This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is ... See more...

Aliases for PRCP Gene

Aliases for PRCP Gene

  • Prolylcarboxypeptidase 2 3 4 5
  • Angiotensinase C 2 3 4
  • Lysosomal Pro-X Carboxypeptidase 3 4
  • Lysosomal Carboxypeptidase C 3 4
  • Proline Carboxypeptidase 3 4
  • EC 3.4.16.2 4 52
  • PCP 3 4
  • Prolylcarboxypeptidase (Angiotensinase C) 2
  • HUMPCP 3

External Ids for PRCP Gene

Previous GeneCards Identifiers for PRCP Gene

  • GC11M084862
  • GC11M084074
  • GC11M082261
  • GC11M082213
  • GC11M082535
  • GC11M078832

Summaries for PRCP Gene

Entrez Gene Summary for PRCP Gene

  • This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for PRCP Gene

PRCP (Prolylcarboxypeptidase) is a Protein Coding gene. Diseases associated with PRCP include Pyruvate Kinase Deficiency Of Red Cells and Congenital Nonspherocytic Hemolytic Anemia. Among its related pathways are Innate Immune System and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include serine-type peptidase activity and serine-type carboxypeptidase activity. An important paralog of this gene is DPP7.

UniProtKB/Swiss-Prot Summary for PRCP Gene

  • Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Gene Wiki entry for PRCP Gene

Additional gene information for PRCP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRCP Gene

Genomics for PRCP Gene

GeneHancer (GH) Regulatory Elements for PRCP Gene

Promoters and enhancers for PRCP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J082899 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 514.1 +70.2 70183 5.2 FOXK2 ZBTB40 ZNF217 ZSCAN5C TCF12 SIN3A NRF1 POLR2G SP1 BCLAF1 DDIAS PRCP PCF11 ANKRD42 RAB30 piR-47675-017
GH11J082969 Enhancer 1 ENCODE dbSUPER 506.1 +0.7 710 1.1 SP1 EP300 RELA MEF2C RCOR1 TRIM22 BCL11A TCF12 CBFB ARNT PRCP DDIAS RAB30 ENSG00000254698 ENSG00000254522 SNORA70E ENSG00000242279
GH11J082971 Enhancer 0.9 ENCODE dbSUPER 500.7 -1.3 -1306 1.2 SP1 RELA POLR2A NFYB CBFB ARNT MEF2B NBN SMARCA5 BATF PRCP DDIAS RAB30-DT lnc-PRCP-1 ENSG00000254698
GH11J082970 Promoter/Enhancer 0.7 EPDnew dbSUPER 500.7 -0.1 -122 0.1 ZBTB33 LARP7 PRCP lnc-PRCP-1 ENSG00000254698
GH11J082857 Enhancer 0.9 Ensembl ENCODE dbSUPER 25.1 +111.4 111383 4.4 EP300 RBM25 KDM1A FOSL2 CEBPB JUN BCOR JUND FOS PRDM6 PRCP DDIAS FAM181B lnc-FAM181B-5 lnc-RAB30-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRCP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRCP

Top Transcription factor binding sites by QIAGEN in the PRCP gene promoter:
  • E47
  • Msx-1
  • NF-AT3
  • NF-AT4
  • Olf-1
  • POU2F1
  • POU2F1a
  • PPAR-alpha
  • SEF-1 (1)
  • Tal-1

Genomic Locations for PRCP Gene

Genomic Locations for PRCP Gene
chr11:82,822,936-82,970,584
(GRCh38/hg38)
Size:
147,649 bases
Orientation:
Minus strand
chr11:82,534,544-82,681,626
(GRCh37/hg19)
Size:
147,083 bases
Orientation:
Minus strand

Genomic View for PRCP Gene

Genes around PRCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRCP Gene

Proteins for PRCP Gene

  • Protein details for PRCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42785-PCP_HUMAN
    Recommended name:
    Lysosomal Pro-X carboxypeptidase
    Protein Accession:
    P42785
    Secondary Accessions:
    • A8MU24
    • B2R7B7
    • B3KRK5
    • B5BU34

    Protein attributes for PRCP Gene

    Size:
    496 amino acids
    Molecular mass:
    55800 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PRCP Gene

    Alternative splice isoforms for PRCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRCP Gene

Selected DME Specific Peptides for PRCP Gene

P42785:
  • LTSEQALAD
  • QKVDHFGF
  • GGSYGGMLAAWFRMKYPH
  • KAMLVFAEHRYYGESLPFG
  • NTGFMWD

Post-translational modifications for PRCP Gene

  • Glycosylation at Thr39, Asn47, Asn101, Asn317, Asn336, Asn345, and Asn415
  • Ubiquitination at Lys77
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Domains & Families for PRCP Gene

Gene Families for PRCP Gene

Protein Domains for PRCP Gene

Blocks:
  • Alpha/beta hydrolase fold
  • Peptidase S28
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRCP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57232, highly similar to Lysosomal Pro-X carboxypeptidase (EC3.4.16.2) (B7Z7Q6_HUMAN)
  • Prolylcarboxypeptidase (PCP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42785

UniProtKB/Swiss-Prot:

PCP_HUMAN :
  • Belongs to the peptidase S28 family.
Family:
  • Belongs to the peptidase S28 family.
genes like me logo Genes that share domains with PRCP: view

Function for PRCP Gene

Molecular function for PRCP Gene

UniProtKB/Swiss-Prot Function:
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Cleavage of a -Pro- -Xaa bond to release a C-terminal amino acid.; EC=3.4.16.2;.
GENATLAS Biochemistry:
angiotensinase C,51kDa,lysosomal

Enzyme Numbers (IUBMB) for PRCP Gene

Phenotypes From GWAS Catalog for PRCP Gene

Gene Ontology (GO) - Molecular Function for PRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity IEA --
GO:0004185 serine-type carboxypeptidase activity TAS --
GO:0005515 protein binding IPI 20517885
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with PRCP: view
genes like me logo Genes that share phenotypes with PRCP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRCP

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRCP

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRCP Gene

Localization for PRCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRCP Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRCP gene
Compartment Confidence
lysosome 5
plasma membrane 4
extracellular 2
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005886 plasma membrane TAS --
GO:0035577 azurophil granule membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0045178 basal part of cell IEA --
genes like me logo Genes that share ontologies with PRCP: view

Pathways & Interactions for PRCP Gene

genes like me logo Genes that share pathways with PRCP: view

SIGNOR curated interactions for PRCP Gene

Inactivates:

Gene Ontology (GO) - Biological Process for PRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002155 regulation of thyroid hormone mediated signaling pathway IEA --
GO:0002353 plasma kallikrein-kinin cascade IEA --
GO:0003085 negative regulation of systemic arterial blood pressure IBA,IEA 21873635
GO:0006508 proteolysis IEA,IBA 21873635
GO:0007597 blood coagulation, intrinsic pathway TAS --
genes like me logo Genes that share ontologies with PRCP: view

Drugs & Compounds for PRCP Gene

(4) Drugs for PRCP Gene - From: PharmGKB, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benazepril Approved, Investigational Pharma 48
Angiotensin III (human, mouse) Pharma Aldosterone stimulator 0

(3) Additional Compounds for PRCP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for PRCP Gene

Compound Action Cas Number
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
genes like me logo Genes that share compounds with PRCP: view

Drug Products

Transcripts for PRCP Gene

mRNA/cDNA for PRCP Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRCP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRCP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - - - -
SP2: - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for PRCP Gene

GeneLoc Exon Structure for
PRCP

Expression for PRCP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRCP Gene

mRNA differential expression in normal tissues according to GTEx for PRCP Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for PRCP Gene

This gene is overexpressed in NK cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRCP Gene



Protein tissue co-expression partners for PRCP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRCP

SOURCE GeneReport for Unigene cluster for PRCP Gene:

Hs.523936

mRNA Expression by UniProt/SwissProt for PRCP Gene:

P42785-PCP_HUMAN
Tissue specificity: Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.

Evidence on tissue expression from TISSUES for PRCP Gene

  • Nervous system(4.8)
  • Kidney(4.5)
  • Liver(4.4)
  • Lung(4.4)
  • Heart(2.6)
  • Blood(2.4)
genes like me logo Genes that share expression patterns with PRCP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRCP Gene

Orthologs for PRCP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRCP 31 30
  • 99.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRCP 31 30
  • 86.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRCP 31 30
  • 85.11 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prcp 17 31 30
  • 82 (n)
rat
(Rattus norvegicus)
Mammalia Prcp 30
  • 81.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRCP 31
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRCP 31
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRCP 31 30
  • 67.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRCP 31
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prcp 30
  • 67.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32860 30
zebrafish
(Danio rerio)
Actinopterygii prcp 31 30
  • 63.38 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2493 31 32 30
  • 52.95 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000994 30
  • 52.68 (n)
worm
(Caenorhabditis elegans)
Secernentea pcp-5 31 30
  • 51.07 (n)
OneToMany
ZK688.6a 32
  • 40 (a)
ZK688.6b 32
  • 40 (a)
pcp-1 31
  • 32 (a)
OneToMany
F56F10.1 32
  • 27 (a)
K12H4.7b 32
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G65760 30
  • 52.69 (n)
rice
(Oryza sativa)
Liliopsida Os01g0767100 30
  • 53.41 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.11612 30
Species where no ortholog for PRCP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRCP Gene

ENSEMBL:
Gene Tree for PRCP (if available)
TreeFam:
Gene Tree for PRCP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRCP: view image

Paralogs for PRCP Gene

Paralogs for PRCP Gene

(2) SIMAP similar genes for PRCP Gene using alignment to 12 proteins:

  • PCP_HUMAN
  • B7Z7Q6_HUMAN
  • E9PIG4_HUMAN
  • E9PKN6_HUMAN
  • E9PL49_HUMAN
  • E9PL85_HUMAN
  • E9PLY4_HUMAN
  • E9PNF7_HUMAN
  • E9PNJ1_HUMAN
  • E9PQB5_HUMAN
  • E9PQN3_HUMAN
  • E9PR42_HUMAN

Pseudogenes.org Pseudogenes for PRCP Gene

genes like me logo Genes that share paralogs with PRCP: view

Variants for PRCP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRCP Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2228312 - p.Thr444Ser
rs2229437 - p.Glu112Asp

Additional dbSNP identifiers (rs#s) for PRCP Gene

Structural Variations from Database of Genomic Variants (DGV) for PRCP Gene

Variant ID Type Subtype PubMed ID
dgv2038n54 CNV loss 21841781
esv2290101 CNV deletion 18987734
esv2673057 CNV deletion 23128226
esv33531 CNV loss 17666407
esv3548070 CNV deletion 23714750
esv3579916 CNV gain 25503493
esv3627005 CNV loss 21293372
esv3627006 CNV loss 21293372
nsv1113415 CNV deletion 24896259
nsv38781 CNV deletion 16902084
nsv515868 CNV gain 19592680
nsv555602 CNV gain 21841781
nsv951048 CNV duplication 24416366

Variation tolerance for PRCP Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRCP Gene

Human Gene Mutation Database (HGMD)
PRCP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRCP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRCP Gene

Disorders for PRCP Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRCP Gene - From: DISEASES

Disorder Aliases PubMed IDs
pyruvate kinase deficiency of red cells
  • pkd
congenital nonspherocytic hemolytic anemia
  • hereditary nonspherocytic hemolytic anemia
hypertension, essential
  • eht
- elite association - COSMIC cancer census association via MalaCards
Search PRCP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRCP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRCP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRCP Gene

Publications for PRCP Gene

  1. Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families. (PMID: 8344943) Tan F … Erdös EG (The Journal of biological chemistry 1993) 2 3 4 23 54
  2. E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients. (PMID: 20079160) Zhang Y … Xu XP (Chinese medical journal 2009) 3 23 41 54
  3. Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia. (PMID: 16681991) Wang L … Wang X (American journal of obstetrics and gynecology 2006) 3 23 41 54
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  5. Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase. (PMID: 20540760) Soisson SM … Lumb KJ (BMC structural biology 2010) 3 4 54

Products for PRCP Gene

Sources for PRCP Gene