Aliases for PRDX2 Gene
External Ids for PRDX2 Gene
Previous HGNC Symbols for PRDX2 Gene
Previous GeneCards Identifiers for PRDX2 Gene
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
GeneCards Summary for PRDX2 Gene
PRDX2 (Peroxiredoxin 2) is a Protein Coding gene. Diseases associated with PRDX2 include In Situ Carcinoma and Hemolytic Anemia. Among its related pathways are Folate Metabolism and Neurodegenerative Diseases. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and peroxiredoxin activity. An important paralog of this gene is PRDX1.
UniProtKB/Swiss-Prot Summary for PRDX2 Gene
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).