This gene is highly expressed in prostate, rectum, colon, and testis. This gene may produce a non-coding RNA or may encode a short protein that might localize to the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] See more...

Aliases for PRAC2 Gene

Aliases for PRAC2 Gene

  • PRAC2 Small Nuclear Protein 2 3 5
  • Prostate, Rectum And Colon Expressed Gene Protein 2 3 4
  • Prostate Cancer Susceptibility Candidate 2 2 3
  • Prostate, Rectum And Colon 2 2 3
  • HOXB Cluster Antisense RNA 5 2 3
  • Putative Protein PRAC2 3 4
  • HOXB13-AS1 3 4
  • NCRNA00253 3 4
  • C17orf93 3 4
  • HOXB-AS5 3 4
  • Prostate, Rectum And Colon Expressed Gene 2 Protein 3
  • HOXB Cluster Antisense RNA 5 (Non-Protein Coding) 2
  • HOXB13 Antisense RNA 1 (Non-Protein Coding) 2
  • Chromosome 17 Open Reading Frame 93 2
  • Small Nuclear Protein PRAC2 3
  • Non-Protein Coding RNA 253 2
  • Putative Protein PRCA2 3
  • HOXBAS5 3
  • PRAC2 5

External Ids for PRAC2 Gene

Previous HGNC Symbols for PRAC2 Gene

  • C17orf93
  • NCRNA00253
  • HOXB13-AS1
  • HOXB-AS5

Previous GeneCards Identifiers for PRAC2 Gene

  • GC17U900086
  • GC17P044155
  • GC17P046806
  • GC17P048725

Summaries for PRAC2 Gene

Entrez Gene Summary for PRAC2 Gene

  • This gene is highly expressed in prostate, rectum, colon, and testis. This gene may produce a non-coding RNA or may encode a short protein that might localize to the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for PRAC2 Gene

PRAC2 (PRAC2 Small Nuclear Protein) is a Protein Coding gene. Diseases associated with PRAC2 include Prostate Cancer.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRAC2 Gene

Genomics for PRAC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRAC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRAC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRAC2

Genomic Locations for PRAC2 Gene

Latest Assembly
chr17:48,720,802-48,724,758
(GRCh38/hg38)
Size:
3,957 bases
Orientation:
Plus strand

Previous Assembly
chr17:46,800,547-46,802,120
(GRCh37/hg19 by Entrez Gene)
Size:
1,574 bases
Orientation:
Plus strand

chr17:46,800,530-46,802,819
(GRCh37/hg19 by Ensembl)
Size:
2,290 bases
Orientation:
Plus strand

Genomic View for PRAC2 Gene

Genes around PRAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAC2 Gene

Proteins for PRAC2 Gene

  • Protein details for PRAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    D3DTV9-PRAC2_HUMAN
    Recommended name:
    Putative protein PRAC2
    Protein Accession:
    D3DTV9

    Protein attributes for PRAC2 Gene

    Size:
    90 amino acids
    Molecular mass:
    10428 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRAC2 Gene

Post-translational modifications for PRAC2 Gene

No Post-translational modifications

Other Protein References for PRAC2 Gene

No data available for DME Specific Peptides for PRAC2 Gene

Domains & Families for PRAC2 Gene

Gene Families for PRAC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
genes like me logo Genes that share domains with PRAC2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRAC2 Gene

Function for PRAC2 Gene

Phenotypes From GWAS Catalog for PRAC2 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRAC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRAC2 Gene

Localization for PRAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRAC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRAC2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for PRAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRAC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRAC2 Gene

Pathways & Interactions for PRAC2 Gene

PathCards logo

SuperPathways for PRAC2 Gene

No Data Available

Interacting Proteins for PRAC2 Gene

Gene Ontology (GO) - Biological Process for PRAC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRAC2 Gene

Drugs & Compounds for PRAC2 Gene

No Compound Related Data Available

Transcripts for PRAC2 Gene

mRNA/cDNA for PRAC2 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRAC2

Alternative Splicing Database (ASD) splice patterns (SP) for PRAC2 Gene

No ASD Table

Relevant External Links for PRAC2 Gene

GeneLoc Exon Structure for
PRAC2

Expression for PRAC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRAC2 Gene

mRNA differential expression in normal tissues according to GTEx for PRAC2 Gene

This gene is overexpressed in Prostate (x18.9), Bladder (x7.9), Vagina (x6.2), and Colon - Transverse (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRAC2

mRNA Expression by UniProt/SwissProt for PRAC2 Gene:

D3DTV9-PRAC2_HUMAN
Tissue specificity: Highly expressed in prostate and testis. Also detected in placenta, muscle, colon, peripheral blood leukocytes and skin.
genes like me logo Genes that share expression patterns with PRAC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRAC2 Gene

Orthologs for PRAC2 Gene

Evolution for PRAC2 Gene

ENSEMBL:
Gene Tree for PRAC2 (if available)
TreeFam:
Gene Tree for PRAC2 (if available)
Alliance of Genome Resources:
Additional Orthologs for PRAC2

No data available for Orthologs for PRAC2 Gene

Paralogs for PRAC2 Gene

Pseudogenes.org Pseudogenes for PRAC2 Gene

genes like me logo Genes that share paralogs with PRAC2: view

No data available for Paralogs for PRAC2 Gene

Variants for PRAC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRAC2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs116043950 Benign: not provided 48,721,857(+) C/T
NM_032391.3(PRAC1):c.118G>A (p.Asp40Asn)
MISSENSE
rs2271891 Benign: not provided 48,724,646(+) C/G
NM_001282275.2(PRAC2):c.236C>G (p.Thr79Arg)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PRAC2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PRAC2 Gene

Variant ID Type Subtype PubMed ID
esv2758694 CNV gain 17122850

Additional Variant Information for PRAC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRAC2
Leiden Open Variation Database (LOVD)
PRAC2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PRAC2 Gene

Disorders for PRAC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRAC2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PRAC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRAC2

genes like me logo Genes that share disorders with PRAC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRAC2 Gene

Publications for PRAC2 Gene

  1. PRAC2: a new gene expressed in human prostate and prostate cancer. (PMID: 12746837) Olsson P … Pastan I (The Prostate 2003) 2 3 4
  2. Inflammation-associated DNA methylation patterns in epithelium of ulcerative colitis. (PMID: 28557546) Barnicle A … Egan LJ (Epigenetics 2017) 2 3
  3. Long noncoding RNA HOXB13-AS1 regulates HOXB13 gene methylation by interacting with EZH2 in glioma. (PMID: 30105866) Xiong Y … Wu L (Cancer medicine 2018) 3
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4

Products for PRAC2 Gene

Sources for PRAC2 Gene