Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRAMEF22 Gene

Aliases for PRAMEF22 Gene

  • PRAME Family Member 22 2 3
  • PRAMEF3L 3

External Ids for PRAMEF22 Gene

Previous GeneCards Identifiers for PRAMEF22 Gene

  • GC01P012957
  • GC01P012958
  • GC01P013035
  • GC01M013222

Summaries for PRAMEF22 Gene

GeneCards Summary for PRAMEF22 Gene

PRAMEF22 (PRAME Family Member 22) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include retinoic acid receptor binding.

Additional gene information for PRAMEF22 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAMEF22 Gene

Genomics for PRAMEF22 Gene

GeneHancer (GH) Regulatory Elements for PRAMEF22 Gene

Top Transcription factor binding sites by QIAGEN in the PRAMEF22 gene promoter:

Genomic Locations for PRAMEF22 Gene

Genomic Locations for PRAMEF22 Gene
577 bases
Plus strand

Genomic View for PRAMEF22 Gene

Genes around PRAMEF22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAMEF22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAMEF22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAMEF22 Gene

Proteins for PRAMEF22 Gene

  • Protein details for PRAMEF22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PRAME family member 22
    Protein Accession:
    Secondary Accessions:
    • A6NMM3

    Protein attributes for PRAMEF22 Gene

    481 amino acids
    Molecular mass:
    55489 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRAMEF22 Gene

Post-translational modifications for PRAMEF22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRAMEF22 Gene

No data available for DME Specific Peptides for PRAMEF22 Gene

Domains & Families for PRAMEF22 Gene

Gene Families for PRAMEF22 Gene

Protein Domains for PRAMEF22 Gene


Suggested Antigen Peptide Sequences for PRAMEF22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PRAME family.
  • Belongs to the PRAME family.
genes like me logo Genes that share domains with PRAMEF22: view

Function for PRAMEF22 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRAMEF22 Gene

Localization for PRAMEF22 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRAMEF22 gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRAMEF22 Gene

Pathways & Interactions for PRAMEF22 Gene

SuperPathways for PRAMEF22 Gene

No Data Available

Interacting Proteins for PRAMEF22 Gene

Gene Ontology (GO) - Biological Process for PRAMEF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0045596 negative regulation of cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PRAMEF22: view

No data available for Pathways by source and SIGNOR curated interactions for PRAMEF22 Gene

Drugs & Compounds for PRAMEF22 Gene

No Compound Related Data Available

Transcripts for PRAMEF22 Gene

mRNA/cDNA for PRAMEF22 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRAMEF22 Gene

No ASD Table

Relevant External Links for PRAMEF22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRAMEF22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRAMEF22 Gene

Protein differential expression in normal tissues from HIPED for PRAMEF22 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRAMEF22 Gene

Protein tissue co-expression partners for PRAMEF22 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRAMEF22 Gene:


SOURCE GeneReport for Unigene cluster for PRAMEF22 Gene:

genes like me logo Genes that share expression patterns with PRAMEF22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRAMEF22 Gene

Orthologs for PRAMEF22 Gene

No data available for Orthologs and Evolution for PRAMEF22 Gene

Paralogs for PRAMEF22 Gene

genes like me logo Genes that share paralogs with PRAMEF22: view

No data available for Paralogs for PRAMEF22 Gene

Variants for PRAMEF22 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRAMEF22 Gene

Variant ID Type Subtype PubMed ID
esv1000242 CNV gain 20482838
esv25471 CNV gain+loss 19812545
nsv1004373 CNV gain 25217958
nsv1075590 CNV deletion 25765185
nsv1112520 CNV deletion 24896259
nsv7172 OTHER inversion 18451855
nsv832981 CNV loss 17160897
nsv8768 CNV gain+loss 18304495
nsv945778 CNV duplication 23825009

Variation tolerance for PRAMEF22 Gene

Gene Damage Index Score: 3.18; 51.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRAMEF22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PRAMEF22 Gene

Disorders for PRAMEF22 Gene

Additional Disease Information for PRAMEF22

No disorders were found for PRAMEF22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRAMEF22 Gene

Publications for PRAMEF22 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Duplication and positive selection among hominin-specific PRAME genes. (PMID: 16159394) Birtle Z … Ponting C (BMC genomics 2005) 3 58

Products for PRAMEF22 Gene

Sources for PRAMEF22 Gene

Loading form....