Aliases for PRCP Gene
External Ids for PRCP Gene
Previous GeneCards Identifiers for PRCP Gene
This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for PRCP Gene
PRCP (Prolylcarboxypeptidase) is a Protein Coding gene. Diseases associated with PRCP include Pyruvate Kinase Deficiency Of Red Cells and Congenital Nonspherocytic Hemolytic Anemia. Among its related pathways are Innate Immune System and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include serine-type peptidase activity and serine-type carboxypeptidase activity. An important paralog of this gene is DPP7.
UniProtKB/Swiss-Prot Summary for PRCP Gene
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.