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This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chrom... See more...
Aliases for PRDX3 Gene
Aliases for PRDX3 Gene
External Ids for PRDX3 Gene
- HGNC: 9354
- Entrez Gene: 10935
- Ensembl: ENSG00000165672
- OMIM: 604769
- UniProtKB: P30048
Previous HGNC Symbols for PRDX3 Gene
- AOP1
Previous GeneCards Identifiers for PRDX3 Gene
- GC10M119845
- GC10M120170
- GC10M121058
- GC10M120591
- GC10M120917
- GC10M114556
- GC10M120928
Summaries for PRDX3 Gene
-
This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
GeneCards Summary for PRDX3 Gene
PRDX3 (Peroxiredoxin 3) is a Protein Coding gene. Diseases associated with PRDX3 include Pre-Descemet Corneal Dystrophy and Fuchs' Endothelial Dystrophy. Among its related pathways are Folate Metabolism and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include identical protein binding and oxidoreductase activity. An important paralog of this gene is PRDX4.
UniProtKB/Swiss-Prot Summary for PRDX3 Gene
-
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477).
Additional gene information for PRDX3 Gene
- HGNC(9354)
- Entrez Gene(10935)
- Ensembl(ENSG00000165672)
- OMIM(604769)
- UniProtKB(P30048)
- Open Targets Platform(ENSG00000165672)
- Monarch Initiative
- Search for PRDX3 at DataMed
- Search for PRDX3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRDX3 Gene
Genomics for PRDX3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PRDX3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRDX3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRDX3
- Top Transcription factor binding sites by QIAGEN in the PRDX3 gene promoter:
-
- CREB
- deltaCREB
- Ik-1
- Msx-1
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- YY1
Genomic Locations for PRDX3 Gene
Genomic Locations for PRDX3 Gene
- chr10:119,167,720-119,178,812
- (GRCh38/hg38)
- Size:
- 11,093 bases
- Orientation:
- Minus strand
- chr10:120,927,215-120,938,345
- (GRCh37/hg19)
- Size:
- 11,131 bases
- Orientation:
- Minus strand
Genomic View for PRDX3 Gene
Genes around PRDX3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.11 by HGNC
- 10q26.11 by Entrez Gene
- 10q26.11 by Ensembl
PRDX3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRDX3 Gene
Proteins for PRDX3 Gene
-
Protein details for PRDX3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30048-PRDX3_HUMAN
- Recommended name:
- Thioredoxin-dependent peroxide reductase, mitochondrial
- Protein Accession:
- P30048
- B2R7Z0
- D3DRC9
- E9PH29
- P35690
- Q0D2H1
- Q13776
- Q5T5V2
- Q96HK4
Protein attributes for PRDX3 Gene
- Size:
- 256 amino acids
- Molecular mass:
- 27693 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked, upon oxidation. 6 homodimers assemble to form a ring-like dodecamer (PubMed:17707404, PubMed:27238969). Interacts with NEK6 (PubMed:20873783). Interacts with LRRK2 (PubMed:21850687). Interacts with MAP3K13 (PubMed:12492477). Interacts with RPS6KC1 (via PX domain) (PubMed:15750338).
- Miscellaneous:
-
- The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
Protein Expression for PRDX3 Gene
Selected DME Specific Peptides for PRDX3 Gene
- P30048:
-
- HGEVCPA
- EVCPANW
- NDLPVGR
- SRDYGVL
- RGLFIID
- DFTFVCP
- HLAWINTPR
Post-translational modifications for PRDX3 Gene
- Phosphorylated by LRRK2; phosphorylation reduces perodixase activity.
- The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.
-
Ubiquitination at Lys83, Lys149, Lys196, and Lys253
- NX_P30048 (NX_P30048-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PRDX3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PRDX3 Antibody
- NSJ Bioreagents Peroxiredoxin 3 Antibody (PRDX3)
- GeneTex Anti-PRX III antibody [N1C3]
-
Custom Antibody ServicesOriGene Antibodies for PRDX3
- Novus Biologicals Antibodies for PRDX3
-
Abcam antibodies for PRDX3
- Invitrogen Antibodies for PRDX3 (AFLGC-PRDX3)
- antibodies-online: Show 44 available PRDX3 Antibodies ranked by validation data
- Compare Top PRDX3 Antibodies
-
Recommended
- 132 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 60 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 55 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRDX3
Protein Products
- G Biosciences Human PRDX3, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for PRDX3
- Origene Custom Protein Services for PRDX3
- ProSpec Recombinant Proteins for PRDX3
-
ProSci Proteins for PRDX3
-
Abcam proteins for PRDX3
Domains & Families for PRDX3 Gene
Gene Families for PRDX3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PRDX3 Gene
- InterPro:
- Blocks:
-
- Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen
- ProtoNet:
Suggested Antigen Peptide Sequences for PRDX3 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein MER5 homolog (PRDX3_HUMAN)
- Humer (Q14579_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P30048- Family:
-
- Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
Function for PRDX3 Gene
Molecular function for PRDX3 Gene
- UniProtKB/Swiss-Prot Function:
- Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.24; Evidence={ECO:0000269|PubMed:17707404, ECO:0000269|PubMed:19462976};.
Enzyme Numbers (IUBMB) for PRDX3 Gene
Phenotypes From GWAS Catalog for PRDX3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004601 | peroxidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 15750338 |
| GO:0008022 | protein C-terminus binding | IPI | 17060495 |
| GO:0008379 | thioredoxin peroxidase activity | IDA | 21850687 |
| GO:0008785 | alkyl hydroperoxide reductase activity | NAS | 7733872 |
Phenotypes for PRDX3 Gene
- MGI mutant phenotypes for PRDX3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PRDX3:
-
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased viability in pancreas lineage
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased POU5F1-GFP protein expression
- Decreased shRNA abundance (Z-score < -2)
- G0/1 arrest
- Decreased viability with paclitaxel
- Decreased viability (cell death)
- Increased G1 length
- Increased G1 length, increased G2 length
- Increased G1 length, increased S length
- Increased S length
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Models for PRDX3 Gene
- MGI Knock Outs for PRDX3:
-
- Prdx3 Prdx3<tm1Hjha>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRDX3 - Select products 50% OFF >
- * PRDX3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PRDX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDX3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDX3
miRNA for PRDX3 Gene
- miRTarBase miRNAs that target PRDX3
-
- hsa-miR-383-5p (MIRT007305)
- mmu-miR-340-5p (MIRT010653)
- hsa-miR-193b-3p (MIRT016299)
- hsa-miR-375 (MIRT019731)
- hsa-miR-181a-5p (MIRT025072)
- hsa-miR-320a (MIRT044454)
- hsa-miR-15b-5p (MIRT046524)
- hsa-miR-15a-5p (MIRT051339)
- mmu-miR-875-5p (MIRT053252)
- hsa-miR-599 (MIRT506034)
- hsa-miR-3161 (MIRT506035)
- hsa-miR-1290 (MIRT506036)
- hsa-miR-876-5p (MIRT506037)
- hsa-miR-3167 (MIRT506038)
- hsa-miR-6839-5p (MIRT506039)
- hsa-miR-378j (MIRT506040)
- hsa-miR-6791-5p (MIRT506041)
- hsa-miR-4292 (MIRT506042)
- hsa-miR-4308 (MIRT506043)
- hsa-miR-501-5p (MIRT506044)
- hsa-miR-500b-5p (MIRT506045)
- hsa-miR-362-5p (MIRT506046)
- hsa-miR-607 (MIRT521702)
- hsa-miR-4698 (MIRT521703)
- hsa-miR-8063 (MIRT521704)
- hsa-miR-3163 (MIRT521705)
- hsa-miR-548at-5p (MIRT521706)
- hsa-miR-374b-5p (MIRT555256)
- hsa-miR-374a-5p (MIRT555257)
- hsa-miR-26a-5p (MIRT734333)
- hsa-miR-23b-3p (MIRT734334)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRDX3
- Browse OriGene Inhibitory RNA Products For PRDX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDX3
Clone Products
- Applied Biological Materials (abm): Clones for PRDX3 - Select products 50% OFF >
- * PRDX3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203317
- MR203317
- MR203317L3
- MR203317L4
- RC205080
- RC205080L1
- RC205080L2
- RC205080L3
- RC205080L4
- RC218419
- RC218419L3
- RC218419L4
- RC236496
- RG205080
- RG218419
- RR202557
- RR202557L3
- RR202557L4
- MR203317L3V
- MR203317L4V
- RC205080L1V
- RC205080L2V
- RC205080L3V
- RC205080L4V
- RC218419L3V
- RC218419L4V
- RR202557L3V
- RR202557L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PRDX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDX3
Cell Line Products
-
Horizon Cell Lines for PRDX3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX3 Gene
Localization for PRDX3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRDX3 Gene
- Mitochondrion. Cytoplasm. Early endosome. Note=Localizes to early endosomes in a RPS6KC1-dependent manner. {ECO:0000269 PubMed:15750338}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| endosome | 5 |
| cytosol | 4 |
| peroxisome | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005737 | cytoplasm | IBA,IDA | 18205602 |
| GO:0005739 | mitochondrion | IBA,IDA | 17893648 |
| GO:0005759 | mitochondrial matrix | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRDX3 Gene
Pathways & Interactions for PRDX3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence (REACTOME) | ||
| 2 | Detoxification of Reactive Oxygen Species | ||
| 3 | Prostaglandin 2 biosynthesis and metabolism FM |
Prostaglandin 2 biosynthesis and metabolism FM
-
|
|
| 4 | Folate Metabolism | ||
| 5 | Validated targets of C-MYC transcriptional activation | ||
Pathways by source for PRDX3 Gene
2 BioSystems pathways for PRDX3 Gene
2 Reactome pathways for PRDX3 Gene
1 GeneGo (Thomson Reuters) pathway for PRDX3 Gene
- Prostaglandin 2 biosynthesis and metabolism FM
Interacting Proteins for PRDX3 Gene
Selected Interacting proteins:
P30048-PRDX3_HUMAN
ENSP00000298510
for PRDX3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PRDX3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001893 | maternal placenta development | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006979 | response to oxidative stress | IMP | 18195003 |
| GO:0007005 | mitochondrion organization | IMP | 12011429 |
| GO:0008284 | positive regulation of cell proliferation | IDA | 12011429 |
No data available for SIGNOR curated interactions for PRDX3 Gene
Drugs & Compounds for PRDX3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Water | Approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human PRDX3, Liquid
Transcripts for PRDX3 Gene
mRNA/cDNA for PRDX3 Gene
- 3 REFSEQ mRNAs :
- 29 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000298510 1553 nts (view in UCSC)
- ENST00000463322 450 nts (view in UCSC)
- ENST00000494433 2277 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRDX3 - Select products 50% OFF >
- * PRDX3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PRDX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDX3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDX3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRDX3
- Browse OriGene Inhibitory RNA Products For PRDX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDX3
Clone Products
- Applied Biological Materials (abm): Clones for PRDX3 - Select products 50% OFF >
- * PRDX3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203317
- MR203317
- MR203317L3
- MR203317L4
- RC205080
- RC205080L1
- RC205080L2
- RC205080L3
- RC205080L4
- RC218419
- RC218419L3
- RC218419L4
- RC236496
- RG205080
- RG218419
- RR202557
- RR202557L3
- RR202557L4
- MR203317L3V
- MR203317L4V
- RC205080L1V
- RC205080L2V
- RC205080L3V
- RC205080L4V
- RC218419L3V
- RC218419L4V
- RR202557L3V
- RR202557L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PRDX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDX3
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||
| SP4: |
Relevant External Links for PRDX3 Gene
- GeneLoc Exon Structure for
- PRDX3
Expression for PRDX3 Gene
This gene is overexpressed in Liver, secretome (7.3) and Adrenal (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRDX3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRDX3
SOURCE GeneReport for Unigene cluster for PRDX3 Gene:
Hs.523302Evidence on tissue expression from TISSUES for PRDX3 Gene
- Nervous system(5)
- Liver(4.9)
- Blood(4.9)
- Lung(4.8)
- Muscle(4.8)
- Kidney(4.5)
- Bone marrow(4.5)
- Skin(4.1)
- Intestine(3.8)
- Heart(3.8)
- Pancreas(3.5)
- Adrenal gland(3.2)
- Thyroid gland(2.8)
- Eye(2.7)
- Lymph node(2.5)
- Stomach(2.5)
- Spleen(2.5)
Primer Products
-
OriGene qPCR primer pairs for PRDX3
-
OriGene qPCR primer pairs and template standards for PRDX3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX3 Gene
Orthologs for PRDX3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PRDX3 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| PRDX3 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | PRDX3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Prdx3 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PRDX3 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Prdx3 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PRDX3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PRDX3 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prdx3 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | prdx3 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Jafrac1 32 |
|
|
|
| Prx5037 32 |
|
|
|||
| Prx3 30 31 |
|
OneToOne | |||
| CG6888 32 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | TPX1 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | R07E5.2 32 |
|
|
|
| prdx-3 30 31 |
|
OneToOne | |||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER312W 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TSA1 31 |
|
ManyToMany | |
| TSA2 30 31 |
|
ManyToMany | |||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B01628g 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4391 31 |
|
OneToOne |
- Species where no ortholog for PRDX3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PRDX3 Gene
- ENSEMBL:
- Gene Tree for PRDX3 (if available)
- TreeFam:
- Gene Tree for PRDX3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRDX3: view image
Paralogs for PRDX3 Gene
(4) SIMAP similar genes for PRDX3 Gene using alignment to 2 proteins:
- PRDX3_HUMAN
- E9PH29_HUMAN
Pseudogenes.org Pseudogenes for PRDX3 Gene
Variants for PRDX3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRDX3 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11554902 | - | p.Arg170Gln | |||
| rs34698541 | - | p.Ser55Arg | |||
| rs35697338 | - | p.Thr234Ile | |||
| rs36064375 | - | p.Ala218Thr |
Residual Variation Intolerance Score:
36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.29;
41.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRDX3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRDX3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX3 Gene
Disorders for PRDX3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pre-descemet corneal dystrophy |
|
|
| fuchs' endothelial dystrophy |
|
|
| prostate cancer |
|
|
| acute promyelocytic leukemia |
|
|
Search PRDX3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRDX3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX3 Gene
Publications for PRDX3 Gene
- Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli. (PMID: 7733872) Tsuji K … Obinata M (The Biochemical journal 1995) 2 3 4 23
- Redox potential and peroxide reactivity of human peroxiredoxin 3. (PMID: 19462976) Cox AG … Hampton MB (Biochemistry 2009) 3 4 23
- Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death. (PMID: 21850687) Angeles DC … Tan EK (Human mutation 2011) 3 4
- Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G … Kobarg J (Journal of proteome research 2010) 3 4
- Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer. (PMID: 20043069) Chua PJ … Bay BH (International journal of oncology 2010) 3 23
Products for PRDX3 Gene
- Custom Antibody ServicesOriGene Antibodies for PRDX3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PRDX3
- Origene Custom Protein Services for PRDX3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRDX3
- Browse OriGene Inhibitory RNA Products For PRDX3
- OriGene qPCR primer pairs for PRDX3
- OriGene qPCR primer pairs and template standards for PRDX3
- OriGene CRISPR knockouts for PRDX3
- MG203317
- MR203317
- MR203317L3
- MR203317L4
- RC205080
- RC205080L1
- RC205080L2
- RC205080L3
- RC205080L4
- RC218419
- RC218419L3
- RC218419L4
- RC236496
- RG205080
- RG218419
- RR202557
- RR202557L3
- RR202557L4
- MR203317L3V
- MR203317L4V
- RC205080L1V
- RC205080L2V
- RC205080L3V
- RC205080L4V
- RC218419L3V
- RC218419L4V
- RR202557L3V
- RR202557L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PRDX3
- Sino Biological Human cDNA Clone for PRDX3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PRDX3
- Novus Biologicals proteins and lysates for PRDX3
- Novus Biologicals ELISA Kits for PRDX3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PRDX3
- Abcam proteins for PRDX3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for PRDX3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PRDX3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PRDX3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PRDX3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PRDX3
- antibodies-online: Show 44 available PRDX3 Antibodies ranked by validation data
- Compare Top PRDX3 Antibodies
- Recommended
- 132 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 60 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 55 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Show 14 available PRDX3 Elisa Kits ranked by validation data
- Compare Top PRDX3 Elisa Kits
- antibodies-online: Show 25 available PRDX3 Proteins ranked by validation data
- Compare Top PRDX3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PRDX3
- Search Santa Cruz Biotechnology (SCBT) for PRDX3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PRDX3
- Search for PRDX3 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for PRDX3
- Horizon Cell Lines for PRDX3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDX3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PRDX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDX3
Sources for PRDX3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB