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Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding differe... See more...
Aliases for PPP3CC Gene
Aliases for PPP3CC Gene
- Protein Phosphatase 3 Catalytic Subunit Gamma 2 3 5
- CALNA3 2 3 4
- Serine/Threonine-Protein Phosphatase 2B Catalytic Subunit Gamma Isoform 3 4
- Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Gamma Isoform 2 3
- Protein Phosphatase 2B, Catalytic Subunit, Gamma Isoform 2 3
- Calmodulin-Dependent Calcineurin A Subunit Gamma Isoform 3 4
- Protein Phosphatase 3, Catalytic Subunit, Gamma Isozyme 2 3
External Ids for PPP3CC Gene
- HGNC: 9316
- Entrez Gene: 5533
- Ensembl: ENSG00000120910
- OMIM: 114107
- UniProtKB: P48454
Previous GeneCards Identifiers for PPP3CC Gene
- GC08M022210
- GC08P022650
- GC08P022118
- GC08P022320
- GC08P022354
- GC08P022298
- GC08P020840
Summaries for PPP3CC Gene
-
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for PPP3CC Gene
PPP3CC (Protein Phosphatase 3 Catalytic Subunit Gamma) is a Protein Coding gene. Diseases associated with PPP3CC include Schizophrenia 11 and Melancholia. Among its related pathways are Nur77 Signaling in T-Cell and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP3CB.
UniProtKB/Swiss-Prot Summary for PPP3CC Gene
-
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.
Additional gene information for PPP3CC Gene
- HGNC(9316)
- Entrez Gene(5533)
- Ensembl(ENSG00000120910)
- OMIM(114107)
- UniProtKB(P48454)
- Open Targets Platform(ENSG00000120910)
- Search for PPP3CC at DataMed
- Search for PPP3CC at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP3CC Gene
Genomics for PPP3CC Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PPP3CC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPP3CC on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP3CC
- Top Transcription factor binding sites by QIAGEN in the PPP3CC gene promoter:
-
- aMEF-2
- En-1
- FOXL1
- HEN1
- HNF-1
- HNF-1A
- MEF-2A
- Nkx2-2
- RFX1
- S8
Genomic Locations for PPP3CC Gene
Genomic Locations for PPP3CC Gene
- chr8:22,440,819-22,541,466
- (GRCh38/hg38)
- Size:
- 100,648 bases
- Orientation:
- Plus strand
- chr8:22,298,332-22,398,652
- (GRCh37/hg19)
- Size:
- 100,321 bases
- Orientation:
- Plus strand
Genomic View for PPP3CC Gene
Genes around PPP3CC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.3 by HGNC
- 8p21.3 by Entrez Gene
- 8p21.3 by Ensembl
PPP3CC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP3CC Gene
Proteins for PPP3CC Gene
-
Protein details for PPP3CC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P48454-PP2BC_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
- Protein Accession:
- P48454
- B4DRT5
- Q9BSS6
- Q9H4M5
Protein attributes for PPP3CC Gene
- Size:
- 512 amino acids
- Molecular mass:
- 58129 Da
- Cofactor:
- Name=Fe(3+); Xref=ChEBI:CHEBI:29034;
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B) (PubMed:19154138). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). In response to an increase in Ca(2+) intracellular levels, forms a complex composed of PPP3CC/calcineurin A, calcineurin B and calmodulin (By similarity). Interacts (via calmodulin-binding domain) with calmodulin; the interaction depends on calmodulin binding to Ca(2+) (By similarity). Interacts with UNC119 (By similarity).
Protein Expression for PPP3CC Gene
Selected DME Specific Peptides for PPP3CC Gene
- P48454:
-
- DLLWSDP
- LLRGNHECRHLT
- GVLSGGKQT
- APITVCGD
- ICSDDEL
- NKIRAIGKMARVF
- NERMPPR
- TIFSAPNY
- VRGCSYF
- DIRKLDRF
- PHPYWLP
- CGDIHGQ
- TGFPSLIT
- NKAAVLKYE
- GYRMYRK
- GDYVDRG
- VDVLKNHLVKEGR
- NVMNIRQF
- KLFEVGG
- LKGLTPTG
- EPPAFGP
- FMDVFTWSLPFVGEKVTEMLV
- LLSIIRAHEAQDAGYRMY
- KAVPFPP
- EKTMIEV
- IRNKIRAIGKM
Post-translational modifications for PPP3CC Gene
Other Protein References for PPP3CC Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents PPP3CC Antibody
-
Custom Antibody ServicesOriGene Antibodies for PPP3CC
- Novus Biologicals Antibodies for PPP3CC
-
Abcam antibodies for PPP3CC
- Invitrogen Antibodies for PPP3CC (AFLGC-PPP3CC)
-
Biorbyt antibodies for PPP3CC
-
Boster Bio Antibodies for PPP3CC
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP3CC
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP3CC
- Origene Custom Protein Services for PPP3CC
-
Signalway Proteins for PPP3CC
-
Abcam proteins for PPP3CC
Domains & Families for PPP3CC Gene
Gene Families for PPP3CC Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PPP3CC Gene
- InterPro:
- Blocks:
-
- Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP3CC Gene
- GenScript: Design optimal peptide antigens:
-
- Serine/threonine-protein phosphatase (B4DRT5_HUMAN)
- Calmodulin-dependent calcineurin A subunit gamma isoform (PP2BC_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P48454UniProtKB/Swiss-Prot:
PP2BC_HUMAN :- The autoinhibitory domain prevents access to the catalytic site.
- Belongs to the PPP phosphatase family. PP-2B subfamily.
- Domain:
-
- The autoinhibitory domain prevents access to the catalytic site.
- The autoinhibitory segment prevents access to the substrate binding site.
- Possible isomerization of Pro-305 within the SAPNY motif triggers a conformation switch which affects the organization and thus accessibility of the active site and the substrate binding region (PxIxIF motif). The trans- to cis-transition may favor calcineurin A activation and substrate binding. The reverse cis- to trans-transition may be enhanced by peptidyl-prolyl isomerases such as PPIA.
- Family:
-
- Belongs to the PPP phosphatase family. PP-2B subfamily.
Function for PPP3CC Gene
Molecular function for PPP3CC Gene
- UniProtKB/Swiss-Prot Function:
- Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:19154138};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:19154138};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=1.27 uM for NFATC1 {ECO:0000269|PubMed:19154138}; KM=0.94 uM for DARPP32 {ECO:0000269|PubMed:19154138};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by Ca(2+)-bound calmodulin following an increase in intracellular Ca(2+). At low Ca(2+) concentrations, the catalytic subunit (also known as calcineurin A) is inactive and is bound to the regulatory subunit (also known as calcineurin B) in which only two high-affinity binding sites are occupied by Ca(2+). In response to elevated calcium levels, the occupancy of the low-affinity sites on calcineurin B by Ca(2+) causes a conformational change of the C-terminal regulatory domain of calcineurin A, resulting in the exposure of the calmodulin-binding domain and in the partial activation of calcineurin A. The subsequent binding of Ca(2+)-bound calmodulin leads to the displacement of the autoinhibitory domain from the active site and possibly of the autoinhibitory segment from the substrate binding site which fully activates calcineurin A.
- GENATLAS Biochemistry:
- calcineurin gamma isoform,calmodulin dependent protein serine/threonine phosphatase,catalytic subunit,type 3,testis specific
Enzyme Numbers (IUBMB) for PPP3CC Gene
Phenotypes From GWAS Catalog for PPP3CC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005516 | calmodulin binding | IBA | 21873635 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0033192 | calmodulin-dependent protein phosphatase activity | IBA,IDA | 19154138 |
Phenotypes for PPP3CC Gene
- MGI mutant phenotypes for PPP3CC:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PPP3CC:
-
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased viability in pancreas lineage
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs
- Increased Akt phosphorylation after EGF stimulation
Animal Models for PPP3CC Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPP3CC - Select products 50% OFF >
- * PPP3CC CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPP3CC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP3CC
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP3CC
miRNA for PPP3CC Gene
- miRTarBase miRNAs that target PPP3CC
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP3CC
- Browse OriGene Inhibitory RNA Products For PPP3CC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP3CC
Clone Products
- Applied Biological Materials (abm): Clones for PPP3CC - Select products 50% OFF >
- * PPP3CC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PPP3CC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP3CC
Cell Line Products
-
Horizon Cell Lines for PPP3CC
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP3CC Gene
Localization for PPP3CC Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 4 |
| nucleus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 0 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,IDA | 19154138 |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005955 | calcineurin complex | IBA | 21873635 |
| GO:0098793 | presynapse | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP3CC Gene
Pathways & Interactions for PPP3CC Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 2 | TCR Signaling (Qiagen) |
PKC-Theta Pathway
.68
TCR Signaling
.68
|
ITK and TCR Signaling
.54
Fc-EpsilonRI Pathway
.49
|
| 3 | Immune response NFAT in immune response |
Immune response ICOS pathway in T-helper cell
.56
Immune response NFAT in immune response
.56
|
Immune response T cell receptor signaling pathway
.52
Immune response CD28 signaling
.52
|
| 4 | Human cytomegalovirus infection | ||
| 5 | Immune response Fc epsilon RI pathway |
Immune response BCR pathway
.44
Immune response Fc epsilon RI pathway
.44
|
|
Pathways by source for PPP3CC Gene
1 Sino Biological pathway for PPP3CC Gene
6 BioSystems pathways for PPP3CC Gene
9 Reactome pathways for PPP3CC Gene
1 PharmGKB pathway for PPP3CC Gene
30 KEGG pathways for PPP3CC Gene
20 GeneGo (Thomson Reuters) pathways for PPP3CC Gene
- Apoptosis and survival APRIL and BAFF signaling
- Apoptosis and survival BAD phosphorylation
- Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
- Development VEGF signaling via VEGFR2 - generic cascades
- Immune response BCR pathway
32 Qiagen pathways for PPP3CC Gene
- 14-3-3 Induced Apoptosis
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- BAD Phosphorylation
- Calcium Mediated T-Cell Apoptosis
2 Cell Signaling Technology pathways for PPP3CC Gene
Interacting Proteins for PPP3CC Gene
Selected Interacting proteins:
P48454-PP2BC_HUMAN
ENSP00000380878
for PPP3CC Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PPP3CC
SIGNOR curated interactions for PPP3CC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IEA,IDA | 19154138 |
| GO:0007420 | brain development | IEA | -- |
| GO:0033173 | calcineurin-NFAT signaling cascade | IDA | 19154138 |
| GO:0097720 | calcineurin-mediated signaling | IBA | 21873635 |
| GO:1900242 | regulation of synaptic vesicle endocytosis | IEA | -- |
Drugs & Compounds for PPP3CC Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14066-19-4, 14265-44-2 |
|
(1) ApexBio Compounds for PPP3CC Gene
| Compound | Action | Cas Number |
|---|---|---|
| Pimecrolimus | 137071-32-0 |
Transcripts for PPP3CC Gene
mRNA/cDNA for PPP3CC Gene
- 3 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000240139 2189 nts (view in UCSC)
- ENST00000289963 2135 nts (view in UCSC)
- ENST00000397775 2094 nts (view in UCSC)
- ENST00000518852 1598 nts (view in UCSC)
- ENST00000521651 680 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPP3CC - Select products 50% OFF >
- * PPP3CC CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPP3CC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP3CC
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP3CC
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP3CC
- Browse OriGene Inhibitory RNA Products For PPP3CC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP3CC
Clone Products
- Applied Biological Materials (abm): Clones for PPP3CC - Select products 50% OFF >
- * PPP3CC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PPP3CC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP3CC
Relevant External Links for PPP3CC Gene
- GeneLoc Exon Structure for
- PPP3CC
Expression for PPP3CC Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Mature Rod Cells Outer Nuclear Layer
-
Neurons
- Mature Rod Cells Outer Nuclear Layer
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for PPP3CC Gene
This gene is overexpressed in Muscle - Skeletal (x5.1).
This gene is overexpressed in Brain (13.0), Testis (11.2), Lymph node (9.3), and CD8 Tcells (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP3CC Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP3CC
SOURCE GeneReport for Unigene cluster for PPP3CC Gene:
Hs.731683mRNA Expression by UniProt/SwissProt for PPP3CC Gene:
P48454-PP2BC_HUMAN
Tissue specificity:
Testis.
Evidence on tissue expression from TISSUES for PPP3CC Gene
- Heart(4.4)
- Nervous system(3.8)
- Muscle(2.4)
- Blood(2.2)
Primer Products
-
OriGene qPCR primer pairs for PPP3CC
-
OriGene qPCR primer pairs and template standards for PPP3CC
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP3CC Gene
Orthologs for PPP3CC Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PPP3CC 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PPP3CC 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PPP3CC 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ppp3cc 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PPP3CC 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ppp3cc 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PPP3CC 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PPP3CC 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppp3cb 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ppp3ccb 31 |
|
OneToMany | |
| ppp3cca 30 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | PpD33 32 |
|
|
|
| Pp2B-14D 31 32 |
|
ManyToMany | |||
| CanA-14F 31 32 |
|
ManyToMany | |||
| CanA1 31 32 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | tax-6 31 |
|
OneToMany | |
| ZC477.2 32 |
|
|
|||
| F42G8.8 32 |
|
|
|||
| F49E11.7 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CNA1 31 33 |
|
ManyToMany | |
| CMP2 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8703 31 |
|
OneToMany |
- Species where no ortholog for PPP3CC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PPP3CC Gene
- ENSEMBL:
- Gene Tree for PPP3CC (if available)
- TreeFam:
- Gene Tree for PPP3CC (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP3CC: view image
Paralogs for PPP3CC Gene
Paralogs for PPP3CC Gene
(10) SIMAP similar genes for PPP3CC Gene using alignment to 6 proteins:
- PP2BC_HUMAN
- E5RJH4_HUMAN
- G3V111_HUMAN
- H0YB02_HUMAN
- H0YB04_HUMAN
- H0YC26_HUMAN
Variants for PPP3CC Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP3CC Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 737660 | Likely Benign: not provided | 22,475,031(+) | A/C | MISSENSE_VARIANT | |
| 773221 | Benign: not provided | 22,531,335(+) | G/A | INTRON_VARIANT | |
| rs1563790727 | Uncertain Significance: Keratoconus | 22,532,282(+) | T/C | MISSENSE_VARIANT | |
| rs28764007 | - | p.Ala501Val |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv451n21 | CNV | loss | 19592680 |
| dgv7136n100 | CNV | gain | 25217958 |
| dgv7137n100 | CNV | loss | 25217958 |
| esv2759604 | CNV | loss | 17122850 |
| esv2764071 | CNV | gain | 21179565 |
| esv3543215 | CNV | deletion | 23714750 |
| esv3616610 | CNV | loss | 21293372 |
| esv3616612 | CNV | loss | 21293372 |
| nsv518646 | CNV | gain | 19592680 |
| nsv831266 | CNV | loss | 17160897 |
| nsv971631 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.77;
47.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP3CC Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPP3CC
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP3CC Gene
Disorders for PPP3CC Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| schizophrenia 11 |
|
|
| melancholia |
|
|
| schizophrenia |
|
|
| schizophrenia 6 |
|
|
| crouzon syndrome with acanthosis nigricans |
|
|
Search PPP3CC in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPP3CC
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PPP3CC Gene
Publications for PPP3CC Gene
- More evidence supports the association of PPP3CC with schizophrenia. (PMID: 17339875) Liu YL … Hwu HG (Molecular psychiatry 2007) 3 23 41
- Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. (PMID: 12851458) Gerber DJ … Tonegawa S (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 23 41
- Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A). (PMID: 1339277) Muramatsu T … Kincaid RL (Biochemical and biophysical research communications 1992) 2 3 4
- Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population. (PMID: 20537399) Kyogoku C … Kumagai S (Psychiatry research 2011) 3 41
- Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So HC … Sham PC (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41
ExternalLinks
Products for PPP3CC Gene
- Custom Antibody ServicesOriGene Antibodies for PPP3CC
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- antibodies-online: Show 45 available PPP3CC Antibodies ranked by validation data
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Sources for PPP3CC Gene
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