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Aliases for PRAME Gene

Aliases for PRAME Gene

  • Preferentially Expressed Antigen In Melanoma 2 3 5
  • Preferentially Expressed Antigen Of Melanoma 3 4
  • Opa-Interacting Protein 4 3 4
  • Cancer/Testis Antigen 130 2 3
  • OIP-4 3 4
  • MAPE 3 4
  • OIP4 3 4
  • Melanoma Antigen Preferentially Expressed In Tumors 3
  • Opa-Interacting Protein OIP4 3
  • CT130 3

External Ids for PRAME Gene

Previous HGNC Symbols for PRAME Gene

  • MAPE

Previous GeneCards Identifiers for PRAME Gene

  • GC22M019588
  • GC22M021214
  • GC22M020673
  • GC22M022890
  • GC22M005860

Summaries for PRAME Gene

Entrez Gene Summary for PRAME Gene

  • This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for PRAME Gene

PRAME (Preferentially Expressed Antigen In Melanoma) is a Protein Coding gene. Diseases associated with PRAME include Melanoma and Leukemia, Chronic Myeloid. Among its related pathways are NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include retinoic acid receptor binding. An important paralog of this gene is PRAMEF12.

UniProtKB/Swiss-Prot for PRAME Gene

  • Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

Gene Wiki entry for PRAME Gene

Additional gene information for PRAME Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAME Gene

Genomics for PRAME Gene

GeneHancer (GH) Regulatory Elements for PRAME Gene

Promoters and enhancers for PRAME Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J022558 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 650.7 +0.2 186 1.4 CLOCK FOXA2 SIN3A GLI4 KLF14 ZNF2 RAD21 ZNF335 GLIS2 ELK1 LL22NC03-63E9.3 PRAME LINC01659 PIR34503 IGL
GH22J022587 Enhancer 0.9 ENCODE 12.5 -27.7 -27744 0.2 HDGF PKNOX1 ATF1 ARNT ZNF280A ARID2 ZNF143 ZFP91 ATF7 REST IGLV2-33 IGLV5-52 TOP3B PPIL2 LL22NC03-63E9.3 PRAME IGLV2-28 IGLV3-27 ENSG00000225544 ENSG00000234630
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRAME on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRAME gene promoter:
  • AML1a

Genomic Locations for PRAME Gene

Genomic Locations for PRAME Gene
11,666 bases
Minus strand
11,646 bases
Minus strand

Genomic View for PRAME Gene

Genes around PRAME on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAME Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAME Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAME Gene

Proteins for PRAME Gene

  • Protein details for PRAME Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma antigen preferentially expressed in tumors
    Protein Accession:
    Secondary Accessions:
    • B2R6Y7
    • O43481
    • Q8IXN8

    Protein attributes for PRAME Gene

    509 amino acids
    Molecular mass:
    57890 Da
    Quaternary structure:
    • Interacts with RARA (via the ligand-binding domain); the interaction is direct and ligand (retinoic acid)-dependent. Interacts with EZH2; required to repress RAR signaling.
    • Tumor antigen recognized by cytolytic T lymphocytes.

neXtProt entry for PRAME Gene

Post-translational modifications for PRAME Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRAME Gene

Domains & Families for PRAME Gene

Gene Families for PRAME Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PRAME Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PRAME family.
  • Belongs to the PRAME family.
genes like me logo Genes that share domains with PRAME: view

Function for PRAME Gene

Molecular function for PRAME Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
GENATLAS Biochemistry:
preferentially expressed antigen in melanoma

Gene Ontology (GO) - Molecular Function for PRAME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16179254
GO:0042974 retinoic acid receptor binding IDA 16179254
genes like me logo Genes that share ontologies with PRAME: view
genes like me logo Genes that share phenotypes with PRAME: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRAME Gene

Localization for PRAME Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRAME Gene

Nucleus. Cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRAME gene
Compartment Confidence
plasma membrane 4
nucleus 4
mitochondrion 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRAME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PRAME: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRAME Gene

Pathways & Interactions for PRAME Gene

SuperPathways for PRAME Gene

SuperPathway Contained pathways
1 NF-kappaB Signaling
genes like me logo Genes that share pathways with PRAME: view

Pathways by source for PRAME Gene

1 Cell Signaling Technology pathway for PRAME Gene

Gene Ontology (GO) - Biological Process for PRAME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0008284 positive regulation of cell proliferation IDA 16179254
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with PRAME: view

No data available for SIGNOR curated interactions for PRAME Gene

Drugs & Compounds for PRAME Gene

(4) Drugs for PRAME Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azacitidine Approved, Investigational Pharma 581
Antimetabolites Pharma 12587
Antimetabolites, Antineoplastic Pharma 7688
Vaccines Pharma 6921
genes like me logo Genes that share compounds with PRAME: view

Transcripts for PRAME Gene

Unigene Clusters for PRAME Gene

Preferentially expressed antigen in melanoma:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRAME Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - - - -
SP7: -
SP8: - -

Relevant External Links for PRAME Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRAME Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRAME Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRAME Gene

This gene is overexpressed in Testis (x43.8).

Protein differential expression in normal tissues from HIPED for PRAME Gene

This gene is overexpressed in Spinal cord (47.5) and Blymphocyte (21.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRAME Gene

Protein tissue co-expression partners for PRAME Gene

NURSA nuclear receptor signaling pathways regulating expression of PRAME Gene:


SOURCE GeneReport for Unigene cluster for PRAME Gene:


mRNA Expression by UniProt/SwissProt for PRAME Gene:

Tissue specificity: Expressed in testis. Detected in samples of kidney, brain and skin.

Evidence on tissue expression from TISSUES for PRAME Gene

  • Skin(4.9)
  • Nervous system(4.7)
  • Blood(2)
genes like me logo Genes that share expression patterns with PRAME: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRAME Gene

Orthologs for PRAME Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRAME Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRAME 34 33
  • 98.23 (n)
(Canis familiaris)
Mammalia PRAME 34 33
  • 79.36 (n)
(Bos Taurus)
Mammalia LOC100300040 33
  • 71.49 (n)
-- 34
  • 66 (a)
-- 34
  • 65 (a)
-- 34
  • 62 (a)
PRAME 34 34
  • 62 (a)
-- 34
  • 53 (a)
-- 34
  • 32 (a)
(Mus musculus)
Mammalia Prame 34
  • 34 (a)
Gm15023 34
  • 32 (a)
AV320801 34
  • 32 (a)
Pramel3 34
  • 32 (a)
Gm7903 34
  • 32 (a)
Gm5128 34
  • 32 (a)
(Monodelphis domestica)
Mammalia PRAME 34
  • 20 (a)
Species where no ortholog for PRAME was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRAME Gene

Gene Tree for PRAME (if available)
Gene Tree for PRAME (if available)
Evolutionary constrained regions (ECRs) for PRAME: view image

Paralogs for PRAME Gene

(26) SIMAP similar genes for PRAME Gene using alignment to 8 proteins:

  • B5MD04_HUMAN
  • E7EW99_HUMAN
  • F5H4B1_HUMAN
  • F8WF80_HUMAN
  • H7C2P3_HUMAN Pseudogenes for PRAME Gene

genes like me logo Genes that share paralogs with PRAME: view

Variants for PRAME Gene

Sequence variations from dbSNP and Humsavar for PRAME Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000046814 -- 22,557,330(-) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000098577 -- 22,557,155(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000688492 -- 22,552,599(-) T/C intron_variant
rs1000700157 -- 22,550,529(-) C/A intron_variant
rs1000864300 -- 22,555,449(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRAME Gene

Variant ID Type Subtype PubMed ID
dgv2442n106 CNV deletion 24896259
dgv38n64 CNV loss 17921354
dgv39n64 CNV loss 17921354
dgv4505n100 CNV loss 25217958
dgv4506n100 CNV loss 25217958
dgv4507n100 CNV loss 25217958
dgv4510n100 CNV loss 25217958
dgv4511n100 CNV gain 25217958
dgv548n27 CNV loss 19166990
dgv550n27 CNV loss 19166990
dgv551n27 CNV loss 19166990
dgv555n27 CNV loss 19166990
dgv557n27 CNV loss 19166990
dgv558n27 CNV loss 19166990
dgv560n27 CNV loss 19166990
dgv731n67 CNV loss 20364138
dgv8004n54 CNV loss 21841781
dgv8005n54 CNV loss 21841781
dgv8010n54 CNV loss 21841781
dgv8012n54 CNV loss 21841781
dgv8014n54 CNV loss 21841781
dgv8015n54 CNV loss 21841781
dgv8016n54 CNV loss 21841781
dgv8017n54 CNV gain+loss 21841781
dgv8018n54 CNV gain 21841781
dgv8019n54 CNV gain 21841781
dgv8020n54 CNV loss 21841781
dgv8021n54 CNV gain+loss 21841781
dgv8022n54 CNV loss 21841781
dgv8023n54 CNV loss 21841781
dgv826e214 CNV loss 21293372
esv1007524 CNV gain 20482838
esv2422480 CNV deletion 17116639
esv3568288 CNV loss 25503493
esv3568289 CNV loss 25503493
esv3568290 CNV loss 25503493
esv3647369 CNV loss 21293372
nsv1060145 CNV gain 25217958
nsv1063128 CNV gain+loss 25217958
nsv1072205 CNV deletion 25765185
nsv433336 CNV loss 18776910
nsv438338 CNV loss 16468122
nsv459421 CNV gain 19166990
nsv459539 CNV loss 19166990
nsv459548 CNV loss 19166990
nsv469742 CNV gain+loss 16826518
nsv479710 CNV novel sequence insertion 20440878
nsv508727 CNV insertion 20534489
nsv511072 OTHER complex 20534489
nsv514963 CNV gain+loss 21397061
nsv526328 CNV gain 19592680
nsv588348 CNV gain 21841781
nsv588469 CNV loss 21841781
nsv588472 CNV loss 21841781
nsv588474 CNV gain 21841781
nsv588475 CNV gain 21841781
nsv588478 CNV gain+loss 21841781
nsv588484 CNV loss 21841781
nsv588491 CNV gain+loss 21841781
nsv588492 CNV loss 21841781
nsv588493 CNV loss 21841781
nsv588498 CNV gain 21841781
nsv588499 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv817937 CNV loss 17921354
nsv817957 CNV gain 17921354
nsv819428 CNV gain 19587683
nsv821694 CNV loss 15273396
nsv828977 CNV loss 20364138
nsv828979 CNV gain+loss 20364138
nsv834149 CNV loss 17160897
nsv834150 CNV loss 17160897

Variation tolerance for PRAME Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRAME Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAME Gene

Disorders for PRAME Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRAME Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
leukemia, chronic myeloid
  • cml
hematologic cancer
  • blood cancer
leukemia, acute myeloid
  • aml
- elite association - COSMIC cancer census association via MalaCards
Search PRAME in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRAME

genes like me logo Genes that share disorders with PRAME: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRAME Gene

Publications for PRAME Gene

  1. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. (PMID: 9047241) Ikeda H … Coulie PG (Immunity 1997) 2 3 4 22 58
  2. The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. (PMID: 16179254) Epping MT … Bernards R (Cell 2005) 3 4 22 58
  3. Identification of genes associated with non-small-cell lung cancer promotion and progression. (PMID: 19473719) Bankovic J … Tanic N (Lung cancer (Amsterdam, Netherlands) 2010) 3 22 58
  4. Expression patterns of WT1 and PRAME in acute myeloid leukemia patients and their usefulness for monitoring minimal residual disease. (PMID: 18950857) Qin Y … Huang X (Leukemia research 2009) 3 22 58
  5. Array CGH analysis of chronic lymphocytic leukemia reveals frequent cryptic monoallelic and biallelic deletions of chromosome 22q11 that include the PRAME gene. (PMID: 19027161) Gunn SR … Robetorye RS (Leukemia research 2009) 3 22 58

Products for PRAME Gene

Sources for PRAME Gene

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