Aliases for PRDX4 Gene
External Ids for PRDX4 Gene
Previous GeneCards Identifiers for PRDX4 Gene
The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRDX4 Gene
PRDX4 (Peroxiredoxin 4) is a Protein Coding gene. Diseases associated with PRDX4 include Hypoascorbemia and Lung Squamous Cell Carcinoma. Among its related pathways are Folate Metabolism and Prostaglandin 2 biosynthesis and metabolism FM. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and antioxidant activity. An important paralog of this gene is PRDX3.
UniProtKB/Swiss-Prot Summary for PRDX4 Gene
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.