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Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
PPP3CC (Protein Phosphatase 3 Catalytic Subunit Gamma) is a Protein Coding gene. Diseases associated with PPP3CC include Schizophrenia 11 and Melancholia. Among its related pathways are Nur77 Signaling in T-Cell and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP3CB.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0005516 | calmodulin binding | IBA | 21873635 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0033192 | calmodulin-dependent protein phosphatase activity | IBA,IDA | 19154138 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA,IDA | 19154138 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005955 | calcineurin complex | IBA | 21873635 |
GO:0098793 | presynapse | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
2 | TCR Signaling (Qiagen) |
PKC-Theta Pathway
.68
TCR Signaling
.68
|
ITK and TCR Signaling
.54
Fc-EpsilonRI Pathway
.49
|
3 | Immune response NFAT in immune response |
Immune response ICOS pathway in T-helper cell
.56
Immune response NFAT in immune response
.56
|
Immune response T cell receptor signaling pathway
.52
Immune response CD28 signaling
.52
|
4 | Human cytomegalovirus infection | ||
5 | Immune response Fc epsilon RI pathway |
Immune response BCR pathway
.44
Immune response Fc epsilon RI pathway
.44
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006470 | protein dephosphorylation | IEA,IDA | 19154138 |
GO:0007420 | brain development | IEA | -- |
GO:0033173 | calcineurin-NFAT signaling cascade | IDA | 19154138 |
GO:0097720 | calcineurin-mediated signaling | IBA | 21873635 |
GO:1900242 | regulation of synaptic vesicle endocytosis | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Phosphate |
|
14066-19-4, 14265-44-2 |
|
Compound | Action | Cas Number |
---|---|---|
Pimecrolimus | 137071-32-0 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PPP3CC 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PPP3CC 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PPP3CC 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ppp3cc 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | PPP3CC 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ppp3cc 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PPP3CC 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PPP3CC 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppp3cb 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ppp3ccb 31 |
|
OneToMany | |
ppp3cca 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | PpD33 32 |
|
|
|
Pp2B-14D 31 32 |
|
ManyToMany | |||
CanA-14F 31 32 |
|
ManyToMany | |||
CanA1 31 32 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | tax-6 31 |
|
OneToMany | |
ZC477.2 32 |
|
|
|||
F42G8.8 32 |
|
|
|||
F49E11.7 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CNA1 31 33 |
|
ManyToMany | |
CMP2 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8703 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
737660 | Likely Benign: not provided | 22,475,031(+) | A/C | MISSENSE_VARIANT | |
773221 | Benign: not provided | 22,531,335(+) | G/A | INTRON_VARIANT | |
rs1563790727 | Uncertain Significance: Keratoconus | 22,532,282(+) | T/C | MISSENSE_VARIANT | |
rs28764007 | - | p.Ala501Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv451n21 | CNV | loss | 19592680 |
dgv7136n100 | CNV | gain | 25217958 |
dgv7137n100 | CNV | loss | 25217958 |
esv2759604 | CNV | loss | 17122850 |
esv2764071 | CNV | gain | 21179565 |
esv3543215 | CNV | deletion | 23714750 |
esv3616610 | CNV | loss | 21293372 |
esv3616612 | CNV | loss | 21293372 |
nsv518646 | CNV | gain | 19592680 |
nsv831266 | CNV | loss | 17160897 |
nsv971631 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
schizophrenia 11 |
|
|
melancholia |
|
|
schizophrenia |
|
|
schizophrenia 6 |
|
|
crouzon syndrome with acanthosis nigricans |
|
|