Aliases for PRDM6 Gene
Aliases for PRDM6 Gene
External Ids for PRDM6 Gene
- HGNC: 9350
- Entrez Gene: 93166
- Ensembl: ENSG00000061455
- OMIM: 616982
- UniProtKB: Q9NQX0
Previous GeneCards Identifiers for PRDM6 Gene
- GC05P122055
- GC05P122751
- GC05P122455
- GC05P122480
- GC05P122452
- GC05U900559
- GC05P117612
- GC05P122424
- GC05P123089
Summaries for PRDM6 Gene
-
The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. Family members contain a PR domain and multiple zinc-finger domains. The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. Mutations in this gene result in patent ductus arteriosus 3 (PDA3). [provided by RefSeq, Apr 2017]
GeneCards Summary for PRDM6 Gene
PRDM6 (PR/SET Domain 6) is a Protein Coding gene. Diseases associated with PRDM6 include Patent Ductus Arteriosus 3 and Familial Patent Arterial Duct. Among its related pathways are Lysine degradation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and histone-lysine N-methyltransferase activity. An important paralog of this gene is PRDM14.
UniProtKB/Swiss-Prot for PRDM6 Gene
-
Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates Lys-20 of histone H4 in vitro. Lys-20 methylation represents a specific tag for epigenetic transcriptional repression.
Additional gene information for PRDM6 Gene
- Monarch Initiative
- Search for PRDM6 at DataMed
- Search for PRDM6 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM6 Gene
Genomics for PRDM6 Gene
GeneHancer (GH) Regulatory Elements for PRDM6 Gene
Promoters and enhancers for PRDM6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRDM6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PRDM6 gene promoter:
-
- ARP-1
- CHOP-10
- C/EBPalpha
- Sp1
- SRF
- SRF (504 AA)
- Pax-4a
- USF2
- USF-1
- USF-1:USF-2
Regulatory Element Products
Genomic Locations for PRDM6 Gene
Genomic Locations for PRDM6 Gene
- chr5:123,035,985-123,194,266
- (GRCh38/hg38)
- Size:
- 158,282 bases
- Orientation:
- Plus strand
- chr5:122,424,816-122,529,960
- (GRCh37/hg19)
- Size:
- 105,145 bases
- Orientation:
- Plus strand
Genomic View for PRDM6 Gene
Genes around PRDM6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q23.2 by Entrez Gene
- 5q23.2 by HGNC
- 5q23.2 by Ensembl
PRDM6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRDM6 Gene
Proteins for PRDM6 Gene
-
Protein details for PRDM6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQX0-PRDM6_HUMAN
- Recommended name:
- Putative histone-lysine N-methyltransferase PRDM6
- Protein Accession:
- Q9NQX0
- B5MCJ4
- Q9NQW9
Protein attributes for PRDM6 Gene
- Size:
- 595 amino acids
- Molecular mass:
- 64452 Da
- Quaternary structure:
-
- Interacts with HDAC1, HDAC2, HDAC3, CBX1 and EP300.
- SequenceCaution:
-
- Sequence=AAF78078.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF78079.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for PRDM6 Gene
Post-translational modifications for PRDM6 Gene
Other Protein References for PRDM6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PRDM6
-
Abcam antibodies for PRDM6
- Invitrogen Antibodies for PRDM6
- GeneTex PRDM6 Antibody for PRDM6
-
Boster Bio Antibodies for PRDM6
Protein Products
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- Search GeneTex for Proteins for PRDM6
Assay Products
No data available for DME Specific Peptides for PRDM6 Gene
Domains & Families for PRDM6 Gene
Gene Families for PRDM6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
- Transcription factors
Protein Domains for PRDM6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRDM6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NQX0UniProtKB/Swiss-Prot:
PRDM6_HUMAN :- Belongs to the class V-like SAM-binding methyltransferase superfamily.
- Family:
-
- Belongs to the class V-like SAM-binding methyltransferase superfamily.
Function for PRDM6 Gene
Molecular function for PRDM6 Gene
- UniProtKB/Swiss-Prot Function:
- Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates Lys-20 of histone H4 in vitro. Lys-20 methylation represents a specific tag for epigenetic transcriptional repression.
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Enzyme Numbers (IUBMB) for PRDM6 Gene
Phenotypes From GWAS Catalog for PRDM6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0005515 | protein binding | IEA | -- |
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for PRDM6 Gene
- MGI mutant phenotypes for PRDM6:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PRDM6:
Animal Models for PRDM6 Gene
- MGI Knock Outs for PRDM6:
-
- Prdm6 Prdm6<tm1.2Jrld>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
OriGene CRISPR knockouts for PRDM6
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- Overview of 46 available PRDM6 gene related products
- Applied Biological Materials CRISPR for PRDM6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDM6
- GenScript: Design CRISPR guide RNA sequences for PRDM6
miRNA for PRDM6 Gene
- miRTarBase miRNAs that target PRDM6
-
- hsa-mir-7-5p (MIRT311376)
- hsa-mir-641 (MIRT311377)
- hsa-mir-3617-5p (MIRT311378)
- hsa-mir-3688-3p (MIRT311379)
- hsa-mir-4802-3p (MIRT311381)
- hsa-mir-5093 (MIRT311382)
- hsa-mir-6728-5p (MIRT311383)
- hsa-mir-4503 (MIRT496218)
- hsa-mir-6792-5p (MIRT496219)
- hsa-mir-4311 (MIRT496220)
- hsa-mir-5187-5p (MIRT560125)
- hsa-mir-6077 (MIRT560126)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRDM6
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- genomics-online: shRNA clones - Search results for 46 available PRDM6 gene related products
- Overview of 46 available PRDM6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PRDM6
- VectorBuilder custom plasmid, inducible vectors for PRDM6
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PRDM6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDM6
- Applied Biological Materials Clones for PRDM6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRDM6
No data available for Transcription Factor Targets and HOMER Transcription for PRDM6 Gene
Localization for PRDM6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRDM6 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for PRDM6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Lysine degradation | ||
Pathways by source for PRDM6 Gene
1 KEGG pathway for PRDM6 Gene
Interacting Proteins for PRDM6 Gene
GPS-Prot Interaction Network for PRDM6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0022008 | neurogenesis | IEA | -- |
No data available for SIGNOR curated interactions for PRDM6 Gene
Drugs & Compounds for PRDM6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| s-adenosylhomocysteine | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| s-adenosylmethionine |
|
485-80-3 |
|
Transcripts for PRDM6 Gene
mRNA/cDNA for PRDM6 Gene
- (2) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000407847 9267 bps (uc003kti.4)
- ENST00000434521 699 bps (uc063glk.1)
- ENST00000464424 514 bps (uc063gll.1)
- ENST00000427739 256 bps (uc063glm.1)
Unigene Clusters for PRDM6 Gene
- PR domain containing 6:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PRDM6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDM6
- genomics-online: gRNA clones - Search results for 46 available PRDM6 gene related products
- Overview of 46 available PRDM6 gene related products
- Applied Biological Materials CRISPR for PRDM6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDM6
- GenScript: Design CRISPR guide RNA sequences for PRDM6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRDM6
- Browse OriGene Inhibitory RNA Products For PRDM6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDM6
- genomics-online: shRNA clones - Search results for 46 available PRDM6 gene related products
- Overview of 46 available PRDM6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PRDM6
- VectorBuilder custom plasmid, inducible vectors for PRDM6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDM6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PRDM6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDM6
- Applied Biological Materials Clones for PRDM6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: |
Expression for PRDM6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
mRNA differential expression in normal tissues according to GTEx for PRDM6 Gene
This gene is overexpressed in Artery - Aorta (x12.0), Bladder (x7.4), Artery - Tibial (x5.6), and Artery - Coronary (x4.7).
This gene is overexpressed in Cerebrospinal fluid (43.5) and Heart (25.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRDM6 Gene
NURSA nuclear receptor signaling pathways regulating expression of PRDM6 Gene:
PRDM6SOURCE GeneReport for Unigene cluster for PRDM6 Gene:
Hs.135118Evidence on tissue expression from TISSUES for PRDM6 Gene
- Heart(2.2)
Primer Products
-
OriGene qPCR primer pairs for PRDM6
- genomics-online: primer clones - Search results for 46 available PRDM6 gene related products
- Overview of 46 available PRDM6 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDM6 Gene
Orthologs for PRDM6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | PRDM6 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | PRDM6 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PRDM6 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PRDM6 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Prdm6 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Prdm6 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PRDM6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PRDM6 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PRDM6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prdm6 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12311 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | prdm6 34 |
|
OneToMany | |
| PRDM6 (2 of 2) 34 |
|
OneToMany | |||
| LOC101886516 33 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | set-17 34 |
|
OneToMany |
- Species where no ortholog for PRDM6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PRDM6 Gene
- ENSEMBL:
- Gene Tree for PRDM6 (if available)
- TreeFam:
- Gene Tree for PRDM6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRDM6: view image
Paralogs for PRDM6 Gene
(45) SIMAP similar genes for PRDM6 Gene using alignment to 2 proteins:
- PRDM6_HUMAN
- H7BZR2_HUMAN
- smap-7
- kr-znf3
- ZNF826P
- ZNF78L1
- ZNF664
- ZFS-5
- HZF16
- ZNF
- ZNF697
- DKFZp434J0650
- ZNF808
- ZFP41
- ZNF702P
- ZNF22
- ZFS-2
- DKFZp686N0199
- DKFZp686M04222
- zf30
- ZSCAN21
- ZNF833P
- ZNF72
- ZNF844
- ZNF323
- ZNF137P
- KLF1
- ZNF876P
- HZF40
- A-328A3.4
- ZNF726P1
- ZNF55
- ZFS-3
- HZF17
- DKFZp686O1631
- DKFZp666C237
- DKFZp547H249
- ZNF600
- ZFS-6
- ZNF138
- ZNF740
- ZNF710
- PLZF
- ZNF589
- ZNF770
- ZNF234
- OVOL3
Variants for PRDM6 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs879253872 | pathogenic, Patent ductus arteriosus 3, Patent ductus arteriosus 3 (PDA3) [MIM:617039] | 123,170,997(+) | A/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs879255278 | pathogenic, Patent ductus arteriosus 3, Patent ductus arteriosus 3 (PDA3) [MIM:617039] | 123,180,296(+) | G/A | coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs879255279 | pathogenic, Patent ductus arteriosus 3, Patent ductus arteriosus 3 (PDA3) [MIM:617039] | 123,099,849(+) | G/C | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000043147 | -- | 123,109,397(+) | G/A | intron_variant | |
| rs1000053908 | -- | 123,123,733(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2730710 | CNV | deletion | 23290073 |
| esv2730712 | CNV | deletion | 23290073 |
| esv2730713 | CNV | deletion | 23290073 |
| esv3575879 | CNV | gain | 25503493 |
| esv3575880 | CNV | gain | 25503493 |
| nsv1016658 | CNV | loss | 25217958 |
| nsv1017500 | CNV | loss | 25217958 |
| nsv4979 | CNV | insertion | 18451855 |
| nsv520349 | CNV | loss | 19592680 |
| nsv950128 | CNV | deletion | 24416366 |
Gene Damage Index Score:
12.09;
93.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRDM6 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM6 Gene
Disorders for PRDM6 Gene
(4) MalaCards diseases for PRDM6 Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| patent ductus arteriosus 3 |
|
|
| familial patent arterial duct |
|
|
| patent ductus arteriosus 1 |
|
|
| chromosome 1p36 deletion syndrome |
|
|
Search PRDM6 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PRDM6_HUMAN- Patent ductus arteriosus 3 (PDA3) [MIM:617039]: A congenital heart defect characterized by the persistent opening of fetal ductus arteriosus that fails to close after birth. Fetal ductus arteriosus connects the pulmonary artery to the descending aorta, allowing unoxygenated blood to bypass the lung and flow to the placenta. Normally, the ductus occludes shortly after birth. {ECO:0000269 PubMed:27181681}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PRDM6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PRDM6 Gene
Publications for PRDM6 Gene
- Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. (PMID: 27716515) Li N … Mani A (American journal of human genetics 2016) 2 3 58
- Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. (PMID: 27181681) Li N … Mani A (American journal of human genetics 2016) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. (PMID: 16537907) Davis CA … Olson EN (Molecular and cellular biology 2006) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for PRDM6
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- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Cyagen custom Knockout/knockin (KOKI) mouse models for PRDM6
- VectorBuilder custom plasmid, inducible vectors for PRDM6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDM6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PRDM6
- antibodies-online: Search results for 33 available PRDM6 Antibodies ranked by validation data
- Compare Top PRDM6 Antibodies
- antibodies-online: Search results for available PRDM6 related products ranked by validation data
- antibodies-online: Search results for 2 available PRDM6 Proteins ranked by validation data
- Compare Top PRDM6 Proteins
- genomics-online: cdna clones - Search results for 46 available PRDM6 gene related products
- Overview of 46 available PRDM6 gene related products
- orf clones - Search results for 46 available PRDM6 gene related products
- Overview of 46 available PRDM6 gene related products
- genomics-online: gRNA clones - Search results for 46 available PRDM6 gene related products
- Overview of 46 available PRDM6 gene related products
- genomics-online: primer clones - Search results for 46 available PRDM6 gene related products
- Overview of 46 available PRDM6 gene related products
- genomics-online: shRNA clones - Search results for 46 available PRDM6 gene related products
- Overview of 46 available PRDM6 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDM6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDM6
- GeneCopoeia miRNA 3'UTR Target clone products for PRDM6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDM6
- Boster Bio Antibodies for PRDM6
- Browse Boster Bio ELISA Kits
Sources for PRDM6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt