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This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]
PRDX5 (Peroxiredoxin 5) is a Protein Coding gene. Diseases associated with PRDX5 include Alopecia Areata and Acatalasemia. Among its related pathways are Detoxification of Reactive Oxygen Species and Prostaglandin 2 biosynthesis and metabolism FM. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein dimerization activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001016 | RNA polymerase III regulatory region DNA binding | IDA | 10095767 |
GO:0004601 | peroxidase activity | IEA,IDA | 10521424 |
GO:0005515 | protein binding | IPI | 10514471 |
GO:0008379 | thioredoxin peroxidase activity | IBA | 21873635 |
GO:0016209 | antioxidant activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 23580065 |
GO:0005634 | nucleus | IDA | 10095767 |
GO:0005737 | cytoplasm | IBA,IDA | 15785239 |
GO:0005739 | mitochondrion | IBA,IDA | 10521424 |
GO:0005759 | mitochondrial matrix | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
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|
2 | Folate Metabolism | ||
3 | Peroxisome | ||
4 | Cellular Senescence (REACTOME) | ||
5 | Detoxification of Reactive Oxygen Species |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | IEA | -- |
GO:0006954 | inflammatory response | TAS | 10521424 |
GO:0006979 | response to oxidative stress | IDA | 10521424 |
GO:0016480 | negative regulation of transcription by RNA polymerase III | IDA | 10095767 |
GO:0034599 | cellular response to oxidative stress | IBA,TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Auranofin | Approved, Investigational | Pharma | Target, inhibitor | Thioredoxin reductase inhibitor; induces MPT | 12 | |
Hydrogen peroxide | Approved, Vet_approved | Pharma | 140 | |||
Water | Approved | Pharma | 0 | |||
Diminazene | Experimental | Pharma | Target | 0 | ||
Polaprezinc | Experimental | Pharma | Enzyme, inducer | 5 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PRDX5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Prdx5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Prdx5 30 |
|
||
Dog (Canis familiaris) |
Mammalia | PRDX5 30 |
|
||
Cow (Bos Taurus) |
Mammalia | PRDX5 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PRDX5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PRDX5 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PRDX5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prdx5 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | prdx5 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9314 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Prx5 30 31 |
|
OneToOne | |
CG7217 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001325 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADL154C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A07271g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | AHP1 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | TPX1 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0675100 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU06880 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPCC330.06c 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_036406 | A breast cancer sample |
p.Phe157Leu |
|||
rs7938623 | - |
p.Tyr33Cys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1963n54 | CNV | loss | 21841781 |
esv2667562 | CNV | deletion | 23128226 |
esv27107 | CNV | loss | 19812545 |
esv3626659 | CNV | loss | 21293372 |
nsv469961 | CNV | loss | 18288195 |
nsv832186 | CNV | loss | 17160897 |
nsv951010 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
alopecia areata |
|
|
acatalasemia |
|
|
vitiligo-associated multiple autoimmune disease susceptibility 1 |
|
|
fuchs' endothelial dystrophy |
|
|
cataract |
|
|