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Aliases for PRDM15 Gene

Aliases for PRDM15 Gene

  • PR/SET Domain 15 2 3 5
  • PR Domain Zinc Finger Protein 15 3 4
  • Zinc Finger Protein 298 3 4
  • PR Domain Containing 15 2 3
  • PR Domain 15 2 3
  • C21orf83 3 4
  • ZNF298 3 4
  • Chromosome 21 Open Reading Frame 83 2
  • PR Domain-Containing Protein 15 4
  • EC 2.1.1.- 4
  • PFM15 3

External Ids for PRDM15 Gene

Previous HGNC Symbols for PRDM15 Gene

  • ZNF298
  • C21orf83

Previous GeneCards Identifiers for PRDM15 Gene

  • GC21M039757
  • GC21M039840
  • GC21M042104
  • GC21M042103
  • GC21M042094
  • GC21M043218
  • GC21M028638

Summaries for PRDM15 Gene

GeneCards Summary for PRDM15 Gene

PRDM15 (PR/SET Domain 15) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and methyltransferase activity. An important paralog of this gene is ZFAT.

UniProtKB/Swiss-Prot for PRDM15 Gene

  • Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264).

Additional gene information for PRDM15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM15 Gene

Genomics for PRDM15 Gene

GeneHancer (GH) Regulatory Elements for PRDM15 Gene

Promoters and enhancers for PRDM15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRDM15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRDM15 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • Nkx2-5

Genomic Locations for PRDM15 Gene

Genomic Locations for PRDM15 Gene
chr21:41,798,225-41,879,482
(GRCh38/hg38)
Size:
81,258 bases
Orientation:
Minus strand
chr21:43,218,385-43,299,591
(GRCh37/hg19)
Size:
81,207 bases
Orientation:
Minus strand

Genomic View for PRDM15 Gene

Genes around PRDM15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDM15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDM15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDM15 Gene

Proteins for PRDM15 Gene

  • Protein details for PRDM15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57071-PRD15_HUMAN
    Recommended name:
    PR domain zinc finger protein 15
    Protein Accession:
    P57071
    Secondary Accessions:
    • E9PDJ6
    • E9PF37
    • E9PGL3
    • Q4W8S0
    • Q4W8S3
    • Q4W8S4
    • Q4W8S5
    • Q8N0X3
    • Q8NEX0
    • Q9NQV3

    Protein attributes for PRDM15 Gene

    Size:
    1507 amino acids
    Molecular mass:
    169269 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL60596.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM53515.1; Type=Erroneous translation; Note=Erroneous CDS prediction.; Evidence={ECO:0000305}; Sequence=AAM53516.1; Type=Erroneous translation; Note=Erroneous CDS prediction.; Evidence={ECO:0000305}; Sequence=BAA95527.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD99015.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD99016.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD99017.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD99018.1; Type=Erroneous translation; Note=Erroneous CDS prediction.; Evidence={ECO:0000305}; Sequence=BAD99020.1; Type=Erroneous translation; Note=Erroneous CDS prediction.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRDM15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDM15 Gene

Post-translational modifications for PRDM15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRDM15 Gene

Domains & Families for PRDM15 Gene

Gene Families for PRDM15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for PRDM15 Gene

Suggested Antigen Peptide Sequences for PRDM15 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 298 (PRD15_HUMAN)
  • Zinc finger protein ZNF298d (Q4W8S0_HUMAN)
  • Zinc finger protein ZNF298d (Q4W8S1_HUMAN)
  • Zinc finger protein ZNF298c (Q4W8S3_HUMAN)
  • Zinc finger protein ZNF298b (Q4W8S4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P57071

UniProtKB/Swiss-Prot:

PRD15_HUMAN :
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
genes like me logo Genes that share domains with PRDM15: view

Function for PRDM15 Gene

Molecular function for PRDM15 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264).

Enzyme Numbers (IUBMB) for PRDM15 Gene

Phenotypes From GWAS Catalog for PRDM15 Gene

Gene Ontology (GO) - Molecular Function for PRDM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISS --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with PRDM15: view

Phenotypes for PRDM15 Gene

genes like me logo Genes that share phenotypes with PRDM15: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PRDM15 - Now 50% OFF >
  • * PRDM15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRDM15 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRDM15 Gene

Localization for PRDM15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDM15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDM15 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRDM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15904895
GO:0005654 nucleoplasm IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with PRDM15: view

Pathways & Interactions for PRDM15 Gene

PathCards logo

SuperPathways for PRDM15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRDM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0032259 methylation IEA --
GO:0043409 negative regulation of MAPK cascade IEA,ISS --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA,ISS --
GO:0090263 positive regulation of canonical Wnt signaling pathway ISS,IEA --
genes like me logo Genes that share ontologies with PRDM15: view

No data available for Pathways by source and SIGNOR curated interactions for PRDM15 Gene

Drugs & Compounds for PRDM15 Gene

No Compound Related Data Available

Transcripts for PRDM15 Gene

mRNA/cDNA for PRDM15 Gene

Unigene Clusters for PRDM15 Gene

PR domain containing 15:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PRDM15 - Now 50% OFF >
  • * PRDM15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRDM15 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PRDM15 Gene

No ASD Table

Relevant External Links for PRDM15 Gene

GeneLoc Exon Structure for
PRDM15
ECgene alternative splicing isoforms for
PRDM15

Expression for PRDM15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRDM15 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRDM15 Gene



Protein tissue co-expression partners for PRDM15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRDM15 Gene:

PRDM15

SOURCE GeneReport for Unigene cluster for PRDM15 Gene:

Hs.473893

mRNA Expression by UniProt/SwissProt for PRDM15 Gene:

P57071-PRD15_HUMAN
Tissue specificity: Detected in all tissues examined.
genes like me logo Genes that share expression patterns with PRDM15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDM15 Gene

Orthologs for PRDM15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRDM15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDM15 35 34
  • 99.17 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRDM15 35 34
  • 89.4 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRDM15 35 34
  • 88.55 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRDM15 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdm15 34
  • 85.5 (n)
mouse
(Mus musculus)
Mammalia Prdm15 17 35 34
  • 85.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRDM15 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRDM15 35 34
  • 74.85 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia prdm15 34
  • 71.97 (n)
zebrafish
(Danio rerio)
Actinopterygii prdm15 35 35 34
  • 66.2 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for PRDM15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRDM15 Gene

ENSEMBL:
Gene Tree for PRDM15 (if available)
TreeFam:
Gene Tree for PRDM15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRDM15: view image

Paralogs for PRDM15 Gene

genes like me logo Genes that share paralogs with PRDM15: view

Variants for PRDM15 Gene

Sequence variations from dbSNP and Humsavar for PRDM15 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000015896 -- 41,829,364(-) C/T intron_variant
rs1000056256 -- 41,825,742(-) C/T intron_variant
rs1000117345 -- 41,860,263(-) G/A intron_variant
rs1000120653 -- 41,841,954(-) A/T intron_variant
rs1000165857 -- 41,856,724(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRDM15 Gene

Variant ID Type Subtype PubMed ID
dgv2395n106 CNV deletion 24896259
dgv710e201 CNV deletion 23290073
dgv7849n54 CNV loss 21841781
dgv7850n54 CNV loss 21841781
dgv7851n54 CNV loss 21841781
esv1344855 CNV insertion 17803354
esv2668746 CNV deletion 23128226
esv2723501 CNV deletion 23290073
esv2723503 CNV deletion 23290073
esv2723507 CNV deletion 23290073
esv2723508 CNV deletion 23290073
esv27733 CNV loss 19812545
esv3310526 CNV novel sequence insertion 20981092
esv3385026 CNV insertion 20981092
esv3416485 CNV insertion 20981092
esv3440793 CNV insertion 20981092
esv3893416 CNV gain 25118596
nsv1071757 CNV deletion 25765185
nsv1073132 CNV deletion 25765185
nsv1125227 CNV insertion 24896259
nsv1143017 CNV tandem duplication 24896259
nsv1144006 CNV deletion 24896259
nsv187187 CNV insertion 16902084
nsv475519 CNV novel sequence insertion 20440878
nsv522791 CNV gain 19592680
nsv528517 CNV loss 19592680
nsv587563 CNV loss 21841781
nsv587564 CNV loss 21841781
nsv587565 CNV loss 21841781
nsv587574 CNV loss 21841781

Variation tolerance for PRDM15 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRDM15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDM15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM15 Gene

Disorders for PRDM15 Gene

Additional Disease Information for PRDM15

No disorders were found for PRDM15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRDM15 Gene

Publications for PRDM15 Gene

  1. Identification of a novel zinc finger protein gene (ZNF298) in the GAP2 of human chromosome 21q. (PMID: 15904895) Shibuya K … Shimizu N (Biochemical and biophysical research communications 2005) 3 4 23 58
  2. Nineteen additional unpredicted transcripts from human chromosome 21. (PMID: 12036297) Reymond A … Antonarakis SE (Genomics 2002) 2 3 4 58
  3. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PMID: 12036298) Gardiner K … Davisson M (Genomics 2002) 2 3 4 58
  4. PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling. (PMID: 28740264) Mzoughi S … Guccione E (Nature genetics 2017) 3 4 58
  5. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N … PD GWAS Consortium (Annals of neurology 2012) 3 45 58

Products for PRDM15 Gene

Sources for PRDM15 Gene

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