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Aliases for PRADC1 Gene

Aliases for PRADC1 Gene

  • Protease Associated Domain Containing 1 2 3 5
  • Protease-Associated Domain-Containing Glycoprotein 21 KDa 2 3
  • Protease-Associated Domain-Containing Protein Of 21 KDa 3 4
  • C2orf7 3 4
  • PAP21 3 4
  • Protease-Associated Domain-Containing Protein 1 3
  • Chromosome 2 Open Reading Frame 7 2
  • HPAP21 4

External Ids for PRADC1 Gene

Previous HGNC Symbols for PRADC1 Gene

  • C2orf7

Previous GeneCards Identifiers for PRADC1 Gene

  • GC02M073455

Summaries for PRADC1 Gene

GeneCards Summary for PRADC1 Gene

PRADC1 (Protease Associated Domain Containing 1) is a Protein Coding gene. Diseases associated with PRADC1 include Pyelitis.

Additional gene information for PRADC1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRADC1 Gene

Genomics for PRADC1 Gene

GeneHancer (GH) Regulatory Elements for PRADC1 Gene

Promoters and enhancers for PRADC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J073232 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 661.5 -1.1 -1095 3.9 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 NFYC CCT7 PRADC1 ENSG00000273245 DUSP11 MOB1A FBXO41 TPRKB ALMS1 DGUOK DGUOK-AS1
GH02J073213 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.5 +18.7 18700 2.5 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 SMYD5 MOB1A DUSP11 PRADC1 ENSG00000273245 CCT7
GH02J073175 Enhancer 1.6 FANTOM5 Ensembl ENCODE 11.9 +56.6 56584 3.2 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF213 E2F8 ALMS1 ENSG00000273245 SMYD5 DUSP11 SFXN5 PRADC1 NOTO SPR EMX1 CCT7
GH02J073212 Enhancer 0.8 ENCODE 20.1 +20.4 20380 0.7 ELF3 RB1 ZSCAN4 ARID4B DMAP1 ZNF48 RAD21 SLC30A9 ZNF121 SCRT2 SMYD5 PRADC1 CCT7 RAB11FIP5 SFXN5 SPR NOTO
GH02J073156 Enhancer 1 Ensembl ENCODE 9.6 +76.5 76457 0.9 ELF3 RB1 ARID4B SIN3A ZNF2 ZNF48 RAD21 ETS1 ARID2 ZNF143 RAB11FIP5 DUSP11 ENSG00000273245 PRADC1 SFXN5 GC02P073186
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRADC1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRADC1 Gene

Genomic Locations for PRADC1 Gene
chr2:73,228,006-73,233,238
(GRCh38/hg38)
Size:
5,233 bases
Orientation:
Minus strand
chr2:73,455,134-73,460,366
(GRCh37/hg19)
Size:
5,233 bases
Orientation:
Minus strand

Genomic View for PRADC1 Gene

Genes around PRADC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRADC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRADC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRADC1 Gene

Proteins for PRADC1 Gene

  • Protein details for PRADC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSG0-PADC1_HUMAN
    Recommended name:
    Protease-associated domain-containing protein 1
    Protein Accession:
    Q9BSG0
    Secondary Accessions:
    • Q2Z1P2

    Protein attributes for PRADC1 Gene

    Size:
    188 amino acids
    Molecular mass:
    21042 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRADC1 Gene

Post-translational modifications for PRADC1 Gene

Other Protein References for PRADC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRADC1 Gene

Domains & Families for PRADC1 Gene

Gene Families for PRADC1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PRADC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRADC1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRADC1: view

No data available for UniProtKB/Swiss-Prot for PRADC1 Gene

Function for PRADC1 Gene

Phenotypes From GWAS Catalog for PRADC1 Gene

Gene Ontology (GO) - Molecular Function for PRADC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PRADC1: view
genes like me logo Genes that share phenotypes with PRADC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRADC1

miRNA for PRADC1 Gene

miRTarBase miRNAs that target PRADC1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRADC1 Gene

Localization for PRADC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRADC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRADC1 gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PRADC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA,IEA 15498570
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with PRADC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRADC1 Gene

Pathways & Interactions for PRADC1 Gene

SuperPathways for PRADC1 Gene

No Data Available

Interacting Proteins for PRADC1 Gene

Gene Ontology (GO) - Biological Process for PRADC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRADC1 Gene

Drugs & Compounds for PRADC1 Gene

No Compound Related Data Available

Transcripts for PRADC1 Gene

mRNA/cDNA for PRADC1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(135) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRADC1 Gene

Protease-associated domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRADC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5
SP1:
SP2: -

Relevant External Links for PRADC1 Gene

GeneLoc Exon Structure for
PRADC1
ECgene alternative splicing isoforms for
PRADC1

Expression for PRADC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRADC1 Gene

Protein differential expression in normal tissues from HIPED for PRADC1 Gene

This gene is overexpressed in Vitreous humor (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRADC1 Gene



Protein tissue co-expression partners for PRADC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRADC1 Gene:

PRADC1

SOURCE GeneReport for Unigene cluster for PRADC1 Gene:

Hs.61268

mRNA Expression by UniProt/SwissProt for PRADC1 Gene:

Q9BSG0-PADC1_HUMAN
Tissue specificity: Highly expressed in skeletal muscle, heart and liver. Expressed at intermediate level in kidney.

Evidence on tissue expression from TISSUES for PRADC1 Gene

  • Muscle(4.4)
genes like me logo Genes that share expression patterns with PRADC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRADC1 Gene

Orthologs for PRADC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRADC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRADC1 34 33
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia C2ORF7 34
  • 98 (a)
OneToOne
PRADC1 33
  • 96.1 (n)
cow
(Bos Taurus)
Mammalia C11H2ORF7 34
  • 98 (a)
OneToOne
PRADC1 33
  • 96.63 (n)
mouse
(Mus musculus)
Mammalia Pradc1 16 34 33
  • 91.31 (n)
rat
(Rattus norvegicus)
Mammalia Pradc1 33
  • 90.6 (n)
oppossum
(Monodelphis domestica)
Mammalia PRADC1 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRADC1 34 33
  • 80.3 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRADC1 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pradc1 33
  • 71.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9849 34 33
  • 52.62 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6766 34
  • 38 (a)
OneToOne
Species where no ortholog for PRADC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRADC1 Gene

ENSEMBL:
Gene Tree for PRADC1 (if available)
TreeFam:
Gene Tree for PRADC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRADC1: view image

Paralogs for PRADC1 Gene

Pseudogenes.org Pseudogenes for PRADC1 Gene

genes like me logo Genes that share paralogs with PRADC1: view

No data available for Paralogs for PRADC1 Gene

Variants for PRADC1 Gene

Sequence variations from dbSNP and Humsavar for PRADC1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000407661 -- 73,231,335(-) G/A intron_variant
rs1000464461 -- 73,231,245(-) G/A intron_variant
rs1000766625 -- 73,230,861(-) A/C intron_variant
rs1001318097 -- 73,234,918(-) T/C upstream_transcript_variant
rs1001522248 -- 73,231,916(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRADC1 Gene

Variant ID Type Subtype PubMed ID
nsv2776 CNV deletion 18451855

Variation tolerance for PRADC1 Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRADC1 Gene

Human Gene Mutation Database (HGMD)
PRADC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRADC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRADC1 Gene

Disorders for PRADC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRADC1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
pyelitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PRADC1

genes like me logo Genes that share disorders with PRADC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRADC1 Gene

Publications for PRADC1 Gene

  1. N-glycosylation is required for efficient secretion of a novel human secreted glycoprotein, hPAP21. (PMID: 15498570) Zhou YB … Han ZG (FEBS letters 2004) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for PRADC1 Gene

Sources for PRADC1 Gene

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