Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP3CB Gene

Aliases for PPP3CB Gene

  • Protein Phosphatase 3 Catalytic Subunit Beta 2 3 5
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Beta Isoform 2 3
  • Calmodulin-Dependent Calcineurin A Subunit Beta Isoform 3 4
  • Protein Phosphatase 2B, Catalytic Subunit, Beta Isoform 2 3
  • Protein Phosphatase 3, Catalytic Subunit, Beta Isozyme 2 3
  • CAM-PRP Catalytic Subunit 3 4
  • Calcineurin A Beta 2 3
  • CNA Beta 3 4
  • CALNA2 3 4
  • CALNB 3 4
  • CNA2 3 4
  • Protein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Beta Isoform (Calcineurin A Beta) 2
  • Serine/Threonine-Protein Phosphatase 2B Catalytic Subunit Beta Isoform 3
  • Protein Phosphatase From PCR Fragment H32 3
  • Calcineurin A2 3
  • EC 4
  • PP2Bbeta 3

External Ids for PPP3CB Gene

Previous HGNC Symbols for PPP3CB Gene


Previous GeneCards Identifiers for PPP3CB Gene

  • GC10M073975
  • GC10M074299
  • GC10M075088
  • GC10M074541
  • GC10M074866
  • GC10M075196
  • GC10M069190

Summaries for PPP3CB Gene

GeneCards Summary for PPP3CB Gene

PPP3CB (Protein Phosphatase 3 Catalytic Subunit Beta) is a Protein Coding gene. Diseases associated with PPP3CB include Pancreatic Ductal Adenocarcinoma. Among its related pathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and hydrolase activity. An important paralog of this gene is PPP3CA.

UniProtKB/Swiss-Prot for PPP3CB Gene

  • Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:26794871). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).

Gene Wiki entry for PPP3CB Gene

Additional gene information for PPP3CB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP3CB Gene

Genomics for PPP3CB Gene

GeneHancer (GH) Regulatory Elements for PPP3CB Gene

Promoters and enhancers for PPP3CB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J073493 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.7 722 3.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF143 PPP3CB PPP3CB-AS1 NDST2 CFAP70 SEC24C AP3M1 ZSWIM8 ECD ENSG00000272140 GLUD1P3
GH10J073640 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 650.1 -145.5 -145503 2.2 ZNF335 MEF2D CEBPB SPI1 MYOZ1 PPP3CB NUDT13 ENSG00000272791 GC10P073609
GH10J073584 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.9 -90.3 -90317 2.9 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF143 GC10P073587 ENSG00000272140 AGAP5 GLUD1P3 SEC24C NUDT13 DUSP8P5 ZSWIM8 ZSWIM8-AS1 ENSG00000242288
GH10J073575 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.7 -81.3 -81285 3 FOXA2 INSM2 ZNF2 IRF4 RAD21 YY1 ZNF335 FOS IKZF2 ZNF362 USP54 SYNPO2L RNU6-883P NUDT13 PPP3CB CAMK2G CFAP70 C10orf55 GC10P073575 GC10P073587
GH10J073588 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.3 -95.3 -95288 5.9 PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 ZNF766 ZNF213 NUDT13 USP54 ECD ZSWIM8-AS1 NDST2 ZSWIM8 RNU6-883P ENSG00000272791 AGAP5 SYNPO2L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP3CB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP3CB gene promoter:
  • AREB6
  • Tal-1beta
  • ITF-2
  • RREB-1
  • p53
  • AML1a
  • Meis-1
  • Meis-1a

Genomic Locations for PPP3CB Gene

Genomic Locations for PPP3CB Gene
59,597 bases
Minus strand
59,597 bases
Minus strand

Genomic View for PPP3CB Gene

Genes around PPP3CB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP3CB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP3CB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP3CB Gene

Proteins for PPP3CB Gene

  • Protein details for PPP3CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    Protein Accession:
    Secondary Accessions:
    • P16299
    • Q5F2F9
    • Q8N1F0
    • Q8N3W4

    Protein attributes for PPP3CB Gene

    524 amino acids
    Molecular mass:
    59024 Da
    Name=Fe(3+); Xref=ChEBI:CHEBI:29034;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). In response to an increase in Ca(2+) intracellular levels, forms a complex composed of PPP3CB/calcineurin A, calcineurin B and calmodulin. Interacts (via calcineurin B binding domain) with regulatory subunit PPP3R1/calcineurin B. Interacts (via calmodulin-binding domain) with calmodulin; the interaction depends on calmodulin binding to Ca(2+).
    • Unlike for protein substrates, PPP3CB activity towards synthetic phosphatase substrate p-nitrophenyl phosphate (pNPP) is increased in presence of the immunosuppressant complex FKBP12-FK506.

    Three dimensional structures from OCA and Proteopedia for PPP3CB Gene

    Alternative splice isoforms for PPP3CB Gene


neXtProt entry for PPP3CB Gene

Post-translational modifications for PPP3CB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP3CB Gene

Domains & Families for PPP3CB Gene

Gene Families for PPP3CB Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • The poly-Pro domain may confer substrate specificity.
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
  • The poly-Pro domain may confer substrate specificity.
  • The autoinhibitory domain prevents access to the catalytic site.
  • The autoinhibitory segment prevents access to the substrate binding site.
  • Belongs to the PPP phosphatase family. PP-2B subfamily.
genes like me logo Genes that share domains with PPP3CB: view

Function for PPP3CB Gene

Molecular function for PPP3CB Gene

UniProtKB/Swiss-Prot Function:
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:26794871). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)-bound calmodulin following an increase in intracellular Ca(2+). At low Ca(2+) concentrations, the catalytic subunit (also known as calcineurin A) is inactive and is bound to the regulatory subunit (also known as calcineurin B) in which only two high-affinity binding sites are occupied by Ca(2+). In response to elevated calcium levels, the occupancy of the low-affinity sites on calcineurin B by Ca(2+) causes a conformational change of the C-terminal regulatory domain of calcineurin A, resulting in the exposure of the calmodulin-binding domain and in the partial activation of calcineurin A. The subsequent binding of Ca(2+)-bound calmodulin leads to the displacement of the autoinhibitory domain from the active site and possibly of the autoinhibitory segment from the substrate binding site which fully activates calcineurin A.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.69 uM for NFATC1 {ECO:0000269 PubMed:19154138}; KM=0.7 uM for DARPP32 {ECO:0000269 PubMed:19154138};
GENATLAS Biochemistry:
calcineurin A beta isoform,calmodulin dependent serine/threonine phosphatase 2B,catalytic subunit,19kDa,also abundantly expressed in the central nervous system,including the hyppocampus,involved in osteoclast regulation

Enzyme Numbers (IUBMB) for PPP3CB Gene

Gene Ontology (GO) - Molecular Function for PPP3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA,NAS 8392375
GO:0005509 calcium ion binding IDA 8524402
GO:0005515 protein binding IPI 21903422
GO:0005516 calmodulin binding NAS 8524402
genes like me logo Genes that share ontologies with PPP3CB: view
genes like me logo Genes that share phenotypes with PPP3CB: view

Animal Models for PPP3CB Gene

MGI Knock Outs for PPP3CB:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPP3CB

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP3CB Gene

Localization for PPP3CB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP3CB Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP3CB gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 19154138
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA,ISS --
GO:0005955 calcineurin complex IDA 8524402
genes like me logo Genes that share ontologies with PPP3CB: view

Pathways & Interactions for PPP3CB Gene

genes like me logo Genes that share pathways with PPP3CB: view

SIGNOR curated interactions for PPP3CB Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PPP3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001915 negative regulation of T cell mediated cytotoxicity IEA --
GO:0001946 lymphangiogenesis IEA --
GO:0006468 protein phosphorylation ISS,IEA --
GO:0006470 protein dephosphorylation IEA,ISS --
GO:0007165 signal transduction NAS 8978785
genes like me logo Genes that share ontologies with PPP3CB: view

Drugs & Compounds for PPP3CB Gene

(6) Drugs for PPP3CB Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
Pimecrolimus Approved, Investigational Pharma 64
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0

(1) Additional Compounds for PPP3CB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
genes like me logo Genes that share compounds with PPP3CB: view

Transcripts for PPP3CB Gene

Unigene Clusters for PPP3CB Gene

Protein phosphatase 3, catalytic subunit, beta isozyme:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP3CB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18a ·
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - -
SP7: - - - - -
SP8: - -
SP9: -
SP10: - - - - - -
SP11: -

ExUns: 18b

Relevant External Links for PPP3CB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP3CB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP3CB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP3CB Gene

This gene is overexpressed in Brain (15.1), Fetal Brain (13.9), Frontal cortex (9.6), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP3CB Gene

Protein tissue co-expression partners for PPP3CB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP3CB Gene:


SOURCE GeneReport for Unigene cluster for PPP3CB Gene:


Evidence on tissue expression from TISSUES for PPP3CB Gene

  • Nervous system(4.4)
  • Muscle(3.2)
  • Heart(2.9)
  • Kidney(2.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with PPP3CB: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP3CB Gene

Orthologs for PPP3CB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPP3CB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP3CB 34 33
  • 99.93 (n)
(Monodelphis domestica)
Mammalia PPP3CB 34
  • 99 (a)
(Canis familiaris)
Mammalia PPP3CB 34 33
  • 97.9 (n)
(Bos Taurus)
Mammalia PPP3CB 34 33
  • 97.84 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 96 (a)
-- 34
  • 82 (a)
(Mus musculus)
Mammalia Ppp3cb 16 34 33
  • 95.94 (n)
(Rattus norvegicus)
Mammalia Ppp3cb 33
  • 95.11 (n)
(Gallus gallus)
Aves PPP3CB 34 33
  • 87.09 (n)
(Anolis carolinensis)
Reptilia PPP3CB 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp3cc 33
  • 84.29 (n)
(Danio rerio)
Actinopterygii ppp3cb 34
  • 84 (a)
fruit fly
(Drosophila melanogaster)
Insecta PpD33 35
  • 80 (a)
Pp2B-14D 34 35
  • 68 (a)
CanA-14F 34 35
  • 66 (a)
CanA1 34 35 33
  • 64.14 (n)
(Caenorhabditis elegans)
Secernentea tax-6 34
  • 68 (a)
C25A6.1 35
  • 47 (a)
F42G8.8 35
  • 33 (a)
ZC477.2 35
  • 33 (a)
F49E11.7 35
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMP2 34 33
  • 59.13 (n)
CNA1 34
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8703 34
  • 68 (a)
Species where no ortholog for PPP3CB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP3CB Gene

Gene Tree for PPP3CB (if available)
Gene Tree for PPP3CB (if available)
Evolutionary constrained regions (ECRs) for PPP3CB: view image

Paralogs for PPP3CB Gene

Paralogs for PPP3CB Gene

(10) SIMAP similar genes for PPP3CB Gene using alignment to 5 proteins:

  • B7Z6P2_HUMAN
  • F5H0F8_HUMAN
  • Q5F2F8_HUMAN
  • Q5F2G0_HUMAN
genes like me logo Genes that share paralogs with PPP3CB: view

Variants for PPP3CB Gene

Sequence variations from dbSNP and Humsavar for PPP3CB Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000032232 -- 73,482,194(-) G/A intron_variant
rs1000041539 -- 73,438,247(-) G/A 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, stop_gained
rs1000042074 -- 73,489,607(-) C/T intron_variant
rs1000146114 -- 73,482,418(-) C/G intron_variant
rs1000257955 -- 73,463,626(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP3CB Gene

Variant ID Type Subtype PubMed ID
esv2534689 CNV deletion 19546169
nsv831911 CNV loss 17160897

Variation tolerance for PPP3CB Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP3CB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP3CB Gene

Disorders for PPP3CB Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP3CB Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP3CB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PPP3CB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP3CB Gene

Publications for PPP3CB Gene

  1. Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. (PMID: 26794871) Li SJ … Wang ZX (Cell research 2016) 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding. (PMID: 19154138) Kilka S … Weiwad M (Biochemistry 2009) 3 4 58
  4. Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2. (PMID: 11005320) Brogan IJ … Hutchinson IV (Transplant immunology 2000) 3 22 58
  5. Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively. (PMID: 8978785) Wang MG … McBride OW (Cytogenetics and cell genetics 1996) 3 22 58

Products for PPP3CB Gene

Sources for PPP3CB Gene

Loading form....