Aliases for PPT2 Gene
External Ids for PPT2 Gene
Previous GeneCards Identifiers for PPT2 Gene
This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for PPT2 Gene
PPT2 (Palmitoyl-Protein Thioesterase 2) is a Protein Coding gene. Diseases associated with PPT2 include Neuronal Ceroid Lipofuscinosis and Narcolepsy. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include thiolester hydrolase activity and palmitoyl hydrolase activity. An important paralog of this gene is PPT2-EGFL8.
UniProtKB/Swiss-Prot for PPT2 Gene
Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.