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Aliases for PRDX1 Gene

Aliases for PRDX1 Gene

  • Peroxiredoxin 1 2 3 5
  • Thioredoxin-Dependent Peroxide Reductase 2 3 4
  • Natural Killer Cell-Enhancing Factor A 3 4
  • Proliferation-Associated Gene Protein 3 4
  • Thioredoxin Peroxidase 2 3 4
  • Peroxiredoxin-1 3 4
  • EC 1.11.1.15 4 56
  • NKEF-A 3 4
  • TDPX2 3 4
  • PAGA 3 4
  • PAGB 3 4
  • PAG 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Natural Killer-Enhancing Factor A 3
  • Proliferation-Associated Gene A 3
  • EC 1.11.1 56
  • MSP23 3
  • NKEFA 3
  • PRX1 3
  • PRXI 3

External Ids for PRDX1 Gene

Previous HGNC Symbols for PRDX1 Gene

  • PAGA

Previous GeneCards Identifiers for PRDX1 Gene

  • GC01M045704
  • GC01M044978
  • GC01M045404
  • GC01M045390
  • GC01M045645
  • GC01M045749
  • GC01M045976
  • GC01M044090

Summaries for PRDX1 Gene

Entrez Gene Summary for PRDX1 Gene

  • This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for PRDX1 Gene

PRDX1 (Peroxiredoxin 1) is a Protein Coding gene. Diseases associated with PRDX1 include Methylmalonic Aciduria And Homocystinuria, Cblc Type and Methylmalonic Acidemia With Homocystinuria. Among its related pathways are Prostaglandin 2 biosynthesis and metabolism FM and Peroxisome. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is PRDX2.

UniProtKB/Swiss-Prot for PRDX1 Gene

  • Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).

Gene Wiki entry for PRDX1 Gene

Additional gene information for PRDX1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX1 Gene

Genomics for PRDX1 Gene

GeneHancer (GH) Regulatory Elements for PRDX1 Gene

Promoters and enhancers for PRDX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J045519 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 626 +1.8 1797 4.9 MTA3 ZNF652 SP1 CC2D1A ZFX ELF3 MNT CBFA2T2 ZNF148 NKRF PRDX1 CCDC163 TOE1 MUTYH LRRC41 GPBP1L1 NASP ZSWIM5 ENSG00000234329 NSUN4
GH01J045498 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 36.9 +23.1 23066 3.3 ZFX SP1 ZNF652 ELF3 SIX5 ZNF148 NKRF POLR2A CEBPG GTF2F1 CCDC163 NASP MMACHC PIR33787 PRDX1 MUTYH LRRC41 AKR1A1 HMGB1P48 TOE1
GH01J045489 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 25.6 +32.3 32346 3 ZFX SP1 CC2D1A ELF3 MNT CBFA2T2 NKRF MLLT1 ZNF121 CEBPG TESK2 CCDC163 NSUN4 PRDX1 LRRC41 TOE1 IPP GPBP1L1 KIF2C ZSWIM5
GH01J045550 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.1 -28.3 -28334 3.2 SP1 ZNF652 ZFX ELF3 ZKSCAN8 MNT CBFA2T2 ZNF148 NKRF POLR2A GC01P045551 AKR1A1 PRDX1 CCDC163 LRRC41 TOE1 GPBP1L1 ENSG00000234329 ENSG00000281133
GH01J045334 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 16.7 +184.9 184927 8.2 CC2D1A ELF3 ZFX MNT SIX5 ZNF148 NKRF POLR2A ZNF121 CEBPG TOE1 MUTYH GPBP1L1 PRDX1 MMACHC LRRC41 CCDC163 TESK2 ENSG00000234329 HECTD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRDX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRDX1 gene promoter:
  • C/EBPbeta
  • NF-AT
  • NF-AT4
  • PPAR-gamma1
  • PPAR-gamma2
  • SEF-1 (1)
  • Sox9

Genomic Locations for PRDX1 Gene

Genomic Locations for PRDX1 Gene
chr1:45,511,035-45,523,047
(GRCh38/hg38)
Size:
12,013 bases
Orientation:
Minus strand
chr1:45,976,707-45,988,719
(GRCh37/hg19)
Size:
12,013 bases
Orientation:
Minus strand

Genomic View for PRDX1 Gene

Genes around PRDX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX1 Gene

Proteins for PRDX1 Gene

  • Protein details for PRDX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06830-PRDX1_HUMAN
    Recommended name:
    Peroxiredoxin-1
    Protein Accession:
    Q06830
    Secondary Accessions:
    • B5BU26
    • D3DPZ8
    • P35703
    • Q2V576
    • Q5T154
    • Q5T155

    Protein attributes for PRDX1 Gene

    Size:
    199 amino acids
    Molecular mass:
    22110 Da
    Quaternary structure:
    • Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer (PubMed:18172504). Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity). Interacts with SESN1 and SESN2 (PubMed:15105503). Interacts with FAM107A (PubMed:21969592).
    Miscellaneous:
    • The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.

    Three dimensional structures from OCA and Proteopedia for PRDX1 Gene

neXtProt entry for PRDX1 Gene

Selected DME Specific Peptides for PRDX1 Gene

Q06830:
  • FKATAVMPDGQFKDISL
  • HGEVCPA
  • LRLVQAFQ
  • VGRSVDE
  • LSDYKGK
  • IDDKGILR
  • EVCPAGWKPG
  • NDLPVGR
  • GRSVDET
  • LRQITVND
  • SKEYFSK
  • RGLFIID
  • DFTFVCP
  • PGSDTIKP
  • ASVDSHFCHLAW

Post-translational modifications for PRDX1 Gene

  • Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.
  • The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
  • Ubiquitination at isoforms=93
  • Modification sites at PhosphoSitePlus

Other Protein References for PRDX1 Gene

Antibody Products

Domains & Families for PRDX1 Gene

Gene Families for PRDX1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRDX1 Gene

GenScript: Design optimal peptide antigens:
  • Thioredoxin-dependent peroxide reductase 2 (PRDX1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q06830

UniProtKB/Swiss-Prot:

PRDX1_HUMAN :
  • Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
Family:
  • Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
genes like me logo Genes that share domains with PRDX1: view

Function for PRDX1 Gene

Molecular function for PRDX1 Gene

UniProtKB/Swiss-Prot Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-dithiol + a hydroperoxide = [protein]-disulfide + an alcohol + H2O; Xref=Rhea:RHEA:10008, Rhea:RHEA-COMP:10593, Rhea:RHEA-COMP:10594, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.15; Evidence={ECO:0000269 PubMed:11986303, ECO:0000269 PubMed:9497357};.
UniProtKB/Swiss-Prot Induction:
Constitutively expressed in most human cells; is induced to higher levels upon serum stimulation in untransformed and transformed cells.

Enzyme Numbers (IUBMB) for PRDX1 Gene

Phenotypes From GWAS Catalog for PRDX1 Gene

Gene Ontology (GO) - Molecular Function for PRDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0004601 peroxidase activity TAS --
GO:0005515 protein binding IPI 15105503
GO:0008379 thioredoxin peroxidase activity IDA 18606987
GO:0016209 antioxidant activity IEA --
genes like me logo Genes that share ontologies with PRDX1: view
genes like me logo Genes that share phenotypes with PRDX1: view

Human Phenotype Ontology for PRDX1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PRDX1 Gene

MGI Knock Outs for PRDX1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRDX1

CRISPR Products

Clone Products

  • Addgene plasmids for PRDX1
  • Applied Biological Materials (abm): Clones for PRDX1 - Now 50% OFF >
  • * PRDX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRDX1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Transcription Factor Targets and HOMER Transcription for PRDX1 Gene

Localization for PRDX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX1 Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDX1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 3
extracellular 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005623 cell IEA --
GO:0005634 nucleus IDA 17603937
GO:0005737 cytoplasm IDA 17603937
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PRDX1: view

Pathways & Interactions for PRDX1 Gene

genes like me logo Genes that share pathways with PRDX1: view

SIGNOR curated interactions for PRDX1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PRDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8089076
GO:0001895 retina homeostasis HEP 23580065
GO:0006979 response to oxidative stress IBA 21873635
GO:0008283 cell proliferation TAS,IEA --
GO:0019430 removal of superoxide radicals IBA 21873635
genes like me logo Genes that share ontologies with PRDX1: view

Drugs & Compounds for PRDX1 Gene

(17) Drugs for PRDX1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anthrax immune globulin human Approved Pharma Target, antibody 0
Copper Approved, Investigational Pharma Target 226
Raxibacumab Approved Pharma Target, antibody 0
Zinc Approved, Investigational Pharma Target 2681
zinc acetate Approved, Investigational Pharma Target 0

(6) Additional Compounds for PRDX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRDX1: view

Transcripts for PRDX1 Gene

Unigene Clusters for PRDX1 Gene

Peroxiredoxin 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for PRDX1
  • Applied Biological Materials (abm): Clones for PRDX1 - Now 50% OFF >
  • * PRDX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRDX1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: - - -
SP9: -
SP10: - - -

Relevant External Links for PRDX1 Gene

GeneLoc Exon Structure for
PRDX1
ECgene alternative splicing isoforms for
PRDX1

Expression for PRDX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRDX1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRDX1 Gene



Protein tissue co-expression partners for PRDX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRDX1 Gene:

PRDX1

SOURCE GeneReport for Unigene cluster for PRDX1 Gene:

Hs.180909

Evidence on tissue expression from TISSUES for PRDX1 Gene

  • Nervous system(5)
  • Liver(4.9)
  • Lung(4.7)
  • Skin(4.7)
  • Pancreas(4.5)
  • Eye(4.4)
  • Intestine(3.9)
  • Kidney(3.9)
  • Muscle(3.4)
  • Bone(3.2)
  • Blood(3)
  • Heart(2.9)
  • Stomach(2.8)
  • Lymph node(2.7)
  • Spleen(2.7)
  • Thyroid gland(2.6)
  • Adrenal gland(2.2)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with PRDX1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX1 Gene

Orthologs for PRDX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRDX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDX1 35 34
  • 99.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRDX1 35 34
  • 93.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRDX1 35 34
  • 93.3 (n)
OneToMany
-- 35
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX1 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRDX1 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdx1 34
  • 91.29 (n)
mouse
(Mus musculus)
Mammalia Prdx1 17 35 34
  • 90.79 (n)
chicken
(Gallus gallus)
Aves PRDX1 35 34
  • 78.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDX1 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731384 34
  • 76.21 (n)
Str.493 34
zebrafish
(Danio rerio)
Actinopterygii prdx1 35 34
  • 73.91 (n)
OneToOne
hmzehl0637 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11565 34
fruit fly
(Drosophila melanogaster)
Insecta Jafrac1 35 36
  • 70 (a)
ManyToMany
Jafrac2 36
  • 65 (a)
Prx5037 36
  • 61 (a)
CG6888 35 36
  • 55 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F09E5.2 36
  • 74 (a)
prdx-2 35
  • 72 (a)
OneToMany
R07E5.2 36
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSA1 35
  • 59 (a)
ManyToMany
TSA2 35
  • 58 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 60 (a)
OneToMany
Species where no ortholog for PRDX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX1 Gene

ENSEMBL:
Gene Tree for PRDX1 (if available)
TreeFam:
Gene Tree for PRDX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRDX1: view image

Paralogs for PRDX1 Gene

Paralogs for PRDX1 Gene

(4) SIMAP similar genes for PRDX1 Gene using alignment to 1 proteins:

  • PRDX1_HUMAN

Pseudogenes.org Pseudogenes for PRDX1 Gene

genes like me logo Genes that share paralogs with PRDX1: view

Variants for PRDX1 Gene

Sequence variations from dbSNP and Humsavar for PRDX1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1044717 benign, Disorders of Intracellular Cobalamin Metabolism 45,510,915(-) A/G downstream_transcript_variant
rs12728919 likely-benign, Disorders of Intracellular Cobalamin Metabolism 45,510,577(-) G/A downstream_transcript_variant
rs1379672870 pathogenic, METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblC TYPE, DIGENIC 45,511,416(-) T/A/C splice_acceptor_variant
rs561153993 uncertain-significance, Disorders of Intracellular Cobalamin Metabolism 45,510,929(-) A/G downstream_transcript_variant
rs5773883 benign, Disorders of Intracellular Cobalamin Metabolism 45,510,592(-) /T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRDX1 Gene

Variant ID Type Subtype PubMed ID
esv1003037 CNV deletion 20482838
esv2665399 CNV deletion 23128226
esv2747819 CNV deletion 23290073
esv2992526 CNV deletion 24192839
esv3893512 CNV gain 25118596
nsv1119684 CNV deletion 24896259
nsv829726 CNV loss 17160897

Variation tolerance for PRDX1 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRDX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDX1
Human Gene Mutation Database (HGMD)
PRDX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX1 Gene

Disorders for PRDX1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PRDX1 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
methylmalonic aciduria and homocystinuria, cblc type
  • mahcc
methylmalonic acidemia with homocystinuria
  • vitamin b12 metabolic defect with combined deficiency of methylmalonyl-coa mutase and homocysteine:methyltetrahydrofolate methyltransferase
fibrosarcoma of bone
  • fibrosarcoma of the bone
anthrax disease
  • gas gangrene
cutaneous anthrax
  • anthrax, skin type
- elite association - COSMIC cancer census association via MalaCards
Search PRDX1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRDX1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRDX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX1 Gene

Publications for PRDX1 Gene

  1. A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins. (PMID: 8496166) Prospéri MT … Goubin G (The Journal of biological chemistry 1993) 2 3 4 23 58
  2. Cloning and sequence analysis of candidate human natural killer-enhancing factor genes. (PMID: 8026862) Shau H … Kim A (Immunogenetics 1994) 3 4 23 58
  3. Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition. (PMID: 21969592) Schmidt MV … Rein T (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 58
  5. Prx1 enhances androgen receptor function in prostate cancer cells by increasing receptor affinity to dihydrotestosterone. (PMID: 19737972) Chhipa RR … Ip C (Molecular cancer research : MCR 2009) 3 23 58

Products for PRDX1 Gene

Sources for PRDX1 Gene