Aliases for PRDX3 Gene
External Ids for PRDX3 Gene
Previous HGNC Symbols for PRDX3 Gene
Previous GeneCards Identifiers for PRDX3 Gene
This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
GeneCards Summary for PRDX3 Gene
PRDX3 (Peroxiredoxin 3) is a Protein Coding gene. Diseases associated with PRDX3 include Fuchs' Endothelial Dystrophy and Prostate Cancer. Among its related pathways are Validated targets of C-MYC transcriptional activation and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include identical protein binding and oxidoreductase activity. An important paralog of this gene is PRDX4.
UniProtKB/Swiss-Prot Summary for PRDX3 Gene
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477).