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Aliases for PPP5C Gene

Aliases for PPP5C Gene

  • Protein Phosphatase 5 Catalytic Subunit 2 3 5
  • Protein Phosphatase T 3 4
  • PPP5 3 4
  • PP-T 3 4
  • PP5 3 4
  • PPT 3 4
  • Protein Phosphatase 5, Catalytic Subunit 2
  • Serine/Threonine-Protein Phosphatase 5 3
  • EC 3.1.3.16 4

External Ids for PPP5C Gene

Previous HGNC Symbols for PPP5C Gene

  • PPP5

Previous GeneCards Identifiers for PPP5C Gene

  • GC19P047494
  • GC19P047241
  • GC19P051526
  • GC19P051542
  • GC19P046850
  • GC19P043278

Summaries for PPP5C Gene

Entrez Gene Summary for PPP5C Gene

  • This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

GeneCards Summary for PPP5C Gene

PPP5C (Protein Phosphatase 5 Catalytic Subunit) is a Protein Coding gene. Among its related pathways are RET signaling and Glucocorticoid receptor regulatory network. Gene Ontology (GO) annotations related to this gene include identical protein binding and hydrolase activity. An important paralog of this gene is PPEF2.

UniProtKB/Swiss-Prot for PPP5C Gene

  • Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.

Gene Wiki entry for PPP5C Gene

Additional gene information for PPP5C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP5C Gene

Genomics for PPP5C Gene

GeneHancer (GH) Regulatory Elements for PPP5C Gene

Promoters and enhancers for PPP5C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J046345 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 693 +0.0 41 2.4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B PPP5C ENSG00000268810 ZC3H4 CCDC61 ENSG00000269148 FBXO46 CCDC9 QPCTL INAFM1 BHMG1
GH19J046348 Enhancer 0.3 Ensembl 650.7 +1.9 1907 0.2 KLF1 PPP5C ENSG00000268810
GH19J046349 Enhancer 1.3 FANTOM5 Ensembl ENCODE 42.3 +3.9 3932 3.3 SMAD1 KLF17 IRF4 ETV6 IKZF2 RUNX3 ELF1 ZNF592 GLIS1 IKZF1 PPP5C ENSG00000268810 PRKD2
GH19J046295 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.9 -46.5 -46467 9.4 PKNOX1 ZNF133 ARID4B SIN3A ZNF121 GLIS2 KLF7 SP3 RXRA SP5 HIF3A PPP5C ENSG00000269124 FOSB IGFL3 MYPOP IRF2BP1 CCDC8 DACT3 GC19M046308
GH19J046371 Enhancer 1.3 FANTOM5 Ensembl ENCODE 37.4 +26.1 26093 3.9 HDGF CLOCK NFIB NEUROD1 SIN3A ZBTB7B RAD21 EGR1 ZNF143 RCOR1 PPP5C HIF3A ENSG00000268810 GC19M046372
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP5C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP5C gene promoter:
  • AP-1
  • p300
  • c-Jun
  • ATF-2
  • Spz1
  • SREBP-1a
  • SREBP-1b

Genomic Locations for PPP5C Gene

Genomic Locations for PPP5C Gene
chr19:46,346,994-46,392,981
(GRCh38/hg38)
Size:
45,988 bases
Orientation:
Plus strand
chr19:46,850,251-46,896,238
(GRCh37/hg19)
Size:
45,988 bases
Orientation:
Plus strand

Genomic View for PPP5C Gene

Genes around PPP5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP5C Gene

Proteins for PPP5C Gene

  • Protein details for PPP5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53041-PPP5_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 5
    Protein Accession:
    P53041
    Secondary Accessions:
    • Q16722
    • Q53XV2

    Protein attributes for PPP5C Gene

    Size:
    499 amino acids
    Molecular mass:
    56879 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (PubMed:29127155). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (PubMed:29127155). Part of a complex with HSP90/HSP90AA1 and steroid receptors (By similarity). Interacts (via TPR repeats) with HSP90AA1 (via TPR repeat-binding motif) or HSPA1A/HSPA1B; the interaction is direct and activates the phosphatase activity (PubMed:15383005, PubMed:15577939, PubMed:16531226). Dissociates from HSPA1A/HSPA1B and HSP90AA1 in response to arachidonic acid (PubMed:15383005). Interacts with CPNE1 (via VWFA domain) (By similarity). Interacts with CDC16, CDC27 (PubMed:9405394). Interacts with KLHDC10 (via the 6 Kelch repeats); inhibits the phosphatase activity on MAP3K5 (PubMed:23102700). Interacts with ATM and ATR; both interactions are induced by DNA damage and enhance ATM and ATR kinase activity (PubMed:14871926). Interacts with RAD17; reduced by DNA damage (PubMed:14871926). Interacts with nuclear receptors such as NR3C1/GCR and PPARG (activated by agonist); regulates their transactivation activities (By similarity). Interacts (via TPR repeats) with S100 proteins S100A1, S100A2, S100A6, S100B and S100P; the interactions are calcium-dependent, strongly activate PPP5C phosphatase activity and compete with HSP90AA1 and MAP3K5 interactions (PubMed:22399290). Interacts with SMAD2 and SMAD3 but not with SMAD1; decreases SMAD3 phosphorylation and protein levels (PubMed:22781750). Interacts (via TPR repeats) with CRY1 and CRY2; the interaction with CRY2 downregulates the phosphatase activity on CSNK1E (PubMed:16790549). Interacts (via TPR repeats) with the active form of RAC1, GNA12 or GNA13; these interactions activate the phosphatase activity and translocate PPP5C to the cell membrane (PubMed:19948726). Interacts with FLCN (PubMed:27353360).

    Three dimensional structures from OCA and Proteopedia for PPP5C Gene

neXtProt entry for PPP5C Gene

Post-translational modifications for PPP5C Gene

  • Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form.
  • Ubiquitination at Lys412 and Lys32
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP5C Gene

No data available for DME Specific Peptides for PPP5C Gene

Domains & Families for PPP5C Gene

Gene Families for PPP5C Gene

Graphical View of Domain Structure for InterPro Entry

P53041

UniProtKB/Swiss-Prot:

PPP5_HUMAN :
  • Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
genes like me logo Genes that share domains with PPP5C: view

Function for PPP5C Gene

Molecular function for PPP5C Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Autoinhibited. In the autoinhibited state, the TPR domain interacts with the catalytic region and prevents substrate access to the catalytic pocket. Allosterically activated by various polyunsaturated fatty acids, free long-chain fatty-acids and long-chain fatty acyl-CoA esters, arachidonic acid being the most effective activator. HSP90A and probably RAC1, GNA12 and GNA13 can also release the autoinhibition by the TPR repeat. Activation by RAC1, GNA12 and GNA13 is synergistic with the one produced by fatty acids binding. Inhibited by okadaic acid.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.847 uM for CSNK1E (at 30 degrees Celsius) {ECO:0000269 PubMed:15546861, ECO:0000269 PubMed:16790549}; KM=13.2 uM for MAPT/TAU (at pH 7.4 and 30 degrees Celsius) {ECO:0000269 PubMed:15546861, ECO:0000269 PubMed:16790549};
GENATLAS Biochemistry:
serine/threorine phosphatase 5,catalytic subunit,ubiquitously expressed,not involved as tumor suppressor gene in glioma

Enzyme Numbers (IUBMB) for PPP5C Gene

Phenotypes From GWAS Catalog for PPP5C Gene

Gene Ontology (GO) - Molecular Function for PPP5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0003723 RNA binding IEA --
GO:0004721 phosphoprotein phosphatase activity TAS,IEA 28386764
GO:0004722 protein serine/threonine phosphatase activity ISS,TAS 15546861
GO:0004871 obsolete signal transducer activity HMP --
genes like me logo Genes that share ontologies with PPP5C: view
genes like me logo Genes that share phenotypes with PPP5C: view

Animal Models for PPP5C Gene

MGI Knock Outs for PPP5C:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPP5C

CRISPR Products

miRNA for PPP5C Gene

miRTarBase miRNAs that target PPP5C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP5C

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP5C Gene

Localization for PPP5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP5C Gene

Nucleus. Cytoplasm. Cell membrane. Note=Predominantly nuclear (PubMed:15383005). But also present in the cytoplasm (PubMed:15383005). Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner (PubMed:19948726). {ECO:0000269 PubMed:15383005, ECO:0000269 PubMed:19948726}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP5C gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7925273
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PPP5C: view

Pathways & Interactions for PPP5C Gene

SuperPathways for PPP5C Gene

SuperPathway Contained pathways
1 RET signaling
2 MAPK signaling pathway
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 DNA Double Strand Break Response
genes like me logo Genes that share pathways with PPP5C: view

Pathways by source for PPP5C Gene

SIGNOR curated interactions for PPP5C Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000278 mitotic cell cycle TAS 7925273
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006281 DNA repair IEA --
GO:0006351 transcription, DNA-templated TAS 7925273
genes like me logo Genes that share ontologies with PPP5C: view

Drugs & Compounds for PPP5C Gene

(12) Drugs for PPP5C Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0
Manganese Approved Nutra 37
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker, Target 0

(5) Additional Compounds for PPP5C Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
15438-31-0
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2
genes like me logo Genes that share compounds with PPP5C: view

Transcripts for PPP5C Gene

mRNA/cDNA for PPP5C Gene

Unigene Clusters for PPP5C Gene

Protein phosphatase 5, catalytic subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP5C

Alternative Splicing Database (ASD) splice patterns (SP) for PPP5C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - -
SP6: - - -
SP7: - - -
SP8:
SP9: -
SP10: -
SP11: - - - -
SP12: -
SP13: - -

ExUns: 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16
SP1: - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PPP5C Gene

GeneLoc Exon Structure for
PPP5C
ECgene alternative splicing isoforms for
PPP5C

Expression for PPP5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP5C Gene

This gene is overexpressed in Lymph node (8.5) and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP5C Gene



Protein tissue co-expression partners for PPP5C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP5C Gene:

PPP5C

SOURCE GeneReport for Unigene cluster for PPP5C Gene:

Hs.654604

mRNA Expression by UniProt/SwissProt for PPP5C Gene:

P53041-PPP5_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PPP5C Gene

  • Nervous system(4.9)
  • Skin(3.3)
  • Lung(2.7)
  • Intestine(2.2)
  • Heart(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PPP5C: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP5C Gene

Orthologs for PPP5C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP5C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP5C 34 33
  • 99.2 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP5C 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP5C 34 33
  • 92.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PPP5C 34 33
  • 91.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp5c 16 34 33
  • 91.05 (n)
rat
(Rattus norvegicus)
Mammalia Ppp5c 33
  • 90.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPP5C 34
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP5C 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp5c 33
  • 69.98 (n)
Str.1816 33
African clawed frog
(Xenopus laevis)
Amphibia PP5 33
zebrafish
(Danio rerio)
Actinopterygii ppp5c 34 33
  • 76.27 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta PpD3 34 35 33
  • 64.38 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004151 33
  • 63.6 (n)
worm
(Caenorhabditis elegans)
Secernentea pph-5 34 33
  • 57.96 (n)
OneToOne
Y39B6A.2 35
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR083C 33
  • 55.17 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10912g 33
  • 50.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPT1 36 34 33
  • 47.67 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PP5.2 33
  • 57.63 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6044 33
rice
(Oryza sativa)
Liliopsida Os05g0204900 33
  • 57.68 (n)
Os.19558 33
corn
(Zea mays)
Liliopsida Zm.15554 33
bread mold
(Neurospora crassa)
Ascomycetes NCU01433 33
  • 58.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5196 34
  • 54 (a)
OneToOne
Cin.6199 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3F6.01c 33
  • 50.79 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6199 33
Species where no ortholog for PPP5C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP5C Gene

ENSEMBL:
Gene Tree for PPP5C (if available)
TreeFam:
Gene Tree for PPP5C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP5C: view image

Paralogs for PPP5C Gene

Paralogs for PPP5C Gene

(14) SIMAP similar genes for PPP5C Gene using alignment to 4 proteins:

  • PPP5_HUMAN
  • A8MU39_HUMAN
  • H0YDU8_HUMAN
  • Q9BPW0_HUMAN
genes like me logo Genes that share paralogs with PPP5C: view

Variants for PPP5C Gene

Sequence variations from dbSNP and Humsavar for PPP5C Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000002479 -- 46,355,093(+) G/T intron_variant
rs1000112174 -- 46,361,305(+) A/G intron_variant
rs1000138893 -- 46,346,494(+) A/T upstream_transcript_variant
rs1000295330 -- 46,383,182(+) T/C intron_variant
rs1000365748 -- 46,345,227(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP5C Gene

Variant ID Type Subtype PubMed ID
esv2718654 CNV deletion 23290073
esv3556479 CNV deletion 23714750
nsv138470 CNV deletion 16902084
nsv475904 CNV novel sequence insertion 20440878

Variation tolerance for PPP5C Gene

Residual Variation Intolerance Score: 16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP5C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP5C

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP5C Gene

Disorders for PPP5C Gene

Additional Disease Information for PPP5C

No disorders were found for PPP5C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP5C Gene

Publications for PPP5C Gene

  1. Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro. (PMID: 19948726) Chatterjee A … Rossie S (The Journal of biological chemistry 2010) 3 4 22 58
  2. Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5. (PMID: 16790549) Partch CL … Sancar A (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 58
  3. Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5. (PMID: 16892053) von Kriegsheim A … Dhillon AS (Nature cell biology 2006) 3 4 22 58
  4. Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease. (PMID: 15546861) Liu F … Gong CX (The Journal of biological chemistry 2005) 3 4 22 58
  5. Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. (PMID: 15577939) Yang J … Barford D (The EMBO journal 2005) 3 4 22 58

Products for PPP5C Gene

Sources for PPP5C Gene

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