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Aliases for PPP5D1 Gene

Aliases for PPP5D1 Gene

  • PPP5 Tetratricopeptide Repeat Domain Containing 1 2 3 5
  • PPP5 TPR Repeat Domain-Containing Protein 1 3 4
  • Protein PPP5D1 3

External Ids for PPP5D1 Gene

Previous GeneCards Identifiers for PPP5D1 Gene

  • GC19M046985

Summaries for PPP5D1 Gene

GeneCards Summary for PPP5D1 Gene

PPP5D1 (PPP5 Tetratricopeptide Repeat Domain Containing 1) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway.

Additional gene information for PPP5D1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP5D1 Gene

Genomics for PPP5D1 Gene

GeneHancer (GH) Regulatory Elements for PPP5D1 Gene

Promoters and enhancers for PPP5D1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J046600 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 665.5 -1.2 -1195 4.6 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC ZC3H11A PPP5D1 CALM3 ENSG00000268423 GC19M046598 ZC3H4 CCDC61 ENSG00000268810 FBXO46 ENSG00000269148 CCDC9
GH19J047225 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 33.7 -628.2 -628181 8.2 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 BBC3 BICRA ENSG00000268810 NOP53-AS1 CCDC9 NOP53 ENSG00000269321 SNORD23 PPP5D1 INAFM1
GH19J047105 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -509.1 -509097 9.2 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZC3H4 ENSG00000268810 BICRA CCDC9 C5AR2 NOP53-AS1 PRKD2 NOP53 SNORD23 ENSG00000268746
GH19J046782 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.2 -184.6 -184582 6.8 MLX FEZF1 DMAP1 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC ZFP41 SLC1A5 ZC3H4 CCDC61 BICRA CCDC9 ENSG00000268810 NOP53-AS1 ENSG00000269148 PRKD2 SYMPK
GH19J046263 Enhancer 0.9 ENCODE 24.4 +338.1 338101 0.2 FEZF1 IRF4 ELK1 ATF7 FOS RUNX3 SP3 YY2 JUNB TSHZ1 IRF2BP1 ZC3H4 CCDC61 PPP5D1 ENSG00000269124 NOVA2 ENSG00000268810 PNMA8A HIF3A IGFL4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP5D1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PPP5D1 Gene

Genomic Locations for PPP5D1 Gene
chr19:46,480,788-46,601,200
(GRCh38/hg38)
Size:
120,413 bases
Orientation:
Minus strand
chr19:46,984,045-47,104,457
(GRCh37/hg19)
Size:
120,413 bases
Orientation:
Minus strand

Genomic View for PPP5D1 Gene

Genes around PPP5D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP5D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP5D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP5D1 Gene

Proteins for PPP5D1 Gene

  • Protein details for PPP5D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E7EU14-PP5D1_HUMAN
    Recommended name:
    Protein PPP5D1
    Protein Accession:
    E7EU14
    Secondary Accessions:
    • B3KSW5

    Protein attributes for PPP5D1 Gene

    Size:
    171 amino acids
    Molecular mass:
    19623 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Shares sequence similarity with serine/threonine-protein phosphatase PPP5C. However, it is much shorter and does not contain the phosphatase catalytic region.

neXtProt entry for PPP5D1 Gene

Post-translational modifications for PPP5D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP5D1 Gene

No data available for DME Specific Peptides for PPP5D1 Gene

Domains & Families for PPP5D1 Gene

Gene Families for PPP5D1 Gene

Protein Domains for PPP5D1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

E7EU14

UniProtKB/Swiss-Prot:

PP5D1_HUMAN :
  • Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
genes like me logo Genes that share domains with PPP5D1: view

No data available for Suggested Antigen Peptide Sequences for PPP5D1 Gene

Function for PPP5D1 Gene

Phenotypes From GWAS Catalog for PPP5D1 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP5D1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP5D1 Gene

Localization for PPP5D1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP5D1 gene
Compartment Confidence
mitochondrion 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP5D1 Gene

Pathways & Interactions for PPP5D1 Gene

SuperPathways for PPP5D1 Gene

SuperPathway Contained pathways
1 MAPK signaling pathway
genes like me logo Genes that share pathways with PPP5D1: view

Pathways by source for PPP5D1 Gene

1 KEGG pathway for PPP5D1 Gene

Interacting Proteins for PPP5D1 Gene

Gene Ontology (GO) - Biological Process for PPP5D1 Gene

None

No data available for SIGNOR curated interactions for PPP5D1 Gene

Drugs & Compounds for PPP5D1 Gene

No Compound Related Data Available

Transcripts for PPP5D1 Gene

mRNA/cDNA for PPP5D1 Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP5D1 Gene

PPP5 tetratricopeptide repeat domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP5D1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP5D1 Gene

No ASD Table

Relevant External Links for PPP5D1 Gene

GeneLoc Exon Structure for
PPP5D1
ECgene alternative splicing isoforms for
PPP5D1

Expression for PPP5D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP5D1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP5D1 Gene:

PPP5D1

SOURCE GeneReport for Unigene cluster for PPP5D1 Gene:

Hs.671661

Evidence on tissue expression from TISSUES for PPP5D1 Gene

  • Stomach(3.1)
  • Nervous system(2.8)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with PPP5D1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP5D1 Gene

Orthologs for PPP5D1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PPP5D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP5D1 34
  • 99 (a)
OneToOne
Species where no ortholog for PPP5D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPP5D1 Gene

ENSEMBL:
Gene Tree for PPP5D1 (if available)
TreeFam:
Gene Tree for PPP5D1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP5D1: view image

Paralogs for PPP5D1 Gene

(30) SIMAP similar genes for PPP5D1 Gene using alignment to 2 proteins:

  • PP5D1_HUMAN
  • M0R196_HUMAN

Pseudogenes.org Pseudogenes for PPP5D1 Gene

genes like me logo Genes that share paralogs with PPP5D1: view

No data available for Paralogs for PPP5D1 Gene

Variants for PPP5D1 Gene

Sequence variations from dbSNP and Humsavar for PPP5D1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1057523541 likely-benign, not specified 46,601,429(-) C/A upstream_transcript_variant
rs201296349 benign, not specified 46,601,421(-) C/A upstream_transcript_variant
rs1000047928 -- 46,516,661(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000070482 -- 46,589,574(-) G/A intron_variant
rs1000071149 -- 46,548,303(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP5D1 Gene

Variant ID Type Subtype PubMed ID
esv2668998 CNV deletion 23128226
esv3415796 CNV insertion 20981092
esv3556483 CNV deletion 23714750
esv3583443 CNV loss 25503493
esv3644532 CNV loss 21293372
nsv527638 CNV loss 19592680
nsv833849 CNV loss 17160897
nsv978831 CNV duplication 23825009

Variation tolerance for PPP5D1 Gene

Gene Damage Index Score: 1.09; 22.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP5D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP5D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP5D1 Gene

Disorders for PPP5D1 Gene

Additional Disease Information for PPP5D1

No disorders were found for PPP5D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP5D1 Gene

Publications for PPP5D1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for PPP5D1 Gene

Sources for PPP5D1 Gene

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