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Aliases for PPP3R1 Gene
Aliases for PPP3R1 Gene
- CNB1 2 3
- Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B (19kD), Alpha Isoform (Calcineurin B, Type I) 2
- Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, 19kDa, Alpha Isoform (Calcineurin B, Type I) 2
- Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, Alpha Isoform 2
- Protein Phosphatase 3 Regulatory Subunit B Alpha Isoform 1 4
- Protein Phosphatase 3, Regulatory Subunit B, Alpha 2
- PPP3R1 5
- CNA2 4
External Ids for PPP3R1 Gene
- HGNC: 9317
- NCBI Entrez Gene: 5534
- Ensembl: ENSG00000221823
- OMIM®: 601302
- UniProtKB/Swiss-Prot: P63098
Previous GeneCards Identifiers for PPP3R1 Gene
- GC02M068539
- GC02M068363
- GC02M068324
- GC02M068380
- GC02M068261
- GC02M068317
- GC02M068259
- GC02M068358
- GC02M068405
Summaries for PPP3R1 Gene
GeneCards Summary for PPP3R1 Gene
PPP3R1 (Protein Phosphatase 3 Regulatory Subunit B, Alpha) is a Protein Coding gene. Diseases associated with PPP3R1 include Deafness, Autosomal Dominant 58 and Crouzon Syndrome With Acanthosis Nigricans. Among its related pathways are MAPK Signaling: Oxidative Stress Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is ENSG00000273398.
UniProtKB/Swiss-Prot Summary for PPP3R1 Gene
-
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Additional gene information for PPP3R1 Gene
- HGNC (9317)
- NCBI Entrez Gene (5534)
- Ensembl (ENSG00000221823)
- OMIM® (601302)
- UniProtKB/Swiss-Prot (P63098)
- Open Targets Platform(ENSG00000221823)
- Monarch Initiative
- Search for PPP3R1 at DataMed
- Search for PPP3R1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP3R1 Gene
Genomics for PPP3R1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PPP3R1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPP3R1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP3R1
- Top Transcription factor binding sites by QIAGEN in the PPP3R1 gene promoter:
-
- aMEF-2
- AP-1
- c-Ets-1
- FOXO4
- GR
- GR-alpha
- MEF-2
- MEF-2A
Genomic Locations for PPP3R1 Gene
Latest Assembly
- chr2:68,178,857-68,256,237
- (GRCh38/hg38)
- Size:
- 77,381 bases
- Orientation:
- Minus strand
Previous Assembly
- chr2:68,405,989-68,479,664
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 73,676 bases
- Orientation:
- Minus strand
- chr2:68,405,989-68,483,369
- (GRCh37/hg19 by Ensembl)
- Size:
- 77,381 bases
- Orientation:
- Minus strand
Genomic View for PPP3R1 Gene
Genes around PPP3R1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p14 by HGNC
- 2p14 by Entrez Gene
- 2p14 by Ensembl
PPP3R1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP3R1 Gene
Proteins for PPP3R1 Gene
-
Protein details for PPP3R1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P63098-CANB1_HUMAN
- Recommended name:
- Calcineurin subunit B type 1
- Protein Accession:
- P63098
- B2RC10
- B5MDU4
- P06705
- P15117
- Q08044
- Q53SL0
Protein attributes for PPP3R1 Gene
- Size:
- 170 amino acids
- Molecular mass:
- 19300 Da
- Quaternary structure:
-
- Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B) (PubMed:8524402, PubMed:12218175, PubMed:12357034, PubMed:17498738, PubMed:22343722, PubMed:23468591, PubMed:26794871, PubMed:27974827). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). Interacts with catalytic subunit PPP3CA/calcineurin A (PubMed:8524402, PubMed:12218175, PubMed:12357034, PubMed:17498738, PubMed:22343722, PubMed:23468591, PubMed:27974827). Interacts with catalytic subunit PPP3CB/calcineurin A (PubMed:26794871). Interacts with CIB1 (via C-terminal region); the interaction increases upon cardiomyocyte hypertrophy (By similarity). Interacts with RCAN1 (PubMed:12809556).
- Miscellaneous:
-
- This protein has four functional calcium-binding sites (PubMed:8524402, PubMed:12218175, PubMed:12357034, PubMed:17498738, PubMed:22343722, PubMed:23468591, PubMed:26794871, PubMed:27974827). Although African swine fever virus infects pigs and not humans, human PPP3R1 and PPP3CA have been used for the crystallization. PPP3CA and PPP3R1 interact with African swine fever virus Mal-047/A238L (via PKIIIT and FLCVK motifs); the interaction does not block catalytic activity per se but inhibits PPP3CA function by blocking the access to the two substrate recognition (PubMed:23468591).
Protein Expression for PPP3R1 Gene
Post-translational modifications for PPP3R1 Gene
Other Protein References for PPP3R1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PPP3R1 / Calcineurin B Antibody (LS-B11682) and PPP3R1 / Calcineurin B Antibody (LS-B13848)
- G Biosciences Immunotag™ PPP3R1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for PPP3R1
- Novus Biologicals Antibodies for PPP3R1
-
Abcam antibodies for PPP3R1
- Invitrogen Antibodies for PPP3R1 (AFLGC-PPP3R1)
-
Custom Antibody ServicesProSci Antibodies for PPP3R1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP3R1
- Sino Biological Antibodies for PPP3R1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP3R1
- Origene Custom Protein Services for PPP3R1
- Sino Biological Recombinant Proteins for PPP3R1
- Sino Biological Cell Lysates for PPP3R1
- ProSpec Recombinant Proteins for PPP3R1
-
ProSci Proteins for PPP3R1
-
Abcam proteins for PPP3R1
Assay products for research
No data available for DME Specific Peptides for PPP3R1 Gene
Domains & Families for PPP3R1 Gene
Gene Families for PPP3R1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PPP3R1 Gene
- InterPro:
- Blocks:
-
- Parvalbumin signature
- Calcium-binding protein, S-100/ICaBP type
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP3R1 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein phosphatase 3 regulatory subunit B alpha isoform 1 (CANB1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P63098- Family:
-
- Belongs to the calcineurin regulatory subunit family.
Function for PPP3R1 Gene
Molecular function for PPP3R1 Gene
- UniProtKB/Swiss-Prot Function:
- Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
- GENATLAS Biochemistry:
- calcineurin B,calmodulin dependent protein serine/threonine phosphatase 3,regulatory subunit
Phenotypes From GWAS Catalog for PPP3R1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity | NAS | 2558868 |
| GO:0005509 | calcium ion binding | IEA,NAS | 2558868 |
| GO:0005515 | protein binding | IPI | 8524402 |
| GO:0005516 | calmodulin binding | NAS | 2558868 |
| GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity | IEA | -- |
Phenotypes for PPP3R1 Gene
- MGI mutant phenotypes for PPP3R1:
-
inferred from 5 alleles
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- mortality/aging
- renal/urinary system phenotype
- hematopoietic system phenotype
- endocrine/exocrine gland phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for PPP3R1:
-
- Decreased viability
- no effect
- shRNA abundance <= 50%
- shRNA abundance <= 25%
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased cell migration
- Moderately decreased NFAT1-GFP nuclear translocation
- Metaphase cells
- Fragmented trans-Golgi
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance, decreased cell spreading
Animal Models for PPP3R1 Gene
- MGI Knock Outs for PPP3R1:
-
- Ppp3r1 Ppp3r1<tm2.1Grc>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PPP3R1 - Starting at $85 >
- * PPP3R1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PPP3R1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP3R1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP3R1
miRNA for PPP3R1 Gene
- miRTarBase miRNAs that target PPP3R1
-
- hsa-miR-30a-5p (MIRT005180)
- mmu-miR-17-5p (MIRT009993)
- mmu-miR-340-5p (MIRT010319)
- mmu-miR-324-3p (MIRT010794)
- mmu-miR-26a-5p (MIRT011170)
- mmu-let-7b-5p (MIRT012073)
- mmu-miR-30e-5p (MIRT013315)
- mmu-miR-181a-5p (MIRT014145)
- mmu-miR-9-5p (MIRT015248)
- hsa-miR-183-5p (MIRT025005)
- hsa-miR-34a-5p (MIRT025426)
- hsa-miR-26b-5p (MIRT029303)
- hsa-miR-24-3p (MIRT030457)
- hsa-miR-532-3p (MIRT037914)
- hsa-miR-5189-3p (MIRT159806)
- hsa-miR-33a-3p (MIRT303230)
- hsa-miR-409-3p (MIRT303233)
- hsa-miR-376a-3p (MIRT439908)
- hsa-miR-369-3p (MIRT439909)
- hsa-miR-20a-5p (MIRT439910)
- hsa-miR-106b-5p (MIRT439911)
- hsa-miR-9-3p (MIRT442615)
- hsa-miR-4714-3p (MIRT442616)
- hsa-miR-656-3p (MIRT442617)
- hsa-miR-6763-3p (MIRT510950)
- hsa-miR-6758-3p (MIRT510951)
- hsa-miR-5587-3p (MIRT510952)
- hsa-miR-4707-5p (MIRT510953)
- hsa-miR-4704-5p (MIRT510954)
- hsa-miR-651-3p (MIRT521719)
- hsa-miR-548as-3p (MIRT521720)
- hsa-miR-548z (MIRT521721)
- hsa-miR-548h-3p (MIRT521722)
- hsa-miR-548d-3p (MIRT521723)
- hsa-miR-548bb-3p (MIRT521724)
- hsa-miR-548ac (MIRT521725)
- hsa-miR-578 (MIRT566293)
- hsa-miR-340-5p (MIRT566294)
- hsa-miR-3185 (MIRT566295)
- hsa-miR-3163 (MIRT566296)
- hsa-miR-5692a (MIRT571779)
- hsa-miR-629-3p (MIRT654811)
- hsa-miR-5006-3p (MIRT654812)
- hsa-miR-4755-5p (MIRT654813)
- hsa-miR-519e-5p (MIRT654814)
- hsa-miR-515-5p (MIRT654815)
- hsa-miR-623 (MIRT654816)
- hsa-miR-6734-3p (MIRT654817)
- hsa-miR-6756-3p (MIRT654818)
- hsa-miR-3127-3p (MIRT654819)
- hsa-miR-211-5p (MIRT654820)
- hsa-miR-204-5p (MIRT654821)
- hsa-miR-519d-3p (MIRT726875)
- hsa-miR-93-5p (MIRT726876)
- hsa-miR-17-5p (MIRT726877)
- hsa-miR-20b-5p (MIRT726878)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP3R1
- Browse OriGene Inhibitory RNA Products For PPP3R1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP3R1
Clone products for research
- Applied Biological Materials (abm): Clones for PPP3R1 - Starting at $45 >
- * PPP3R1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PPP3R1
- Addgene plasmids for PPP3R1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP3R1
Cell Lines for research
-
Horizon Cell Lines for PPP3R1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP3R1 Gene
Localization for PPP3R1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP3R1 Gene
- Cytoplasm, cytosol. Cell membrane. Cell membrane, sarcolemma. Cell membrane. Lipid-anchor. Note=Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy. {ECO:0000250 UniProtKB:Q63810}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 4 |
| cytosol | 4 |
| mitochondrion | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
Pathways & Interactions for PPP3R1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 2 | TCR Signaling (Qiagen) |
PKC-Theta Pathway
.68
TCR Signaling
.68
|
ITK and TCR Signaling
.54
Fc-EpsilonRI Pathway
.49
|
| 3 | CDK-mediated phosphorylation and removal of Cdc6 |
.41
|
.31
|
| 4 | Pathways of neurodegeneration - multiple diseases | ||
| 5 | Human cytomegalovirus infection | ||
Pathways by source for PPP3R1 Gene
3 Sino Biological pathways for PPP3R1 Gene
4 BioSystems pathways for PPP3R1 Gene
19 Reactome pathways for PPP3R1 Gene
1 PharmGKB pathway for PPP3R1 Gene
31 KEGG pathways for PPP3R1 Gene
4 GeneGo (Thomson Reuters) pathways for PPP3R1 Gene
- Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
- Immune response CD16 signaling in NK cells
- Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
- Signal transduction Activation of PKC via G-Protein coupled receptor
2 R&D Systems pathways for PPP3R1 Gene
32 Qiagen pathways for PPP3R1 Gene
- 14-3-3 Induced Apoptosis
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- BAD Phosphorylation
- Calcium Mediated T-Cell Apoptosis
Interacting Proteins for PPP3R1 Gene
Selected Interacting proteins:
P63098-CANB1_HUMAN
ENSP00000234310
for PPP3R1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PPP3R1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0007223 | Wnt signaling pathway, calcium modulating pathway | TAS | -- |
| GO:0033173 | calcineurin-NFAT signaling cascade | IDA | 22688515 |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | -- |
| GO:0043666 | regulation of phosphoprotein phosphatase activity | IEA | -- |
No data available for SIGNOR curated interactions for PPP3R1 Gene
Drugs & Compounds for PPP3R1 Gene
(1) ApexBio Compounds for PPP3R1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Pimecrolimus | 137071-32-0 |
Drug products for research
- ApexBio compounds for PPP3R1
Transcripts for PPP3R1 Gene
mRNA/cDNA for PPP3R1 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000234310 3024 nts (view in UCSC)
- ENST00000409377 684 nts (view in UCSC)
- ENST00000409752 851 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PPP3R1 - Starting at $85 >
- * PPP3R1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PPP3R1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP3R1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP3R1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP3R1
- Browse OriGene Inhibitory RNA Products For PPP3R1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP3R1
Clone products for research
- Applied Biological Materials (abm): Clones for PPP3R1 - Starting at $45 >
- * PPP3R1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PPP3R1
- Addgene plasmids for PPP3R1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP3R1
Relevant External Links for PPP3R1 Gene
- GeneLoc Exon Structure for
- PPP3R1
Expression for PPP3R1 Gene
mRNA differential expression in normal tissues according to GTEx for PPP3R1 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.5).
This gene is overexpressed in Brain (24.9) and Fetal Brain (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP3R1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP3R1
SOURCE GeneReport for Unigene cluster for PPP3R1 Gene:
Hs.280604Evidence on tissue expression from TISSUES for PPP3R1 Gene
- Blood(4.5)
- Nervous system(3.3)
- Muscle(2.7)
- Spleen(2.6)
- Heart(2.5)
- Kidney(2.5)
- Liver(2.5)
- Lung(2.4)
- Intestine(2.3)
Primer products for research
-
OriGene qPCR primer pairs for PPP3R1
-
OriGene qPCR primer pairs and template standards for PPP3R1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP3R1 Gene
Orthologs for PPP3R1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PPP3R1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Cow (Bos Taurus) |
Mammalia | PPP3R1 30 31 |
|
ManyToMany | |
| WDR92 31 |
|
ManyToMany | |||
| Dog (Canis familiaris) |
Mammalia | PPP3R1 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Ppp3r1 30 17 31 |
|
ManyToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Ppp3r1 30 |
|
||
| Chicken (Gallus gallus) |
Aves | PPP3R1 30 31 |
|
ManyToMany | |
| WDR92 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppp3r1 30 |
|
||
| MGC75600 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | ppp3r1a 30 31 |
|
ManyToMany | |
| wdr92 31 |
|
ManyToMany | |||
| nrarpa 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CanB 32 |
|
|
|
| CanB2 30 32 |
|
||||
| CG14353 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004298 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | cnb-1 30 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D02992g 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CNB1 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER096C 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G18430 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os08g0442300 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPCC830.06 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU03833 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.14820 30 |
|
- Species where no ortholog for PPP3R1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PPP3R1 Gene
- ENSEMBL:
- Gene Tree for PPP3R1 (if available)
- TreeFam:
- Gene Tree for PPP3R1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP3R1: view image
Paralogs for PPP3R1 Gene
Paralogs for PPP3R1 Gene
(30) SIMAP similar genes for PPP3R1 Gene using alignment to 3 proteins:
- CANB1_HUMAN
- D3YTA9_HUMAN
- F6U1T9_HUMAN
Variants for PPP3R1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP3R1 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs3039851 | Not Provided: not provided | 68,218,181(-) |
ATTAAT/A NM_000945.4(PPP3R1):c.4-1055_4-1051del |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1072948 | CNV | deletion | 25765185 |
| nsv1126551 | CNV | deletion | 24896259 |
| nsv834251 | CNV | loss | 17160897 |
| nsv953138 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
55.3% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP3R1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPP3R1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP3R1 Gene
Disorders for PPP3R1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal dominant 58 |
|
|
| crouzon syndrome with acanthosis nigricans |
|
|
| spinocerebellar ataxia, x-linked 1 |
|
|
| spinocerebellar ataxia, x-linked 3 |
|
|
| spinocerebellar ataxia, x-linked 4 |
|
|
Search PPP3R1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPP3R1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PPP3R1 Gene
Publications for PPP3R1 Gene
- Identification of a novel 5-base pair deletion in calcineurin B (PPP3R1) promoter region and its association with left ventricular hypertrophy. (PMID: 16209992) Tang W … Ferrell RE (American heart journal 2005) 3 23 41
- Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase. (PMID: 2558868) Guerini D … Klee CB (DNA (Mary Ann Liebert, Inc.) 1989) 2 3 4
- Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. (PMID: 26794871) Li SJ … Wang ZX (Cell research 2016) 3 4
- Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM. (PMID: 27974827) Sheftic SR … Peti W (Scientific reports 2016) 3 4
- The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin. (PMID: 23468591) Grigoriu S … Peti W (PLoS biology 2013) 3 4
ExternalLinks
Products for PPP3R1 Gene
- Custom Antibody ServicesOriGene Antibodies for PPP3R1
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP3R1
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- Novus Biologicals Antibodies for PPP3R1
- Novus Biologicals proteins and lysates for PPP3R1
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- VectorBuilder Custom and pre-made DNA vectors for PPP3R1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PPP3R1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PPP3R1 (ie. knockout, knockin, CRISPRa, CRISPRi)
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- VectorBuilder Stable cell line generation for PPP3R1
- Addgene plasmids for PPP3R1
- antibodies-online: Show 27 available PPP3R1 Antibodies ranked by validation data
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- antibodies-online: Show 12 available PPP3R1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for PPP3R1
- Search Santa Cruz Biotechnology (SCBT) for PPP3R1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PPP3R1
- Custom Antibody ServicesProSci Antibodies for PPP3R1
- ProSci Proteins for PPP3R1
- Horizon Cell Lines for PPP3R1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP3R1
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for PPP3R1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP3R1
Sources for PPP3R1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
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- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (139) DataMed
- (140) HumanCyc
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- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
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- (159) GeneImprint
- (160) Synthego
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- (177) MirGeneDB