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Aliases for PPP4R3B Gene
Aliases for PPP4R3B Gene
External Ids for PPP4R3B Gene
- HGNC: 29267
- Entrez Gene: 57223
- Ensembl: ENSG00000275052
- OMIM: 610352
- UniProtKB: Q5MIZ7
Previous HGNC Symbols for PPP4R3B Gene
- SMEK2
Summaries for PPP4R3B Gene
GeneCards Summary for PPP4R3B Gene
PPP4R3B (Protein Phosphatase 4 Regulatory Subunit 3B) is a Protein Coding gene. Diseases associated with PPP4R3B include Rectum Adenocarcinoma and Optic Nerve Hypoplasia, Bilateral. Among its related pathways are Glucagon signaling pathway and Integrated Breast Cancer Pathway. An important paralog of this gene is PPP4R3A.
UniProtKB/Swiss-Prot Summary for PPP4R3B Gene
-
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers.
Additional gene information for PPP4R3B Gene
- HGNC(29267)
- Entrez Gene(57223)
- Ensembl(ENSG00000275052)
- OMIM(610352)
- UniProtKB(Q5MIZ7)
- Open Targets Platform(ENSG00000275052)
- Monarch Initiative
- Search for PPP4R3B at DataMed
- Search for PPP4R3B at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP4R3B Gene
Genomics for PPP4R3B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PPP4R3B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPP4R3B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP4R3B
Genomic Locations for PPP4R3B Gene
Genomic Locations for PPP4R3B Gene
- chr2:55,547,292-55,618,880
- (GRCh38/hg38)
- Size:
- 71,589 bases
- Orientation:
- Minus strand
- chr2:55,774,428-55,846,015
- (GRCh37/hg19)
- Size:
- 71,588 bases
- Orientation:
- Minus strand
Genomic View for PPP4R3B Gene
Genes around PPP4R3B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p16.1 by HGNC
- 2p16.1 by Entrez Gene
- 2p16.1 by Ensembl
PPP4R3B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP4R3B Gene
Proteins for PPP4R3B Gene
-
Protein details for PPP4R3B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5MIZ7-P4R3B_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 4 regulatory subunit 3B
- Protein Accession:
- Q5MIZ7
- Q6P9B0
- Q86XB8
- Q9BQJ0
- Q9BRK2
- Q9H913
- Q9P2G0
Protein attributes for PPP4R3B Gene
- Size:
- 849 amino acids
- Molecular mass:
- 97458 Da
- Quaternary structure:
-
- Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3B.
- SequenceCaution:
-
- Sequence=BAA92625.1; Type=Erroneous initiation; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 4]: May be due to intron retention.
Post-translational modifications for PPP4R3B Gene
Other Protein References for PPP4R3B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PPP4R3B
- Novus Biologicals Antibodies for PPP4R3B
-
Abcam antibodies for PPP4R3B
- Invitrogen Antibodies for PPP4R3B (AFLGC-PPP4R3B)
Protein Products
-
OriGene Purified Proteins for PPP4R3B
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP4R3B
- Origene Custom Protein Services for PPP4R3B
No data available for DME Specific Peptides for PPP4R3B Gene
Domains & Families for PPP4R3B Gene
Gene Families for PPP4R3B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PPP4R3B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP4R3B Gene
- GenScript: Design optimal peptide antigens:
-
- SMEK homolog 2 (P4R3B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q5MIZ7- Family:
-
- Belongs to the SMEK family.
Function for PPP4R3B Gene
Molecular function for PPP4R3B Gene
- UniProtKB/Swiss-Prot Function:
- Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers.
Phenotypes From GWAS Catalog for PPP4R3B Gene
Phenotypes for PPP4R3B Gene
- MGI mutant phenotypes for PPP4R3B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PPP4R3B:
Animal Models for PPP4R3B Gene
- MGI Knock Outs for PPP4R3B:
-
- Ppp4r3b Ppp4r3b<tm1b(EUCOMM)Hmgu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPP4R3B - Select products 50% OFF >
- * PPP4R3B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPP4R3B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP4R3B
miRNA for PPP4R3B Gene
- miRTarBase miRNAs that target PPP4R3B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP4R3B
- Browse OriGene Inhibitory RNA Products For PPP4R3B
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Clone Products
- Applied Biological Materials (abm): Clones for PPP4R3B - Select products 50% OFF >
- * PPP4R3B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PPP4R3B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP4R3B
Cell Line Products
-
Horizon Cell Lines for PPP4R3B
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP4R3B Gene
Localization for PPP4R3B Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP4R3B Gene
- Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and (with higher levels) the nucleus. During metaphase located in pericentriolar regions.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Centrosome (3)
- Nuclear speckles (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | -- |
| GO:0005815 | microtubule organizing center | IEA | -- |
Pathways & Interactions for PPP4R3B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucagon signaling pathway | ||
| 2 | Integrated Breast Cancer Pathway | ||
Pathways by source for PPP4R3B Gene
1 BioSystems pathway for PPP4R3B Gene
1 KEGG pathway for PPP4R3B Gene
Interacting Proteins for PPP4R3B Gene
GPS-Prot Interaction Network for PPP4R3B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0019216 | regulation of lipid metabolic process | IEA | -- |
| GO:0045722 | positive regulation of gluconeogenesis | IEA | -- |
No data available for SIGNOR curated interactions for PPP4R3B Gene
Transcripts for PPP4R3B Gene
mRNA/cDNA for PPP4R3B Gene
- 3 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000470801 597 nts (view in UCSC)
- ENST00000482826 435 nts (view in UCSC)
- ENST00000611717 5243 nts (view in UCSC)
- ENST00000612688 2981 nts (view in UCSC)
- ENST00000616288 4310 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPP4R3B - Select products 50% OFF >
- * PPP4R3B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPP4R3B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP4R3B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP4R3B
- Browse OriGene Inhibitory RNA Products For PPP4R3B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP4R3B
Clone Products
- Applied Biological Materials (abm): Clones for PPP4R3B - Select products 50% OFF >
- * PPP4R3B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PPP4R3B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP4R3B
Relevant External Links for PPP4R3B Gene
- GeneLoc Exon Structure for
- PPP4R3B
Expression for PPP4R3B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP4R3B
mRNA Expression by UniProt/SwissProt for PPP4R3B Gene:
Q5MIZ7-P4R3B_HUMAN
Tissue specificity:
Moderately expressed in tissues and specific brain regions examined.
Evidence on tissue expression from TISSUES for PPP4R3B Gene
- Nervous system(4.9)
- Kidney(2.3)
- Skin(2.3)
- Liver(2.3)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs for PPP4R3B
-
OriGene qPCR primer pairs and template standards for PPP4R3B
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP4R3B Gene
Orthologs for PPP4R3B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SMEK2 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | SMEK2 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | SMEK2 30 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Smek2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Smek2 30 |
|
||
| Ppp4r3b 17 |
|
||||
| Chicken (Gallus gallus) |
Aves | SMEK2 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | smek2 30 |
|
||
| Str.10217 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53159 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | smek2 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | flfl 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003402 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os.16549 30 |
|
- Species where no ortholog for PPP4R3B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PPP4R3B Gene
- ENSEMBL:
- Gene Tree for PPP4R3B (if available)
- TreeFam:
- Gene Tree for PPP4R3B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP4R3B: view image
Paralogs for PPP4R3B Gene
Pseudogenes.org Pseudogenes for PPP4R3B Gene
Variants for PPP4R3B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP4R3B Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2903704 | - | p.Ile503Val | |||
| rs34999684 | - | p.Ser293Thr |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759050 | CNV | gain | 17122850 |
| esv3575244 | CNV | gain | 25503493 |
| nsv1160801 | CNV | duplication | 26073780 |
| nsv520581 | CNV | loss | 19592680 |
| nsv525434 | CNV | loss | 19592680 |
| nsv829430 | CNV | loss | 20364138 |
| nsv834080 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
3.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.49;
43.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP4R3B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPP4R3B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP4R3B Gene
Disorders for PPP4R3B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rectum adenocarcinoma |
|
|
| optic nerve hypoplasia, bilateral |
|
|
Search PPP4R3B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPP4R3B
No data available for UniProtKB/Swiss-Prot and Genatlas for PPP4R3B Gene
Publications for PPP4R3B Gene
- A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. (PMID: 18614045) Chowdhury D … Lieberman J (Molecular cell 2008) 2 3 4
- A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. (PMID: 16085932) Gingras AC … Aebersold R (Molecular & cellular proteomics : MCP 2005) 2 3 4
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for PPP4R3B Gene
- Custom Antibody ServicesOriGene Antibodies for PPP4R3B
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- OriGene qPCR primer pairs for PPP4R3B
- OriGene qPCR primer pairs and template standards for PPP4R3B
- OriGene CRISPR knockouts for PPP4R3B
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- Sino Biological Human cDNA Clone for PPP4R3B
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- Novus Biologicals proteins and lysates for PPP4R3B
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- Invitrogen Antibodies for PPP4R3B (AFLGC-PPP4R3B)
- VectorBuilder Custom and pre-made DNA vectors for PPP4R3B (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 16 available SMEK2 Antibodies ranked by validation data
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- Horizon Cell Lines for PPP4R3B
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for PPP4R3B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP4R3B
Sources for PPP4R3B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (53) PubMed
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- (55) TGDB
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- (57) Abcam
- (58) Novus Biologicals
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- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
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- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
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- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
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- (148) RNACentral
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- (159) GeneImprint
- (160) Synthego
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- (164) LncBook
- (165) LNCipedia
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- (178) MirGeneDB