The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the ... See more...

Aliases for PRAM1 Gene

Aliases for PRAM1 Gene

  • PML-RARA Regulated Adaptor Molecule 1 2 3 5
  • PML-RARA-Regulated Adapter Molecule 1 3 4
  • PRAM-1 3 4
  • PRAM 3 4
  • PML-RARA Target Gene Encoding An Adaptor Molecule-1 3
  • PML-RAR 3

External Ids for PRAM1 Gene

Previous GeneCards Identifiers for PRAM1 Gene

  • GC19M008461
  • GC19M008210
  • GC19M008554

Summaries for PRAM1 Gene

Entrez Gene Summary for PRAM1 Gene

  • The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]

GeneCards Summary for PRAM1 Gene

PRAM1 (PML-RARA Regulated Adaptor Molecule 1) is a Protein Coding gene. Diseases associated with PRAM1 include Acute Promyelocytic Leukemia and Retinitis Pigmentosa 58. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is FYB1.

UniProtKB/Swiss-Prot Summary for PRAM1 Gene

  • May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.

Gene Wiki entry for PRAM1 Gene

Additional gene information for PRAM1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRAM1 Gene

Genomics for PRAM1 Gene

GeneHancer (GH) Regulatory Elements for PRAM1 Gene

Promoters and enhancers for PRAM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J008499 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 514.2 +0.8 775 4.2 ZIC2 HES1 ZNF341 WT1 SPI1 NR2F2 ZNF213 NR2F1 REST GLIS1 PRAM1 piR-61945-243 MYO1F ZNF414 MARCHF2 ZNF558
GH19J008504 Enhancer 0.9 ENCODE dbSUPER 500.7 -1.9 -1881 0.7 HES1 MYC RUNX1 CTBP1 ZNF282 SRF MAX TAL1 NR2F1 HDAC2 PRAM1 ZNF414 lnc-PRAM1-1
GH19J008511 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.4 -12.7 -12684 9.9 ZBTB40 EP300 SIN3A NRF1 POLR2G GTF2E2 PHF8 CTCF ZNF10 ZBTB5 ZNF414 lnc-HNRNPM-6 lnc-ZNF414-1 MYO1F ZNF177 ZNF317 PRAM1 ZNF699 ENSG00000267273 STXBP2
GH19J008469 Enhancer 1.1 Ensembl ENCODE dbSUPER 21.8 +29.8 29756 6.2 SP1 EP300 TRIM22 BCL11A TCF12 CBFB MAFF ZNF263 MAFK RBM22 lnc-KANK3-3 MARCHF2 PRAM1 piR-43107-136 HNRNPM
GH19J008566 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 11.5 -69.9 -69874 11.3 SP1 GTF2E2 JUND FOS EP300 ZIC2 AFF1 HES1 TSC22D4 TOE1 MYO1F piR-57138-029 PRAM1 ENSG00000267986 ZNF558 XAB2 MARCHF2 RAB11B lnc-ADAMTS10-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRAM1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRAM1

Top Transcription factor binding sites by QIAGEN in the PRAM1 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • c-Myc
  • E47
  • FOXC1
  • Max
  • RORalpha1
  • Tal-1

Genomic Locations for PRAM1 Gene

Genomic Locations for PRAM1 Gene
chr19:8,490,055-8,502,654
(GRCh38/hg38)
Size:
12,600 bases
Orientation:
Minus strand
chr19:8,554,940-8,567,996
(GRCh37/hg19)
Size:
13,057 bases
Orientation:
Minus strand

Genomic View for PRAM1 Gene

Genes around PRAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAM1 Gene

Proteins for PRAM1 Gene

  • Protein details for PRAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QH2-PRAM_HUMAN
    Recommended name:
    PML-RARA-regulated adapter molecule 1
    Protein Accession:
    Q96QH2
    Secondary Accessions:
    • Q8N6W7

    Protein attributes for PRAM1 Gene

    Size:
    670 amino acids
    Molecular mass:
    73969 Da
    Quaternary structure:
    • Interacts with SKAP2, LCP2 and DBNL. May interact with LYN. Interacts with NEK6.

neXtProt entry for PRAM1 Gene

Post-translational modifications for PRAM1 Gene

Other Protein References for PRAM1 Gene

No data available for DME Specific Peptides for PRAM1 Gene

Domains & Families for PRAM1 Gene

Gene Families for PRAM1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRAM1 Gene

Blocks:
  • SH3 domain signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRAM1 Gene

GenScript: Design optimal peptide antigens:
  • PML-RARA-regulated adapter molecule 1 (PRAM_HUMAN)
  • PML-RAR protein (Q15156_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96QH2

UniProtKB/Swiss-Prot:

PRAM_HUMAN :
  • The SH3 domain binds to PtdIns(4)P.
Domain:
  • The SH3 domain binds to PtdIns(4)P.
genes like me logo Genes that share domains with PRAM1: view

Function for PRAM1 Gene

Molecular function for PRAM1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.
UniProtKB/Swiss-Prot Induction:
Down-regulated by the PML-RARA oncogene, a fusion protein expressed in a vast majority of acute promyelocytic leukemia. Up-regulated by retinoic acid or arsenic trioxide in cells expressing PML-RARA.

Phenotypes From GWAS Catalog for PRAM1 Gene

Gene Ontology (GO) - Molecular Function for PRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21163940
GO:0008289 lipid binding IEA --
GO:0019901 protein kinase binding IPI 20873783
genes like me logo Genes that share ontologies with PRAM1: view
genes like me logo Genes that share phenotypes with PRAM1: view

Animal Models for PRAM1 Gene

MGI Knock Outs for PRAM1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRAM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRAM1 Gene

Localization for PRAM1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRAM1 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0032991 protein-containing complex IDA 20873783
genes like me logo Genes that share ontologies with PRAM1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRAM1 Gene

Pathways & Interactions for PRAM1 Gene

PathCards logo

SuperPathways for PRAM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007229 integrin-mediated signaling pathway IEA,IBA 21873635
GO:0043313 regulation of neutrophil degranulation IEA --
GO:0050852 T cell receptor signaling pathway IBA 21873635
GO:0072659 protein localization to plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with PRAM1: view

No data available for Pathways by source and SIGNOR curated interactions for PRAM1 Gene

Drugs & Compounds for PRAM1 Gene

No Compound Related Data Available

Transcripts for PRAM1 Gene

mRNA/cDNA for PRAM1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRAM1

Alternative Splicing Database (ASD) splice patterns (SP) for PRAM1 Gene

No ASD Table

Relevant External Links for PRAM1 Gene

GeneLoc Exon Structure for
PRAM1

Expression for PRAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRAM1 Gene

This gene is overexpressed in Whole Blood (x29.6).

Protein differential expression in normal tissues from HIPED for PRAM1 Gene

This gene is overexpressed in Monocytes (40.7) and Peripheral blood mononuclear cells (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRAM1 Gene



Protein tissue co-expression partners for PRAM1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRAM1

SOURCE GeneReport for Unigene cluster for PRAM1 Gene:

Hs.465812

mRNA Expression by UniProt/SwissProt for PRAM1 Gene:

Q96QH2-PRAM_HUMAN
Tissue specificity: Expressed in peripheral blood leukocytes and bone marrow. Expressed in monocytes, and to a lesser extent in granulocytes and lymphocytes. Not expressed in non hematopoietic tissues except in lung.

Evidence on tissue expression from TISSUES for PRAM1 Gene

  • Blood(4.6)
  • Bone marrow(3.2)
genes like me logo Genes that share expression patterns with PRAM1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRAM1 Gene

Orthologs for PRAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRAM1 31 30
  • 99.12 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRAM1 31 30
  • 78.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRAM1 31 30
  • 74.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pram1 17 31 30
  • 72.35 (n)
rat
(Rattus norvegicus)
Mammalia Pram1 30
  • 67.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 22 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU855733.1 31
  • 29 (a)
OneToOne
Species where no ortholog for PRAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRAM1 Gene

ENSEMBL:
Gene Tree for PRAM1 (if available)
TreeFam:
Gene Tree for PRAM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRAM1: view image

Paralogs for PRAM1 Gene

Paralogs for PRAM1 Gene

(1) SIMAP similar genes for PRAM1 Gene using alignment to 3 proteins:

  • PRAM_HUMAN
  • K4DI84_HUMAN
  • M0R149_HUMAN
genes like me logo Genes that share paralogs with PRAM1: view

Variants for PRAM1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRAM1 Gene

PRAM_HUMAN-Q96QH2
Some transcripts displayed additional 12 amino acid repeats of K-P-P-[PQ]-P-[EQ]-[VAF]-T-D-L-P-K (PubMed:11301322). We cannot rule out that they may represent genetic variants.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRAM1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
730319 Benign: not provided 8,499,727(-) C/T SYNONYMOUS_VARIANT
768965 Benign: not provided 8,499,028(-) G/T MISSENSE_VARIANT
769953 Benign: not provided 8,499,582(-) C/A MISSENSE_VARIANT
769954 Benign: not provided 8,499,585(-) C/G MISSENSE_VARIANT
769955 Benign: not provided 8,499,590(-) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for PRAM1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRAM1 Gene

Variant ID Type Subtype PubMed ID
dgv137n111 CNV deletion 26073780
dgv396n27 CNV loss 19166990
dgv6258n54 CNV loss 21841781
nsv137944 CNV insertion 16902084
nsv458350 CNV loss 19166990
nsv578559 CNV loss 21841781

Variation tolerance for PRAM1 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.17; 80.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRAM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRAM1

SNP Genotyping and Copy Number Assay Products

Disorders for PRAM1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRAM1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PRAM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRAM1

genes like me logo Genes that share disorders with PRAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRAM1 Gene

Publications for PRAM1 Gene

  1. PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. (PMID: 11301322) Moog-Lutz C … Koretzky G (The Journal of biological chemistry 2001) 2 3 4 23 54
  2. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G … Kobarg J (Journal of proteome research 2010) 3 4 54
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 41 54
  4. Lipid-binding hSH3 domains in immune cell adapter proteins. (PMID: 16831444) Heuer K … Freund C (Journal of molecular biology 2006) 3 4 54
  5. PRAM-1 potentiates arsenic trioxide-induced JNK activation. (PMID: 15637062) Denis FM … Lutz PG (The Journal of biological chemistry 2005) 3 4 54

Products for PRAM1 Gene

Sources for PRAM1 Gene