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This gene encodes a member of a family of proteins that may have roles in transcription and other nuclear processes. The encoded protein contains a KRAB (Kruppel-associated box) domain -A box and a SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain and may function as a histone methyltransferase. [provided by RefSeq, Aug 2013]
PRDM7 (PR/SET Domain 7) is a Protein Coding gene. Among its related pathways are Lysine degradation and Metabolism. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and histone-lysine N-methyltransferase activity. An important paralog of this gene is PRDM11.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IBA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008168 | methyltransferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005694 | chromosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
|
|
2 | Lysine degradation | ||
3 | Metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006325 | chromatin organization | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0010452 | histone H3-K36 methylation | IEA | -- |
GO:0010468 | regulation of gene expression | IBA | 21873635 |
GO:0010845 | positive regulation of reciprocal meiotic recombination | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
s-adenosylhomocysteine | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
s-adenosylmethionine |
|
485-80-3 |
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PRDM7 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PRDM7 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PRDM7 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PRDM7 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | PRDM7 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG43347 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | set-17 30 |
|
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs12925933 | - | p.Asp90Glu | |||
rs2078478 | - | p.Arg131Lys | |||
rs7206111 | - | p.Asn435Lys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3067n100 | CNV | gain | 25217958 |
esv1938258 | CNV | deletion | 18987734 |
esv2550224 | CNV | deletion | 19546169 |
esv2660381 | CNV | deletion | 23128226 |
esv28486 | CNV | loss | 19812545 |
esv3553924 | CNV | deletion | 23714750 |
esv3639606 | CNV | gain | 21293372 |
esv3639607 | CNV | gain | 21293372 |
esv3639609 | CNV | loss | 21293372 |
esv3639610 | CNV | gain | 21293372 |
esv3639611 | CNV | loss | 21293372 |
esv3639612 | CNV | gain | 21293372 |
nsv1059965 | CNV | gain | 25217958 |
nsv1062080 | CNV | loss | 25217958 |
nsv1064351 | CNV | gain+loss | 25217958 |
nsv1067164 | CNV | gain+loss | 25217958 |
nsv1934 | CNV | deletion | 18451855 |
nsv428331 | CNV | gain+loss | 18775914 |
nsv457626 | CNV | loss | 19166990 |
nsv471119 | CNV | loss | 18288195 |
nsv471120 | CNV | gain | 18288195 |
nsv482951 | CNV | loss | 15286789 |
nsv509641 | CNV | insertion | 20534489 |
nsv514823 | CNV | gain | 21397061 |
nsv573841 | CNV | loss | 21841781 |
nsv9482 | CNV | loss | 18304495 |
nsv978180 | CNV | duplication | 23825009 |
No disorders were found for PRDM7 Gene.