Aliases for PPP6R2 Gene
External Ids for PPP6R2 Gene
Previous HGNC Symbols for PPP6R2 Gene
Previous GeneCards Identifiers for PPP6R2 Gene
The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]
GeneCards Summary for PPP6R2 Gene
PPP6R2 (Protein Phosphatase 6 Regulatory Subunit 2) is a Protein Coding gene. Diseases associated with PPP6R2 include Retinitis Pigmentosa 10. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PPP6R3.
UniProtKB/Swiss-Prot Summary for PPP6R2 Gene
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.