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This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
PRDX3 (Peroxiredoxin 3) is a Protein Coding gene. Diseases associated with PRDX3 include Pre-Descemet Corneal Dystrophy and Fuchs' Endothelial Dystrophy. Among its related pathways are Folate Metabolism and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include identical protein binding and oxidoreductase activity. An important paralog of this gene is PRDX4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004601 | peroxidase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 15750338 |
GO:0008022 | protein C-terminus binding | IPI | 17060495 |
GO:0008379 | thioredoxin peroxidase activity | IDA | 21850687 |
GO:0008785 | alkyl hydroperoxide reductase activity | NAS | 7733872 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | IBA,IDA | 18205602 |
GO:0005739 | mitochondrion | IBA,IDA | 17893648 |
GO:0005759 | mitochondrial matrix | TAS | -- |
GO:0005768 | endosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cellular Senescence (REACTOME) | ||
2 | Detoxification of Reactive Oxygen Species | ||
3 | Prostaglandin 2 biosynthesis and metabolism FM |
Prostaglandin 2 biosynthesis and metabolism FM
-
|
|
4 | Folate Metabolism | ||
5 | Validated targets of C-MYC transcriptional activation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001893 | maternal placenta development | IEA | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0006979 | response to oxidative stress | IMP | 18195003 |
GO:0007005 | mitochondrion organization | IMP | 12011429 |
GO:0008284 | positive regulation of cell proliferation | IDA | 12011429 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Water | Approved | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PRDX3 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
PRDX3 30 |
|
||||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | PRDX3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Prdx3 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PRDX3 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Prdx3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | PRDX3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PRDX3 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prdx3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | prdx3 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Jafrac1 32 |
|
|
|
Prx5037 32 |
|
|
|||
Prx3 30 31 |
|
OneToOne | |||
CG6888 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | TPX1 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | R07E5.2 32 |
|
|
|
prdx-3 30 31 |
|
OneToOne | |||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER312W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TSA1 31 |
|
ManyToMany | |
TSA2 30 31 |
|
ManyToMany | |||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B01628g 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4391 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11554902 | - | p.Arg170Gln | |||
rs34698541 | - | p.Ser55Arg | |||
rs35697338 | - | p.Thr234Ile | |||
rs36064375 | - | p.Ala218Thr |
Disorder | Aliases | PubMed IDs |
---|---|---|
pre-descemet corneal dystrophy |
|
|
fuchs' endothelial dystrophy |
|
|
prostate cancer |
|
|
acute promyelocytic leukemia |
|
|