dihydro-3-Methyl-adenosine OSCN-hypothiocyanite ion Hypothiocyanite ion	MalaCards Medline Plus	63296-34-4	124985
methanol	Carbinol CH3OH MeOH Methyl alcohol Methylalkohol	MalaCards Medline Plus	67-56-1	887

Drug Products

G Biosciences Human peroxiredoxin 6/PRDX6/AOP2, Liquid

Browse Tocris compounds for PRDX6

Browse compounds at ApexBio

Transcripts for PRDX6 Gene

mRNA/cDNA for PRDX6 Gene

1 REFSEQ mRNAs :

NM_004905.3

11 NCBI additional mRNA sequence :

3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

ENST00000340385 1690 nts (view in UCSC)
ENST00000460950 809 nts (view in UCSC)
ENST00000470017 859 nts (view in UCSC)

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for PRDX6 - Select products 50% OFF >
* PRDX6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene CRISPR knockouts for PRDX6
- GA106422
- GA200201
- KN407780
- KN513845

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDX6

Santa Cruz Biotechnology (SCBT) CRISPR for PRDX6

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for PRDX6

Browse OriGene miRNA Products For PRDX6

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for PRDX6
Browse OriGene Inhibitory RNA Products For PRDX6

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDX6

Search Santa Cruz Biotechnology (SCBT) for PRDX6 siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for PRDX6 - Select products 50% OFF >
* PRDX6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene clones in human,mouse,rat for PRDX6
- SC211606
- MC203805
- MC226261
- RN208912
- SC117092
OriGene ORF clones in human,mouse,rat for PRDX6
- MG202605
- MG202617
- MR202605
- MR202605L3
- MR202605L4
- MR202617
- MR202617L3
- MR202617L4
- MR228472
- RC207780
- RC207780L1
- RC207780L2
- RC207780L3
- RC207780L4
- RG207780
- RR208912
- RR208912L3
- RR208912L4
- MR202605L3V
- MR202605L4V
- MR202617L3V
- MR202617L4V
- RC207780L1V
- RC207780L2V
- RC207780L3V
- RC207780L4V
- RR208912L3V
- RR208912L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for PRDX6

Search Addgene for plasmids for PRDX6

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDX6

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX6 Gene

No ASD Table

Relevant External Links for PRDX6 Gene

GeneLoc Exon Structure for: PRDX6

Expression for PRDX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRDX6 Gene

mRNA expression in normal human tissues for PRDX6 Gene

mRNA expression by BioGPS for PRDX6 Gene

mRNA differential expression in normal tissues according to GTEx for PRDX6 Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRDX6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MaxQB, and MOPED for PRDX6 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for PRDX6 Gene

Protein tissue co-expression partners for PRDX6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRDX6

SOURCE GeneReport for Unigene cluster for PRDX6 Gene:

Hs.120

Evidence on tissue expression from TISSUES for PRDX6 Gene

Nervous system(5)
Liver(4.7)
Blood(4.6)
Bone marrow(4.5)
Lung(4.5)
Skin(4.2)
Eye(4)
Kidney(3.8)
Heart(3.8)
Intestine(3.7)
Muscle(3.4)
Adrenal gland(2.8)
Spleen(2.7)
Stomach(2.6)
Lymph node(2.6)
Pancreas(2.6)
Thyroid gland(2.5)

Primer Products

OriGene qPCR primer pairs for PRDX6
- HP208150
- MP210733
OriGene qPCR primer pairs and template standards for PRDX6
- HK205848
- MK203181

Gene Expression Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for PRDX6

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX6 Gene

Orthologs for PRDX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX6 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
Chimpanzee (Pan troglodytes)	Mammalia	-- ³¹	100 (a)	OneToMany	8:118355707-118357371
		-- ³¹	100 (a)	OneToMany	1:151949356-151959833
		PRDX6 ³⁰	99.7 (n)		469589 XM_524972.4 XP_524972.2
Cow (Bos Taurus)	Mammalia	PRDX6 ³⁰ ³¹	92.86 (n)	OneToOne	282438 NM_174643.1 NP_777068.1 16:56389804-56399714
Dog (Canis familiaris)	Mammalia	PRDX6 ³⁰ ³¹	91.52 (n)	OneToOne	480069 XM_537190.4 XP_537190.3 7:25664091-25675877
Rat (Rattus norvegicus)	Mammalia	Prdx6 ³⁰	88.84 (n)		94167 NM_053576.2 NP_446028.1
Mouse (Mus musculus)	Mammalia	Prdx6 ³⁰ ¹⁷ ³¹	87.35 (n)	OneToMany	11758 NM_007453.3 NP_031479.1 161240112 1:161240112-161251219
Mouse (Mus musculus)	Mammalia	Prdx6b ³¹	79 (a)	OneToMany	2:80292470-80295358
Platypus (Ornithorhynchus anatinus)	Mammalia	PRDX6 ³¹	86 (a)	OneToOne	Ultra341:2966172-2982731
Oppossum (Monodelphis domestica)	Mammalia	PRDX6 ³¹	85 (a)	OneToOne	2:65883375-65907916
Chicken (Gallus gallus)	Aves	PRDX6 ³⁰ ³¹	77.98 (n)	OneToOne	429062 NM_001039329.2 NP_001034418.1 8:4296031-4302926
Lizard (Anolis carolinensis)	Reptilia	PRDX6 ³¹	81 (a)	OneToOne	4:71284129-71304057
Tropical Clawed Frog (Silurana tropicalis)	Amphibia	prdx6 ³⁰	71.04 (n)		394706 NM_203771.1 NP_989102.1
Tropical Clawed Frog (Silurana tropicalis)	Amphibia	MGC76137 ³⁰			BC062510.1
Zebrafish (Danio rerio)	Actinopterygii	prdx6 ³⁰ ³¹	67.27 (n)	OneToOne	393778 NM_200805.1 NP_957099.1 20:15170289-15190620
Zebrafish (Danio rerio)	Actinopterygii	-- ³⁰			393778 BC059671.1
African malaria mosquito (Anopheles gambiae)	Insecta	TPX5 ³⁰	59.73 (n)		1270086 XM_308753.3 XP_308753.2
Fruit Fly (Drosophila melanogaster)	Insecta	Prx6005 ³⁰ ³¹	58.87 (n)	OneToMany	33493 NM_078739.3 NP_523463.2 2L:2877091-2878232
		Prx2540-2 ³¹	53 (a)	OneToMany	2R:6306223-6307266
		Prx2540-1 ³¹	53 (a)	OneToMany	2R:6311941-6312976
		CG12896 ³¹	52 (a)	OneToMany	2R:6314385-6315418
Worm (Caenorhabditis elegans)	Secernentea	prdx-6 ³⁰ ³¹	55.56 (n)	OneToOne	176837 NM_171241.3 NP_741287.1 IV:218551-220858
A. gosspyii yeast (Eremothecium gossypii)	Saccharomycetes	AGOS_AGR368W ³⁰	55.45 (n)		4623337 NM_212096.2 NP_987034.2
Baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	PRX1 ³⁰ ³¹ ³³	54.81 (n)	OneToOne	852215 NP_009489.1 II:100371-101156
K. Lactis Yeast (Kluyveromyces lactis)	Saccharomycetes	KLLA0E20285g ³⁰	54.65 (n)		2894670 XM_454869.1 XP_454869.1
Thale Cress (Arabidopsis thaliana)	eudicotyledons	PER1 ³⁰	55.77 (n)		841231 NM_103709.3 NP_175247.1
Rice (Oryza sativa)	Liliopsida	Os07g0638400 ³⁰	56.53 (n)		4344046 NM_001066943.1 NP_001060408.1
Bread mold (Neurospora crassa)	Ascomycetes	NCU06031 ³⁰	58.73 (n)		3875759 XM_954528.2 XP_959621.1
Sea Squirt (Ciona savignyi)	Ascidiacea	CSA.10477 ³¹	55 (a)	OneToOne	reftig_140:402425-405882
Sea Vase (Ciona intestinalis)	Ascidiacea	Cin.4007 ³⁰			AV897014.1

Species where no ortholog for PRDX6 was found in the sources mined by GeneCards:

Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
Alicante grape (Vitis vinifera)
Alpha proteobacteria (Wolbachia pipientis)
Amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
Barley (Hordeum vulgare)
Beta proteobacteria (Neisseria meningitidis)
Chromalveolata (Phytophthora infestans)
Common water flea (Daphnia pulex)
Corn (Zea mays)
E. coli (Escherichia coli)
Filamentous fungi (Aspergillus nidulans)
Firmicute Bacteria (Streptococcus pneumoniae)
Fission Yeast (Schizosaccharomyces pombe)
Green Algae (Chlamydomonas reinhardtii)
Honey Bee (Apis mellifera)
Loblloly Pine (Pinus taeda)
Malaria Parasite (Plasmodium falciparum)
Medicago Trunc (Medicago Truncatula)
Moss (Physcomitrella patens)
Orangutan (Pongo pygmaeus)
Pig (Sus scrofa)
Rainbow Trout (Oncorhynchus mykiss)
Rice Blast Fungus (Magnaporthe grisea)
Schistosome Parasite (Schistosoma mansoni)
Sea Anemone (Nematostella vectensis)
Sea Urchin (Strongylocentrotus purpuratus)
Sorghum (Sorghum bicolor)
Soybean (Glycine max)
Stem Rust Fungus (Puccinia graminis)
Sugarcane (Saccharum officinarum)
Tomato (Lycopersicon esculentum)
Toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
Wheat (Triticum aestivum)

Evolution for PRDX6 Gene

ENSEMBL:: Gene Tree for PRDX6 (if available)
TreeFam:: Gene Tree for PRDX6 (if available)
Aminode:: Evolutionary constrained regions (ECRs) for PRDX6: view image

Paralogs for PRDX6 Gene

PRDX1 ⁵
PRDX2 ⁵
PRDX3 ⁵
PRDX4 ⁵

(1) SIMAP similar genes for PRDX6 Gene using alignment to 1 proteins:

PRDX6_HUMAN

PRDX1

Pseudogenes.org Pseudogenes for PRDX6 Gene

Variants for PRDX6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRDX6 Gene

SNP ID	Clinical significance and condition	Chr 01 pos	Variation	AA Info	Type
767728	Benign: not provided	173,481,318(+)	C/G		INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for PRDX6 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRDX6 Gene

Variant ID	Type	Subtype	PubMed ID
nsv831915	CNV	gain+loss	17160897

Variation tolerance for PRDX6 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 0.39; 8.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRDX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for: PRDX6

SNP Genotyping and Copy Number Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for PRDX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX6 Gene

Disorders for PRDX6 Gene

(7) MalaCards diseases for PRDX6 Gene - From: DISEASES and GeneCards

Disorder	Aliases	PubMed IDs
fuchs' endothelial dystrophy	fced
retinoschisis 1, x-linked, juvenile	rs1
bullous retinoschisis
gnathomiasis	gnathostomiasis
intrahepatic cholestasis of pregnancy	gravidic intrahepatic cholestasis

- elite association - COSMIC cancer census association via MalaCards

Search PRDX6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRDX6

Genetic Association Database: (GAD)
Human Genome Epidemiology Navigator: (HuGE)
: ATLAS of Genetics and Cytogenetics in Oncology and Haematology
: Open Targets Platform

Search disorders for PRDX6 gene in PubMed and other databases

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX6 Gene

Publications for PRDX6 Gene

1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. (PMID: 10893423) Chen JW … Fisher AB (The Journal of biological chemistry 2000) ³ ⁴ ²³
AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant. (PMID: 11233154) Phelan SA (Antioxidants & redox signaling 1999) ² ³ ²³
Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. (PMID: 9497358) Kang SW … Rhee SG (The Journal of biological chemistry 1998) ³ ⁴ ²³
Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. (PMID: 9587003) Choi HJ … Ryu SE (Nature structural biology 1998) ³ ⁴ ²³
Crystal structures of human peroxiredoxin 6 in different oxidation states. (PMID: 27353378) Kim KH … Kim EE (Biochemical and biophysical research communications 2016) ³ ⁴