Aliases for PRAF2 Gene

Aliases for PRAF2 Gene

  • PRA1 Domain Family Member 2 2 3 5
  • PRA1 Family Protein 2 3 4
  • Yip6a 2 3
  • JM4 2 3
  • PRA1 Domain Family, Member 2 2
  • PRA1 Domain Family 2 2
  • Jena-Muenchen 4 3
  • PRAF2 5

External Ids for PRAF2 Gene

Previous GeneCards Identifiers for PRAF2 Gene

  • GC0XM048685
  • GC0XM048815
  • GC0XM048928
  • GC0XM046585
  • GC0XM049072

Summaries for PRAF2 Gene

GeneCards Summary for PRAF2 Gene

PRAF2 (PRA1 Domain Family Member 2) is a Protein Coding gene. Diseases associated with PRAF2 include Neuroblastoma. An important paralog of this gene is ARL6IP5.

UniProtKB/Swiss-Prot Summary for PRAF2 Gene

  • May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis.

Additional gene information for PRAF2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRAF2 Gene

Genomics for PRAF2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRAF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRAF2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRAF2

Top Transcription factor binding sites by QIAGEN in the PRAF2 gene promoter:
  • CREB
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • E47
  • PPAR-gamma2
  • Tal-1beta

Genomic Locations for PRAF2 Gene

Genomic Locations for PRAF2 Gene
2,842 bases
Minus strand
2,918 bases
Minus strand

Genomic View for PRAF2 Gene

Genes around PRAF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAF2 Gene

Proteins for PRAF2 Gene

  • Protein details for PRAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PRA1 family protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RD20

    Protein attributes for PRAF2 Gene

    178 amino acids
    Molecular mass:
    19258 Da
    Quaternary structure:
    • Interacts with CCR5 and GDE1.

neXtProt entry for PRAF2 Gene

Post-translational modifications for PRAF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRAF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRAF2 Gene

Domains & Families for PRAF2 Gene

Gene Families for PRAF2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for PRAF2 Gene


Suggested Antigen Peptide Sequences for PRAF2 Gene

GenScript: Design optimal peptide antigens:
  • PRA1 family protein 2 (PRAF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PRA1 family.
  • Belongs to the PRA1 family.
genes like me logo Genes that share domains with PRAF2: view

Function for PRAF2 Gene

Molecular function for PRAF2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis.

Phenotypes From GWAS Catalog for PRAF2 Gene

genes like me logo Genes that share phenotypes with PRAF2: view

Animal Models for PRAF2 Gene

MGI Knock Outs for PRAF2:
  • Praf2 Praf2<tm1e(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for PRAF2

CRISPR Products

miRNA for PRAF2 Gene

miRTarBase miRNAs that target PRAF2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRAF2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRAF2 Gene

Localization for PRAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRAF2 Gene

Endosome membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRAF2 gene
Compartment Confidence
endosome 3
endoplasmic reticulum 2
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0010008 endosome membrane IEA --
GO:0016020 membrane IEA,IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRAF2: view

Pathways & Interactions for PRAF2 Gene

PathCards logo

SuperPathways for PRAF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0015813 L-glutamate transmembrane transport ISS --
genes like me logo Genes that share ontologies with PRAF2: view

No data available for Pathways by source and SIGNOR curated interactions for PRAF2 Gene

Drugs & Compounds for PRAF2 Gene

No Compound Related Data Available

Transcripts for PRAF2 Gene

mRNA/cDNA for PRAF2 Gene

8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRAF2

Alternative Splicing Database (ASD) splice patterns (SP) for PRAF2 Gene

No ASD Table

Relevant External Links for PRAF2 Gene

GeneLoc Exon Structure for

Expression for PRAF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRAF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRAF2 Gene

This gene is overexpressed in Nasal epithelium (8.5) and Fetal testis (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRAF2 Gene

Protein tissue co-expression partners for PRAF2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRAF2

SOURCE GeneReport for Unigene cluster for PRAF2 Gene:


mRNA Expression by UniProt/SwissProt for PRAF2 Gene:

Tissue specificity: Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non-neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles.

Evidence on tissue expression from TISSUES for PRAF2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with PRAF2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRAF2 Gene

Orthologs for PRAF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRAF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRAF2 30
  • 99.44 (n)
(Bos Taurus)
Mammalia PRAF2 30 31
  • 90.82 (n)
(Canis familiaris)
Mammalia PRAF2 30 31
  • 89.89 (n)
(Rattus norvegicus)
Mammalia Praf2 30
  • 87.27 (n)
(Mus musculus)
Mammalia Praf2 30 17 31
  • 86.7 (n)
(Anolis carolinensis)
Reptilia PRAF2 31
  • 66 (a)
(Danio rerio)
Actinopterygii praf2 30 31
  • 58.8 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Jwa 31
  • 29 (a)
(Caenorhabditis elegans)
Secernentea praf-3 31
  • 28 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9659 31
  • 43 (a)
Species where no ortholog for PRAF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for PRAF2 Gene

Gene Tree for PRAF2 (if available)
Gene Tree for PRAF2 (if available)
Evolutionary constrained regions (ECRs) for PRAF2: view image

Paralogs for PRAF2 Gene

Paralogs for PRAF2 Gene

(2) SIMAP similar genes for PRAF2 Gene using alignment to 2 proteins:

  • A6NP52_HUMAN
genes like me logo Genes that share paralogs with PRAF2: view

Variants for PRAF2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRAF2 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs34565429 - p.Leu56Phe

Additional dbSNP identifiers (rs#s) for PRAF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRAF2 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV gain+loss 17666407
nsv528292 CNV gain 19592680

Variation tolerance for PRAF2 Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRAF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAF2 Gene

Disorders for PRAF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRAF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • nb
- elite association - COSMIC cancer census association via MalaCards
Search PRAF2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PRAF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRAF2 Gene

Publications for PRAF2 Gene

  1. Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PMID: 16481131) Fo CS … Bachmann AS (Gene 2006) 2 3 4 23
  2. Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles. (PMID: 18395978) Koomoa DL … Bachmann AS (Neuroscience letters 2008) 3 4 23
  3. Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation. (PMID: 17975142) Geerts D … Bachmann AS (Clinical cancer research : an official journal of the American Association for Cancer Research 2007) 3 4
  4. JM4 is a four-transmembrane protein binding to the CCR5 receptor. (PMID: 15757671) Schweneker M … Moelling K (FEBS letters 2005) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for PRAF2 Gene

  • Boster Bio Antibodies for PRAF2
  • Boster Bio ELISA Kits for PRAF2

Sources for PRAF2 Gene