Aliases for PPP3CB Gene

Aliases for PPP3CB Gene

  • Protein Phosphatase 3 Catalytic Subunit Beta 2 3 5
  • CALNA2 2 3 4
  • CNA2 2 3 4
  • Serine/Threonine-Protein Phosphatase 2B Catalytic Subunit Beta Isoform 3 4
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Beta Isoform 2 3
  • Protein Phosphatase 2B, Catalytic Subunit, Beta Isoform 2 3
  • Calmodulin-Dependent Calcineurin A Subunit Beta Isoform 3 4
  • Protein Phosphatase 3, Catalytic Subunit, Beta Isozyme 2 3
  • CAM-PRP Catalytic Subunit 3 4
  • Calcineurin A Beta 2 3
  • EC 3.1.3.16 4 51
  • PP2Bbeta 2 3
  • CNA Beta 3 4
  • CALNB 3 4
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Beta Isoform (Calcineurin A Beta) 2
  • Protein Phosphatase From PCR Fragment H32 3
  • Calcineurin A2 3
  • PPP3CB 5

External Ids for PPP3CB Gene

Previous HGNC Symbols for PPP3CB Gene

  • CALNB

Previous GeneCards Identifiers for PPP3CB Gene

  • GC10M073975
  • GC10M074299
  • GC10M075088
  • GC10M074541
  • GC10M074866
  • GC10M075196
  • GC10M069190

Summaries for PPP3CB Gene

GeneCards Summary for PPP3CB Gene

PPP3CB (Protein Phosphatase 3 Catalytic Subunit Beta) is a Protein Coding gene. Diseases associated with PPP3CB include Pancreatic Ductal Adenocarcinoma and Kidney Hypertrophy. Among its related pathways are Nur77 Signaling in T-Cell and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include calcium ion binding and hydrolase activity. An important paralog of this gene is PPP3CA.

UniProtKB/Swiss-Prot Summary for PPP3CB Gene

  • Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:26794871). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).

Gene Wiki entry for PPP3CB Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP3CB Gene

Genomics for PPP3CB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP3CB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP3CB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP3CB

Top Transcription factor binding sites by QIAGEN in the PPP3CB gene promoter:
  • AML1a
  • AREB6
  • ITF-2
  • Meis-1
  • Meis-1a
  • p53
  • RREB-1
  • Tal-1beta

Genomic Locations for PPP3CB Gene

Genomic Locations for PPP3CB Gene
chr10:73,436,428-73,496,024
(GRCh38/hg38)
Size:
59,597 bases
Orientation:
Minus strand
chr10:75,196,186-75,255,782
(GRCh37/hg19)
Size:
59,597 bases
Orientation:
Minus strand

Genomic View for PPP3CB Gene

Genes around PPP3CB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP3CB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP3CB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3CB Gene

Proteins for PPP3CB Gene

  • Protein details for PPP3CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16298-PP2BB_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    Protein Accession:
    P16298
    Secondary Accessions:
    • P16299
    • Q5F2F9
    • Q8N1F0
    • Q8N3W4

    Protein attributes for PPP3CB Gene

    Size:
    524 amino acids
    Molecular mass:
    59024 Da
    Cofactor:
    Name=Fe(3+); Xref=ChEBI:CHEBI:29034;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). In response to an increase in Ca(2+) intracellular levels, forms a complex composed of PPP3CB/calcineurin A, calcineurin B and calmodulin. Interacts (via calcineurin B binding domain) with regulatory subunit PPP3R1/calcineurin B. Interacts (via calmodulin-binding domain) with calmodulin; the interaction depends on calmodulin binding to Ca(2+). Interacts with SLC12A1 (By similarity). Interacts with SORL1 (By similarity). Interacts with UNC119 (By similarity).
    Miscellaneous:
    • Unlike for protein substrates, PPP3CB activity towards synthetic phosphatase substrate p-nitrophenyl phosphate (pNPP) is increased in presence of the immunosuppressant complex FKBP12-FK506.

    Three dimensional structures from OCA and Proteopedia for PPP3CB Gene

    Alternative splice isoforms for PPP3CB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP3CB Gene

Selected DME Specific Peptides for PPP3CB Gene

P16298:
  • DLLWSDP
  • LLRGNHECRHLT
  • APITVCGD
  • ICSDDEL
  • NKIRAIGKMARVF
  • EDFGNEK
  • NERMPPR
  • TIFSAPNY
  • VRGCSYF
  • PHPYWLP
  • CGDIHGQ
  • TGFPSLIT
  • NKAAVLKYE
  • GYRMYRK
  • GDYVDRG
  • VDVLKNHLVKEGR
  • NVMNIRQF
  • QTLQSATVEAIEA
  • KLFEVGG
  • DRFKEPP
  • LKGLTPTG
  • EPPAFGP
  • ACMEAFD
  • FMDVFTWSLPFVGEKVTEMLV
  • CVHGGLSP
  • LLSIIRAHEAQDAGYRMY
  • KAVPFPP
  • EKTMIEV
  • IRNKIRAIGKM

Post-translational modifications for PPP3CB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PPP3CB Gene

Gene Families for PPP3CB Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PPP3CB Gene

InterPro:
Blocks:
  • Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
ProtoNet:

Suggested Antigen Peptide Sequences for PPP3CB Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53100, highly similar to Serine/threonine-protein phosphatase 2Bcatalytic subunit beta isoform (EC 3.1.3.16) (B7Z6P2_HUMAN)
  • Serine/threonine-protein phosphatase (F5H0F8_HUMAN)
  • Calmodulin-dependent calcineurin A subunit beta isoform (PP2BB_HUMAN)
  • Serine/threonine-protein phosphatase (Q5F2F8_HUMAN)
  • Protein phosphatase 3 (Formerly 2B), catalytic subunit, beta isoform (Q5F2G0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P16298

UniProtKB/Swiss-Prot:

PP2BB_HUMAN :
  • The poly-Pro domain may confer substrate specificity.
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
Domain:
  • The poly-Pro domain may confer substrate specificity.
  • The autoinhibitory domain prevents access to the catalytic site.
  • The autoinhibitory segment prevents access to the substrate binding site.
  • Possible isomerization of Pro-318 within the SAPNY motif triggers a conformation switch which affects the organization and thus accessibility of the active site and the substrate binding region (PxIxIF motif). The trans- to cis-transition may favor calcineurin A activation and substrate binding. The reverse cis- to trans-transition may be enhanced by peptidyl-prolyl isomerases such as PPIA.
Family:
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
genes like me logo Genes that share domains with PPP3CB: view

Function for PPP3CB Gene

Molecular function for PPP3CB Gene

UniProtKB/Swiss-Prot Function:
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:26794871). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:26794871};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:26794871};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.69 uM for NFATC1 {ECO:0000269|PubMed:19154138}; KM=0.7 uM for DARPP32 {ECO:0000269|PubMed:19154138};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)-bound calmodulin following an increase in intracellular Ca(2+). At low Ca(2+) concentrations, the catalytic subunit (also known as calcineurin A) is inactive and is bound to the regulatory subunit (also known as calcineurin B) in which only two high-affinity binding sites are occupied by Ca(2+). In response to elevated calcium levels, the occupancy of the low-affinity sites on calcineurin B by Ca(2+) causes a conformational change of the C-terminal regulatory domain of calcineurin A, resulting in the exposure of the calmodulin-binding domain and in the partial activation of calcineurin A. The subsequent binding of Ca(2+)-bound calmodulin leads to the displacement of the autoinhibitory domain from the active site and possibly of the autoinhibitory segment from the substrate binding site which fully activates calcineurin A.
GENATLAS Biochemistry:
calcineurin A beta isoform,calmodulin dependent serine/threonine phosphatase 2B,catalytic subunit,19kDa,also abundantly expressed in the central nervous system,including the hyppocampus,involved in osteoclast regulation

Enzyme Numbers (IUBMB) for PPP3CB Gene

Phenotypes From GWAS Catalog for PPP3CB Gene

Gene Ontology (GO) - Molecular Function for PPP3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA,NAS 8392375
GO:0005509 calcium ion binding IDA 8524402
GO:0005515 protein binding IPI 21903422
GO:0005516 calmodulin binding IBA,NAS 8524402
genes like me logo Genes that share ontologies with PPP3CB: view
genes like me logo Genes that share phenotypes with PPP3CB: view

Animal Models for PPP3CB Gene

MGI Knock Outs for PPP3CB:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPP3CB

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP3CB

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP3CB Gene

Localization for PPP3CB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP3CB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP3CB gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,IDA 19154138
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA,ISS --
GO:0005955 calcineurin complex IDA 8524402
genes like me logo Genes that share ontologies with PPP3CB: view

Pathways & Interactions for PPP3CB Gene

PathCards logo

SuperPathways for PPP3CB Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
2 TCR Signaling (Qiagen)
.68
.68
.54
.49
3 Immune response NFAT in immune response
.56
.56
.52
.52
4 Human cytomegalovirus infection
5 Immune response Fc epsilon RI pathway
.44
.44
genes like me logo Genes that share pathways with PPP3CB: view

Pathways by source for PPP3CB Gene

21 GeneGo (Thomson Reuters) pathways for PPP3CB Gene
  • Apoptosis and survival APRIL and BAFF signaling
  • Apoptosis and survival BAD phosphorylation
  • Development Beta-adrenergic receptors signaling via cAMP
  • Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
  • Development VEGF signaling via VEGFR2 - generic cascades
32 Qiagen pathways for PPP3CB Gene
  • 14-3-3 Induced Apoptosis
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • BAD Phosphorylation
  • Calcium Mediated T-Cell Apoptosis
2 Cell Signaling Technology pathways for PPP3CB Gene

SIGNOR curated interactions for PPP3CB Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PPP3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001915 negative regulation of T cell mediated cytotoxicity IEA --
GO:0001946 lymphangiogenesis IEA --
GO:0006468 protein phosphorylation IEA,ISS --
GO:0006470 protein dephosphorylation IEA,ISS --
GO:0007165 signal transduction NAS 8978785
genes like me logo Genes that share ontologies with PPP3CB: view

Drugs & Compounds for PPP3CB Gene

(5) Drugs for PPP3CB Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pimecrolimus Approved, Investigational Pharma 66
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Voclosporin Investigational Pharma inhibitor 0
Calcium Nutra 6556

(1) Additional Compounds for PPP3CB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2

(1) ApexBio Compounds for PPP3CB Gene

Compound Action Cas Number
Pimecrolimus 137071-32-0
genes like me logo Genes that share compounds with PPP3CB: view

Drug Products

Transcripts for PPP3CB Gene

mRNA/cDNA for PPP3CB Gene

5 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP3CB

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3CB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a ·
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - -
SP6:
SP7: - - - - -
SP8: - -
SP9: -
SP10: - - - - - -
SP11: -

ExUns: 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for PPP3CB Gene

GeneLoc Exon Structure for
PPP3CB

Expression for PPP3CB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP3CB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP3CB Gene

This gene is overexpressed in Brain (15.1), Fetal Brain (13.9), Frontal cortex (9.6), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP3CB Gene



Protein tissue co-expression partners for PPP3CB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP3CB

SOURCE GeneReport for Unigene cluster for PPP3CB Gene:

Hs.500067

Evidence on tissue expression from TISSUES for PPP3CB Gene

  • Nervous system(4.5)
  • Muscle(3.4)
  • Heart(3)
  • Kidney(2.6)
  • Blood(2.4)
  • Spleen(2.3)
  • Skin(2.2)
  • Liver(2.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with PPP3CB: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP3CB Gene

Orthologs for PPP3CB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3CB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP3CB 30 31
  • 99.93 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPP3CB 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP3CB 30 31
  • 97.9 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP3CB 30 31
  • 97.84 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 96 (a)
OneToMany
-- 31
  • 82 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ppp3cb 30 17 31
  • 95.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ppp3cb 30
  • 95.11 (n)
Chicken
(Gallus gallus)
Aves PPP3CB 30 31
  • 87.09 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP3CB 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp3cc 30
  • 84.29 (n)
Zebrafish
(Danio rerio)
Actinopterygii ppp3cb 31
  • 84 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta PpD33 32
  • 80 (a)
Pp2B-14D 31 32
  • 68 (a)
ManyToMany
CanA-14F 31 32
  • 66 (a)
ManyToMany
CanA1 30 31 32
  • 64.14 (n)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea tax-6 31
  • 68 (a)
OneToMany
C25A6.1 32
  • 47 (a)
F42G8.8 32
  • 33 (a)
ZC477.2 32
  • 33 (a)
F49E11.7 32
  • 32 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMP2 30 31
  • 59.13 (n)
ManyToMany
CNA1 31
  • 47 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8703 31
  • 68 (a)
OneToMany
Species where no ortholog for PPP3CB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PPP3CB Gene

ENSEMBL:
Gene Tree for PPP3CB (if available)
TreeFam:
Gene Tree for PPP3CB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP3CB: view image

Paralogs for PPP3CB Gene

(10) SIMAP similar genes for PPP3CB Gene using alignment to 5 proteins:

  • PP2BB_HUMAN
  • B7Z6P2_HUMAN
  • F5H0F8_HUMAN
  • Q5F2F8_HUMAN
  • Q5F2G0_HUMAN
genes like me logo Genes that share paralogs with PPP3CB: view

Variants for PPP3CB Gene

Additional dbSNP identifiers (rs#s) for PPP3CB Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP3CB Gene

Variant ID Type Subtype PubMed ID
esv2534689 CNV deletion 19546169
nsv831911 CNV loss 17160897

Variation tolerance for PPP3CB Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP3CB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP3CB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP3CB Gene

Disorders for PPP3CB Gene

MalaCards: The human disease database

(3) MalaCards diseases for PPP3CB Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
kidney hypertrophy
  • hypertrophy of kidney
crouzon syndrome with acanthosis nigricans
  • can
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP3CB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PPP3CB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP3CB Gene

Publications for PPP3CB Gene

  1. Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. (PMID: 26794871) Li SJ … Wang ZX (Cell research 2016) 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding. (PMID: 19154138) Kilka S … Weiwad M (Biochemistry 2009) 3 4
  4. Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2. (PMID: 11005320) Brogan IJ … Hutchinson IV (Transplant immunology 2000) 3 23
  5. Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively. (PMID: 8978785) Wang MG … McBride OW (Cytogenetics and cell genetics 1996) 3 23

Products for PPP3CB Gene

  • Signalway ELISA kits for PPP3CB

Sources for PPP3CB Gene