Aliases for PRDX1 Gene
External Ids for PRDX1 Gene
Previous HGNC Symbols for PRDX1 Gene
Previous GeneCards Identifiers for PRDX1 Gene
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for PRDX1 Gene
PRDX1 (Peroxiredoxin 1) is a Protein Coding gene. Diseases associated with PRDX1 include Methylmalonic Aciduria And Homocystinuria, Cblc Type and Methylmalonic Acidemia With Homocystinuria. Among its related pathways are Gene Expression and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is PRDX2.
UniProtKB/Swiss-Prot Summary for PRDX1 Gene
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).