Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRAP1 Gene

Aliases for PRAP1 Gene

  • Proline Rich Acidic Protein 1 2 3 5
  • Epididymis Tissue Protein Li 178 3 4
  • UPA 3 4
  • Uterine-Specific Proline-Rich Acidic Protein 4
  • Proline-Rich Acidic Protein 1 3
  • PRO1195 3

External Ids for PRAP1 Gene

Previous GeneCards Identifiers for PRAP1 Gene

  • GC10P134635
  • GC10P135049
  • GC10P135010
  • GC10P135160
  • GC10P128704
  • GC10P133309

Summaries for PRAP1 Gene

GeneCards Summary for PRAP1 Gene

PRAP1 (Proline Rich Acidic Protein 1) is a Protein Coding gene. Among its related pathways are Autophagy - animal.

UniProtKB/Swiss-Prot for PRAP1 Gene

  • May play an important role in maintaining normal growth homeostasis in epithelial cells.

Additional gene information for PRAP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAP1 Gene

Genomics for PRAP1 Gene

GeneHancer (GH) Regulatory Elements for PRAP1 Gene

Promoters and enhancers for PRAP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J133346 Promoter/Enhancer 1.3 EPDnew ENCODE 657.9 +0.6 616 2.2 ARID4B STAT5A THRB ZNF48 RAD21 RARA YY1 CREM EGR2 RXRA PRAP1 FUOM ECHS1 ENSG00000226699 ZNF511-PRAP1
GH10J133356 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 6.9 +11.7 11680 4.5 FOXA2 MLX ZFP64 ARID4B YY1 POLR2B E2F8 ZNF207 ZNF143 MXD4 FUOM GC10P133357 GC10P133359 SCART1 TUBGCP2 ENSG00000235245 PRAP1 ECHS1 PAOX PIR54449
GH10J133372 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.3 +26.4 26407 2.3 HDGF ARID4B SIN3A GLI4 BRCA1 YY1 POLR2B GLIS2 ZNF207 KLF7 ECHS1 ENSG00000274685 MIR3944 PRAP1 PAOX
GH10J133329 Enhancer 1.3 FANTOM5 Ensembl ENCODE 6.6 -17.2 -17243 1 ARID4B ZNF2 ZNF48 YY1 ZNF121 GLIS2 ZNF213 ARID2 ZNF143 KLF7 CFAP46 PRAP1 CALY GC10M133326 ZNF511-PRAP1
GH10J133529 Enhancer 0.7 FANTOM5 4.6 +182.2 182152 0.1 NRF1 MAX ZNF148 KLF16 POLR2A WT1 MYC ZBTB17 NR2C2 ZBTB20 ENSG00000278518 PRAP1 CYP2E1 FUOM ECHS1 KNDC1 PIR52458
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRAP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRAP1 gene promoter:
  • RFX1
  • MyoD
  • c-Myb
  • GATA-1
  • Zic1
  • Pax-5
  • Elk-1
  • HOXA3
  • GATA-2
  • deltaCREB

Genomic Locations for PRAP1 Gene

Genomic Locations for PRAP1 Gene
chr10:133,347,146-133,352,683
(GRCh38/hg38)
Size:
5,538 bases
Orientation:
Plus strand
chr10:135,160,650-135,166,187
(GRCh37/hg19)
Size:
5,538 bases
Orientation:
Plus strand

Genomic View for PRAP1 Gene

Genes around PRAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAP1 Gene

Proteins for PRAP1 Gene

  • Protein details for PRAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NZ9-PRAP1_HUMAN
    Recommended name:
    Proline-rich acidic protein 1
    Protein Accession:
    Q96NZ9
    Secondary Accessions:
    • B7ZL57
    • B7ZL58
    • E9KL31
    • Q5VWY4
    • Q7Z4X5
    • Q8IWR3
    • Q8NCS2

    Protein attributes for PRAP1 Gene

    Size:
    151 amino acids
    Molecular mass:
    17208 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP97247.1; Type=Frameshift; Positions=81, 86; Evidence={ECO:0000305};

    Alternative splice isoforms for PRAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRAP1 Gene

Post-translational modifications for PRAP1 Gene

  • Glycosylation at posLast=111111, Thr89, and Thr72
  • Modification sites at PhosphoSitePlus

Other Protein References for PRAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRAP1 Gene

Domains & Families for PRAP1 Gene

Gene Families for PRAP1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PRAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRAP1: view

No data available for UniProtKB/Swiss-Prot for PRAP1 Gene

Function for PRAP1 Gene

Molecular function for PRAP1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in maintaining normal growth homeostasis in epithelial cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated by butyrate, trichostatin A and 5-aza-2 deoxycytidine.

Phenotypes From GWAS Catalog for PRAP1 Gene

Gene Ontology (GO) - Molecular Function for PRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PRAP1: view
genes like me logo Genes that share phenotypes with PRAP1: view

Animal Models for PRAP1 Gene

MGI Knock Outs for PRAP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRAP1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRAP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRAP1 Gene

Localization for PRAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRAP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRAP1 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Plasma membrane (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PRAP1: view

Pathways & Interactions for PRAP1 Gene

SuperPathways for PRAP1 Gene

SuperPathway Contained pathways
1 Autophagy - animal
genes like me logo Genes that share pathways with PRAP1: view

Pathways by source for PRAP1 Gene

1 KEGG pathway for PRAP1 Gene

Gene Ontology (GO) - Biological Process for PRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with PRAP1: view

No data available for SIGNOR curated interactions for PRAP1 Gene

Drugs & Compounds for PRAP1 Gene

(2) Drugs for PRAP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PRAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRAP1: view

Transcripts for PRAP1 Gene

mRNA/cDNA for PRAP1 Gene

Unigene Clusters for PRAP1 Gene

Proline-rich acidic protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRAP1

Alternative Splicing Database (ASD) splice patterns (SP) for PRAP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1:
SP2: -
SP3:

Relevant External Links for PRAP1 Gene

GeneLoc Exon Structure for
PRAP1
ECgene alternative splicing isoforms for
PRAP1

Expression for PRAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRAP1 Gene

This gene is overexpressed in Testis (x17.2) and Liver (x7.1).

Protein differential expression in normal tissues from HIPED for PRAP1 Gene

This gene is overexpressed in Serum (50.0) and Synovial fluid (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRAP1 Gene



Protein tissue co-expression partners for PRAP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRAP1 Gene:

PRAP1

SOURCE GeneReport for Unigene cluster for PRAP1 Gene:

Hs.15951

mRNA Expression by UniProt/SwissProt for PRAP1 Gene:

Q96NZ9-PRAP1_HUMAN
Tissue specificity: Abundantly expressed in the epithelial cells of the liver, kidney, gastrointestinal tract and cervix. Significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. Expressed in epididymis (at protein level).

Evidence on tissue expression from TISSUES for PRAP1 Gene

  • Liver(4.5)
  • Pancreas(4.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with PRAP1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRAP1 Gene

Orthologs for PRAP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRAP1 33
  • 78.81 (n)
cow
(Bos Taurus)
Mammalia PRAP1 34 33
  • 73.43 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prap1 33
  • 72.14 (n)
dog
(Canis familiaris)
Mammalia PRAP1 34 33
  • 70.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prap1 16 34 33
  • 70 (n)
Species where no ortholog for PRAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRAP1 Gene

ENSEMBL:
Gene Tree for PRAP1 (if available)
TreeFam:
Gene Tree for PRAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRAP1: view image

Paralogs for PRAP1 Gene

(1) SIMAP similar genes for PRAP1 Gene using alignment to 1 proteins:

  • PRAP1_HUMAN
genes like me logo Genes that share paralogs with PRAP1: view

No data available for Paralogs for PRAP1 Gene

Variants for PRAP1 Gene

Sequence variations from dbSNP and Humsavar for PRAP1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000394913 -- 133,350,536(+) C/A intron_variant
rs1000427476 -- 133,350,804(+) C/A intron_variant
rs1001157769 -- 133,345,542(+) T/A upstream_transcript_variant
rs1001565324 -- 133,350,256(+) T/C intron_variant
rs1001932617 -- 133,349,897(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRAP1 Gene

Variant ID Type Subtype PubMed ID
dgv2e196 CNV duplication 17116639
dgv3e196 CNV duplication 17116639
esv2750853 CNV gain 17911159
esv2759793 CNV gain+loss 17122850
esv3625030 CNV gain 21293372
esv3625043 CNV gain 21293372
nsv1037772 CNV gain 25217958
nsv1040726 CNV loss 25217958
nsv1052904 CNV gain 25217958
nsv428243 CNV gain 18775914
nsv467509 CNV loss 19166990
nsv470980 CNV loss 18288195
nsv527785 CNV loss 19592680
nsv528260 CNV loss 19592680
nsv552589 CNV gain 21841781
nsv552644 CNV loss 21841781
nsv832036 CNV loss 17160897
nsv832040 CNV loss 17160897
nsv8751 CNV gain 18304495
nsv952707 CNV deletion 24416366

Variation tolerance for PRAP1 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRAP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAP1 Gene

Disorders for PRAP1 Gene

Additional Disease Information for PRAP1

No disorders were found for PRAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRAP1 Gene

Publications for PRAP1 Gene

  1. The proline-rich acidic protein is epigenetically regulated and inhibits growth of cancer cell lines. (PMID: 14583459) Zhang J … Hooi SC (Cancer research 2003) 2 3 4 22 58
  2. Uterine luminal epithelium-specific proline-rich acidic protein 1 (PRAP1) as a marker for successful embryo implantation. (PMID: 20674898) Diao H … Ye X (Fertility and sterility 2010) 2 3 58
  3. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J … Liu Y (Molecular & cellular proteomics : MCP 2010) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PRAP1 Gene

Sources for PRAP1 Gene

Content
Loading form....