Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPTC7 Gene

Aliases for PPTC7 Gene

  • PTC7 Protein Phosphatase Homolog 2 3 5
  • EC 4 56
  • TA-PP2C 3 4
  • TAPP2C 3 4
  • PTC7 Protein Phosphatase Homolog (S. Cerevisiae) 2
  • T-Cell Activation Protein Phosphatase 2C-Like 4
  • T Cell Activation Protein Phosphatase 2C 2
  • T-Cell Activation Protein Phosphatase 2C 4
  • Protein Phosphatase PTC7 Homolog 3

External Ids for PPTC7 Gene

Previous GeneCards Identifiers for PPTC7 Gene

  • GC12M109456
  • GC12M110972
  • GC12M107991

Summaries for PPTC7 Gene

GeneCards Summary for PPTC7 Gene

PPTC7 (PTC7 Protein Phosphatase Homolog) is a Protein Coding gene. Among its related pathways are Development Dopamine D2 receptor transactivation of EGFR and Regulation of CFTR activity (norm and CF). Gene Ontology (GO) annotations related to this gene include phosphoprotein phosphatase activity.

Additional gene information for PPTC7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPTC7 Gene

Genomics for PPTC7 Gene

GeneHancer (GH) Regulatory Elements for PPTC7 Gene

Promoters and enhancers for PPTC7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I110580 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 554.3 -0.3 -251 5.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF213 PPTC7 MYL2 FAM216A ATP2A2 GPN3 GLTP ARPC3 TCTN1
GH12I110589 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -7.9 -7881 3.4 PKNOX1 FOXA2 ARID4B DMAP1 YY1 ZNF121 ATF7 RXRA SP5 REST ARPC3 TCTN1 PPTC7 FAM216A HVCN1
GH12I110555 Enhancer 1.1 Ensembl ENCODE dbSUPER 13.1 +27.3 27345 1.8 MEIS2 MAX SCRT2 SCRT1 SMARCC1 L3MBTL2 HLF CEBPB PRDM6 JUND GPN3 PPTC7 TCTN1 FAM216A VPS29
GH12I110552 Enhancer 0.8 ENCODE 13.1 +30.8 30819 0.2 ELF3 SOX13 CTCF ZNF449 ARID4B MAX CEBPG RAD21 TEAD3 ZNF143 PPTC7 TCTN1 VPS29
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPTC7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPTC7 gene promoter:

Genomic Locations for PPTC7 Gene

Genomic Locations for PPTC7 Gene
50,076 bases
Minus strand

Genomic View for PPTC7 Gene

Genes around PPTC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPTC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPTC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPTC7 Gene

Proteins for PPTC7 Gene

  • Protein details for PPTC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase PTC7 homolog
    Protein Accession:
    Secondary Accessions:
    • B3KWC5
    • Q68DZ7
    • Q6UY82

    Protein attributes for PPTC7 Gene

    304 amino acids
    Molecular mass:
    32646 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for PPTC7 Gene

Selected DME Specific Peptides for PPTC7 Gene


Post-translational modifications for PPTC7 Gene

No Post-translational modifications

Other Protein References for PPTC7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPTC7 Gene

Gene Families for PPTC7 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PPTC7 Gene

Suggested Antigen Peptide Sequences for PPTC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PP2C family.
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPTC7: view

Function for PPTC7 Gene

Molecular function for PPTC7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Induction:
Up-regulated during lymphocyte activation.

Enzyme Numbers (IUBMB) for PPTC7 Gene

Phenotypes From GWAS Catalog for PPTC7 Gene

Gene Ontology (GO) - Molecular Function for PPTC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPTC7: view
genes like me logo Genes that share phenotypes with PPTC7: view

Animal Model Products

CRISPR Products

miRNA for PPTC7 Gene

miRTarBase miRNAs that target PPTC7

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPTC7 Gene

Localization for PPTC7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPTC7 gene
Compartment Confidence
mitochondrion 3
cytosol 3
plasma membrane 2
extracellular 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPTC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with PPTC7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPTC7 Gene

Pathways & Interactions for PPTC7 Gene

genes like me logo Genes that share pathways with PPTC7: view

Pathways by source for PPTC7 Gene

Gene Ontology (GO) - Biological Process for PPTC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
genes like me logo Genes that share ontologies with PPTC7: view

No data available for SIGNOR curated interactions for PPTC7 Gene

Drugs & Compounds for PPTC7 Gene

(4) Drugs for PPTC7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Magnesium Approved Nutra 0
Manganese Approved Nutra 37
genes like me logo Genes that share compounds with PPTC7: view

Transcripts for PPTC7 Gene

mRNA/cDNA for PPTC7 Gene

Unigene Clusters for PPTC7 Gene

PTC7 protein phosphatase homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPTC7 Gene

No ASD Table

Relevant External Links for PPTC7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPTC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPTC7 Gene

mRNA differential expression in normal tissues according to GTEx for PPTC7 Gene

This gene is overexpressed in Muscle - Skeletal (x7.6).

Protein differential expression in normal tissues from HIPED for PPTC7 Gene

This gene is overexpressed in Heart (33.7) and CD8 Tcells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPTC7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PPTC7 Gene:


SOURCE GeneReport for Unigene cluster for PPTC7 Gene:


Evidence on tissue expression from TISSUES for PPTC7 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with PPTC7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPTC7 Gene

Orthologs for PPTC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPTC7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPTC7 33 34
  • 99.56 (n)
(Ornithorhynchus anatinus)
Mammalia PPTC7 34
  • 99 (a)
(Monodelphis domestica)
Mammalia PPTC7 34
  • 96 (a)
(Canis familiaris)
Mammalia PPTC7 33 34
  • 94.08 (n)
(Bos Taurus)
Mammalia PPTC7 33 34
  • 93.75 (n)
(Mus musculus)
Mammalia Pptc7 33 16 34
  • 89.14 (n)
(Rattus norvegicus)
Mammalia Pptc7 33
  • 89.04 (n)
(Gallus gallus)
Aves PPTC7 33 34
  • 83.61 (n)
(Anolis carolinensis)
Reptilia PPTC7 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pptc7 33
  • 79.12 (n)
(Danio rerio)
Actinopterygii pptc7a 34
  • 94 (a)
pptc7b 33 34
  • 76.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12091 33 34
  • 56.82 (n)
fig 34
  • 39 (a)
CG15035 34
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002141 33
  • 52.99 (n)
(Caenorhabditis elegans)
Secernentea W09D10.4 33 34
  • 51.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC7 33 34 36
  • 46.3 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13134g 33
  • 45.64 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16580 33
  • 48.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2135 34
  • 64 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00958 33
  • 48.02 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes azr1 33
  • 44.88 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2504 33
Species where no ortholog for PPTC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPTC7 Gene

Gene Tree for PPTC7 (if available)
Gene Tree for PPTC7 (if available)

Paralogs for PPTC7 Gene

No data available for Paralogs for PPTC7 Gene

Variants for PPTC7 Gene

Sequence variations from dbSNP and Humsavar for PPTC7 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000298667 -- 110,564,243(-) T/C intron_variant
rs1000307267 -- 110,565,010(-) G/A intron_variant
rs1000341259 -- 110,541,312(-) A/G intron_variant
rs1000380052 -- 110,582,273(-) T/C intron_variant
rs1000440394 -- 110,548,138(-) T/C intron_variant

Variation tolerance for PPTC7 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPTC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPTC7 Gene

Disorders for PPTC7 Gene

Additional Disease Information for PPTC7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPTC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPTC7 Gene

Publications for PPTC7 Gene

  1. T lymphocyte activation gene identification by coregulated expression on DNA microarrays. (PMID: 15177553) Mao M … Linsley PS (Genomics 2004) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58

Products for PPTC7 Gene

Sources for PPTC7 Gene

Loading form....