This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chrom... See more...

Aliases for PRDX3 Gene

Aliases for PRDX3 Gene

  • Peroxiredoxin 3 2 3 5
  • Antioxidant Protein 1 2 3 4
  • Thioredoxin-Dependent Peroxide Reductase, Mitochondrial 3 4
  • Protein MER5 Homolog 3 4
  • Peroxiredoxin III 3 4
  • EC 1.11.1.15 4 52
  • Prx-III 3 4
  • HBC189 3 4
  • AOP-1 3 4
  • AOP1 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Peroxiredoxin-3 4
  • PRO1748 3
  • SP-22 3
  • MER5 3

External Ids for PRDX3 Gene

Previous HGNC Symbols for PRDX3 Gene

  • AOP1

Previous GeneCards Identifiers for PRDX3 Gene

  • GC10M119845
  • GC10M120170
  • GC10M121058
  • GC10M120591
  • GC10M120917
  • GC10M114556
  • GC10M120928

Summaries for PRDX3 Gene

Entrez Gene Summary for PRDX3 Gene

  • This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

GeneCards Summary for PRDX3 Gene

PRDX3 (Peroxiredoxin 3) is a Protein Coding gene. Diseases associated with PRDX3 include Fuchs' Endothelial Dystrophy and Prostate Cancer. Among its related pathways are Validated targets of C-MYC transcriptional activation and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include identical protein binding and oxidoreductase activity. An important paralog of this gene is PRDX4.

UniProtKB/Swiss-Prot Summary for PRDX3 Gene

  • Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477).

Gene Wiki entry for PRDX3 Gene

Additional gene information for PRDX3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRDX3 Gene

Genomics for PRDX3 Gene

GeneHancer (GH) Regulatory Elements for PRDX3 Gene

Promoters and enhancers for PRDX3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRDX3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRDX3

Top Transcription factor binding sites by QIAGEN in the PRDX3 gene promoter:
  • CREB
  • deltaCREB
  • Ik-1
  • Msx-1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • YY1

Genomic Locations for PRDX3 Gene

Genomic Locations for PRDX3 Gene
chr10:119,167,699-119,178,865
(GRCh38/hg38)
Size:
11,167 bases
Orientation:
Minus strand
chr10:120,927,215-120,938,345
(GRCh37/hg19)
Size:
11,131 bases
Orientation:
Minus strand

Genomic View for PRDX3 Gene

Genes around PRDX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX3 Gene

Proteins for PRDX3 Gene

  • Protein details for PRDX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30048-PRDX3_HUMAN
    Recommended name:
    Thioredoxin-dependent peroxide reductase, mitochondrial
    Protein Accession:
    P30048
    Secondary Accessions:
    • B2R7Z0
    • D3DRC9
    • E9PH29
    • P35690
    • Q0D2H1
    • Q13776
    • Q5T5V2
    • Q96HK4

    Protein attributes for PRDX3 Gene

    Size:
    256 amino acids
    Molecular mass:
    27693 Da
    Quaternary structure:
    • Homodimer; disulfide-linked, upon oxidation. 6 homodimers assemble to form a ring-like dodecamer (PubMed:17707404, PubMed:27238969). Interacts with NEK6 (PubMed:20873783). Interacts with LRRK2 (PubMed:21850687). Interacts with MAP3K13 (PubMed:12492477). Interacts with RPS6KC1 (via PX domain) (PubMed:15750338).
    Miscellaneous:
    • The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.

    Three dimensional structures from OCA and Proteopedia for PRDX3 Gene

    Alternative splice isoforms for PRDX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDX3 Gene

Selected DME Specific Peptides for PRDX3 Gene

P30048:
  • HGEVCPA
  • EVCPANW
  • NDLPVGR
  • SRDYGVL
  • RGLFIID
  • DFTFVCP
  • HLAWINTPR

Post-translational modifications for PRDX3 Gene

  • Phosphorylated by LRRK2; phosphorylation reduces perodixase activity.
  • The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.
  • Ubiquitination at Lys83, Lys149, Lys196, and Lys253
  • Modification sites at PhosphoSitePlus

Other Protein References for PRDX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PRDX3 Gene

Gene Families for PRDX3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PRDX3 Gene

Blocks:
  • Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRDX3 Gene

GenScript: Design optimal peptide antigens:
  • Protein MER5 homolog (PRDX3_HUMAN)
  • Humer (Q14579_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30048

UniProtKB/Swiss-Prot:

PRDX3_HUMAN :
  • Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
Family:
  • Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
genes like me logo Genes that share domains with PRDX3: view

Function for PRDX3 Gene

Molecular function for PRDX3 Gene

UniProtKB/Swiss-Prot Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-dithiol + a hydroperoxide = [protein]-disulfide + an alcohol + H2O; Xref=Rhea:RHEA:10008, Rhea:RHEA-COMP:10593, Rhea:RHEA-COMP:10594, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.15; Evidence=. ;.

Enzyme Numbers (IUBMB) for PRDX3 Gene

Phenotypes From GWAS Catalog for PRDX3 Gene

Gene Ontology (GO) - Molecular Function for PRDX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
GO:0005515 protein binding IPI 15750338
GO:0008022 protein C-terminus binding IPI 17060495
GO:0008379 thioredoxin peroxidase activity IDA 21850687
GO:0008785 alkyl hydroperoxide reductase activity NAS 7733872
genes like me logo Genes that share ontologies with PRDX3: view
genes like me logo Genes that share phenotypes with PRDX3: view

Animal Models for PRDX3 Gene

MGI Knock Outs for PRDX3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDX3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX3 Gene

Localization for PRDX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX3 Gene

Mitochondrion. Cytoplasm. Early endosome. Note=Localizes to early endosomes in a RPS6KC1-dependent manner. {ECO:0000269 PubMed:15750338}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDX3 gene
Compartment Confidence
mitochondrion 5
endosome 5
cytosol 4
peroxisome 3
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRDX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IBA,IDA 18205602
GO:0005739 mitochondrion IDA,IBA 17893648
GO:0005759 mitochondrial matrix TAS --
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with PRDX3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRDX3 Gene

Pathways & Interactions for PRDX3 Gene

genes like me logo Genes that share pathways with PRDX3: view

Pathways by source for PRDX3 Gene

1 GeneGo (Thomson Reuters) pathway for PRDX3 Gene
  • Prostaglandin 2 biosynthesis and metabolism FM

Gene Ontology (GO) - Biological Process for PRDX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001893 maternal placenta development IEA --
GO:0006915 apoptotic process IEA --
GO:0006979 response to oxidative stress IMP 18195003
GO:0007005 mitochondrion organization IMP 12011429
GO:0008284 positive regulation of cell proliferation IDA 12011429
genes like me logo Genes that share ontologies with PRDX3: view

No data available for SIGNOR curated interactions for PRDX3 Gene

Drugs & Compounds for PRDX3 Gene

(4) Drugs for PRDX3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0

(3) Additional Compounds for PRDX3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRDX3: view

Transcripts for PRDX3 Gene

mRNA/cDNA for PRDX3 Gene

3 REFSEQ mRNAs :
29 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDX3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - -
SP2:
SP3: - - -
SP4:

Relevant External Links for PRDX3 Gene

GeneLoc Exon Structure for
PRDX3

Expression for PRDX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRDX3 Gene

Protein differential expression in normal tissues from HIPED for PRDX3 Gene

This gene is overexpressed in Liver, secretome (7.3) and Adrenal (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRDX3 Gene



Protein tissue co-expression partners for PRDX3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRDX3

SOURCE GeneReport for Unigene cluster for PRDX3 Gene:

Hs.523302

Evidence on tissue expression from TISSUES for PRDX3 Gene

  • Nervous system(5)
  • Liver(4.9)
  • Blood(4.8)
  • Lung(4.8)
  • Kidney(4.4)
  • Muscle(3.8)
  • Skin(3.5)
  • Intestine(3.3)
  • Pancreas(3.1)
  • Heart(2.9)
  • Adrenal gland(2.8)
  • Eye(2.2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with PRDX3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX3 Gene

Orthologs for PRDX3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRDX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDX3 31 30
  • 99.61 (n)
OneToMany
-- 31
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 91 (a)
OneToMany
PRDX3 30
  • 88.15 (n)
-- 31
  • 88 (a)
OneToMany
-- 31
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PRDX3 31 30
  • 88.8 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prdx3 17 31 30
  • 84.24 (n)
oppossum
(Monodelphis domestica)
Mammalia PRDX3 31
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdx3 30
  • 83.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX3 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRDX3 31 30
  • 71.73 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx3 30
  • 70.69 (n)
zebrafish
(Danio rerio)
Actinopterygii prdx3 31 30
  • 66.8 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Jafrac1 32
  • 64 (a)
Prx5037 32
  • 63 (a)
Prx3 31 30
  • 61.74 (n)
OneToOne
CG6888 32
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta TPX1 30
  • 58.6 (n)
worm
(Caenorhabditis elegans)
Secernentea R07E5.2 32
  • 66 (a)
prdx-3 31 30
  • 60.43 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER312W 30
  • 59.55 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSA1 31
  • 59 (a)
ManyToMany
TSA2 31 30
  • 57.12 (n)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01628g 30
  • 58.68 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4391 31
  • 66 (a)
OneToOne
Species where no ortholog for PRDX3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX3 Gene

ENSEMBL:
Gene Tree for PRDX3 (if available)
TreeFam:
Gene Tree for PRDX3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRDX3: view image

Paralogs for PRDX3 Gene

Paralogs for PRDX3 Gene

(4) SIMAP similar genes for PRDX3 Gene using alignment to 2 proteins:

  • PRDX3_HUMAN
  • E9PH29_HUMAN
genes like me logo Genes that share paralogs with PRDX3: view

Variants for PRDX3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRDX3 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs11554902 - p.Arg170Gln
rs34698541 - p.Ser55Arg
rs35697338 - p.Thr234Ile
rs36064375 - p.Ala218Thr

Additional dbSNP identifiers (rs#s) for PRDX3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRDX3 Gene

Variant ID Type Subtype PubMed ID
nsv1041093 CNV gain 25217958
nsv552214 CNV loss 21841781
nsv825583 CNV gain 20364138
nsv825584 CNV gain 20364138

Variation tolerance for PRDX3 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRDX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDX3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX3 Gene

Disorders for PRDX3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRDX3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fuchs' endothelial dystrophy
  • fced
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PRDX3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRDX3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRDX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX3 Gene

Publications for PRDX3 Gene

  1. Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli. (PMID: 7733872) Tsuji K … Obinata M (The Biochemical journal 1995) 2 3 4 23 54
  2. Redox potential and peroxide reactivity of human peroxiredoxin 3. (PMID: 19462976) Cox AG … Hampton MB (Biochemistry 2009) 3 4 23 54
  3. Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death. (PMID: 21850687) Angeles DC … Tan EK (Human mutation 2011) 3 4 54
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  5. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G … Kobarg J (Journal of proteome research 2010) 3 4 54

Products for PRDX3 Gene

Sources for PRDX3 Gene