This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to resul... See more...

Aliases for PRDX5 Gene

Aliases for PRDX5 Gene

  • Peroxiredoxin 5 2 3 5
  • Peroxisomal Antioxidant Enzyme 2 3 4
  • Liver Tissue 2D-Page Spot 71B 2 3 4
  • Thioredoxin Peroxidase PMP20 2 3 4
  • Antioxidant Enzyme B166 2 3 4
  • TPx Type VI 2 3 4
  • Peroxiredoxin-5, Mitochondrial 3 4
  • Alu Co-Repressor 1 2 3
  • Peroxiredoxin V 3 4
  • EC 1.11.1.15 4 54
  • AOEB166 3 4
  • Prx-V 3 4
  • ACR1 3 4
  • PLP 3 4
  • Epididymis Secretory Protein Li 55 3
  • Thioredoxin Reductase 3
  • Alu Corepressor 1 4
  • HEL-S-55 3
  • SBBI10 3
  • PMP20 3
  • PRDX6 3
  • B166 3
  • PRXV 3

External Ids for PRDX5 Gene

Previous GeneCards Identifiers for PRDX5 Gene

  • GC11P066601
  • GC11P065767
  • GC11P064336
  • GC11P063860
  • GC11P063842
  • GC11P064085
  • GC11P060413

Summaries for PRDX5 Gene

Entrez Gene Summary for PRDX5 Gene

  • This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]

GeneCards Summary for PRDX5 Gene

PRDX5 (Peroxiredoxin 5) is a Protein Coding gene. Diseases associated with PRDX5 include Alopecia Areata and Corticobasal Degeneration. Among its related pathways are Cellular Senescence (REACTOME) and Selenium Micronutrient Network. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein dimerization activity.

UniProtKB/Swiss-Prot Summary for PRDX5 Gene

  • Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

Gene Wiki entry for PRDX5 Gene

Additional gene information for PRDX5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRDX5 Gene

Genomics for PRDX5 Gene

GeneHancer (GH) Regulatory Elements for PRDX5 Gene

Promoters and enhancers for PRDX5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRDX5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRDX5 gene promoter:
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for PRDX5 Gene

Genomic Locations for PRDX5 Gene
chr11:64,318,088-64,321,823
(GRCh38/hg38)
Size:
3,736 bases
Orientation:
Plus strand
chr11:64,085,560-64,089,295
(GRCh37/hg19)
Size:
3,736 bases
Orientation:
Plus strand

Genomic View for PRDX5 Gene

Genes around PRDX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX5 Gene

Proteins for PRDX5 Gene

  • Protein details for PRDX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30044-PRDX5_HUMAN
    Recommended name:
    Peroxiredoxin-5, mitochondrial
    Protein Accession:
    P30044
    Secondary Accessions:
    • A6NC19
    • A6NG06
    • B7ZLJ4
    • B7ZVW3
    • Q14CK0
    • Q6IAF2
    • Q9UBU5
    • Q9UJU4
    • Q9UKX4

    Protein attributes for PRDX5 Gene

    Size:
    214 amino acids
    Molecular mass:
    22086 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys Prx, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
    SequenceCaution:
    • Sequence=AAF17200.1; Type=Frameshift; Positions=14, 30; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRDX5 Gene

    Alternative splice isoforms for PRDX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDX5 Gene

Selected DME Specific Peptides for PRDX5 Gene

P30044:
  • KVNLAELFK
  • VPGAFTP
  • PGAFTPGCSKTHLPGFVEQA
  • FGNRRLKRFSMV
  • VEVFEGEPG
  • FGKETDLLLDDSL

Post-translational modifications for PRDX5 Gene

  • Ubiquitination at Lys83
  • Modification sites at PhosphoSitePlus

Other Protein References for PRDX5 Gene

Antibody Products

Domains & Families for PRDX5 Gene

Gene Families for PRDX5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRDX5 Gene

GenScript: Design optimal peptide antigens:
  • Peroxiredoxin 5 (B7ZLJ4_HUMAN)
  • Peroxiredoxin 5 (B7ZVW3_HUMAN)
  • Thioredoxin reductase (PRDX5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30044

UniProtKB/Swiss-Prot:

PRDX5_HUMAN :
  • Belongs to the peroxiredoxin family. Prx5 subfamily.
Family:
  • Belongs to the peroxiredoxin family. Prx5 subfamily.
genes like me logo Genes that share domains with PRDX5: view

Function for PRDX5 Gene

Molecular function for PRDX5 Gene

UniProtKB/Swiss-Prot Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-dithiol + a hydroperoxide = [protein]-disulfide + an alcohol + H2O; Xref=Rhea:RHEA:10008, Rhea:RHEA-COMP:10593, Rhea:RHEA-COMP:10594, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.15; Evidence=. ;.

Enzyme Numbers (IUBMB) for PRDX5 Gene

Phenotypes From GWAS Catalog for PRDX5 Gene

Gene Ontology (GO) - Molecular Function for PRDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001016 RNA polymerase III regulatory region DNA binding IDA 10095767
GO:0004601 peroxidase activity IEA,IDA 10521424
GO:0005515 protein binding IPI 10514471
GO:0008379 thioredoxin peroxidase activity IBA 21873635
GO:0016209 antioxidant activity IEA --
genes like me logo Genes that share ontologies with PRDX5: view
genes like me logo Genes that share phenotypes with PRDX5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRDX5

CRISPR Products

Clone Products

  • Addgene plasmids for PRDX5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRDX5 Gene

Localization for PRDX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX5 Gene

Isoform Mitochondrial: Mitochondrion.
Isoform Cytoplasmic+peroxisomal: Cytoplasm. Peroxisome matrix. Note=Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5. {ECO:0000269 PubMed:10514471}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDX5 gene
Compartment Confidence
mitochondrion 5
peroxisome 5
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Mitochondria (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 23580065
GO:0005634 nucleus IDA 10095767
GO:0005737 cytoplasm IBA,IDA 15785239
GO:0005739 mitochondrion IDA,IBA 10521424
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with PRDX5: view

Pathways & Interactions for PRDX5 Gene

genes like me logo Genes that share pathways with PRDX5: view

Pathways by source for PRDX5 Gene

SIGNOR curated interactions for PRDX5 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PRDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response TAS 10521424
GO:0006979 response to oxidative stress IDA 10521424
GO:0016480 negative regulation of transcription by RNA polymerase III IDA 10095767
GO:0034599 cellular response to oxidative stress TAS,IBA --
genes like me logo Genes that share ontologies with PRDX5: view

Drugs & Compounds for PRDX5 Gene

(51) Drugs for PRDX5 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Auranofin Approved, Investigational Pharma Activation, Activator, Target, inhibitor Thioredoxin reductase inhibitor; induces MPT 12
Benzoic acid Approved, Investigational Pharma Target 11
Hydrogen peroxide Approved, Vet_approved Pharma 98
Water Approved Pharma 0
Diminazene Experimental Pharma Target 4

(52) Additional Compounds for PRDX5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRDX5: view

Transcripts for PRDX5 Gene

mRNA/cDNA for PRDX5 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for PRDX5

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: - - - - - -
SP6: - - - - - - -
SP7:
SP8:

Relevant External Links for PRDX5 Gene

GeneLoc Exon Structure for
PRDX5
ECgene alternative splicing isoforms for
PRDX5

Expression for PRDX5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRDX5 Gene

Protein differential expression in normal tissues from HIPED for PRDX5 Gene

This gene is overexpressed in Nasal epithelium (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRDX5 Gene



Protein tissue co-expression partners for PRDX5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRDX5 Gene:

PRDX5

SOURCE GeneReport for Unigene cluster for PRDX5 Gene:

Hs.502823

mRNA Expression by UniProt/SwissProt for PRDX5 Gene:

P30044-PRDX5_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PRDX5 Gene

  • Nervous system(4.8)
  • Liver(4.7)
  • Lung(4.7)
  • Adrenal gland(4.5)
  • Heart(3.1)
  • Kidney(3.1)
  • Muscle(3)
  • Thyroid gland(2.9)
  • Eye(2.8)
  • Blood(2.7)
  • Skin(2.7)
  • Intestine(2.6)
  • Stomach(2.1)
  • Bone marrow(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with PRDX5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX5 Gene

Orthologs for PRDX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDX5 33 32
  • 99.69 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prdx5 17 33 32
  • 86.11 (n)
rat
(Rattus norvegicus)
Mammalia Prdx5 32
  • 85.31 (n)
dog
(Canis familiaris)
Mammalia PRDX5 32
  • 84.94 (n)
cow
(Bos Taurus)
Mammalia PRDX5 33 32
  • 83.77 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRDX5 33
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX5 33
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDX5 33
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx5 32
  • 65.2 (n)
zebrafish
(Danio rerio)
Actinopterygii prdx5 33 32
  • 63.96 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9314 32
fruit fly
(Drosophila melanogaster)
Insecta Prx5 33 32
  • 62.37 (n)
OneToOne
CG7217 34
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001325 32
  • 60.86 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL154C 32
  • 48.41 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07271g 32
  • 46.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AHP1 35 33
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TPX1 32
  • 50.53 (n)
rice
(Oryza sativa)
Liliopsida Os01g0675100 32
  • 49.9 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06880 32
  • 52.8 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC330.06c 32
  • 42.7 (n)
Species where no ortholog for PRDX5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRDX5 Gene

ENSEMBL:
Gene Tree for PRDX5 (if available)
TreeFam:
Gene Tree for PRDX5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRDX5: view image

Paralogs for PRDX5 Gene

genes like me logo Genes that share paralogs with PRDX5: view

No data available for Paralogs for PRDX5 Gene

Variants for PRDX5 Gene

Sequence variations from dbSNP and Humsavar for PRDX5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
VAR_036406 A breast cancer sample p.Phe157Leu
rs1000039151 -- 64,317,749(+) C/T upstream_transcript_variant
rs1000505630 -- 64,320,113(+) A/G intron_variant
rs1002157591 -- 64,318,958(+) G/T intron_variant
rs1002492776 -- 64,318,856(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRDX5 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv2667562 CNV deletion 23128226
esv27107 CNV loss 19812545
esv3626659 CNV loss 21293372
nsv469961 CNV loss 18288195
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for PRDX5 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRDX5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDX5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX5 Gene

Disorders for PRDX5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRDX5 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PRDX5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRDX5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRDX5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX5 Gene

Publications for PRDX5 Gene

  1. Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. (PMID: 10521424) Knoops B … Bernard A (The Journal of biological chemistry 1999) 2 3 4 23 56
  2. The crystal structures of oxidized forms of human peroxiredoxin 5 with an intramolecular disulfide bond confirm the proposed enzymatic mechanism for atypical 2-Cys peroxiredoxins. (PMID: 18489898) Smeets A … Declercq JP (Archives of biochemistry and biophysics 2008) 3 4 23 56
  3. Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution. (PMID: 11518528) Declercq JP … Knoops B (Journal of molecular biology 2001) 3 4 23 56
  4. Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. (PMID: 10751410) Seo MS … Rhee SG (The Journal of biological chemistry 2000) 3 4 23 56
  5. Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis. (PMID: 10679306) Zhou Y … Jin DY (Biochemical and biophysical research communications 2000) 3 4 23 56

Products for PRDX5 Gene

  • Addgene plasmids for PRDX5

Sources for PRDX5 Gene