Aliases for PRDX5 Gene
External Ids for PRDX5 Gene
Previous GeneCards Identifiers for PRDX5 Gene
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]
GeneCards Summary for PRDX5 Gene
PRDX5 (Peroxiredoxin 5) is a Protein Coding gene. Diseases associated with PRDX5 include Alopecia Areata and Corticobasal Degeneration. Among its related pathways are Cellular Senescence (REACTOME) and Selenium Micronutrient Network. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein dimerization activity.
UniProtKB/Swiss-Prot Summary for PRDX5 Gene
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.