Aliases for PRDX5 Gene
Aliases for PRDX5 Gene
External Ids for PRDX5 Gene
- HGNC: 9355
- Entrez Gene: 25824
- Ensembl: ENSG00000126432
- OMIM: 606583
- UniProtKB: P30044
Previous GeneCards Identifiers for PRDX5 Gene
- GC11P066601
- GC11P065767
- GC11P064336
- GC11P063860
- GC11P063842
- GC11P064085
- GC11P060413
Summaries for PRDX5 Gene
-
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]
GeneCards Summary for PRDX5 Gene
PRDX5 (Peroxiredoxin 5) is a Protein Coding gene. Diseases associated with PRDX5 include Fuchs' Endothelial Dystrophy and Corticobasal Degeneration. Among its related pathways are Gene Expression and Folate Metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein dimerization activity.
UniProtKB/Swiss-Prot for PRDX5 Gene
-
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Additional gene information for PRDX5 Gene
- Monarch Initiative
- Search for PRDX5 at DataMed
- Search for PRDX5 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX5 Gene
Genomics for PRDX5 Gene
GeneHancer (GH) Regulatory Elements for PRDX5 Gene
Promoters and enhancers for PRDX5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRDX5 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PRDX5 gene promoter:
-
- c-Jun
- ATF-2
- deltaCREB
- CREB
- PPAR-gamma1
- PPAR-gamma2
Regulatory Element Products
Genomic Locations for PRDX5 Gene
Genomic Locations for PRDX5 Gene
- chr11:64,318,088-64,321,823
- (GRCh38/hg38)
- Size:
- 3,736 bases
- Orientation:
- Plus strand
- chr11:64,085,560-64,089,295
- (GRCh37/hg19)
- Size:
- 3,736 bases
- Orientation:
- Plus strand
Genomic View for PRDX5 Gene
Genes around PRDX5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
- 11q13.1 by Ensembl
PRDX5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRDX5 Gene
Proteins for PRDX5 Gene
-
Protein details for PRDX5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30044-PRDX5_HUMAN
- Recommended name:
- Peroxiredoxin-5, mitochondrial
- Protein Accession:
- P30044
- A6NC19
- A6NG06
- B7ZLJ4
- B7ZVW3
- Q14CK0
- Q6IAF2
- Q9UBU5
- Q9UJU4
- Q9UKX4
Protein attributes for PRDX5 Gene
- Size:
- 214 amino acids
- Molecular mass:
- 22086 Da
- Quaternary structure:
-
- Monomer.
- Miscellaneous:
-
- The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys Prx, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
- SequenceCaution:
-
- Sequence=AAF17200.1; Type=Frameshift; Positions=14, 30; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for PRDX5 Gene
Protein Expression for PRDX5 Gene
Post-translational modifications for PRDX5 Gene
Other Protein References for PRDX5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PRDX5 (Peroxiredoxin 5)
- Novus Biologicals Antibodies for PRDX5
-
Abcam antibodies for PRDX5
- Invitrogen Antibodies for PRDX5
- antibodies-online: Search results for 122 available Peroxiredoxin 5 Antibodies ranked by validation data
- Compare Top Peroxiredoxin 5 Antibodies
-
Recommended
- GeneTex PRDX5 Antibody for PRDX5
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRDX5
- Sino Biological Antibodies for PRDX5
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PRDX5
- Origene Custom Protein Services for PRDX5
- Sino Biological Recombinant Proteins for PRDX5
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for PRDX5
- Search GeneTex for Proteins for PRDX5
-
ProSci Proteins for PRDX5
-
Abcam proteins for PRDX5
No data available for DME Specific Peptides for PRDX5 Gene
Domains & Families for PRDX5 Gene
Gene Families for PRDX5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PRDX5 Gene
Suggested Antigen Peptide Sequences for PRDX5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P30044- Family:
-
- Belongs to the peroxiredoxin family. Prx5 subfamily.
Function for PRDX5 Gene
Molecular function for PRDX5 Gene
- UniProtKB/Swiss-Prot Function:
- Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
Enzyme Numbers (IUBMB) for PRDX5 Gene
Phenotypes From GWAS Catalog for PRDX5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001016 | RNA polymerase III regulatory region DNA binding | IDA | 10095767 |
| GO:0004601 | peroxidase activity | IEA,IDA | 10521424 |
| GO:0005102 | signaling receptor binding | IPI | 20178365 |
| GO:0008379 | thioredoxin peroxidase activity | IBA,EXP | -- |
| GO:0016209 | antioxidant activity | IEA | -- |
Phenotypes for PRDX5 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for PRDX5
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRDX5
-
CRISPR Products
-
OriGene CRISPR knockouts for PRDX5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDX5
- genomics-online: gRNA clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
-
Recommended
- Applied Biological Materials CRISPR for PRDX5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDX5
- GenScript: Design CRISPR guide RNA sequences for PRDX5
miRNA for PRDX5 Gene
- miRTarBase miRNAs that target PRDX5
-
- hsa-mir-744-5p (MIRT037717)
- hsa-mir-4722-5p (MIRT470282)
- hsa-mir-4764-5p (MIRT470283)
- hsa-mir-1286 (MIRT470284)
- hsa-mir-873-5p (MIRT470285)
- hsa-mir-219b-3p (MIRT470286)
- hsa-mir-570-3p (MIRT470287)
- hsa-mir-1205 (MIRT470288)
- hsa-mir-4733-3p (MIRT470289)
- hsa-mir-3688-3p (MIRT470290)
- hsa-mir-1265 (MIRT470291)
- hsa-mir-302f (MIRT470292)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PRDX5
- Browse OriGene Inhibitory RNA Products For PRDX5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDX5
- genomics-online: shRNA clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for PRDX5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PRDX5
- VectorBuilder custom plasmid, inducible vectors for PRDX5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDX5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PRDX5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDX5
- genomics-online: cdna clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
-
Recommended
- orf clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
-
Recommended
- Applied Biological Materials Clones for PRDX5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRDX5
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRDX5 Gene
Localization for PRDX5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRDX5 Gene
- Isoform Mitochondrial: Mitochondrion.
- Isoform Cytoplasmic+peroxisomal: Cytoplasm. Peroxisome matrix. Note=Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5. {ECO:0000269 PubMed:10514471}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| peroxisome | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (4)
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 23580065 |
| GO:0005634 | nucleus | IDA | 10095767 |
| GO:0005737 | cytoplasm | IEA,IDA | 15785239 |
| GO:0005739 | mitochondrion | IEA,IDA | 10521424 |
| GO:0005759 | mitochondrial matrix | TAS | -- |
Pathways & Interactions for PRDX5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | Folate Metabolism | ||
| 3 | Peroxisome | ||
| 4 | Cellular Senescence (REACTOME) | ||
| 5 | Detoxification of Reactive Oxygen Species | ||
Pathways by source for PRDX5 Gene
2 BioSystems pathways for PRDX5 Gene
6 Reactome pathways for PRDX5 Gene
1 KEGG pathway for PRDX5 Gene
1 GeneGo (Thomson Reuters) pathway for PRDX5 Gene
Interacting Proteins for PRDX5 Gene
Selected Interacting proteins:
P30044-PRDX5_HUMAN
ENSP00000265462
for PRDX5 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for PRDX5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006954 | inflammatory response | TAS | 10521424 |
| GO:0006979 | response to oxidative stress | IDA | 10521424 |
| GO:0016480 | negative regulation of transcription by RNA polymerase III | IDA | 10095767 |
| GO:0034599 | cellular response to oxidative stress | TAS | -- |
No data available for SIGNOR curated interactions for PRDX5 Gene
Drugs & Compounds for PRDX5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Auranofin | Approved, Investigational | Pharma | Activation, Activator, Target, inhibitor | Thioredoxin reductase inhibitor; induces MPT | 11 | |
| Benzoic Acid | Approved, Investigational | Pharma | Target | 8 | ||
| Polaprezinc | Approved, Investigational | Pharma | Enzyme | 2 | ||
| Hydrogen peroxide | Approved, Vet_approved | Pharma | 73 | |||
| Water | Approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for PRDX5 Gene
mRNA/cDNA for PRDX5 Gene
- (5) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (828) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000265462 893 bps (uc001nzu.4)
- ENST00000352435 596 bps (uc001nzv.4)
- ENST00000347941 463 bps (uc001nzw.4)
Unigene Clusters for PRDX5 Gene
- Peroxiredoxin 5:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PRDX5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDX5
- genomics-online: gRNA clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
-
Recommended
- Applied Biological Materials CRISPR for PRDX5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDX5
- GenScript: Design CRISPR guide RNA sequences for PRDX5
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PRDX5
- Browse OriGene Inhibitory RNA Products For PRDX5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDX5
- genomics-online: shRNA clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for PRDX5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PRDX5
- VectorBuilder custom plasmid, inducible vectors for PRDX5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDX5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PRDX5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDX5
- genomics-online: cdna clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
-
Recommended
- orf clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
-
Recommended
- Applied Biological Materials Clones for PRDX5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for PRDX5 Gene
This gene is overexpressed in Nasal epithelium (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRDX5 Gene
NURSA nuclear receptor signaling pathways regulating expression of PRDX5 Gene:
PRDX5SOURCE GeneReport for Unigene cluster for PRDX5 Gene:
Hs.502823mRNA Expression by UniProt/SwissProt for PRDX5 Gene:
P30044-PRDX5_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for PRDX5 Gene
- Nervous system(4.8)
- Liver(4.7)
- Lung(4.7)
- Adrenal gland(4.5)
- Heart(3.1)
- Kidney(3.1)
- Muscle(3)
- Thyroid gland(2.9)
- Eye(2.8)
- Blood(2.7)
- Skin(2.7)
- Intestine(2.6)
- Stomach(2.1)
- Bone marrow(2)
- Pancreas(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for PRDX5
-
OriGene qPCR primer pairs for PRDX5
- genomics-online: primer clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX5 Gene
Orthologs for PRDX5 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PRDX5 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Prdx5 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Prdx5 33 |
|
||
| dog (Canis familiaris) |
Mammalia | PRDX5 33 |
|
||
| cow (Bos Taurus) |
Mammalia | PRDX5 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PRDX5 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PRDX5 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PRDX5 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prdx5 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | prdx5 34 33 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9314 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Prx5 34 33 |
|
OneToOne | |
| CG7217 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001325 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADL154C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A07271g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | AHP1 36 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | TPX1 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0675100 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06880 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPCC330.06c 33 |
|
- Species where no ortholog for PRDX5 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PRDX5 Gene
- ENSEMBL:
- Gene Tree for PRDX5 (if available)
- TreeFam:
- Gene Tree for PRDX5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRDX5: view image
Paralogs for PRDX5 Gene
Pseudogenes.org Pseudogenes for PRDX5 Gene
No data available for Paralogs for PRDX5 Gene
Variants for PRDX5 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036406 | A breast cancer sample | p.Phe157Leu | |||
| rs1000039151 | -- | 64,317,749(+) | C/T | upstream_transcript_variant | |
| rs1000505630 | -- | 64,320,113(+) | A/G | intron_variant | |
| rs1002157591 | -- | 64,318,958(+) | G/T | intron_variant | |
| rs1002492776 | -- | 64,318,856(+) | G/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1963n54 | CNV | loss | 21841781 |
| esv2667562 | CNV | deletion | 23128226 |
| esv27107 | CNV | loss | 19812545 |
| esv3626659 | CNV | loss | 21293372 |
| nsv469961 | CNV | loss | 18288195 |
| nsv832186 | CNV | loss | 17160897 |
| nsv951010 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.17;
23.56% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRDX5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRDX5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX5 Gene
Disorders for PRDX5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fuchs' endothelial dystrophy |
|
|
| corticobasal degeneration |
|
|
| morgagni cataract |
|
|
| malaria |
|
Search PRDX5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRDX5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX5 Gene
Publications for PRDX5 Gene
- Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. (PMID: 10521424) Knoops B … Bernard A (The Journal of biological chemistry 1999) 2 3 4 22 58
- The crystal structures of oxidized forms of human peroxiredoxin 5 with an intramolecular disulfide bond confirm the proposed enzymatic mechanism for atypical 2-Cys peroxiredoxins. (PMID: 18489898) Smeets A … Declercq JP (Archives of biochemistry and biophysics 2008) 3 4 22 58
- Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution. (PMID: 11518528) Declercq JP … Knoops B (Journal of molecular biology 2001) 3 4 22 58
- Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis. (PMID: 10679306) Zhou Y … Jin DY (Biochemical and biophysical research communications 2000) 3 4 22 58
- Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. (PMID: 10751410) Seo MS … Rhee SG (The Journal of biological chemistry 2000) 3 4 22 58
Products for PRDX5 Gene
- R&D Systems Antibodies for PRDX5 (Peroxiredoxin 5)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PRDX5
- Origene Custom Protein Services for PRDX5
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PRDX5
- Browse OriGene Inhibitory RNA Products For PRDX5
- OriGene qPCR primer pairs and template standards for PRDX5
- OriGene qPCR primer pairs for PRDX5
- OriGene CRISPR knockouts for PRDX5
- OriGene ORF clones in human for PRDX5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PRDX5
- GenScript: Next-day shipping of latest version cDNA ORF clones for PRDX5 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PRDX5
- GenScript Custom Assay Services for PRDX5
- GenScript Custom overexpressing Cell Line Services for PRDX5
- GenScript: Design CRISPR guide RNA sequences for PRDX5
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- GenScript Custom Peptide Services for PRDX5
- Sino Biological Human cDNA Clone for PRDX5
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- Sino Biological Antibodies for PRDX5
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PRDX5
- Novus Biologicals lysates and proteins for PRDX5
- Novus Biologicals ELISA Kits for PRDX5
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PRDX5
- Abcam proteins for PRDX5
- Find your target
- Browse Primary Antibodies
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for PRDX5
- Taconic Biosciences Mouse Models for PRDX5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PRDX5
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRDX5
- VectorBuilder custom plasmid, inducible vectors for PRDX5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDX5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PRDX5
- antibodies-online: Search results for 122 available Peroxiredoxin 5 Antibodies ranked by validation data
- Compare Top Peroxiredoxin 5 Antibodies
- Recommended
- antibodies-online: Search results for 27 available Peroxiredoxin 5 Elisa Kits ranked by validation data
- Compare Top Peroxiredoxin 5 Elisa Kits
- antibodies-online: Search results for 30 available Peroxiredoxin 5 Proteins ranked by validation data
- Compare Top Peroxiredoxin 5 Proteins
- GeneTex PRDX5 Antibody for PRDX5
- Search GeneTex for Proteins for PRDX5
- Santa Cruz Biotechnology (SCBT) Antibodies for PRDX5
- Search Santa Cruz Biotechnology (SCBT) for PRDX5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PRDX5
- Search for PRDX5 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for PRDX5
- Horizon Cell Lines for PRDX5
- genomics-online: cdna clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
- Recommended
- orf clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
- Recommended
- genomics-online: primer clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 147 available Peroxiredoxin 5 gene related products
- Overview of 147 available Peroxiredoxin 5 gene related products
- Recommended
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDX5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDX5
- GeneCopoeia miRNA 3'UTR Target clone products for PRDX5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDX5
Sources for PRDX5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt