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The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the developm... See more...
Aliases for PRDM10 Gene
Aliases for PRDM10 Gene
External Ids for PRDM10 Gene
- HGNC: 13995
- NCBI Entrez Gene: 56980
- Ensembl: ENSG00000170325
- OMIM®: 618319
- UniProtKB/Swiss-Prot: Q9NQV6
Previous GeneCards Identifiers for PRDM10 Gene
- GC11M131770
- GC11M131282
- GC11M129803
- GC11M129307
- GC11M129274
- GC11M125721
- GC11M129769
Summaries for PRDM10 Gene
-
The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRDM10 Gene
PRDM10 (PR/SET Domain 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and methyltransferase activity. An important paralog of this gene is ZNF143.
UniProtKB/Swiss-Prot Summary for PRDM10 Gene
-
May be involved in transcriptional regulation.
Additional gene information for PRDM10 Gene
- HGNC (13995)
- NCBI Entrez Gene (56980)
- Ensembl (ENSG00000170325)
- OMIM® (618319)
- UniProtKB/Swiss-Prot (Q9NQV6)
- Open Targets Platform(ENSG00000170325)
- Search for PRDM10 at DataMed
- Search for PRDM10 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRDM10 Gene
Genomics for PRDM10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PRDM10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRDM10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRDM10
- Top Transcription factor binding sites by QIAGEN in the PRDM10 gene promoter:
-
- aMEF-2
- AML1a
- CUTL1
- E47
- IRF-1
- MEF-2A
- Tal-1beta
- YY1
Genomic Locations for PRDM10 Gene
Latest Assembly
- chr11:129,899,706-130,003,097
- (GRCh38/hg38)
- Size:
- 103,392 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:129,769,606-129,872,730
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 103,125 bases
- Orientation:
- Minus strand
- chr11:129,769,601-129,872,730
- (GRCh37/hg19 by Ensembl)
- Size:
- 103,130 bases
- Orientation:
- Minus strand
Genomic View for PRDM10 Gene
Genes around PRDM10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.3 by HGNC
- 11q24.3 by Entrez Gene
- 11q24.3 by Ensembl
PRDM10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRDM10 Gene
Proteins for PRDM10 Gene
-
Protein details for PRDM10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQV6-PRD10_HUMAN
- Recommended name:
- PR domain zinc finger protein 10
- Protein Accession:
- Q9NQV6
- B7ZL71
- G3XAE5
- J3KP23
- Q17R90
- Q2KHR4
- Q863Z2
- Q9NXI4
- Q9ULI9
Protein attributes for PRDM10 Gene
- Size:
- 1147 amino acids
- Molecular mass:
- 130136 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA91026.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for PRDM10 Gene
Post-translational modifications for PRDM10 Gene
Other Protein References for PRDM10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ PRDM10 Antibody and Immunotag™ PRD10 Polyclonal Antibody
-
Custom Antibody ServicesOriGene Antibodies for PRDM10
- Novus Biologicals Antibodies for PRDM10
- Invitrogen Antibodies for PRDM10 (AFLGC-PRDM10)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRDM10
Protein products for research
-
OriGene Purified Proteins for PRDM10
- Search Origene for MassSpec and Protein Over-expression Lysates for PRDM10
- Origene Custom Protein Services for PRDM10
- antibodies-online: Show 3 available PRDM10 Proteins ranked by validation data
- Compare Top PRDM10 Proteins
-
Quality Products:
Assay products for research
No data available for DME Specific Peptides for PRDM10 Gene
Domains & Families for PRDM10 Gene
Gene Families for PRDM10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for PRDM10 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRDM10 Gene
- GenScript: Design optimal peptide antigens:
-
- PRDM10 protein (B7ZL72_HUMAN)
- Tristanin (PRD10_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NQV6UniProtKB/Swiss-Prot:
PRD10_HUMAN :- The SET domain is degenerated, suggesting that it has lost methyltransferase activity.
- Belongs to the class V-like SAM-binding methyltransferase superfamily.
- Domain:
-
- The SET domain is degenerated, suggesting that it has lost methyltransferase activity.
- Family:
-
- Belongs to the class V-like SAM-binding methyltransferase superfamily.
Function for PRDM10 Gene
Molecular function for PRDM10 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Enzyme Numbers (IUBMB) for PRDM10 Gene
Phenotypes From GWAS Catalog for PRDM10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for PRDM10 Gene
- MGI mutant phenotypes for PRDM10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PRDM10:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased Nanog expression
- Increased shRNA abundance (Z-score > 2)
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
- Decreased Sindbis virus (SINV) infection
- Decreased HIV-1 infection
Animal Models for PRDM10 Gene
- MGI Knock Outs for PRDM10:
-
- Prdm10 Prdm10<tm1b(EUCOMM)Hmgu>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PRDM10 - Starting at $85 >
- * PRDM10 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PRDM10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDM10
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDM10
miRNA for PRDM10 Gene
- miRTarBase miRNAs that target PRDM10
-
- hsa-miR-548c-3p (MIRT058532)
- hsa-miR-3185 (MIRT544464)
- hsa-miR-6873-3p (MIRT619469)
- hsa-miR-6817-3p (MIRT619470)
- hsa-miR-7110-3p (MIRT619471)
- hsa-miR-6826-5p (MIRT619472)
- hsa-miR-513c-3p (MIRT619473)
- hsa-miR-513a-3p (MIRT619474)
- hsa-miR-3606-3p (MIRT619475)
- hsa-miR-4282 (MIRT619476)
- hsa-miR-6809-3p (MIRT638410)
- hsa-miR-4776-3p (MIRT646457)
- hsa-miR-607 (MIRT646458)
- hsa-miR-4659b-5p (MIRT646459)
- hsa-miR-4659a-5p (MIRT646460)
- hsa-miR-5590-5p (MIRT646461)
- hsa-miR-664b-3p (MIRT646462)
- hsa-miR-579-3p (MIRT646463)
- hsa-miR-3671 (MIRT646464)
- hsa-miR-676-5p (MIRT646465)
- hsa-miR-1236-3p (MIRT646466)
- hsa-miR-6515-3p (MIRT646467)
- hsa-miR-4762-5p (MIRT646468)
- hsa-miR-7850-5p (MIRT666816)
- hsa-miR-1305 (MIRT700624)
- hsa-miR-374b-3p (MIRT700625)
- hsa-miR-505-3p (MIRT700626)
- hsa-miR-5191 (MIRT700627)
- hsa-miR-1250-3p (MIRT700628)
- hsa-miR-194-3p (MIRT700629)
- hsa-miR-1182 (MIRT700630)
- hsa-miR-1178-5p (MIRT700631)
- hsa-miR-6833-3p (MIRT713838)
- hsa-miR-4768-5p (MIRT713839)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRDM10
- Browse OriGene Inhibitory RNA Products For PRDM10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDM10
Clone products for research
- Applied Biological Materials (abm): Clones for PRDM10 - Starting at $45 >
- * PRDM10 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG221103
- MR221103
- MR221103L3
- MR221103L4
- RC211078
- RC211078L1
- RC211078L2
- RC211078L3
- RC211078L4
- RC220530
- RC220530L3
- RC220530L4
- RC221532
- RC221532L3
- RC221532L4
- RC222028
- RC222028L3
- RC222028L4
- RG211078
- RG220530
- RG221532
- RG222028
- MR221103L3V
- MR221103L4V
- RC211078L1V
- RC211078L2V
- RC211078L3V
- RC211078L4V
- RC220530L3V
- RC220530L4V
- RC221532L3V
- RC221532L4V
- RC222028L3V
- RC222028L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PRDM10
- Addgene plasmids for PRDM10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDM10
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDM10 Gene
Localization for PRDM10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRDM10 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
- Nucleoli fibrillar center (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IDA | 31143550 |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0017053 | transcriptional repressor complex | IDA | 31143550 |
Pathways & Interactions for PRDM10 Gene
Interacting Proteins for PRDM10 Gene
Selected Interacting proteins:
Q9NQV6-PRD10_HUMAN
ENSP00000351686
for PRDM10 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PRDM10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010468 | regulation of gene expression | IBA | 21873635 |
| GO:0032259 | methylation | IEA | -- |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 31143550 |
No data available for Pathways by source and SIGNOR curated interactions for PRDM10 Gene
Transcripts for PRDM10 Gene
mRNA/cDNA for PRDM10 Gene
- 14 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000304538 5817 nts (view in UCSC)
- ENST00000358825 6322 nts (view in UCSC)
- ENST00000360871 6305 nts (view in UCSC)
- ENST00000423662 5998 nts (view in UCSC)
- ENST00000526082 3308 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PRDM10 - Starting at $85 >
- * PRDM10 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PRDM10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDM10
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDM10
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRDM10
- Browse OriGene Inhibitory RNA Products For PRDM10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDM10
Clone products for research
- Applied Biological Materials (abm): Clones for PRDM10 - Starting at $45 >
- * PRDM10 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG221103
- MR221103
- MR221103L3
- MR221103L4
- RC211078
- RC211078L1
- RC211078L2
- RC211078L3
- RC211078L4
- RC220530
- RC220530L3
- RC220530L4
- RC221532
- RC221532L3
- RC221532L4
- RC222028
- RC222028L3
- RC222028L4
- RG211078
- RG220530
- RG221532
- RG222028
- MR221103L3V
- MR221103L4V
- RC211078L1V
- RC211078L2V
- RC211078L3V
- RC211078L4V
- RC220530L3V
- RC220530L4V
- RC221532L3V
- RC221532L4V
- RC222028L3V
- RC222028L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PRDM10
- Addgene plasmids for PRDM10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDM10
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for PRDM10 Gene
- GeneLoc Exon Structure for
- PRDM10
Expression for PRDM10 Gene
This gene is overexpressed in Heart (42.2), Plasma (12.2), and Placenta (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRDM10 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRDM10
SOURCE GeneReport for Unigene cluster for PRDM10 Gene:
Hs.275086Evidence on tissue expression from TISSUES for PRDM10 Gene
- Nervous system(4.4)
- Intestine(4.3)
Primer products for research
-
OriGene qPCR primer pairs for PRDM10
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDM10 Gene
Orthologs for PRDM10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PRDM10 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PRDM10 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PRDM10 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PRDM10 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Prdm10 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Prdm10 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PRDM10 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PRDM10 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PRDM10 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | prdm10 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | prdm10 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for PRDM10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PRDM10 Gene
- ENSEMBL:
- Gene Tree for PRDM10 (if available)
- TreeFam:
- Gene Tree for PRDM10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRDM10: view image
Paralogs for PRDM10 Gene
Paralogs for PRDM10 Gene
- ZNF143 5
- ZNF384 5
- MTF1 5
- ZNF281 5
- ZNF76 5
- ZNF451 5
- ZNF148 5
- ZBTB7C 5
- ZNF362 5
- PRDM6 5
- HIC2 5
- PATZ1 5
- HIC1 5
- PRDM14 5
- ZBTB1 5
- ZNF410 5
- PRDM1 5
- ZNF296 5
- ZNF276 5
- ZBTB16 5
- ZNF653 5
- MAZ 5
- ZFP91 5
- ZFP91-CNTF 5
- ZNF575 5
- ZBTB20 5
- VEZF1 5
- ZBTB45 5
- ZNF692 5
- SCRT2 5
- SCRT1 5
- ZBTB42 5
- ZBTB18 5
- SNAI2 5
- ZBTB32 5
- SNAI3 5
- SNAI1 5
- ENSG00000267477 5
(37) SIMAP similar genes for PRDM10 Gene using alignment to 6 proteins:
- PRD10_HUMAN
- B7ZL72_HUMAN
- E9PIB4_HUMAN
- E9PLV1_HUMAN
- E9PRS0_HUMAN
- E9PS52_HUMAN
Variants for PRDM10 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRDM10 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs116002683 | Benign: not provided | 129,944,828(-) |
G/A NM_020228.3(PRDM10):c.705C>T (p.Pro235=) |
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR | |
| rs141414113 | Benign: not provided | 129,942,635(-) |
C/T NM_199437.2(PRDM10):c.763-6G>A |
INTRON | |
| rs147100201 | Benign: not provided | 129,910,599(-) |
A/T NM_199437.2(PRDM10):c.3040T>A (p.Ser1014Thr) |
MISSENSE | |
| rs1486661396 | Uncertain Significance: not provided | 129,942,513(-) |
G/T NM_199437.2(PRDM10):c.879C>A (p.His293Gln) |
MISSENSE | |
| rs149863373 | Likely Benign: not provided | 129,947,280(-) |
T/C NM_199437.2(PRDM10):c.385A>G (p.Arg129Gly) |
MISSENSE_VARIANT,FIVE_PRIME_UTR |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3386494 | CNV | insertion | 20981092 |
| nsv1138087 | CNV | deletion | 24896259 |
| nsv1144599 | CNV | deletion | 24896259 |
| nsv39533 | CNV | deletion | 16902084 |
| nsv468893 | CNV | gain | 19166990 |
| nsv556564 | CNV | gain | 21841781 |
| nsv556565 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.09;
87.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRDM10 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM10 Gene
Disorders for PRDM10 Gene
Additional Disease Information for PRDM10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for PRDM10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRDM10 Gene
Publications for PRDM10 Gene
- Ectopic dendrite initiation: CNS pathogenesis as a model of CNS development. (PMID: 12175877) Siegel DA … Becker SF (International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2002) 2 3 4
- Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PMID: 20095854) Bhatti P … Sigurdson AJ (Radiation research 2010) 3 41
- Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 41
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4
- Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3
ExternalLinks
Products for PRDM10 Gene
- Custom Antibody ServicesOriGene Antibodies for PRDM10
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PRDM10
- Search Origene for MassSpec and Protein Over-expression Lysates for PRDM10
- Origene Custom Protein Services for PRDM10
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRDM10
- Browse OriGene Inhibitory RNA Products For PRDM10
- OriGene qPCR primer pairs for PRDM10
- OriGene CRISPR knockouts for PRDM10
- MG221103
- MR221103
- MR221103L3
- MR221103L4
- RC211078
- RC211078L1
- RC211078L2
- RC211078L3
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- RC222028L3
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- RG211078
- RG220530
- RG221532
- RG222028
- MR221103L3V
- MR221103L4V
- RC211078L1V
- RC211078L2V
- RC211078L3V
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- RC220530L3V
- RC220530L4V
- RC221532L3V
- RC221532L4V
- RC222028L3V
- RC222028L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PRDM10
- Sino Biological Human cDNA Clone for PRDM10
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PRDM10
- Novus Biologicals proteins and lysates for PRDM10
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for PRDM10 (AFLGC-PRDM10)
- VectorBuilder Custom and pre-made DNA vectors for PRDM10 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PRDM10 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PRDM10 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PRDM10 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PRDM10
- Addgene plasmids for PRDM10
- antibodies-online: Show 22 available PRDM10 Antibodies ranked by validation data
- Compare Top PRDM10 Antibodies
- antibodies-online: Search results for available PRDM10 related products ranked by validation data
- antibodies-online: Show 3 available PRDM10 Proteins ranked by validation data
- Compare Top PRDM10 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for PRDM10
- Search Santa Cruz Biotechnology (SCBT) for PRDM10 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PRDM10
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRDM10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRDM10
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PRDM10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRDM10
Sources for PRDM10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB