Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRB4 Gene

Aliases for PRB4 Gene

  • Proline Rich Protein BstNI Subfamily 4 2 3 5
  • Salivary Proline-Rich Protein II-1 3 4
  • Salivary Proline-Rich Protein Po 3 4
  • Parotid O Protein 3 4
  • BstNI Type Basic Salivary Proline-Rich Protein 4 3
  • Basic Salivary Proline-Rich Protein 4 3
  • Po 3

External Ids for PRB4 Gene

Previous GeneCards Identifiers for PRB4 Gene

  • GC12P011096
  • GC12M011563
  • GC12M011319
  • GC12M011310
  • GC12M011313
  • GC12M011351
  • GC12M011460
  • GC12M011225

Summaries for PRB4 Gene

Entrez Gene Summary for PRB4 Gene

  • This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Small" allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]

GeneCards Summary for PRB4 Gene

PRB4 (Proline Rich Protein BstNI Subfamily 4) is a Protein Coding gene. Diseases associated with PRB4 include Hypopharynx Cancer. An important paralog of this gene is PRB3.

Gene Wiki entry for PRB4 Gene

Additional gene information for PRB4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRB4 Gene

Genomics for PRB4 Gene

GeneHancer (GH) Regulatory Elements for PRB4 Gene

Promoters and enhancers for PRB4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J011310 Promoter 0.5 EPDnew 650.7 0.0 -18 0.1 PRB4 PRB1
GH12J011307 Enhancer 0.2 FANTOM5 65.3 +2.7 2698 0.1 PRB1 PRB4 PRB3 PRB2 PRH1 PRH2
GH12J011355 Promoter 0.5 EPDnew 0.2 -45.2 -45176 0.1 PRB1 PRB4 GC12M012309
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRB4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRB4 gene promoter:
  • TBP
  • TFIID
  • Sox5
  • Zic3
  • Sox9

Genomic Locations for PRB4 Gene

Genomic Locations for PRB4 Gene
chr12:11,307,081-11,310,435
(GRCh38/hg38)
Size:
3,355 bases
Orientation:
Minus strand
chr12:11,460,015-11,463,369
(GRCh37/hg19)
Size:
3,355 bases
Orientation:
Minus strand

Genomic View for PRB4 Gene

Genes around PRB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRB4 Gene

Proteins for PRB4 Gene

  • Protein details for PRB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10163-PRB4_HUMAN
    Recommended name:
    Basic salivary proline-rich protein 4
    Protein Accession:
    P10163
    Secondary Accessions:
    • A1L439
    • O00600
    • P02813
    • P10161
    • P10162
    • P81489

    Protein attributes for PRB4 Gene

    Size:
    310 amino acids
    Molecular mass:
    31326 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA30543.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA30729.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PRB4 Gene

Post-translational modifications for PRB4 Gene

  • N-glycosylated.
  • Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly lysine. The endoprotease may be of microbial origin. Pyroglutamate formation found on at least Gln-46, Gln-48, Gln-67, Gln-88; Gln-90; Gln-193; Gln-288 Gln-214 and Gln-295, preferentially in diabetic, and head and neck cancer patients.
  • Glycosylation at Asn234, posLast=213213, Asn192, Asn171, posLast=150150, posLast=108108, Asn87, and Asn66

Other Protein References for PRB4 Gene

No data available for DME Specific Peptides for PRB4 Gene

Domains & Families for PRB4 Gene

Gene Families for PRB4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PRB4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRB4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRB4: view

No data available for UniProtKB/Swiss-Prot for PRB4 Gene

Function for PRB4 Gene

Molecular function for PRB4 Gene

GENATLAS Biochemistry:
salivary proline-rich protein,basic,glycosylated,BstNI subfamily 4,including the polymorphic variants Po+/-,and glycoprotein II-1

Gene Ontology (GO) - Molecular Function for PRB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PRB4: view
genes like me logo Genes that share phenotypes with PRB4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRB4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRB4 Gene

Localization for PRB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRB4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRB4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PRB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 8373986
genes like me logo Genes that share ontologies with PRB4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRB4 Gene

Pathways & Interactions for PRB4 Gene

No Data Available

Interacting Proteins for PRB4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000279575%0d%0a9606.ENSP00000268171%0d%0a
Selected Interacting proteins: ENSP00000279575 P10163-PRB4_HUMAN for PRB4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PRB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRB4: view

No data available for Pathways by source and SIGNOR curated interactions for PRB4 Gene

Drugs & Compounds for PRB4 Gene

No Compound Related Data Available

Transcripts for PRB4 Gene

mRNA/cDNA for PRB4 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRB4 Gene

Proline-rich protein BstNI subfamily 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRB4

Alternative Splicing Database (ASD) splice patterns (SP) for PRB4 Gene

No ASD Table

Relevant External Links for PRB4 Gene

GeneLoc Exon Structure for
PRB4
ECgene alternative splicing isoforms for
PRB4

Expression for PRB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRB4 Gene

mRNA differential expression in normal tissues according to GTEx for PRB4 Gene

This gene is overexpressed in Testis (x17.3), Skin - Sun Exposed (Lower leg) (x14.1), and Skin - Not Sun Exposed (Suprapubic) (x10.9).

NURSA nuclear receptor signaling pathways regulating expression of PRB4 Gene:

PRB4

SOURCE GeneReport for Unigene cluster for PRB4 Gene:

Hs.528651

Evidence on tissue expression from TISSUES for PRB4 Gene

  • Saliva(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with PRB4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRB4 Gene

Orthologs for PRB4 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRB4 34
  • 97 (a)
OneToOne
Species where no ortholog for PRB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRB4 Gene

ENSEMBL:
Gene Tree for PRB4 (if available)
TreeFam:
Gene Tree for PRB4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRB4: view image

Paralogs for PRB4 Gene

Paralogs for PRB4 Gene

genes like me logo Genes that share paralogs with PRB4: view

Variants for PRB4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRB4 Gene

PRB4_HUMAN-P10163
The number of repeats is polymorphic and varies among different alleles. Allele S (short), allele M (medium) and allele L (long) contain 6, 7 and 9 tandem repeats respectively.

Sequence variations from dbSNP and Humsavar for PRB4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000199978 -- 11,306,593(-) G/A downstream_transcript_variant
rs1000575347 -- 11,307,448(-) C/T intron_variant
rs1000842520 -- 11,311,105(-) C/T upstream_transcript_variant
rs1001878593 -- 11,310,023(-) G/T intron_variant
rs1003799516 -- 11,309,052(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRB4 Gene

Variant ID Type Subtype PubMed ID
dgv175e201 CNV deletion 23290073
dgv252e214 CNV gain 21293372
esv1229106 CNV insertion 17803354
esv2421975 CNV duplication 20811451
esv2674351 CNV deletion 23128226
esv2745560 CNV deletion 23290073
esv2759879 CNV loss 17122850
esv3584654 CNV gain 24956385
nsv1038277 CNV loss 25217958
nsv428272 CNV gain+loss 18775914
nsv509455 CNV insertion 20534489
nsv516262 CNV gain+loss 19592680
nsv818885 CNV gain 17921354
nsv8920 CNV loss 18304495
nsv975451 CNV duplication 23825009

Variation tolerance for PRB4 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRB4 Gene

Human Gene Mutation Database (HGMD)
PRB4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRB4

SNP Genotyping and Copy Number Assay Products

Disorders for PRB4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRB4 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
hypopharynx cancer
  • hypopharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards
Search PRB4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRB4

genes like me logo Genes that share disorders with PRB4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRB4 Gene

Publications for PRB4 Gene

  1. PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins. (PMID: 8554050) Azen EA … Niece RL (American journal of human genetics 1996) 3 4 22 58
  2. Finding new posttranslational modifications in salivary proline-rich proteins. (PMID: 20879038) Vitorino R … Amado FL (Proteomics 2010) 3 4 58
  3. Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases. (PMID: 18463091) Helmerhorst EJ … Oppenheim FG (The Journal of biological chemistry 2008) 3 4 58
  4. Alignment of amino acid and DNA sequences of human proline-rich proteins. (PMID: 8373986) Kauffman DL … Blum M (Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 1993) 3 4 58
  5. Basic proline-rich proteins from human parotid saliva: relationships of the covalent structures of ten proteins from a single individual. (PMID: 1849422) Kauffman DL … Keller PJ (Biochemistry 1991) 3 4 58

Products for PRB4 Gene

Sources for PRB4 Gene

Content
Loading form....