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Aliases for PRAMEF10 Gene

Aliases for PRAMEF10 Gene

  • PRAME Family Member 10 2 3 3 5

External Ids for PRAMEF10 Gene

Previous GeneCards Identifiers for PRAMEF10 Gene

  • GC01M012888
  • GC01M012876
  • GC01M012952
  • GC01M012082

Summaries for PRAMEF10 Gene

GeneCards Summary for PRAMEF10 Gene

PRAMEF10 (PRAME Family Member 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include retinoic acid receptor binding. An important paralog of this gene is PRAMEF33.

Additional gene information for PRAMEF10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAMEF10 Gene

Genomics for PRAMEF10 Gene

GeneHancer (GH) Regulatory Elements for PRAMEF10 Gene


Top Transcription factor binding sites by QIAGEN in the PRAMEF10 gene promoter:
  • AREB6
  • p53
  • GR
  • GR-alpha
  • Nkx2-5

Genomic Locations for PRAMEF10 Gene

Genomic Locations for PRAMEF10 Gene
chr1:12,892,896-12,898,270
(GRCh38/hg38)
Size:
5,375 bases
Orientation:
Minus strand
chr1:12,952,727-12,958,101
(GRCh37/hg19)
Size:
5,375 bases
Orientation:
Minus strand

Genomic View for PRAMEF10 Gene

Genes around PRAMEF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAMEF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAMEF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAMEF10 Gene

Proteins for PRAMEF10 Gene

  • Protein details for PRAMEF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60809-PRA10_HUMAN
    Recommended name:
    PRAME family member 10
    Protein Accession:
    O60809
    Secondary Accessions:
    • Q2M1V2

    Protein attributes for PRAMEF10 Gene

    Size:
    474 amino acids
    Molecular mass:
    55211 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA17876.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PRAMEF10 Gene

Post-translational modifications for PRAMEF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRAMEF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRAMEF10 Gene

Domains & Families for PRAMEF10 Gene

Gene Families for PRAMEF10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRAMEF10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRAMEF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60809

UniProtKB/Swiss-Prot:

PRA10_HUMAN :
  • Belongs to the PRAME family.
Family:
  • Belongs to the PRAME family.
genes like me logo Genes that share domains with PRAMEF10: view

Function for PRAMEF10 Gene

genes like me logo Genes that share phenotypes with PRAMEF10: view

Animal Model Products

miRNA for PRAMEF10 Gene

miRTarBase miRNAs that target PRAMEF10

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRAMEF10 Gene

Localization for PRAMEF10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRAMEF10 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRAMEF10 Gene

Pathways & Interactions for PRAMEF10 Gene

SuperPathways for PRAMEF10 Gene

No Data Available

Interacting Proteins for PRAMEF10 Gene

Gene Ontology (GO) - Biological Process for PRAMEF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0045596 negative regulation of cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PRAMEF10: view

No data available for Pathways by source and SIGNOR curated interactions for PRAMEF10 Gene

Drugs & Compounds for PRAMEF10 Gene

No Compound Related Data Available

Transcripts for PRAMEF10 Gene

mRNA/cDNA for PRAMEF10 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRAMEF10 Gene

PRAME family member 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRAMEF10 Gene

No ASD Table

Relevant External Links for PRAMEF10 Gene

GeneLoc Exon Structure for
PRAMEF10
ECgene alternative splicing isoforms for
PRAMEF10

Expression for PRAMEF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRAMEF10 Gene

mRNA differential expression in normal tissues according to GTEx for PRAMEF10 Gene

This gene is overexpressed in Liver (x46.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRAMEF10 Gene



NURSA nuclear receptor signaling pathways regulating expression of PRAMEF10 Gene:

PRAMEF10

SOURCE GeneReport for Unigene cluster for PRAMEF10 Gene:

Hs.684629
genes like me logo Genes that share expression patterns with PRAMEF10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRAMEF10 Gene

Orthologs for PRAMEF10 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for PRAMEF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRAMEF10 34 33
  • 98.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gm12790 34
  • 37 (a)
OneToMany
Species where no ortholog for PRAMEF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRAMEF10 Gene

ENSEMBL:
Gene Tree for PRAMEF10 (if available)
TreeFam:
Gene Tree for PRAMEF10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRAMEF10: view image

Paralogs for PRAMEF10 Gene

Variants for PRAMEF10 Gene

Sequence variations from dbSNP and Humsavar for PRAMEF10 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001548482 -- 12,892,781(-) T/C downstream_transcript_variant
rs1002727101 -- 12,898,447(-) C/A/T upstream_transcript_variant
rs1003169509 -- 12,898,713(-) G/A upstream_transcript_variant
rs1005417122 -- 12,892,750(-) A/G downstream_transcript_variant
rs1006165307 -- 12,898,416(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRAMEF10 Gene

Variant ID Type Subtype PubMed ID
dgv125n54 CNV loss 21841781
dgv129n54 CNV loss 21841781
dgv134n54 CNV gain 21841781
dgv135n54 CNV loss 21841781
dgv21n100 CNV loss 25217958
dgv28n100 CNV gain+loss 25217958
dgv6n111 CNV duplication 26073780
dgv7n111 CNV deletion 26073780
esv2421662 OTHER complex 20811451
esv2665195 CNV deletion 23128226
esv2678231 CNV deletion 23128226
esv2743853 CNV deletion 23290073
esv28644 CNV gain+loss 19812545
esv32750 CNV gain 17666407
esv3585250 CNV loss 21293372
esv3891414 CNV gain+loss 25118596
esv3891748 CNV gain+loss 25118596
nsv1161165 CNV duplication 26073780
nsv2965 CNV deletion 18451855
nsv433182 CNV loss 18776910
nsv545457 CNV loss 21841781
nsv545532 CNV loss 21841781
nsv7172 OTHER inversion 18451855
nsv820528 CNV deletion 20802225
nsv832869 CNV gain+loss 17160897
nsv8768 CNV gain+loss 18304495
nsv945774 CNV duplication 23825009
nsv999194 CNV gain 25217958

Variation tolerance for PRAMEF10 Gene

Gene Damage Index Score: 4.88; 67.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRAMEF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRAMEF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAMEF10 Gene

Disorders for PRAMEF10 Gene

Additional Disease Information for PRAMEF10

No disorders were found for PRAMEF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRAMEF10 Gene

Publications for PRAMEF10 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for PRAMEF10 Gene

  • Biorbyt antibodies for PRAMEF10

Sources for PRAMEF10 Gene

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