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Aliases for PRDM10 Gene

Aliases for PRDM10 Gene

  • PR/SET Domain 10 2 3 5
  • Tristanin 2 3 4
  • PRDM Zinc Finger Transcription Factor 2 3
  • PR Domain-Containing Protein 10 3 4
  • PR-Domain Family Member 7 2 3
  • PR Domain Containing 10 2 3
  • PR Domain 10 2 3
  • PFM7 3 4
  • PR Domain Zinc Finger Protein 10 3
  • EC 2.1.1.- 4
  • KIAA1231 4
  • TRIS 4

External Ids for PRDM10 Gene

Previous GeneCards Identifiers for PRDM10 Gene

  • GC11M131770
  • GC11M131282
  • GC11M129803
  • GC11M129307
  • GC11M129274
  • GC11M125721
  • GC11M129769

Summaries for PRDM10 Gene

Entrez Gene Summary for PRDM10 Gene

  • The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRDM10 Gene

PRDM10 (PR/SET Domain 10) is a Protein Coding gene. Diseases associated with PRDM10 include Intraventricular Meningioma and Undifferentiated Pleomorphic Sarcoma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and methyltransferase activity. An important paralog of this gene is ZNF425.

UniProtKB/Swiss-Prot for PRDM10 Gene

  • May be involved in transcriptional regulation.

Additional gene information for PRDM10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM10 Gene

Genomics for PRDM10 Gene

GeneHancer (GH) Regulatory Elements for PRDM10 Gene

Promoters and enhancers for PRDM10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I129995 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.5 2537 9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF143 SP3 NFYC SSRP1 PRDM10 NFRKB APLP2 ELOBP2 ARHGAP32 LINC00167 GC11M129932 PIR42969
GH11I129947 Promoter/Enhancer 0.9 EPDnew ENCODE 550.2 +55.4 55409 0.2 CTCF POLR2A PRDM10 PIR42969 GC11M129932 LINC00167
GH11I129971 Promoter 0.6 EPDnew 561.8 +31.8 31770 0.1 ZBTB33 PRDM10 LINC00167 APLP2 GC11M129932 PIR42969
GH11I130068 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.8 -67.6 -67593 4.8 HDGF SMAD1 FOXA2 ARID4B SIN3A FEZF1 YY1 POLR2B ZNF207 FOS APLP2 PRDM10 LINC00167 NFRKB ST14 GC11P130082
GH11I130120 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -122.3 -122335 10.3 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 ATF7 FOS APLP2 PRDM10 LINC00167 NFRKB ST14 GC11M130115 ENSG00000274197 PIR61423
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRDM10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRDM10 gene promoter:

Genomic Locations for PRDM10 Gene

Genomic Locations for PRDM10 Gene
chr11:129,899,706-130,003,050
(GRCh38/hg38)
Size:
103,345 bases
Orientation:
Minus strand
chr11:129,769,601-129,872,730
(GRCh37/hg19)

Genomic View for PRDM10 Gene

Genes around PRDM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDM10 Gene

Proteins for PRDM10 Gene

  • Protein details for PRDM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQV6-PRD10_HUMAN
    Recommended name:
    PR domain zinc finger protein 10
    Protein Accession:
    Q9NQV6
    Secondary Accessions:
    • B7ZL71
    • G3XAE5
    • J3KP23
    • Q17R90
    • Q2KHR4
    • Q863Z2
    • Q9NXI4
    • Q9ULI9

    Protein attributes for PRDM10 Gene

    Size:
    1147 amino acids
    Molecular mass:
    130136 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91026.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRDM10 Gene

    Alternative splice isoforms for PRDM10 Gene

neXtProt entry for PRDM10 Gene

Post-translational modifications for PRDM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRDM10 Gene

Domains & Families for PRDM10 Gene

Gene Families for PRDM10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for PRDM10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQV6

UniProtKB/Swiss-Prot:

PRD10_HUMAN :
  • The SET domain is degenerated, suggesting that it has lost methyltransferase activity.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Domain:
  • The SET domain is degenerated, suggesting that it has lost methyltransferase activity.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
genes like me logo Genes that share domains with PRDM10: view

Function for PRDM10 Gene

Molecular function for PRDM10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Enzyme Numbers (IUBMB) for PRDM10 Gene

Gene Ontology (GO) - Molecular Function for PRDM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRDM10: view
genes like me logo Genes that share phenotypes with PRDM10: view

Animal Models for PRDM10 Gene

MGI Knock Outs for PRDM10:

Animal Model Products

CRISPR Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDM10 Gene

Localization for PRDM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDM10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDM10 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
mitochondrion 2
cytosol 2
cytoskeleton 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRDM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PRDM10: view

Pathways & Interactions for PRDM10 Gene

SuperPathways for PRDM10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRDM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with PRDM10: view

No data available for Pathways by source and SIGNOR curated interactions for PRDM10 Gene

Drugs & Compounds for PRDM10 Gene

No Compound Related Data Available

Transcripts for PRDM10 Gene

Unigene Clusters for PRDM10 Gene

PR domain containing 10:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDM10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1:
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for PRDM10 Gene

GeneLoc Exon Structure for
PRDM10
ECgene alternative splicing isoforms for
PRDM10

Expression for PRDM10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRDM10 Gene

Protein differential expression in normal tissues from HIPED for PRDM10 Gene

This gene is overexpressed in Heart (42.2), Plasma (12.2), and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRDM10 Gene



Protein tissue co-expression partners for PRDM10 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRDM10 Gene:

PRDM10

SOURCE GeneReport for Unigene cluster for PRDM10 Gene:

Hs.275086

Evidence on tissue expression from TISSUES for PRDM10 Gene

  • Nervous system(4.5)
  • Intestine(4.4)
  • Blood(2.3)
  • Kidney(2.3)
  • Liver(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PRDM10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDM10 Gene

Orthologs for PRDM10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRDM10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDM10 33 34
  • 97.33 (n)
oppossum
(Monodelphis domestica)
Mammalia PRDM10 34
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRDM10 33 34
  • 88.68 (n)
cow
(Bos Taurus)
Mammalia PRDM10 33 34
  • 88.19 (n)
rat
(Rattus norvegicus)
Mammalia Prdm10 33
  • 87.98 (n)
mouse
(Mus musculus)
Mammalia Prdm10 33 16 34
  • 85.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRDM10 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRDM10 33 34
  • 78.35 (n)
lizard
(Anolis carolinensis)
Reptilia PRDM10 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdm10 33
  • 70.42 (n)
zebrafish
(Danio rerio)
Actinopterygii prdm10 33 34
  • 67.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToMany
Species where no ortholog for PRDM10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRDM10 Gene

ENSEMBL:
Gene Tree for PRDM10 (if available)
TreeFam:
Gene Tree for PRDM10 (if available)

Paralogs for PRDM10 Gene

Variants for PRDM10 Gene

Sequence variations from dbSNP and Humsavar for PRDM10 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000002154 -- 129,935,173(-) C/T coding_sequence_variant, missense_variant
rs1000002878 -- 129,972,182(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000039688 -- 129,990,723(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000102716 -- 129,985,879(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000113135 -- 129,969,802(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRDM10 Gene

Variant ID Type Subtype PubMed ID
esv3386494 CNV insertion 20981092
nsv1138087 CNV deletion 24896259
nsv1144599 CNV deletion 24896259
nsv39533 CNV deletion 16902084
nsv468893 CNV gain 19166990
nsv556564 CNV gain 21841781
nsv556565 CNV loss 21841781

Variation tolerance for PRDM10 Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.09; 87.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRDM10 Gene

Human Gene Mutation Database (HGMD)
PRDM10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM10 Gene

Disorders for PRDM10 Gene

MalaCards: The human disease database

(9) MalaCards diseases for PRDM10 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
intraventricular meningioma
undifferentiated pleomorphic sarcoma
  • malignant fibrohistiocytic tumors
tinea unguium
  • cellulitis and abscess
pyosalpinx
  • pyosalpingitis
branch retinal artery occlusion
  • arterial retinal branch occlusion
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PRDM10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRDM10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDM10 Gene

Publications for PRDM10 Gene

  1. Ectopic dendrite initiation: CNS pathogenesis as a model of CNS development. (PMID: 12175877) Siegel DA … Becker SF (International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2002) 2 3 4 58
  2. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PMID: 20095854) Bhatti P … Sigurdson AJ (Radiation research 2010) 3 44 58
  3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PRDM10 Gene

Sources for PRDM10 Gene

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