Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]
PRDM14 (PR/SET Domain 14) is a Protein Coding gene. Diseases associated with PRDM14 include Brain Germinoma and Pineal Region Germinoma. Among its related pathways are Developmental Biology and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is ZBTB20.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08J070073 | Promoter/Enhancer | 1.5 | EPDnew FANTOM5 Ensembl ENCODE | 259.7 | +0.8 | 793 | 4.2 | ETS1 SIN3A CTCF YY1 SMARCA4 TAF1 BMI1 EGR1 EZH2 NANOG | PRDM14 LOC101929759 SLCO5A1 RF00017-7119 | |
GH08J069953 | Enhancer | 0.4 | Ensembl | 11.8 | +117.4 | 117392 | 1 | RXRA HNF4A NR2F2 | RNU1-101P PRDM14 SLCO5A1 LOC101929759 SDCBPP2 RF00876-026 | |
GH08J070042 | Enhancer | 0.2 | Ensembl | 12.3 | +29.2 | 29193 | 1.4 | PRDM14 RNU1-101P LOC101929759 SLCO5A1 piR-57460-647 RF00017-7119 | ||
GH08J070089 | Promoter | 0.8 | CraniofacialAtlas | 0.4 | -16.7 | -16673 | 0.4 | ZNF217 ZIC2 CEBPB CTCF MBD1 RB1 L3MBTL2 ZXDB HLF ZEB2 | LOC101929759 SLCO5A1 RF00017-7120 RNU1-101P RF00003-089 PRDM14 NCOA2 | |
GH08J070074 | Enhancer | 0.4 | Ensembl ENCODE | 0.7 | -3.3 | -3330 | 1.2 | JUND | LOC101929759 SLCO5A1 PRDM14 RF00003-089 RNU1-101P RF00017-7119 NCOA2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA,IBA | 21873635 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003723 | RNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 21516116 |
GO:0008168 | methyltransferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Developmental Biology | ||
2 | Transcriptional regulation of pluripotent stem cells | ||
3 | Mesodermal Commitment Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0000902 | cell morphogenesis | IEA | -- |
GO:0001708 | cell fate specification | IEA | -- |
GO:0001827 | inner cell mass cell fate commitment | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PRDM14 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PRDM14 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PRDM14 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PRDM14 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PRDM14 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC100365184 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Prdm14 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PRDM14 31 |
|
OneToOne | |
LOC100858709 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | PRDM14 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prdm14 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | prdm14 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | F47E1.3 31 32 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs3750228 | - |
p.Lys244Glu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1023889 | CNV | gain+loss | 25217958 |
nsv1034456 | CNV | gain | 25217958 |
nsv1068714 | OTHER | inversion | 25765185 |
nsv508513 | CNV | deletion | 20534489 |
nsv527289 | CNV | gain | 19592680 |
nsv611487 | CNV | loss | 21841781 |
nsv831352 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
brain germinoma |
|
|
pineal region germinoma |
|
|
testicular cancer |
|
|
breast cancer |
|
|