Aliases for PRC1 Gene
External Ids for PRC1 Gene
Previous GeneCards Identifiers for PRC1 Gene
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
GeneCards Summary for PRC1 Gene
PRC1 (Protein Regulator Of Cytokinesis 1) is a Protein Coding gene. Diseases associated with PRC1 include Bladder Cancer. Among its related pathways are Signaling by Rho GTPases and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include identical protein binding and microtubule binding.
UniProtKB/Swiss-Prot for PRC1 Gene
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).