Aliases for PPP3R2 Gene

Aliases for PPP3R2 Gene

  • Protein Phosphatase 3 Regulatory Subunit B, Beta 2 3 5
  • Protein Phosphatase 2B Regulatory Subunit 2 2 3 4
  • PPP3RL 2 3 4
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B (19kD), Beta Isoform (Calcineurin B, Type II) 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, 19kDa, Beta Isoform (Calcineurin B, Type II) 2 3
  • Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, Beta Isoform 2 3
  • Protein Phosphatase 3 Regulatory Subunit B Beta Isoform 3 4
  • Calcineurin B, Type II (19kDa) 2 3
  • Calcineurin Subunit B Type 2 3 4
  • Calcineurin B-Like Protein 3 4
  • Calcineurin BII 3 4
  • CNBII 3 4
  • CBLP 3 4
  • Protein Phosphatase 3, Regulatory Subunit B (Calcineurin B)-Like 2
  • Protein Phosphatase 3, Regulatory Subunit B, Beta 2
  • PPP3R1-Like 4
  • PPP3R2 5

External Ids for PPP3R2 Gene

Previous GeneCards Identifiers for PPP3R2 Gene

  • GC00U990278
  • GC09M096097
  • GC09M097811
  • GC09M099733
  • GC09M101433
  • GC09M103393
  • GC09M104353
  • GC09M073954

Summaries for PPP3R2 Gene

GeneCards Summary for PPP3R2 Gene

PPP3R2 (Protein Phosphatase 3 Regulatory Subunit B, Beta) is a Protein Coding gene. Diseases associated with PPP3R2 include Arachnoiditis and Cauda Equina Syndrome. Among its related pathways are Nur77 Signaling in T-Cell and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PPP3R1.

UniProtKB/Swiss-Prot Summary for PPP3R2 Gene

  • Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Gene Wiki entry for PPP3R2 Gene

Additional gene information for PPP3R2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP3R2 Gene

Genomics for PPP3R2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP3R2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J101594 Promoter 0.3 EPDnew 600.7 +0.0 32 0.1 LOC105376186 PPP3R2 piR-30502 piR-36670 lnc-RNF20-3 piR-32227 RNF20 GRIN3A
GH09J101569 Enhancer 0.8 Ensembl ENCODE 12.1 +23.9 23921 7.8 CTCF ATF7 PKNOX1 HMBOX1 RAD21 JUNB SMC3 BATF TAL1 NR2F6 PPP3R2 PGAP4 RNF20 TMEM246-AS1 piR-57134-113 piR-32227 GRIN3A
GH09J101636 Enhancer 0.3 Ensembl 11.2 -41.4 -41380 0.4 SPI1 PPP3R2 TMEM246-AS1 lnc-PPP3R2-1 piR-32023-261 GRIN3A
GH09J101673 Enhancer 0.3 ENCODE 10.4 -78.9 -78854 1.4 SPI1 GRIN3A PPP3R2 TMEM246-AS1 piR-32023-261 lnc-PPP3R2-1
GH09J101625 Enhancer 0.2 Ensembl 16.8 -31.6 -31579 2 PPP3R2 TMEM246-AS1 lnc-PPP3R2-1 piR-32023-261 GRIN3A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP3R2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP3R2

Top Transcription factor binding sites by QIAGEN in the PPP3R2 gene promoter:
  • AML1a
  • AREB6
  • E47
  • Evi-1
  • FOXO1
  • FOXO1a
  • Lmo2
  • Nkx2-5
  • S8
  • Tal-1

Genomic Locations for PPP3R2 Gene

Genomic Locations for PPP3R2 Gene
chr9:101,591,604-101,595,021
(GRCh38/hg38)
Size:
3,418 bases
Orientation:
Minus strand
chr9:104,353,897-104,357,283
(GRCh37/hg19)
Size:
3,387 bases
Orientation:
Minus strand

Genomic View for PPP3R2 Gene

Genes around PPP3R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP3R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP3R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3R2 Gene

Proteins for PPP3R2 Gene

  • Protein details for PPP3R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LZ3-CANB2_HUMAN
    Recommended name:
    Calcineurin subunit B type 2
    Protein Accession:
    Q96LZ3
    Secondary Accessions:
    • Q5VTR4
    • Q7Z4V8
    • Q8WYJ4

    Protein attributes for PPP3R2 Gene

    Size:
    170 amino acids
    Molecular mass:
    19533 Da
    Quaternary structure:
    • Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2).
    SequenceCaution:
    • Sequence=AAH30595.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH66299.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAP57772.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB71521.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=EAW58961.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • This protein has four functional calcium-binding sites.

neXtProt entry for PPP3R2 Gene

Post-translational modifications for PPP3R2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP3R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP3R2 Gene

Domains & Families for PPP3R2 Gene

Gene Families for PPP3R2 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for PPP3R2 Gene

InterPro:
Blocks:
  • Parvalbumin signature
ProtoNet:

Suggested Antigen Peptide Sequences for PPP3R2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51579, highly similar to Calcineurin subunit B isoform 2 (B4DYQ6_HUMAN)
  • Protein phosphatase 3 regulatory subunit B beta isoform (CANB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96LZ3

UniProtKB/Swiss-Prot:

CANB2_HUMAN :
  • Belongs to the calcineurin regulatory subunit family.
Family:
  • Belongs to the calcineurin regulatory subunit family.
genes like me logo Genes that share domains with PPP3R2: view

Function for PPP3R2 Gene

Molecular function for PPP3R2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Gene Ontology (GO) - Molecular Function for PPP3R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPP3R2: view
genes like me logo Genes that share phenotypes with PPP3R2: view

Animal Models for PPP3R2 Gene

MGI Knock Outs for PPP3R2:
  • Ppp3r2 Ppp3r2<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for PPP3R2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP3R2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP3R2 Gene

Localization for PPP3R2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP3R2 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP3R2 Gene

Pathways & Interactions for PPP3R2 Gene

PathCards logo

SuperPathways for PPP3R2 Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
2 TCR Signaling (Qiagen)
.68
.68
.54
.49
3 Human cytomegalovirus infection
4 ICos-ICosL Pathway in T-Helper Cell
.66
.66
.31
5 NFAT and Cardiac Hypertrophy
.42
.42
.37
genes like me logo Genes that share pathways with PPP3R2: view

Pathways by source for PPP3R2 Gene

4 GeneGo (Thomson Reuters) pathways for PPP3R2 Gene
  • Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
  • Immune response CD16 signaling in NK cells
  • Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
  • Signal transduction Activation of PKC via G-Protein coupled receptor
32 Qiagen pathways for PPP3R2 Gene
  • 14-3-3 Induced Apoptosis
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • BAD Phosphorylation
  • Calcium Mediated T-Cell Apoptosis

Gene Ontology (GO) - Biological Process for PPP3R2 Gene

None

No data available for SIGNOR curated interactions for PPP3R2 Gene

Drugs & Compounds for PPP3R2 Gene

(6) Drugs for PPP3R2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibitor, Inhibition, Target, inhibitor Immunosuppressive agent, Calcineurin inhibitor 0
Pimecrolimus Approved, Investigational Pharma 66
Voclosporin Investigational Pharma Target 0
Calcium Nutra 6556
CYCLOSPORINE A Pharma 0

(1) ApexBio Compounds for PPP3R2 Gene

Compound Action Cas Number
Pimecrolimus 137071-32-0
genes like me logo Genes that share compounds with PPP3R2: view

Drug Products

Transcripts for PPP3R2 Gene

mRNA/cDNA for PPP3R2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP3R2

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3R2 Gene

No ASD Table

Relevant External Links for PPP3R2 Gene

GeneLoc Exon Structure for
PPP3R2

Expression for PPP3R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP3R2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for PPP3R2 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for PPP3R2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP3R2 Gene



Protein tissue co-expression partners for PPP3R2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP3R2

SOURCE GeneReport for Unigene cluster for PPP3R2 Gene:

Hs.151167

mRNA Expression by UniProt/SwissProt for PPP3R2 Gene:

Q96LZ3-CANB2_HUMAN
Tissue specificity: Testis-specific.

Evidence on tissue expression from TISSUES for PPP3R2 Gene

  • Skin(2)
genes like me logo Genes that share expression patterns with PPP3R2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP3R2 Gene

Orthologs for PPP3R2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3R2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP3R2 30
  • 99.61 (n)
Cow
(Bos Taurus)
Mammalia PPP3R2 30
  • 85.88 (n)
Dog
(Canis familiaris)
Mammalia PPP3R2 30
  • 84.69 (n)
Rat
(Rattus norvegicus)
Mammalia Ppp3r2 30
  • 83.53 (n)
Mouse
(Mus musculus)
Mammalia Ppp3r2 30 17 31
  • 81.76 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CanB2 31
  • 76 (a)
OneToMany
CanB 31
  • 74 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cnb-1 31
  • 74 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNB1 31
  • 54 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4810 31
  • 75 (a)
OneToOne
Species where no ortholog for PPP3R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for PPP3R2 Gene

ENSEMBL:
Gene Tree for PPP3R2 (if available)
TreeFam:
Gene Tree for PPP3R2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP3R2: view image

Paralogs for PPP3R2 Gene

Paralogs for PPP3R2 Gene

(21) SIMAP similar genes for PPP3R2 Gene using alignment to 1 proteins:

  • CANB2_HUMAN
genes like me logo Genes that share paralogs with PPP3R2: view

Variants for PPP3R2 Gene

Additional dbSNP identifiers (rs#s) for PPP3R2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP3R2 Gene

Variant ID Type Subtype PubMed ID
nsv831672 CNV gain 17160897

Variation tolerance for PPP3R2 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP3R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP3R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP3R2 Gene

Disorders for PPP3R2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PPP3R2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
arachnoiditis
  • spinal arachnoiditis
cauda equina syndrome
  • polyradiculopathy
causalgia
  • complex regional pain syndrome, type ii
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP3R2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PPP3R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP3R2 Gene

Publications for PPP3R2 Gene

  1. Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis. (PMID: 15865209) Liu L … Yu L (Molecular biology reports 2005) 2 3 4 23
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need AC … Goldstein DB (European journal of human genetics : EJHG 2009) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for PPP3R2 Gene

  • Signalway Proteins for PPP3R2

Sources for PPP3R2 Gene