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Aliases for PRB3 Gene

Aliases for PRB3 Gene

  • Proline Rich Protein BstNI Subfamily 3 2 3 5
  • Parotid Salivary Glycoprotein G1 3 4
  • Proline-Rich Protein G1 3 4
  • BstNI Type Basic Salivary Proline-Rich Protein 3 3
  • Basic Salivary Proline-Rich Protein 3 3
  • G1 Parotid Salivary Glycoprotein 3
  • PRG 3
  • G1 3

External Ids for PRB3 Gene

Previous GeneCards Identifiers for PRB3 Gene

  • GC12U990078
  • GC12M011564
  • GC12M011320
  • GC12M011311
  • GC12M011312
  • GC12M011315
  • GC12M011316
  • GC12M011418
  • GC12M011184

Summaries for PRB3 Gene

Entrez Gene Summary for PRB3 Gene

  • This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Long" allele. The protein isoforms encoded by this gene are recognized as the "first line of oral defense" against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015]

GeneCards Summary for PRB3 Gene

PRB3 (Proline Rich Protein BstNI Subfamily 3) is a Protein Coding gene. An important paralog of this gene is PRB2.

UniProtKB/Swiss-Prot for PRB3 Gene

  • Acts as a receptor for the Gram-negative bacterium F.nucleatum.

Gene Wiki entry for PRB3 Gene

Additional gene information for PRB3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRB3 Gene

Genomics for PRB3 Gene

GeneHancer (GH) Regulatory Elements for PRB3 Gene

Promoters and enhancers for PRB3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J011307 Enhancer 0.2 FANTOM5 64.8 -37.9 -37932 0.1 PRB1 PRB4 PRB3 PRB2 PRH1 PRH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRB3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRB3 gene promoter:
  • Pbx1a
  • Sox5
  • Zic3
  • ZIC2

Genomic Locations for PRB3 Gene

Genomic Locations for PRB3 Gene
3,892 bases
Minus strand
3,883 bases
Minus strand

Genomic View for PRB3 Gene

Genes around PRB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRB3 Gene

Proteins for PRB3 Gene

  • Protein details for PRB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Basic salivary proline-rich protein 3
    Protein Accession:
    Secondary Accessions:
    • Q15188
    • Q4VAY3
    • Q4VAY4
    • Q7M4M9
    • Q9UCT9

    Protein attributes for PRB3 Gene

    309 amino acids
    Molecular mass:
    30980 Da
    Quaternary structure:
    • The Gl-8 variant forms a disulfide-bonded heterodimer with salivary perodixase.
    • Sequence=CAA30477.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for PRB3 Gene

Post-translational modifications for PRB3 Gene

  • The Gl-8 variant contains an interchain disulfide bond with salivary peroxidase.
  • N- and O-glycosylated; contains about 50% carbohydrate. This is composed of highly fucosylated N-linked saccharides, the major structure is a biantennary asialosaccharide containing 2 fucose residues on one antenna and an unsubstituted terminal lactosamine sequence on the other. The Gram-negative bacterium F.nucleatum binds to carbohydrates containing unsubstituted GalBeta1,4GlcNAc residues. N-glycosylation on Asn-87 is prevalent in head and neck cancer patients.
  • Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly lysine. The endoprotease may be of microbial origin. Besides on the N-terminal of mature PRB3, pyroglutamate formation found on at least Gln-67, Gln-88, Gln-214 and Gln-295.
  • Glycosylation at Asn255, Asn213, Asn192, posLast=171171, posLast=150150, Asn129, Asn108, posLast=8989, posLast=8787, and posLast=6666
  • Modification sites at PhosphoSitePlus

Other Protein References for PRB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRB3 Gene

Domains & Families for PRB3 Gene

Gene Families for PRB3 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PRB3 Gene


Suggested Antigen Peptide Sequences for PRB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRB3: view

No data available for UniProtKB/Swiss-Prot for PRB3 Gene

Function for PRB3 Gene

Molecular function for PRB3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a receptor for the Gram-negative bacterium F.nucleatum.
GENATLAS Biochemistry:
salivary proline-rich protein,basic,glycosylated,BstNI subfamily 3,including among others,the polymorphic variant concavalin A-binding protein
genes like me logo Genes that share phenotypes with PRB3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRB3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRB3 Gene

Localization for PRB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRB3 Gene


Gene Ontology (GO) - Cellular Components for PRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 1894623
genes like me logo Genes that share ontologies with PRB3: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PRB3 Gene

Pathways & Interactions for PRB3 Gene

No Data Available

Interacting Proteins for PRB3 Gene

Gene Ontology (GO) - Biological Process for PRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0050829 defense response to Gram-negative bacterium NAS 1894623
genes like me logo Genes that share ontologies with PRB3: view

No data available for Pathways by source and SIGNOR curated interactions for PRB3 Gene

Drugs & Compounds for PRB3 Gene

No Compound Related Data Available

Transcripts for PRB3 Gene

mRNA/cDNA for PRB3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRB3 Gene

Proline-rich protein BstNI subfamily 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRB3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRB3 Gene

No ASD Table

Relevant External Links for PRB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRB3 Gene

mRNA differential expression in normal tissues according to GTEx for PRB3 Gene

This gene is overexpressed in Testis (x16.9), Skin - Sun Exposed (Lower leg) (x6.7), Skin - Not Sun Exposed (Suprapubic) (x5.5), and Bladder (x4.5).

Protein differential expression in normal tissues from HIPED for PRB3 Gene

This gene is overexpressed in Nasal epithelium (54.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRB3 Gene

Protein tissue co-expression partners for PRB3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRB3 Gene:


SOURCE GeneReport for Unigene cluster for PRB3 Gene:

genes like me logo Genes that share expression patterns with PRB3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRB3 Gene

Orthologs for PRB3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRB3 33
  • 93.88 (n)
Species where no ortholog for PRB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRB3 Gene

Gene Tree for PRB3 (if available)
Gene Tree for PRB3 (if available)
Evolutionary constrained regions (ECRs) for PRB3: view image

Paralogs for PRB3 Gene

Paralogs for PRB3 Gene

genes like me logo Genes that share paralogs with PRB3: view

Variants for PRB3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRB3 Gene

The number of repeats is polymorphic and varies among different alleles. The sequence shown is that of allele L (long). There is an allele S (short) which contains 6 tandem repeats.

Sequence variations from dbSNP and Humsavar for PRB3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs71455367 pathogenic, PRB3S(CYS) 11,268,104(-) G/A/C coding_sequence_variant, missense_variant
rs1000676497 -- 11,271,223(-) C/T upstream_transcript_variant
rs1001192013 -- 11,271,423(-) T/C upstream_transcript_variant
rs1001340491 -- 11,268,122(-) C/T coding_sequence_variant, missense_variant
rs1001922342 -- 11,269,945(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRB3 Gene

Variant ID Type Subtype PubMed ID
dgv175e201 CNV deletion 23290073
esv1018672 CNV deletion 17803354
esv1318358 CNV deletion 17803354
esv2586387 CNV deletion 19546169
esv2745557 CNV deletion 23290073
esv2745559 CNV deletion 23290073
esv2759879 CNV loss 17122850
esv994058 CNV deletion 20482838
nsv1038277 CNV loss 25217958
nsv1050050 CNV loss 25217958
nsv1143558 CNV deletion 24896259
nsv428272 CNV gain+loss 18775914
nsv975451 CNV duplication 23825009

Variation tolerance for PRB3 Gene

Gene Damage Index Score: 3.26; 52.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRB3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for PRB3 Gene

Additional Disease Information for PRB3

No disorders were found for PRB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRB3 Gene

Publications for PRB3 Gene

  1. Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein. (PMID: 1894623) Gillece-Castro BL … Fisher SJ (The Journal of biological chemistry 1991) 2 3 4 22 58
  2. Alleles at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl 8) and a null in an Ashkenazi Jew. (PMID: 2171329) Azen EA … Kim HS (American journal of human genetics 1990) 3 4 22 58
  3. Finding new posttranslational modifications in salivary proline-rich proteins. (PMID: 20879038) Vitorino R … Amado FL (Proteomics 2010) 3 4 58
  4. Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases. (PMID: 18463091) Helmerhorst EJ … Oppenheim FG (The Journal of biological chemistry 2008) 3 4 58
  5. PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro. (PMID: 8406834) Azen E … Fisher SJ (Infection and immunity 1993) 3 22 58

Products for PRB3 Gene

Sources for PRB3 Gene

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