Aliases for PRDM15 Gene
External Ids for PRDM15 Gene
Previous HGNC Symbols for PRDM15 Gene
Previous GeneCards Identifiers for PRDM15 Gene
GeneCards Summary for PRDM15 Gene
PRDM15 (PR/SET Domain 15) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and methyltransferase activity. An important paralog of this gene is ZFAT.
UniProtKB/Swiss-Prot Summary for PRDM15 Gene
Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264).