This gene is predominantly expressed in the retina, and mutations in this gene are the cause of autosomal recessive retinal degeneration in both humans and dogs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010] See more...

Aliases for PRCD Gene

Aliases for PRCD Gene

  • Photoreceptor Disc Component 2 3 5
  • Progressive Rod-Cone Degeneration Protein 3 4
  • Photoreceptor Disk Component PRCD 3 4
  • Progressive Rod-Cone Degeneration 2
  • RP36 3

External Ids for PRCD Gene

Previous GeneCards Identifiers for PRCD Gene

  • GC17U900816
  • GC17P072046
  • GC17P074523
  • GC17P069951

Summaries for PRCD Gene

Entrez Gene Summary for PRCD Gene

  • This gene is predominantly expressed in the retina, and mutations in this gene are the cause of autosomal recessive retinal degeneration in both humans and dogs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for PRCD Gene

PRCD (Photoreceptor Disc Component) is a Protein Coding gene. Diseases associated with PRCD include Retinitis Pigmentosa 36 and Retinitis Pigmentosa.

UniProtKB/Swiss-Prot Summary for PRCD Gene

Additional gene information for PRCD Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRCD Gene

Genomics for PRCD Gene

GeneHancer (GH) Regulatory Elements for PRCD Gene

Promoters and enhancers for PRCD Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J076527 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +2.6 2637 6.2 GTF3C2 ZBTB40 MLX RBPJ POLR2A NR2F1 NR2F6 CREB1 MIXL1 MYC PRCD lnc-RHBDF2-2 ENSG00000267543 SRSF2 UNK TRIM65 MFSD11 ENSG00000266980 CYGB SRP68
GH17J076539 Promoter/Enhancer 0.6 EPDnew dbSUPER 750.4 +12.4 12439 0.1 CBFA2T3 lnc-ST6GALNAC2-27 PRCD lnc-PRCD-5 CYGB
GH17J076526 Promoter/Enhancer 0.5 Ensembl dbSUPER 750.6 -0.8 -785 0.4 PRCD lnc-CYGB-5
GH17J076694 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +171.0 170959 8.3 ZBTB6 LCORL MLX RBPJ SMARCE1 MIXL1 ZNF362 ZNF133 ZNF701 L3MBTL2 MXRA7 UNK SRSF2 METTL23 ENSG00000266980 TRIM65 SNHG20 ENSG00000267342 RNU6-227P JMJD6
GH17J076564 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 12.2 +40.0 40039 6 FOXK2 SIN3A SREBF1 MLX RBPJ POLR2A NR2F6 HLF L3MBTL2 ELF3 ST6GALNAC2 UNK ENSG00000267543 ENSG00000267342 RECQL5 TRIM65 CDK3 SNHG16 PRCD ENSG00000267546
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRCD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRCD gene promoter:
  • Egr-2
  • GATA-3
  • HNF-3beta
  • NF-kappaB
  • RelA
  • Sp1
  • XBP-1
  • ZIC2

Genomic Locations for PRCD Gene

Genomic Locations for PRCD Gene
25,995 bases
Plus strand
25,993 bases
Plus strand

Genomic View for PRCD Gene

Genes around PRCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRCD Gene

Proteins for PRCD Gene

  • Protein details for PRCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Photoreceptor disk component PRCD
    Protein Accession:
    Secondary Accessions:
    • B9EJD4

    Protein attributes for PRCD Gene

    54 amino acids
    Molecular mass:
    6007 Da
    Quaternary structure:
    • Interacts with RHO/rhodopsin; the interaction promotes PRCD stability.

neXtProt entry for PRCD Gene

Post-translational modifications for PRCD Gene

  • Palmitoylated at Cys-2 (PubMed:27613864). Palmitoylation is essential for protein stability and trafficking to the photoreceptor outer segment, but does not appear to be essential for membrane localization (PubMed:27613864). Probably palmitoylated by ZDHHC3 (PubMed:27613864).
  • Phosphorylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRCD Gene

No data available for DME Specific Peptides for PRCD Gene

Domains & Families for PRCD Gene

Gene Families for PRCD Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Protein Domains for PRCD Gene


Suggested Antigen Peptide Sequences for PRCD Gene

GenScript: Design optimal peptide antigens:
  • Progressive rod-cone degeneration protein (PRCD_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PRCD family.
  • Belongs to the PRCD family.
genes like me logo Genes that share domains with PRCD: view

Function for PRCD Gene

Molecular function for PRCD Gene

UniProtKB/Swiss-Prot Function:
Involved in vision.

Phenotypes From GWAS Catalog for PRCD Gene

genes like me logo Genes that share phenotypes with PRCD: view

Human Phenotype Ontology for PRCD Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRCD Gene

Localization for PRCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRCD Gene

Cell projection, cilium, photoreceptor outer segment. Membrane; Lipid-anchor; Cytoplasmic side. Endoplasmic reticulum. Golgi apparatus. Note=Localizes to photoreceptor disk membranes in the photoreceptor outer segment (PubMed:27613864). The secretion in media described in PubMed:24992209 is probably an experimental artifact (PubMed:24992209). {ECO:0000269 PubMed:24992209, ECO:0000269 PubMed:27613864}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRCD gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PRCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 24992209
GO:0005737 cytoplasm IDA 24992209
GO:0005783 endoplasmic reticulum IEA,IDA 24992209
GO:0005794 Golgi apparatus IEA,IDA 24992209
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PRCD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRCD Gene

Pathways & Interactions for PRCD Gene

PathCards logo

SuperPathways for PRCD Gene

No Data Available

Interacting Proteins for PRCD Gene

Gene Ontology (GO) - Biological Process for PRCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with PRCD: view

No data available for Pathways by source and SIGNOR curated interactions for PRCD Gene

Drugs & Compounds for PRCD Gene

No Compound Related Data Available

Transcripts for PRCD Gene

mRNA/cDNA for PRCD Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRCD Gene

No ASD Table

Relevant External Links for PRCD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRCD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRCD Gene

mRNA differential expression in normal tissues according to GTEx for PRCD Gene

This gene is overexpressed in Brain - Cerebellum (x4.8) and Brain - Cerebellar Hemisphere (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of PRCD Gene:


SOURCE GeneReport for Unigene cluster for PRCD Gene:


Evidence on tissue expression from TISSUES for PRCD Gene

  • Nervous system(4.2)
  • Eye(2.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PRCD Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • middle ear
  • nose
  • outer ear
  • skull
  • penis
  • testicle
  • blood
  • blood vessel
  • peripheral nervous system
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with PRCD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PRCD Gene

Orthologs for PRCD Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRCD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRCD 33 32
  • 99.38 (n)
(Bos Taurus)
Mammalia PRCD 33
  • 87 (a)
(Canis familiaris)
Mammalia PRCD 33
  • 80 (a)
(Mus musculus)
Mammalia Gm11744 33
  • 74 (a)
Species where no ortholog for PRCD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRCD Gene

Gene Tree for PRCD (if available)
Gene Tree for PRCD (if available)
Evolutionary constrained regions (ECRs) for PRCD: view image

Paralogs for PRCD Gene

No data available for Paralogs for PRCD Gene

Variants for PRCD Gene

Sequence variations from dbSNP and Humsavar for PRCD Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs117784164 uncertain-significance, Retinitis Pigmentosa, Recessive 76,544,582(+) C/T 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs121918369 pathogenic, Retinitis pigmentosa 36, Retinitis pigmentosa 36 (RP36) [MIM:610599] 76,540,146(+) G/A coding_sequence_variant, intron_variant, missense_variant
rs139602114 uncertain-significance, Retinitis Pigmentosa, Recessive 76,545,130(+) C/G 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs144319284 uncertain-significance, Retinitis Pigmentosa, Recessive 76,544,240(+) C/A/G/T 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs144852411 uncertain-significance, Retinitis Pigmentosa, Recessive 76,544,909(+) G/A/C 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRCD Gene

Variant ID Type Subtype PubMed ID
nsv1058263 CNV gain 25217958
nsv833549 CNV gain 17160897
nsv952370 CNV deletion 24416366

Variation tolerance for PRCD Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRCD Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRCD Gene

Disorders for PRCD Gene

MalaCards: The human disease database

(5) MalaCards diseases for PRCD Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 36
  • rp36
retinitis pigmentosa
  • retinitis pigmentosa 1
retinitis pigmentosa 17
  • rp17
cone-rod dystrophy 6
  • retinitis pigmentosa 6
- elite association - COSMIC cancer census association via MalaCards
Search PRCD in MalaCards View complete list of genes associated with diseases


  • Retinitis pigmentosa 36 (RP36) [MIM:610599]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO:0000269 PubMed:16938425, ECO:0000269 PubMed:24992209, ECO:0000269 PubMed:27613864}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PRCD

genes like me logo Genes that share disorders with PRCD: view

No data available for Genatlas for PRCD Gene

Publications for PRCD Gene

  1. Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans. (PMID: 16938425) Zangerl B … Aguirre GD (Genomics 2006) 2 3 4 56
  2. Palmitoylation of Progressive Rod-Cone Degeneration (PRCD) Regulates Protein Stability and Localization. (PMID: 27613864) Murphy J … Kolandaivelu S (The Journal of biological chemistry 2016) 3 4 56
  3. The progressive rod-cone degeneration (PRCD) protein is secreted through the conventional ER/Golgi-dependent pathway. (PMID: 24992209) Remez L … Ben-Yosef T (Experimental eye research 2014) 3 4 56
  4. Identification of a novel mutation in the PRCD gene causing autosomal recessive retinitis pigmentosa in a Turkish family. (PMID: 23805042) Pach J … Zobor D (Molecular vision 2013) 3 56
  5. Identification of a prevalent founder mutation in an Israeli Muslim Arab village confirms the role of PRCD in the aetiology of retinitis pigmentosa in humans. (PMID: 20507925) Nevet MJ … Ben-Yosef T (Journal of medical genetics 2010) 3 56

Products for PRCD Gene

Sources for PRCD Gene