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Aliases for PPP3CB Gene

Aliases for PPP3CB Gene

  • Protein Phosphatase 3 Catalytic Subunit Beta 2 3 5
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Beta Isoform 2 3
  • Protein Phosphatase 2B, Catalytic Subunit, Beta Isoform 2 3
  • Calmodulin-Dependent Calcineurin A Subunit Beta Isoform 3 4
  • Protein Phosphatase 3, Catalytic Subunit, Beta Isozyme 2 3
  • CAM-PRP Catalytic Subunit 3 4
  • Calcineurin A Beta 2 3
  • EC 3.1.3.16 4 56
  • CALNA2 3 4
  • CALNB 3 4
  • CNA2 3 4
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Beta Isoform (Calcineurin A Beta) 2
  • Serine/Threonine-Protein Phosphatase 2B Catalytic Subunit Beta Isoform 3
  • Protein Phosphatase From PCR Fragment H32 3
  • Calcineurin A2 3
  • PP2Bbeta 3

External Ids for PPP3CB Gene

Previous HGNC Symbols for PPP3CB Gene

  • CALNB

Previous GeneCards Identifiers for PPP3CB Gene

  • GC10M073975
  • GC10M074299
  • GC10M075088
  • GC10M074541
  • GC10M074866
  • GC10M075196
  • GC10M069190

Summaries for PPP3CB Gene

GeneCards Summary for PPP3CB Gene

PPP3CB (Protein Phosphatase 3 Catalytic Subunit Beta) is a Protein Coding gene. Among its related pathways are NFAT and Cardiac Hypertrophy and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include calcium ion binding and hydrolase activity. An important paralog of this gene is PPP3CA.

UniProtKB/Swiss-Prot for PPP3CB Gene

  • Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Gene Wiki entry for PPP3CB Gene

Additional gene information for PPP3CB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3CB Gene

Genomics for PPP3CB Gene

GeneHancer (GH) Regulatory Elements for PPP3CB Gene

Promoters and enhancers for PPP3CB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I073493 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.7 722 3.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF143 PPP3CB PPP3CB-AS1 NDST2 CFAP70 SEC24C AP3M1 ZSWIM8 ECD ENSG00000272140 GLUD1P3
GH10I073584 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.9 -90.3 -90317 2.9 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF143 GC10P073587 ENSG00000272140 AGAP5 GLUD1P3 SEC24C NUDT13 DUSP8P5 ZSWIM8 BMS1P4 ZSWIM8-AS1
GH10I073588 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.3 -95.3 -95288 5.9 PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 ZNF766 ZNF213 NUDT13 USP54 RNU6-883P SYNPO2L CAMK2G PPP3CB CFAP70 GC10P073587 GC10P073609
GH10I073576 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 2.7 -81.3 -81285 3 FOXA2 INSM2 ZNF2 IRF4 RAD21 YY1 ZNF335 FOS IKZF2 ZNF362 USP54 SYNPO2L RNU6-883P NUDT13 PPP3CB CAMK2G CFAP70 C10orf55 GC10P073575 GC10P073587
GH10I073646 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.6 -156.0 -156041 11 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B ETS1 ZNF280A TCF12 GATA2 SYNPO2L LOC105378360 MYOZ1 FUT11 NUDT13 USP54 PPP3CB CAMK2G CFAP70 GC10P073609
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPP3CB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP3CB gene promoter:

Genomic Locations for PPP3CB Gene

Genomic Locations for PPP3CB Gene
chr10:73,436,428-73,496,024
(GRCh38/hg38)
Size:
59,597 bases
Orientation:
Minus strand
chr10:75,196,186-75,255,782
(GRCh37/hg19)

Genomic View for PPP3CB Gene

Genes around PPP3CB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP3CB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP3CB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3CB Gene

Proteins for PPP3CB Gene

  • Protein details for PPP3CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16298-PP2BB_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    Protein Accession:
    P16298
    Secondary Accessions:
    • P16299
    • Q5F2F9
    • Q8N1F0
    • Q8N3W4

    Protein attributes for PPP3CB Gene

    Size:
    524 amino acids
    Molecular mass:
    59024 Da
    Cofactor:
    Name=Fe(3+); Xref=ChEBI:CHEBI:29034;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

    Three dimensional structures from OCA and Proteopedia for PPP3CB Gene

    Alternative splice isoforms for PPP3CB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP3CB Gene

Selected DME Specific Peptides for PPP3CB Gene

P16298:
  • DLLWSDP
  • LLRGNHECRHLT
  • APITVCGD
  • ICSDDEL
  • NKIRAIGKMARVF
  • EDFGNEK
  • NERMPPR
  • TIFSAPNY
  • VRGCSYF
  • PHPYWLP
  • CGDIHGQ
  • TGFPSLIT
  • NKAAVLKYE
  • GYRMYRK
  • GDYVDRG
  • VDVLKNHLVKEGR
  • NVMNIRQF
  • QTLQSATVEAIEA
  • KLFEVGG
  • DRFKEPP
  • LKGLTPTG
  • EPPAFGP
  • ACMEAFD
  • FMDVFTWSLPFVGEKVTEMLV
  • CVHGGLSP
  • LLSIIRAHEAQDAGYRMY
  • KAVPFPP
  • EKTMIEV
  • IRNKIRAIGKM

Post-translational modifications for PPP3CB Gene

No Post-translational modifications

Domains & Families for PPP3CB Gene

Gene Families for PPP3CB Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P16298

UniProtKB/Swiss-Prot:

PP2BB_HUMAN :
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
genes like me logo Genes that share domains with PPP3CB: view

Function for PPP3CB Gene

Molecular function for PPP3CB Gene

GENATLAS Biochemistry:
calcineurin A beta isoform,calmodulin dependent serine/threonine phosphatase 2B,catalytic subunit,19kDa,also abundantly expressed in the central nervous system,including the hyppocampus,involved in osteoclast regulation
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Enzyme Numbers (IUBMB) for PPP3CB Gene

Gene Ontology (GO) - Molecular Function for PPP3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity NAS,IEA 8392375
GO:0005509 calcium ion binding IDA 8524402
GO:0005515 protein binding IPI 21903422
GO:0005516 calmodulin binding NAS 8524402
genes like me logo Genes that share ontologies with PPP3CB: view
genes like me logo Genes that share phenotypes with PPP3CB: view

Animal Models for PPP3CB Gene

MGI Knock Outs for PPP3CB:

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP3CB Gene

Localization for PPP3CB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP3CB gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA,ISS --
GO:0005955 calcineurin complex IDA 8524402
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with PPP3CB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP3CB Gene

Pathways & Interactions for PPP3CB Gene

genes like me logo Genes that share pathways with PPP3CB: view

SIGNOR curated interactions for PPP3CB Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001915 negative regulation of T cell mediated cytotoxicity IEA --
GO:0001946 lymphangiogenesis IEA --
GO:0006468 protein phosphorylation ISS,IEA --
GO:0006470 protein dephosphorylation IEA,ISS --
GO:0007165 signal transduction NAS 8978785
genes like me logo Genes that share ontologies with PPP3CB: view

Drugs & Compounds for PPP3CB Gene

(6) Drugs for PPP3CB Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
Pimecrolimus Approved, Investigational Pharma 64
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0

(1) Additional Compounds for PPP3CB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2

(2) ApexBio Compounds for PPP3CB Gene

Compound Action Cas Number
Cyclosporine Immunosuppressant drug 79217-60-0
Pimecrolimus 137071-32-0
genes like me logo Genes that share compounds with PPP3CB: view

Drug Products

Transcripts for PPP3CB Gene

Unigene Clusters for PPP3CB Gene

Protein phosphatase 3, catalytic subunit, beta isozyme:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3CB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a ·
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - -
SP6:
SP7: - - - - -
SP8: - -
SP9: -
SP10: - - - - - -
SP11: -

ExUns: 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for PPP3CB Gene

GeneLoc Exon Structure for
PPP3CB
ECgene alternative splicing isoforms for
PPP3CB

Expression for PPP3CB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP3CB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP3CB Gene

This gene is overexpressed in Brain (15.1), Fetal Brain (13.9), Frontal cortex (9.6), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP3CB Gene



Protein tissue co-expression partners for PPP3CB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP3CB Gene:

PPP3CB

SOURCE GeneReport for Unigene cluster for PPP3CB Gene:

Hs.500067

Evidence on tissue expression from TISSUES for PPP3CB Gene

  • Nervous system(4.4)
  • Muscle(3.2)
  • Heart(2.9)
  • Kidney(2.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with PPP3CB: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP3CB Gene

Orthologs for PPP3CB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3CB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP3CB 33 34
  • 99.93 (n)
oppossum
(Monodelphis domestica)
Mammalia PPP3CB 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP3CB 33 34
  • 97.9 (n)
cow
(Bos Taurus)
Mammalia PPP3CB 33 34
  • 97.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ppp3cb 33 16 34
  • 95.94 (n)
rat
(Rattus norvegicus)
Mammalia Ppp3cb 33
  • 95.11 (n)
chicken
(Gallus gallus)
Aves PPP3CB 33 34
  • 87.09 (n)
lizard
(Anolis carolinensis)
Reptilia PPP3CB 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp3cc 33
  • 84.29 (n)
zebrafish
(Danio rerio)
Actinopterygii ppp3cb 34
  • 84 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta PpD33 35
  • 80 (a)
CanA-14F 35 34
  • 78 (a)
Pp2B-14D 35 34
  • 78 (a)
CanA1 35 33 34
  • 64.14 (n)
worm
(Caenorhabditis elegans)
Secernentea tax-6 34
  • 68 (a)
OneToMany
C25A6.1 35
  • 47 (a)
F42G8.8 35
  • 33 (a)
ZC477.2 35
  • 33 (a)
F49E11.7 35
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMP2 33 34
  • 59.13 (n)
CNA1 34
  • 47 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8703 34
  • 68 (a)
OneToMany
Species where no ortholog for PPP3CB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP3CB Gene

ENSEMBL:
Gene Tree for PPP3CB (if available)
TreeFam:
Gene Tree for PPP3CB (if available)

Paralogs for PPP3CB Gene

Paralogs for PPP3CB Gene

(10) SIMAP similar genes for PPP3CB Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PPP3CB: view

Variants for PPP3CB Gene

Sequence variations from dbSNP and Humsavar for PPP3CB Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000032232 -- 73,482,194(-) G/A intron_variant
rs1000041539 -- 73,438,247(-) G/A 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, stop_gained
rs1000042074 -- 73,489,607(-) C/T intron_variant
rs1000146114 -- 73,482,418(-) C/G intron_variant
rs1000257955 -- 73,463,626(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP3CB Gene

Variant ID Type Subtype PubMed ID
esv2534689 CNV deletion 19546169
nsv831911 CNV loss 17160897

Variation tolerance for PPP3CB Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP3CB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP3CB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP3CB Gene

Disorders for PPP3CB Gene

Additional Disease Information for PPP3CB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPP3CB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP3CB Gene

Publications for PPP3CB Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2. (PMID: 11005320) Brogan IJ … Hutchinson IV (Transplant immunology 2000) 3 22 58
  3. Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively. (PMID: 8978785) Wang MG … McBride OW (Cytogenetics and cell genetics 1996) 3 22 58
  4. Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2B beta. (PMID: 1848109) McPartlin AE … Cohen PT (Biochimica et biophysica acta 1991) 3 4 58
  5. Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit. (PMID: 1659808) Giri PR … Kincaid RL (Biochemical and biophysical research communications 1991) 2 3 58

Products for PPP3CB Gene

Sources for PPP3CB Gene

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