Aliases for PPP4R2 Gene
External Ids for PPP4R2 Gene
Previous GeneCards Identifiers for PPP4R2 Gene
The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
GeneCards Summary for PPP4R2 Gene
PPP4R2 (Protein Phosphatase 4 Regulatory Subunit 2) is a Protein Coding gene. Diseases associated with PPP4R2 include Ulceroglandular Tularemia and Retinitis Pigmentosa 6. Among its related pathways are DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include protein binding, bridging.
UniProtKB/Swiss-Prot Summary for PPP4R2 Gene
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.