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PPP3CC Gene(Protein Coding)

Protein Phosphatase 3 Catalytic Subunit Gamma

GCID:
GC08P022440
GIFtS:
53
Genes Participants
UDN Logo

Aliases for PPP3CC Gene

Aliases for PPP3CC Gene

  • Protein Phosphatase 3 Catalytic Subunit Gamma 2 3 5
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Gamma Isoform 2 3
  • Protein Phosphatase 2B, Catalytic Subunit, Gamma Isoform 2 3
  • Calmodulin-Dependent Calcineurin A Subunit Gamma Isoform 3 4
  • Protein Phosphatase 3, Catalytic Subunit, Gamma Isozyme 2 3
  • Calcineurin, Testis-Specific Catalytic Subunit 3 4
  • CAM-PRP Catalytic Subunit 3 4
  • EC 3.1.3.16 4 56
  • CALNA3 3 4
  • CNA3 3 4
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Gamma Isoform (Calcineurin A Gamma) 2
  • Serine/Threonine-Protein Phosphatase 2B Catalytic Subunit Gamma Isoform 3
  • Calcineurin A Gamma 2
  • PP2Bgamma 3

External Ids for PPP3CC Gene

Previous GeneCards Identifiers for PPP3CC Gene

  • GC08M022210
  • GC08P022650
  • GC08P022118
  • GC08P022320
  • GC08P022354
  • GC08P022298
  • GC08P020840

Summaries for PPP3CC Gene

Entrez Gene Summary for PPP3CC Gene

  • Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for PPP3CC Gene

PPP3CC (Protein Phosphatase 3 Catalytic Subunit Gamma) is a Protein Coding gene. Diseases associated with PPP3CC include Schizophrenia. Among its related pathways are NFAT and Cardiac Hypertrophy and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP3CB.

UniProtKB/Swiss-Prot for PPP3CC Gene

  • Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Gene Wiki entry for PPP3CC Gene

Additional gene information for PPP3CC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3CC Gene

Genomics for PPP3CC Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for PPP3CC Gene

Promoters and enhancers for PPP3CC Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08I022439 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 573.7 +3.8 3846 10.2 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A ZNF2 IRF4 YY1 PPP3CC ENSG00000253200 CCAR2 C8orf58 SORBS3 ENSG00000251034 FAM160B2 POLR3D BIN3 XPO7
GH08I022545 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.5 +109.4 109364 10 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 IRF4 GLIS2 FOS SP5 SORBS3 GC08M022549 PPP3CC RNU6-336P PDLIM2 ENSG00000248235 CCAR2 ENSG00000253200 XPO7 SLC39A14
GH08I022363 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.1 -73.2 -73177 8.3 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC39A14 PIWIL2 PPP3CC PDLIM2 ENSG00000248235 RNU6-336P ENSG00000253616 BTF3P3 POLR3D DMTN
GH08I022409 Enhancer 1 ENCODE dbSUPER 27 -29.6 -29632 2.9 FOXA2 MLX RAD21 RARA YY1 PAF1 RXRA NFYC MXD4 REST PPP3CC RNU6-336P C8orf58 PDLIM2 ENSG00000248235 GC08M022420 RPL21P77 SLC39A14
GH08I022537 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 19.7 +99.6 99610 6 ZNF146 KLF1 FEZF1 BCL11B ZNF664 POLR2A ZSCAN29 ZNF687 CEBPB OVOL3 PPP3CC RNU6-336P PDLIM2 ENSG00000248235 ENSG00000251034 SORBS3 GC08M022506
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPP3CC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP3CC gene promoter:

Genomic Locations for PPP3CC Gene

Genomic Locations for PPP3CC Gene
chr8:22,440,819-22,541,144
(GRCh38/hg38)
Size:
100,326 bases
Orientation:
Plus strand
chr8:22,298,332-22,398,652
(GRCh37/hg19)

Genomic View for PPP3CC Gene

Genes around PPP3CC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP3CC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP3CC Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PPP3CC Gene

Proteins for PPP3CC Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PPP3CC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48454-PP2BC_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
    Protein Accession:
    P48454
    Secondary Accessions:
    • B4DRT5
    • Q9BSS6
    • Q9H4M5

    Protein attributes for PPP3CC Gene

    Size:
    512 amino acids
    Molecular mass:
    58129 Da
    Cofactor:
    Name=Fe(3+); Xref=ChEBI:CHEBI:29034;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

    Alternative splice isoforms for PPP3CC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP3CC Gene

Protein Expression for PPP3CC Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PPP3CC Gene

P48454:
  • DLLWSDP
  • LLRGNHECRHLT
  • GVLSGGKQT
  • APITVCGD
  • ICSDDEL
  • NKIRAIGKMARVF
  • NERMPPR
  • TIFSAPNY
  • VRGCSYF
  • DIRKLDRF
  • PHPYWLP
  • CGDIHGQ
  • TGFPSLIT
  • NKAAVLKYE
  • GYRMYRK
  • GDYVDRG
  • VDVLKNHLVKEGR
  • NVMNIRQF
  • KLFEVGG
  • LKGLTPTG
  • EPPAFGP
  • FMDVFTWSLPFVGEKVTEMLV
  • LLSIIRAHEAQDAGYRMY
  • KAVPFPP
  • EKTMIEV
  • IRNKIRAIGKM

Post-translational modifications for PPP3CC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP3CC Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPP3CC Gene

Gene Families for PPP3CC Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PPP3CC Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP3CC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48454

UniProtKB/Swiss-Prot:

PP2BC_HUMAN :
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
genes like me logo Genes that share domains with PPP3CC: view

Function for PPP3CC Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PPP3CC Gene

GENATLAS Biochemistry:
calcineurin gamma isoform,calmodulin dependent protein serine/threonine phosphatase,catalytic subunit,type 3,testis specific
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Enzyme Numbers (IUBMB) for PPP3CC Gene

Phenotypes From GWAS Catalog for PPP3CC Gene

Gene Ontology (GO) - Molecular Function for PPP3CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005516 calmodulin binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPP3CC: view
genes like me logo Genes that share phenotypes with PPP3CC: view

Animal Models for PPP3CC Gene

MGI Knock Outs for PPP3CC:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP3CC Gene

Localization for PPP3CC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP3CC gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 4
plasma membrane 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP3CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with PPP3CC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP3CC Gene

Pathways & Interactions for PPP3CC Gene

genes like me logo Genes that share pathways with PPP3CC: view

SIGNOR curated interactions for PPP3CC Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP3CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007420 brain development IEA --
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS --
genes like me logo Genes that share ontologies with PPP3CC: view

Drugs & Compounds for PPP3CC Gene

Products:

  1. Drug

(6) Drugs for PPP3CC Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
Pimecrolimus Approved, Investigational Pharma 64
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0

(1) Additional Compounds for PPP3CC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
 14265-44-2

(2) ApexBio Compounds for PPP3CC Gene

Compound Action Cas Number
Cyclosporine Immunosuppressant drug 79217-60-0
Pimecrolimus 137071-32-0
genes like me logo Genes that share compounds with PPP3CC: view

Drug Products

Transcripts for PPP3CC Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PPP3CC Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(171) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP3CC Gene

Protein phosphatase 3, catalytic subunit, gamma isozyme:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3CC Gene

No ASD Table

Relevant External Links for PPP3CC Gene

GeneLoc Exon Structure for
PPP3CC
ECgene alternative splicing isoforms for
PPP3CC

Expression for PPP3CC Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP3CC Gene

mRNA expression in normal human tissues for PPP3CC Gene
mRNA expression by BioGPS for PPP3CC GenemRNA expression by GTEx for PPP3CC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP3CC Gene

This gene is overexpressed in Muscle - Skeletal (x5.1).

Protein differential expression in normal tissues from HIPED for PPP3CC Gene

This gene is overexpressed in Brain (13.0), Testis (11.2), Lymph node (9.3), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP3CC Gene



Protein tissue co-expression partners for PPP3CC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP3CC Gene:

PPP3CC

SOURCE GeneReport for Unigene cluster for PPP3CC Gene:

Hs.731683

mRNA Expression by UniProt/SwissProt for PPP3CC Gene:

P48454-PP2BC_HUMAN
Tissue specificity: Testis.

Evidence on tissue expression from TISSUES for PPP3CC Gene

  • Heart(4.3)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with PPP3CC: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP3CC Gene

Orthologs for PPP3CC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3CC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PPP3CC 33 34
  • 99.62 (n)
cow
(Bos Taurus)
 Mammalia PPP3CC 33 34
  • 92.02 (n)
dog
(Canis familiaris)
 Mammalia PPP3CC 33 34
  • 91.55 (n)
rat
(Rattus norvegicus)
 Mammalia Ppp3cc 33
  • 87.46 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia PPP3CC 34
  • 87 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ppp3cc 33 16 34
  • 86.51 (n)
oppossum
(Monodelphis domestica)
 Mammalia PPP3CC 34
  • 81 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia PPP3CC 34
  • 86 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ppp3cb 33
  • 74.6 (n)
zebrafish
(Danio rerio)
 Actinopterygii ppp3ccb 34
  • 81 (a)
 OneToMany
ppp3cca 33 34
  • 74.47 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CanA-14F 35 34
  • 76 (a)
PpD33 35
  • 76 (a)
Pp2B-14D 35 34
  • 74 (a)
CanA1 35 34
  • 70 (a)
worm
(Caenorhabditis elegans)
 Secernentea tax-6 34
  • 64 (a)
 OneToMany
ZC477.2 35
  • 33 (a)
F42G8.8 35
  • 32 (a)
F49E11.7 35
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CNA1 34 36
  • 47 (a)
 ManyToMany
CMP2 34
  • 44 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.8703 34
  • 66 (a)
 OneToMany
Species where no ortholog for PPP3CC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP3CC Gene

ENSEMBL:
Gene Tree for PPP3CC (if available)
TreeFam:
Gene Tree for PPP3CC (if available)

Paralogs for PPP3CC Gene

Paralogs for PPP3CC Gene

(10) SIMAP similar genes for PPP3CC Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PPP3CC: view

Variants for PPP3CC Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for PPP3CC Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000005555 -- 22,448,047(+) A/G intron_variant
rs1000008614 -- 22,508,949(+) A/G intron_variant
rs1000045710 -- 22,455,130(+) T/C intron_variant
rs1000061864 -- 22,475,436(+) T/C intron_variant
rs1000122709 -- 22,470,327(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP3CC Gene

Variant ID Type Subtype PubMed ID
dgv451n21 CNV loss 19592680
dgv7136n100 CNV gain 25217958
dgv7137n100 CNV loss 25217958
esv2759604 CNV loss 17122850
esv2764071 CNV gain 21179565
esv3543215 CNV deletion 23714750
esv3616610 CNV loss 21293372
esv3616612 CNV loss 21293372
nsv518646 CNV gain 19592680
nsv831266 CNV loss 17160897
nsv971631 CNV duplication 23825009

Variation tolerance for PPP3CC Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP3CC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP3CC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP3CC Gene

Disorders for PPP3CC Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP3CC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP3CC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PPP3CC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP3CC Gene

Publications for PPP3CC Gene

  1. More evidence supports the association of PPP3CC with schizophrenia. (PMID: 17339875) Liu YL … Hwu HG (Molecular psychiatry 2007) 3 22 44 58
  2. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. (PMID: 12851458) Gerber DJ … Tonegawa S (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 22 44 58
  3. Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A). (PMID: 1339277) Muramatsu T … Kincaid RL (Biochemical and biophysical research communications 1992) 2 3 4 58
  4. Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population. (PMID: 20537399) Kyogoku C … Kumagai S (Psychiatry research 2011) 3 44 58
  5. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So HC … Sham PC (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58

Products for PPP3CC Gene

Sources for PPP3CC Gene

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