Aliases for PRAM1 Gene
External Ids for PRAM1 Gene
Previous GeneCards Identifiers for PRAM1 Gene
The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]
GeneCards Summary for PRAM1 Gene
PRAM1 (PML-RARA Regulated Adaptor Molecule 1) is a Protein Coding gene. Diseases associated with PRAM1 include Acute Promyelocytic Leukemia and Leukemia, Acute Myeloid. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is FYB1.
UniProtKB/Swiss-Prot for PRAM1 Gene
May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.