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Aliases for PRCP Gene

Aliases for PRCP Gene

  • Prolylcarboxypeptidase 2 3 4 5
  • Angiotensinase C 2 3 4
  • Lysosomal Carboxypeptidase C 3 4
  • Proline Carboxypeptidase 3 4
  • PCP 3 4
  • Prolylcarboxypeptidase (Angiotensinase C) 2
  • Lysosomal Pro-X Carboxypeptidase 3
  • EC 4
  • HUMPCP 3

External Ids for PRCP Gene

Previous GeneCards Identifiers for PRCP Gene

  • GC11M084862
  • GC11M084074
  • GC11M082261
  • GC11M082213
  • GC11M082535
  • GC11M078832

Summaries for PRCP Gene

Entrez Gene Summary for PRCP Gene

  • This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for PRCP Gene

PRCP (Prolylcarboxypeptidase) is a Protein Coding gene. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Innate Immune System. Gene Ontology (GO) annotations related to this gene include serine-type peptidase activity and serine-type carboxypeptidase activity. An important paralog of this gene is DPP7.

UniProtKB/Swiss-Prot for PRCP Gene

  • Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Gene Wiki entry for PRCP Gene

Additional gene information for PRCP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRCP Gene

Genomics for PRCP Gene

GeneHancer (GH) Regulatory Elements for PRCP Gene

Promoters and enhancers for PRCP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J082899 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 664.1 +69.6 69629 3.8 CLOCK DMAP1 YY1 E2F8 ZNF143 SP3 NFYC GLIS1 NBN KDM1A DDIAS PRCP PCF11 ENSG00000254676 ENSG00000254551 ANKRD42 RAB30 RPL7AP54
GH11J082971 Enhancer 1.1 Ensembl ENCODE dbSUPER 650.7 -1.3 -1306 1.2 PKNOX1 IRF3 BATF RELA POLR2A EED ZNF143 ATF7 ZSCAN29 NR2F6 PRCP DDIAS RAB30-AS1 GC11M082975 ENSG00000254698
GH11J082969 Enhancer 1 ENCODE dbSUPER 656.2 +0.7 710 1.1 PKNOX1 BACH1 PAX8 BMI1 KLF5 IRF4 RELA NFATC1 ATF7 ETV6 PRCP DDIAS RAB30 ENSG00000254698 ENSG00000254522 SNORA70E ENSG00000242279
GH11J082970 Promoter/Enhancer 0.8 EPDnew dbSUPER 650.7 -0.1 -122 0.1 ZBTB33 PRCP GC11M082975 ENSG00000254698
GH11J082867 Enhancer 1.1 Ensembl ENCODE dbSUPER 18.9 +103.0 103024 0.9 CTCF ZNF654 ZNF362 RB1 HLF TRIM22 REST ZNF384 NR3C1 RAD21 DDIAS PRCP FAM181B ENSG00000255234 CCDC90B RAB30 ENSG00000254441
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRCP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRCP gene promoter:
  • PPAR-alpha
  • SEF-1 (1)
  • Tal-1
  • E47
  • POU2F1a
  • POU2F1
  • Msx-1
  • Olf-1
  • NF-AT4
  • NF-AT3

Genomic Locations for PRCP Gene

Genomic Locations for PRCP Gene
147,083 bases
Minus strand
147,083 bases
Minus strand

Genomic View for PRCP Gene

Genes around PRCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRCP Gene

Proteins for PRCP Gene

  • Protein details for PRCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysosomal Pro-X carboxypeptidase
    Protein Accession:
    Secondary Accessions:
    • A8MU24
    • B2R7B7
    • B3KRK5
    • B5BU34

    Protein attributes for PRCP Gene

    496 amino acids
    Molecular mass:
    55800 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PRCP Gene

    Alternative splice isoforms for PRCP Gene


neXtProt entry for PRCP Gene

Post-translational modifications for PRCP Gene

  • Glycosylation at Asn415, posLast=345345, posLast=336336, Asn317, Asn101, posLast=4747, and posLast=3939
  • Ubiquitination at posLast=7777
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRCP Gene

Domains & Families for PRCP Gene

Gene Families for PRCP Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PRCP Gene

Suggested Antigen Peptide Sequences for PRCP Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S28 family.
  • Belongs to the peptidase S28 family.
genes like me logo Genes that share domains with PRCP: view

Function for PRCP Gene

Molecular function for PRCP Gene

UniProtKB/Swiss-Prot Function:
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of a -Pro- -Xaa bond to release a C-terminal amino acid.
GENATLAS Biochemistry:
angiotensinase C,51kDa,lysosomal

Enzyme Numbers (IUBMB) for PRCP Gene

Phenotypes From GWAS Catalog for PRCP Gene

Gene Ontology (GO) - Molecular Function for PRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity IEA --
GO:0004185 serine-type carboxypeptidase activity TAS --
GO:0005515 protein binding IPI 20517885
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with PRCP: view
genes like me logo Genes that share phenotypes with PRCP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRCP

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRCP

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRCP Gene

Localization for PRCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRCP Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRCP gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005886 plasma membrane TAS --
GO:0035577 azurophil granule membrane TAS --
GO:0045178 basal part of cell IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with PRCP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRCP Gene

Pathways & Interactions for PRCP Gene

genes like me logo Genes that share pathways with PRCP: view

Gene Ontology (GO) - Biological Process for PRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002155 regulation of thyroid hormone mediated signaling pathway IEA --
GO:0002353 plasma kallikrein-kinin cascade IEA --
GO:0003085 negative regulation of systemic arterial blood pressure IEA,IBA --
GO:0006508 proteolysis IEA,IBA --
GO:0007597 blood coagulation, intrinsic pathway TAS --
genes like me logo Genes that share ontologies with PRCP: view

No data available for SIGNOR curated interactions for PRCP Gene

Drugs & Compounds for PRCP Gene

(4) Drugs for PRCP Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benazepril Approved, Investigational Pharma 46
Angiotensin III (human, mouse) Pharma Aldosterone stimulator 0

(3) Additional Compounds for PRCP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRCP: view

Transcripts for PRCP Gene

mRNA/cDNA for PRCP Gene

Unigene Clusters for PRCP Gene

Prolylcarboxypeptidase (angiotensinase C):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRCP

Alternative Splicing Database (ASD) splice patterns (SP) for PRCP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - - - -
SP2: - - - - -
SP3: -

Relevant External Links for PRCP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRCP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRCP Gene

mRNA differential expression in normal tissues according to GTEx for PRCP Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for PRCP Gene

This gene is overexpressed in NK cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRCP Gene

Protein tissue co-expression partners for PRCP Gene

NURSA nuclear receptor signaling pathways regulating expression of PRCP Gene:


SOURCE GeneReport for Unigene cluster for PRCP Gene:


mRNA Expression by UniProt/SwissProt for PRCP Gene:

Tissue specificity: Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.

Evidence on tissue expression from TISSUES for PRCP Gene

  • Nervous system(4.8)
  • Kidney(4.5)
  • Liver(4.4)
  • Lung(4.4)
  • Heart(2.6)
  • Blood(2.4)
genes like me logo Genes that share expression patterns with PRCP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRCP Gene

Orthologs for PRCP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRCP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRCP 34 33
  • 99.73 (n)
(Canis familiaris)
Mammalia PRCP 34 33
  • 86.22 (n)
(Bos Taurus)
Mammalia PRCP 34 33
  • 85.11 (n)
(Mus musculus)
Mammalia Prcp 16 34 33
  • 82 (n)
(Rattus norvegicus)
Mammalia Prcp 33
  • 81.7 (n)
(Ornithorhynchus anatinus)
Mammalia PRCP 34
  • 70 (a)
(Monodelphis domestica)
Mammalia PRCP 34
  • 61 (a)
(Gallus gallus)
Aves PRCP 34 33
  • 67.81 (n)
(Anolis carolinensis)
Reptilia PRCP 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prcp 33
  • 67.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32860 33
(Danio rerio)
Actinopterygii prcp 34 33
  • 63.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2493 34 35 33
  • 52.95 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000994 33
  • 52.68 (n)
(Caenorhabditis elegans)
Secernentea pcp-5 34 33
  • 51.07 (n)
ZK688.6b 35
  • 40 (a)
ZK688.6a 35
  • 40 (a)
pcp-1 34
  • 32 (a)
F56F10.1 35
  • 27 (a)
K12H4.7b 35
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G65760 33
  • 52.69 (n)
(Oryza sativa)
Liliopsida Os01g0767100 33
  • 53.41 (n)
(Hordeum vulgare)
Liliopsida Hv.11612 33
Species where no ortholog for PRCP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRCP Gene

Gene Tree for PRCP (if available)
Gene Tree for PRCP (if available)
Evolutionary constrained regions (ECRs) for PRCP: view image

Paralogs for PRCP Gene

Paralogs for PRCP Gene

(2) SIMAP similar genes for PRCP Gene using alignment to 12 proteins:

  • B7Z7Q6_HUMAN
  • E9PL49_HUMAN
  • E9PL85_HUMAN
  • E9PR42_HUMAN Pseudogenes for PRCP Gene

genes like me logo Genes that share paralogs with PRCP: view

Variants for PRCP Gene

Sequence variations from dbSNP and Humsavar for PRCP Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000074086 -- 82,893,324(-) C/A intron_variant
rs1000087398 -- 82,869,428(-) G/A/T intron_variant
rs1000099422 -- 82,830,767(-) T/C intron_variant
rs1000222440 -- 82,834,226(-) A/G intron_variant
rs1000224229 -- 82,869,095(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRCP Gene

Variant ID Type Subtype PubMed ID
dgv2038n54 CNV loss 21841781
esv2290101 CNV deletion 18987734
esv2673057 CNV deletion 23128226
esv33531 CNV loss 17666407
esv3548070 CNV deletion 23714750
esv3579916 CNV gain 25503493
esv3627005 CNV loss 21293372
esv3627006 CNV loss 21293372
nsv1113415 CNV deletion 24896259
nsv38781 CNV deletion 16902084
nsv515868 CNV gain 19592680
nsv555602 CNV gain 21841781
nsv951048 CNV duplication 24416366

Variation tolerance for PRCP Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRCP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRCP Gene

Disorders for PRCP Gene

Additional Disease Information for PRCP

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PRCP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRCP Gene

Publications for PRCP Gene

  1. Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families. (PMID: 8344943) Tan F … Erdös EG (The Journal of biological chemistry 1993) 2 3 4 22 58
  2. E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients. (PMID: 20079160) Zhang Y … Xu XP (Chinese medical journal 2009) 3 22 44 58
  3. Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia. (PMID: 16681991) Wang L … Wang X (American journal of obstetrics and gynecology 2006) 3 22 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Expression, purification and crystallization of human prolylcarboxypeptidase. (PMID: 20516604) Abeywickrema PD … Sharma S (Acta crystallographica. Section F, Structural biology and crystallization communications 2010) 3 22 58

Products for PRCP Gene

Sources for PRCP Gene

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