Aliases for PRDM16 Gene
Aliases for PRDM16 Gene
External Ids for PRDM16 Gene
- HGNC: 14000
- Entrez Gene: 63976
- Ensembl: ENSG00000142611
- OMIM: 605557
- UniProtKB: Q9HAZ2
Previous GeneCards Identifiers for PRDM16 Gene
- GC01P002423
- GC01P002942
- GC01P002559
- GC01P002768
- GC01P003008
- GC01P002280
Summaries for PRDM16 Gene
-
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRDM16 Gene
PRDM16 (PR/SET Domain 16) is a Protein Coding gene. Diseases associated with PRDM16 include Left Ventricular Noncompaction 8 and Left Ventricular Noncompaction. Among its related pathways are Differentiation of white and brown adipocyte and PKMTs methylate histone lysines. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription coactivator activity. An important paralog of this gene is MECOM.
UniProtKB/Swiss-Prot for PRDM16 Gene
-
Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation.
Additional gene information for PRDM16 Gene
- Monarch Initiative
- Search for PRDM16 at DataMed
- Search for PRDM16 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM16 Gene
Genomics for PRDM16 Gene
GeneHancer (GH) Regulatory Elements for PRDM16 Gene
Promoters and enhancers for PRDM16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PRDM16 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PRDM16 Gene
Genomic Locations for PRDM16 Gene
- chr1:3,068,227-3,438,621
- (GRCh38/hg38)
- Size:
- 370,395 bases
- Orientation:
- Plus strand
- chr1:2,985,732-3,355,185
- (GRCh37/hg19)
Genomic View for PRDM16 Gene
Genes around PRDM16 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.32 by Ensembl
- 1p36.32 by Entrez Gene
- 1p36.32 by HGNC
PRDM16 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRDM16 Gene
Proteins for PRDM16 Gene
-
Protein details for PRDM16 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HAZ2-PRD16_HUMAN
- Recommended name:
- PR domain zinc finger protein 16
- Protein Accession:
- Q9HAZ2
- A6NHQ8
- B1AJP7
- B1AJP8
- B1AJP9
- B1WB48
- Q8WYJ9
- Q9C0I8
Protein attributes for PRDM16 Gene
- Size:
- 1276 amino acids
- Molecular mass:
- 140251 Da
- Quaternary structure:
-
- Interacts with CEBPA, CEBPB and CEBPD; the interaction is direct. Interacts with PPARG and PPARA; controls brown adipocytes differentiation. Interacts with CTBP1 and CTBP2; represses the expression of WAT-specific genes. Interacts with PPARGC1A and PPARGC1B; interaction with PPARGC1A or PPARGC1B activates the transcription of BAT-specific gene (By similarity). Interacts with HDAC1, SKI, SMAD2 and SMAD3; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes (PubMed:19049980). Interacts with ZNF516; the interaction is direct and may play a role in the transcription of brown adipose tissue-specific gene (PubMed:25578880).
- SequenceCaution:
-
- Sequence=BAB21766.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for PRDM16 Gene
Post-translational modifications for PRDM16 Gene
Other Protein References for PRDM16 Gene
Antibody Products
- R&D Systems Antibodies for PRDM16 (PRDM16/MEL1)
-
Custom Antibody ServicesOriGene Antibodies for PRDM16
- Novus Biologicals Antibodies for PRDM16
-
Abcam antibodies for PRDM16
- Invitrogen Antibodies for PRDM16
- GeneTex PRDM16 antibody for PRDM16
-
Custom Antibody ServicesProSci Antibodies for PRDM16
Protein Products
-
OriGene Purified Proteins for PRDM16
- Search Origene for MassSpec and Protein Over-expression Lysates for PRDM16
- Origene Custom Protein Services for PRDM16
- Novus Biologicals proteins for PRDM16
- Search GeneTex for Proteins for PRDM16
Assay Products
No data available for DME Specific Peptides for PRDM16 Gene
Domains & Families for PRDM16 Gene
Gene Families for PRDM16 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for PRDM16 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRDM16 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for PRDM16 Gene
Function for PRDM16 Gene
Molecular function for PRDM16 Gene
- UniProtKB/Swiss-Prot Function:
- Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation.
Phenotypes From GWAS Catalog for PRDM16 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003713 | transcription coactivator activity | IEA,ISS | -- |
| GO:0005515 | protein binding | IPI | 19049980 |
| GO:0018024 | histone-lysine N-methyltransferase activity | TAS | -- |
Phenotypes for PRDM16 Gene
- MGI mutant phenotypes for PRDM16:
-
inferred from 3 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for PRDM16:
Animal Model Products
-
Taconic Biosciences Mouse Models for PRDM16
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRDM16
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PRDM16 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM16 gene
- Search ViGene Biosciences for PRDM16
CRISPR Products
-
OriGene CRISPR knockouts for PRDM16
- genomics-online: gRNA clones - Search results for 71 available PRDM16 gene related products
- Overview of 71 available PRDM16 gene related products
- Applied Biological Materials CRISPR for PRDM16
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDM16
- GenScript: Design CRISPR guide RNA sequences for PRDM16
miRNA for PRDM16 Gene
- miRTarBase miRNAs that target PRDM16
miRNA Products
- Search ViGene Biosciences for PRDM16
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRDM16
- Browse OriGene Inhibitory RNA Products For PRDM16
- genomics-online: shRNA clones - Search results for 71 available PRDM16 gene related products
- Overview of 71 available PRDM16 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM16 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PRDM16
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDM16
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PRDM16
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRDM16
-
ViGene Biosciences adenoviral particle packaged cDNA for PRDM16 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PRDM16 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM16 gene
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PRDM16 Gene
Localization for PRDM16 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRDM16 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| peroxisome | 2 |
| extracellular | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 19049980 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | TAS,IDA | -- |
| GO:0016235 | aggresome | IDA | -- |
| GO:0017053 | transcriptional repressor complex | IEA,ISS | -- |
Pathways & Interactions for PRDM16 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin organization | ||
| 2 | PKMTs methylate histone lysines | ||
| 3 | Differentiation of white and brown adipocyte | ||
| 4 | FTO Obesity Variant Mechanism | ||
Pathways by source for PRDM16 Gene
2 BioSystems pathways for PRDM16 Gene
3 Reactome pathways for PRDM16 Gene
Interacting Proteins for PRDM16 Gene
Selected Interacting proteins:
ENSP00000270722
Q9HAZ2-PRD16_HUMAN
for PRDM16 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 19049980 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0019827 | stem cell population maintenance | IEA | -- |
| GO:0022008 | neurogenesis | IEA | -- |
Transcripts for PRDM16 Gene
mRNA/cDNA for PRDM16 Gene
- (8) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (29) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PRDM16 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PRDM16
- genomics-online: gRNA clones - Search results for 71 available PRDM16 gene related products
- Overview of 71 available PRDM16 gene related products
- Applied Biological Materials CRISPR for PRDM16
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDM16
- GenScript: Design CRISPR guide RNA sequences for PRDM16
miRNA Products
- Search ViGene Biosciences for PRDM16
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRDM16
- Browse OriGene Inhibitory RNA Products For PRDM16
- genomics-online: shRNA clones - Search results for 71 available PRDM16 gene related products
- Overview of 71 available PRDM16 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM16 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for PRDM16
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDM16
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PRDM16
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PRDM16 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
- Bone (Muscoskeletal System)
- NULL (Uncategorized)
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Skeletal Muscle (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
-
Limb (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
mRNA differential expression in normal tissues according to GTEx for PRDM16 Gene
This gene is overexpressed in Artery - Aorta (x7.2), Artery - Tibial (x5.8), and Artery - Coronary (x5.2).
This gene is overexpressed in Monocytes (36.3), Islet of Langerhans (23.2), and Adipocyte (9.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRDM16 Gene
NURSA nuclear receptor signaling pathways regulating expression of PRDM16 Gene:
PRDM16SOURCE GeneReport for Unigene cluster for PRDM16 Gene:
Hs.99500mRNA Expression by UniProt/SwissProt for PRDM16 Gene:
Q9HAZ2-PRD16_HUMAN
Tissue specificity:
Expressed in uterus and kidney. Expressed in both cardiomyocytes and interstitial cells.
Evidence on tissue expression from TISSUES for PRDM16 Gene
- Nervous system(4.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDM16 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- cerebrospinal fluid
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- hypothalamus
- jaw
- lip
- mandible
- maxilla
- meninges
- middle ear
- mouth
- neck
- nose
- outer ear
- pharynx
- pituitary gland
- scalp
- skull
- thyroid
Thorax:
- chest wall
- clavicle
- esophagus
- heart
- heart valve
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- intestine
- kidney
- large intestine
- small intestine
- stomach
Pelvis:
- anus
- pelvis
- penis
- rectum
- testicle
- urethra
- uterus
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- coagulation system
- hair
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for PRDM16
- genomics-online: primer clones - Search results for 71 available PRDM16 gene related products
- Overview of 71 available PRDM16 gene related products
Gene Expression Assay Products
Orthologs for PRDM16 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PRDM16 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PRDM16 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PRDM16 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Prdm16 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Prdm16 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PRDM16 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PRDM16 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PRDM16 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PRDM16 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prdm16 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | prdm16 33 34 |
|
||
| wufc09g08 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10348 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | egl-43 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MSN2 34 |
|
ManyToMany | |
| MSN4 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for PRDM16 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PRDM16 Gene
(78) SIMAP similar genes for PRDM16 Gene using alignment to 8 proteins:
- kr-znf3
- ZNF72
- ZFS-5
- ZSCAN31
- ZFS-4
- DKFZp686N0199
- EVI1
- ZNF78L1
- ZNF55
- MECOM
- ZNF75A
- ZIC1
- ZFP64
- KLF1
- GZF1
- zf30
- DKFZp686O1631
- ZNF
- HZF16
- ZNF22
- ZFP41
- A-328A3.4
- ZNF808
- ZNF600
- ZNF56
- ZNF525
- PLZF
- HZF17
- ZNF876P
- ZNF331
- ZKSCAN1
- ZFS-2
- DKFZp686M04222
- smap-7
- ZNF702P
- ZNF581
- ZNF391
- ZFS-6
- OVOL3
- HZF40
- HZF30
- DKFZp547H249
- ZNF660
- ZNF570
- ZNF501
- ZNF468
- ZNF323
- HZF36
- DKFZp434J0650
- DKFZp313M0722
- ZNF844
- ZNF833P
- ZNF778
- ZNF726P1
- ZNF710
- ZNF697
- ZNF234
- ZNF2
- ZNF138
- ZNF137P
- ZBTB17
- PRDM5
- DKFZp686D2168
- ZNF664
- ZNF558
- ZNF83
- ZNF80
- ZNF585B
- ZNF566
- ZNF146
- ZNF140
- Nbla00121
- DKFZp762K012
- DKFZp666M039
- DKFZp666C237
- DKFZp570I0164
- DKFZp434G1930
- ZNF589
Variants for PRDM16 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1016599754 | uncertain-significance, Left ventricular noncompaction 8 | 3,412,181(+) | G/A | coding_sequence_variant, missense_variant | |
| rs1049463147 | likely-benign, Left ventricular noncompaction 8 | 3,405,487(+) | C/G/T | intron_variant | |
| rs1060500997 | uncertain-significance, Left ventricular noncompaction 8 | 3,412,640(+) | C/T | coding_sequence_variant, stop_gained | |
| rs1060501005 | uncertain-significance, Left ventricular noncompaction 8 | 3,186,287(+) | C/T | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
| rs1060504134 | likely-benign, Left ventricular noncompaction 8 | 3,414,602(+) | G/A | coding_sequence_variant, synonymous_variant |
Residual Variation Intolerance Score:
15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.70;
78.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRDM16 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM16 Gene
Disorders for PRDM16 Gene
(8) MalaCards diseases for PRDM16 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| left ventricular noncompaction 8 |
|
|
| left ventricular noncompaction |
|
|
| familial isolated dilated cardiomyopathy |
|
|
| chromosome 1p36 deletion syndrome |
|
|
| myelodysplastic syndrome |
|
Search PRDM16 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PRD16_HUMAN- Cardiomyopathy, dilated 1LL (CMD1LL) [MIM:615373]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269 PubMed:23768516}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Left ventricular non-compaction 8 (LVNC8) [MIM:615373]: A disease due to an arrest of myocardial morphogenesis. It is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies. {ECO:0000269 PubMed:23768516}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia. {ECO:0000269 PubMed:11050005, ECO:0000269 PubMed:12557231}.
Additional Disease Information for PRDM16
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PRDM16 Gene
Publications for PRDM16 Gene
- A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells. (PMID: 11050005) Mochizuki N … Morishita K (Blood 2000) 2 3 4 22 58
- Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells. (PMID: 14656887) Yoshida M … Matsuoka M (Blood 2004) 3 4 22 58
- Breakpoints at 1p36.3 in three MDS/AML(M4) patients with t(1;3)(p36;q21) occur in the first intron and in the 5' region of MEL1. (PMID: 12557231) Xinh PT … Sato Y (Genes, chromosomes & cancer 2003) 3 4 22 58
- A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation. (PMID: 12816872) Nishikata I … Morishita K (Blood 2003) 3 4 22 58
- PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity. (PMID: 27151440) Zhou B … Dou Y (Molecular cell 2016) 2 3 58
Products for PRDM16 Gene
- R&D Systems Antibodies for PRDM16 (PRDM16/MEL1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PRDM16
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PRDM16
- Search Origene for MassSpec and Protein Over-expression Lysates for PRDM16
- Origene Custom Protein Services for PRDM16
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRDM16
- Browse OriGene Inhibitory RNA Products For PRDM16
- OriGene qPCR primer pairs for PRDM16
- OriGene CRISPR knockouts for PRDM16
- OriGene ORF clones in human for PRDM16
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PRDM16
- GenScript: Next-day shipping of latest version cDNA ORF clones for PRDM16 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PRDM16
- GenScript Custom Assay Services for PRDM16
- GenScript Custom overexpressing Cell Line Services for PRDM16
- GenScript: Design CRISPR guide RNA sequences for PRDM16
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PRDM16
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PRDM16
- Novus Biologicals proteins for PRDM16
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PRDM16
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for PRDM16
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PRDM16
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRDM16
- VectorBuilder custom plasmid, inducible vectors for PRDM16
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDM16
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 68 available PRDM16 Antibodies ranked by validation data
- Compare Top PRDM16 Antibodies
- antibodies-online: Search results for 1 available PRDM16 Elisa Kits ranked by validation data
- Compare Top PRDM16 Elisa Kits
- Recommended
- antibodies-online: Search results for 11 available PRDM16 Proteins ranked by validation data
- Compare Top PRDM16 Proteins
- GeneTex PRDM16 antibody for PRDM16
- Search GeneTex for Proteins for PRDM16
- ViGene Biosciences adenoviral particle packaged cDNA for PRDM16 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PRDM16 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PRDM16 gene
- Search ViGene Biosciences for PRDM16
- Custom Antibody ServicesProSci Antibodies for PRDM16
- Search for PRDM16 Proteins at ProSci
- Horizon Cell Lines for PRDM16
- genomics-online: cdna clones - Search results for 71 available PRDM16 gene related products
- Overview of 71 available PRDM16 gene related products
- orf clones - Search results for 71 available PRDM16 gene related products
- Overview of 71 available PRDM16 gene related products
- genomics-online: gRNA clones - Search results for 71 available PRDM16 gene related products
- Overview of 71 available PRDM16 gene related products
- genomics-online: primer clones - Search results for 71 available PRDM16 gene related products
- Overview of 71 available PRDM16 gene related products
- genomics-online: shRNA clones - Search results for 71 available PRDM16 gene related products
- Overview of 71 available PRDM16 gene related products
Sources for PRDM16 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems