Aliases for PRAME Gene
External Ids for PRAME Gene
Previous HGNC Symbols for PRAME Gene
Previous GeneCards Identifiers for PRAME Gene
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
GeneCards Summary for PRAME Gene
PRAME (PRAME Nuclear Receptor Transcriptional Regulator) is a Protein Coding gene. Diseases associated with PRAME include Melanoma and Childhood Acute Myeloid Leukemia. Among its related pathways are NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include retinoic acid receptor binding. An important paralog of this gene is PRAMEF12.
UniProtKB/Swiss-Prot Summary for PRAME Gene
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.