Aliases for PRDM14 Gene
External Ids for PRDM14 Gene
Previous GeneCards Identifiers for PRDM14 Gene
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]
GeneCards Summary for PRDM14 Gene
PRDM14 (PR/SET Domain 14) is a Protein Coding gene. Diseases associated with PRDM14 include Brain Germinoma and Pineal Region Germinoma. Among its related pathways are Mesodermal Commitment Pathway and Transcriptional regulation of pluripotent stem cells. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is ZBTB20.
UniProtKB/Swiss-Prot Summary for PRDM14 Gene
Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.