Free for academic non-profit institutions. Other users need a Commercial license
PPP4R3B (Protein Phosphatase 4 Regulatory Subunit 3B) is a Protein Coding gene. Diseases associated with PPP4R3B include Rectum Adenocarcinoma and Optic Nerve Hypoplasia, Bilateral. Among its related pathways are Glucagon signaling pathway and Integrated Breast Cancer Pathway. An important paralog of this gene is PPP4R3A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005813 | centrosome | IDA | -- |
GO:0005815 | microtubule organizing center | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glucagon signaling pathway | ||
2 | Integrated Breast Cancer Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006470 | protein dephosphorylation | IEA | -- |
GO:0019216 | regulation of lipid metabolic process | IEA | -- |
GO:0045722 | positive regulation of gluconeogenesis | IEA | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SMEK2 30 |
|
||
Dog (Canis familiaris) |
Mammalia | SMEK2 30 |
|
||
Cow (Bos Taurus) |
Mammalia | SMEK2 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Smek2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Smek2 30 |
|
||
Ppp4r3b 17 |
|
||||
Chicken (Gallus gallus) |
Aves | SMEK2 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | smek2 30 |
|
||
Str.10217 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | MGC53159 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | smek2 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | flfl 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003402 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os.16549 30 |
|
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2903704 | - | p.Ile503Val | |||
rs34999684 | - | p.Ser293Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759050 | CNV | gain | 17122850 |
esv3575244 | CNV | gain | 25503493 |
nsv1160801 | CNV | duplication | 26073780 |
nsv520581 | CNV | loss | 19592680 |
nsv525434 | CNV | loss | 19592680 |
nsv829430 | CNV | loss | 20364138 |
nsv834080 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
rectum adenocarcinoma |
|
|
optic nerve hypoplasia, bilateral |
|
|