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Aliases for PRDX2 Gene

Aliases for PRDX2 Gene

  • Peroxiredoxin 2 2 3 5
  • Thioredoxin-Dependent Peroxide Reductase 1 2 3 4
  • Thioredoxin Peroxidase 1 2 3 4
  • Natural Killer Cell-Enhancing Factor B 3 4
  • Thiol-Specific Antioxidant 1 2 3
  • NKEF-B 3 4
  • Torin 2 3
  • TDPX1 3 4
  • NKEFB 3 4
  • PRP 3 4
  • TSA 3 4
  • Epididymis Secretory Sperm Binding Protein Li 2a 3
  • Thiol-Specific Antioxidant Protein 4
  • Natural Killer-Enhancing Factor B 2
  • Peroxiredoxin-2 3
  • EC 4
  • HEL-S-2a 3
  • PRXII 3
  • PRX2 3
  • PTX1 3
  • TPX1 3

External Ids for PRDX2 Gene

Previous HGNC Symbols for PRDX2 Gene

  • TDPX1

Previous GeneCards Identifiers for PRDX2 Gene

  • GC19M013039
  • GC19M013130
  • GC19M012752
  • GC19M012768
  • GC19M012907
  • GC19M012479

Summaries for PRDX2 Gene

Entrez Gene Summary for PRDX2 Gene

  • This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

GeneCards Summary for PRDX2 Gene

PRDX2 (Peroxiredoxin 2) is a Protein Coding gene. Diseases associated with PRDX2 include Hereditary Spherocytosis and In Situ Carcinoma. Among its related pathways are Gene Expression and Neurodegenerative Diseases. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and peroxiredoxin activity. An important paralog of this gene is PRDX1.

UniProtKB/Swiss-Prot for PRDX2 Gene

  • Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Gene Wiki entry for PRDX2 Gene

Additional gene information for PRDX2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX2 Gene

Genomics for PRDX2 Gene

GeneHancer (GH) Regulatory Elements for PRDX2 Gene

Promoters and enhancers for PRDX2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J012800 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 655.5 +0.4 409 2.8 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RNASEH2A PRDX2 THSD8 ZNF136 CCDC130 TRMT1 ZNF791 ZNF442 WDR83OS ZNF564
GH19J012765 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 19.3 +35.8 35783 1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 ZNF121 ZNF207 PRDX2 RNASEH2A MAST1 DNASE2 GC19M012791 GC19M012792 GC19M012790 BEST2 HOOK2
GH19J012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.2 +12.6 12612 16 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 IER2 ZNF136 CCDC130 ZNF44 ZNF791 ZNF564 TRMT1 WDR83OS ZNF442 ZNF700
GH19J012825 Enhancer 1.1 Ensembl ENCODE 12.3 -23.9 -23912 1.4 PKNOX1 ATF1 ARID4B SIN3A SLC30A9 GLIS2 ZNF143 ATF7 NFKBIZ SP3 GC19M012830 LOC105372281 TRMT1 ZNF799 ZNF136 ZNF763 ZNF20 CCDC130 ZNF44 TRIR
GH19J012805 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 5.1 -4.8 -4845 1.6 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RNASEH2A ZNF136 ZNF20 ZNF763 CCDC130 TRMT1 ZNF700 ZNF44 ZNF442 ZNF625
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRDX2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRDX2 gene promoter:
  • c-Jun
  • ATF-2
  • AP-1
  • STAT1

Genomic Locations for PRDX2 Gene

Genomic Locations for PRDX2 Gene
5,091 bases
Minus strand
5,061 bases
Minus strand

Genomic View for PRDX2 Gene

Genes around PRDX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX2 Gene

Proteins for PRDX2 Gene

  • Protein details for PRDX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K0C0
    • P31945
    • P32118
    • P35701
    • Q6FHG4
    • Q92763
    • Q9UC23

    Protein attributes for PRDX2 Gene

    198 amino acids
    Molecular mass:
    21892 Da
    Quaternary structure:
    • Homodimer; disulfide-linked, upon oxidation (PubMed:27892488). 5 homodimers assemble to form a ring-like decamer (PubMed:27892488). Interacts with TIPIN (PubMed:17141802).
    • The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.

    Three dimensional structures from OCA and Proteopedia for PRDX2 Gene

    Alternative splice isoforms for PRDX2 Gene


neXtProt entry for PRDX2 Gene

Post-translational modifications for PRDX2 Gene

  • The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
  • Ubiquitination at posLast=135135, Lys92, Lys26, and posLast=1616
  • Modification sites at PhosphoSitePlus

Other Protein References for PRDX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRDX2 Gene

Domains & Families for PRDX2 Gene

Gene Families for PRDX2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
  • Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
genes like me logo Genes that share domains with PRDX2: view

Function for PRDX2 Gene

Molecular function for PRDX2 Gene

UniProtKB/Swiss-Prot Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
UniProtKB/Swiss-Prot CatalyticActivity:
2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.

Enzyme Numbers (IUBMB) for PRDX2 Gene

Phenotypes From GWAS Catalog for PRDX2 Gene

Gene Ontology (GO) - Molecular Function for PRDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17557078
GO:0008379 thioredoxin peroxidase activity IDA,TAS 18606987
GO:0016209 antioxidant activity NAS 12943237
GO:0016491 oxidoreductase activity IEA --
GO:0051920 peroxiredoxin activity IEA --
genes like me logo Genes that share ontologies with PRDX2: view
genes like me logo Genes that share phenotypes with PRDX2: view

Animal Models for PRDX2 Gene

MGI Knock Outs for PRDX2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRDX2

Clone Products

  • Addgene plasmids for PRDX2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX2 Gene

Localization for PRDX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDX2 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
cytoskeleton 2
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PRDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with PRDX2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRDX2 Gene

Pathways & Interactions for PRDX2 Gene

genes like me logo Genes that share pathways with PRDX2: view

Gene Ontology (GO) - Biological Process for PRDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress NAS 11904290
GO:0019430 removal of superoxide radicals IDA 20978343
GO:0034599 cellular response to oxidative stress TAS,IDA --
GO:0042744 hydrogen peroxide catabolic process TAS 18606987
GO:0042981 regulation of apoptotic process IMP 12943237
genes like me logo Genes that share ontologies with PRDX2: view

No data available for SIGNOR curated interactions for PRDX2 Gene

Drugs & Compounds for PRDX2 Gene

(17) Drugs for PRDX2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
Water Approved Pharma 0
calcium Approved Nutra 0
3-Sulfinoalanine Experimental Pharma Target 0
N-Carbamoyl-Alanine Experimental Pharma Target 0

(9) Additional Compounds for PRDX2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRDX2: view

Transcripts for PRDX2 Gene

mRNA/cDNA for PRDX2 Gene

Unigene Clusters for PRDX2 Gene

Peroxiredoxin 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for PRDX2

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5: - - -

Relevant External Links for PRDX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRDX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRDX2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRDX2 Gene

Protein tissue co-expression partners for PRDX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRDX2 Gene:


SOURCE GeneReport for Unigene cluster for PRDX2 Gene:


Evidence on tissue expression from TISSUES for PRDX2 Gene

  • Blood(5)
  • Nervous system(5)
  • Lung(4.8)
  • Liver(4.6)
  • Skin(4.5)
  • Intestine(3.9)
  • Kidney(3.4)
  • Heart(3.1)
  • Muscle(3)
  • Eye(2.9)
  • Bone marrow(2.7)
  • Adrenal gland(2.3)
  • Thyroid gland(2.3)
  • Pancreas(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with PRDX2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX2 Gene

Orthologs for PRDX2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRDX2 34 33
  • 99.83 (n)
(Mus musculus)
Mammalia Prdx2 16 34 33
  • 88.22 (n)
Gm5225 34
  • 72 (a)
(Canis familiaris)
Mammalia PRDX2 34 33
  • 88.22 (n)
(Bos Taurus)
Mammalia PRDX2 34 33
  • 87.39 (n)
(Rattus norvegicus)
Mammalia Prdx2 33
  • 87.04 (n)
(Monodelphis domestica)
Mammalia PRDX2 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia PRDX2 34
  • 83 (a)
(Anolis carolinensis)
Reptilia PRDX2 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx2 33
  • 72.43 (n)
(Danio rerio)
Actinopterygii prdx2 34 33
  • 72.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta Jafrac1 34 35 33
  • 67.38 (n)
Jafrac2 35
  • 67 (a)
Prx5037 35
  • 62 (a)
CG6888 34 35
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta TPX2 33
  • 65.97 (n)
(Caenorhabditis elegans)
Secernentea F09E5.2 35
  • 70 (a)
prdx-2 34 33
  • 66.67 (n)
R07E5.2 35
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSA1 36 34 33
  • 61.14 (n)
TSA2 34
  • 61 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11630 33
  • 61.35 (n)
(Oryza sativa)
Liliopsida Os02g0537700 33
  • 61.52 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tpx1 33
  • 60.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
Species where no ortholog for PRDX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX2 Gene

Gene Tree for PRDX2 (if available)
Gene Tree for PRDX2 (if available)
Evolutionary constrained regions (ECRs) for PRDX2: view image

Paralogs for PRDX2 Gene

Paralogs for PRDX2 Gene

(3) SIMAP similar genes for PRDX2 Gene using alignment to 2 proteins:

  • A6NIW5_HUMAN Pseudogenes for PRDX2 Gene

genes like me logo Genes that share paralogs with PRDX2: view

Variants for PRDX2 Gene

Sequence variations from dbSNP and Humsavar for PRDX2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000287165 -- 12,803,528(-) C/T upstream_transcript_variant
rs1000657412 -- 12,803,148(-) A/T upstream_transcript_variant
rs1002013450 -- 12,798,628(-) G/A intron_variant
rs1002440054 -- 12,798,604(-) G/A intron_variant
rs1002574924 -- 12,803,197(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRDX2 Gene

Variant ID Type Subtype PubMed ID
dgv138n111 CNV deletion 26073780
nsv1160586 CNV duplication 26073780
nsv953977 CNV deletion 24416366

Variation tolerance for PRDX2 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRDX2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX2 Gene

Disorders for PRDX2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRDX2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hereditary spherocytosis
  • spherocytosis, type 1
in situ carcinoma
  • carcinoma in situ
hemolytic anemia
  • anemia hemolytic
fuchs' endothelial dystrophy
  • fced
- elite association - COSMIC cancer census association via MalaCards
Search PRDX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRDX2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRDX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX2 Gene

Publications for PRDX2 Gene

  1. Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions. (PMID: 18682255) Schläwicke Engström K … Broberg K (Mutation research 2009) 3 22 44 58
  2. Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12. (PMID: 7607688) Pahl P … Patterson D (Genomics 1995) 2 3 22 58
  3. The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions. (PMID: 8144038) Lim YS … Kim IH (Gene 1994) 3 4 22 58
  4. Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic. (PMID: 19896490) Engström KS … Broberg K (Mutation research 2010) 3 44 58
  5. Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis. (PMID: 20363977) Besgen P … Prinz JC (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 22 58

Products for PRDX2 Gene

Sources for PRDX2 Gene

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