Aliases for PRDM12 Gene
External Ids for PRDM12 Gene
Previous GeneCards Identifiers for PRDM12 Gene
This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia. [provided by RefSeq, Mar 2017]
GeneCards Summary for PRDM12 Gene
PRDM12 (PR/SET Domain 12) is a Protein Coding gene. Diseases associated with PRDM12 include Neuropathy, Hereditary Sensory And Autonomic, Type Viii and Factitious Disorder. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is ZNF683.
UniProtKB/Swiss-Prot Summary for PRDM12 Gene
Involved in the positive regulation of histone H3-K9 dimethylation.