Aliases for PRAMEF14 Gene

Aliases for PRAMEF14 Gene

  • PRAME Family Member 14 2 3 4 5
  • OTTHUMG00000007916 2
  • PRAMEF14 5

External Ids for PRAMEF14 Gene

Previous GeneCards Identifiers for PRAMEF14 Gene

  • GC01U901386
  • GC01M013541
  • GC01M013668

Summaries for PRAMEF14 Gene

GeneCards Summary for PRAMEF14 Gene

PRAMEF14 (PRAME Family Member 14) is a Protein Coding gene. Diseases associated with PRAMEF14 include Retroperitoneum Carcinoma and Dandy-Walker Syndrome. Gene Ontology (GO) annotations related to this gene include retinoic acid receptor binding. An important paralog of this gene is PRAMEF1.

Additional gene information for PRAMEF14 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRAMEF14 Gene

Genomics for PRAMEF14 Gene

GeneHancer (GH) Regulatory Elements Pubs


Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRAMEF14

Top Transcription factor binding sites by QIAGEN in the PRAMEF14 gene promoter:
  • AP-2rep
  • AREB6
  • GR
  • GR-alpha
  • TGIF

Genomic Locations for PRAMEF14 Gene

Genomic Locations for PRAMEF14 Gene
chr1:13,341,892-13,347,134
(GRCh38/hg38)
Size:
5,243 bases
Orientation:
Minus strand
chr1:13,668,269-13,673,511
(GRCh37/hg19)
Size:
5,243 bases
Orientation:
Minus strand

Genomic View for PRAMEF14 Gene

Genes around PRAMEF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAMEF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAMEF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAMEF14 Gene

Proteins for PRAMEF14 Gene

  • Protein details for PRAMEF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SWL7-PRA14_HUMAN
    Recommended name:
    PRAME family member 14
    Protein Accession:
    Q5SWL7

    Protein attributes for PRAMEF14 Gene

    Size:
    426 amino acids
    Molecular mass:
    49433 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRAMEF14 Gene

Post-translational modifications for PRAMEF14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRAMEF14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRAMEF14 Gene

Domains & Families for PRAMEF14 Gene

Gene Families for PRAMEF14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRAMEF14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRAMEF14 Gene

GenScript: Design optimal peptide antigens:
  • PRAME family member 14 (PRA14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5SWL7

UniProtKB/Swiss-Prot:

PRA14_HUMAN :
  • Belongs to the PRAME family.
Family:
  • Belongs to the PRAME family.
genes like me logo Genes that share domains with PRAMEF14: view

Function for PRAMEF14 Gene

genes like me logo Genes that share phenotypes with PRAMEF14: view

Animal Model Products

CRISPR Products

miRNA for PRAMEF14 Gene

miRTarBase miRNAs that target PRAMEF14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRAMEF14

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRAMEF14 Gene

Localization for PRAMEF14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRAMEF14 gene
Compartment Confidence
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRAMEF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with PRAMEF14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PRAMEF14 Gene

Pathways & Interactions for PRAMEF14 Gene

PathCards logo

SuperPathways for PRAMEF14 Gene

No Data Available

Interacting Proteins for PRAMEF14 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000334410 for PRAMEF14 Gene via STRING

Gene Ontology (GO) - Biological Process for PRAMEF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0045596 negative regulation of cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PRAMEF14: view

No data available for Pathways by source and SIGNOR curated interactions for PRAMEF14 Gene

Drugs & Compounds for PRAMEF14 Gene

No Compound Related Data Available

Transcripts for PRAMEF14 Gene

mRNA/cDNA for PRAMEF14 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRAMEF14

Alternative Splicing Database (ASD) splice patterns (SP) for PRAMEF14 Gene

No ASD Table

Relevant External Links for PRAMEF14 Gene

GeneLoc Exon Structure for
PRAMEF14

Expression for PRAMEF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRAMEF14 Gene

mRNA differential expression in normal tissues according to GTEx for PRAMEF14 Gene

This gene is overexpressed in Testis (x53.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRAMEF14

SOURCE GeneReport for Unigene cluster for PRAMEF14 Gene:

Hs.745511
genes like me logo Genes that share expression patterns with PRAMEF14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRAMEF14 Gene

Orthologs for PRAMEF14 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for PRAMEF14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 96 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Gm12790 31
  • 34 (a)
OneToMany
Species where no ortholog for PRAMEF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PRAMEF14 Gene

ENSEMBL:
Gene Tree for PRAMEF14 (if available)
TreeFam:
Gene Tree for PRAMEF14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRAMEF14: view image

Paralogs for PRAMEF14 Gene

genes like me logo Genes that share paralogs with PRAMEF14: view

Variants for PRAMEF14 Gene

Additional dbSNP identifiers (rs#s) for PRAMEF14 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRAMEF14 Gene

Variant ID Type Subtype PubMed ID
dgv141n54 CNV loss 21841781
esv1001235 CNV gain 20482838
esv25471 CNV gain+loss 19812545
esv2743986 CNV deletion 23290073
nsv1004373 CNV gain 25217958
nsv1008245 CNV gain+loss 25217958
nsv1139473 CNV duplication 24896259
nsv1141130 CNV duplication 24896259
nsv1149900 CNV duplication 26484159
nsv1161189 OTHER complex 26073780
nsv442562 CNV gain+loss 18776908
nsv545564 CNV loss 21841781
nsv545566 CNV loss 21841781
nsv832981 CNV loss 17160897
nsv8768 CNV gain+loss 18304495
nsv953510 CNV duplication 24416366
nsv953512 CNV duplication 24416366

Variation tolerance for PRAMEF14 Gene

Gene Damage Index Score: 0.40; 8.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRAMEF14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRAMEF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRAMEF14 Gene

Disorders for PRAMEF14 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRAMEF14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retroperitoneum carcinoma
  • carcinoma of retroperitoneum
dandy-walker syndrome
  • dws
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with PRAMEF14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRAMEF14 Gene

Publications for PRAMEF14 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for PRAMEF14 Gene

Sources for PRAMEF14 Gene